Journal of the Iranian Chemical Society最新文献

{"title":"Deep eutectic solvent-modified magnetic NiFe2O4 polyamidoamine dendrimers for the simultaneous separation and extraction of naproxen and nabumetone and determination by HPLC: isotherm and thermodynamic study","authors":"Maryam Dehghani Soltani,&nbsp;Shayessteh Dadfarnia,&nbsp;Ali Mohammad Haji Shabani","doi":"10.1007/s13738-024-03153-0","DOIUrl":"10.1007/s13738-024-03153-0","url":null,"abstract":"<div><p>A novel dispersive magnetic micro-solid-phase extraction (DM-µ-SPE) method based on the magnetic NiFe₂O₄ polyamidoamine dendrimers modified with deep eutectic solvent sorbent has been developed for the extraction of naproxen and nabumetone. The extracted analytes were quantified by a high-performance liquid chromatographic (HPLC) method with UV detection at 280 nm. The linearity was in the range of 1–400 µg L⁻¹ for naproxen and 3–400 µg L⁻¹ for nabumetone. The developed DM-µ-SPE/HPLC–UV method has been characterized by excellent intra- and inter-day repeatability of 2.3, 3.3, and 2.5, 4.0%, respectively, for naproxen and nabumetone at the concentration level of 70.0 µg L⁻¹ (<i>n</i> = 5). Enhancement factors of 157.7 and 151.8 and limit of detections of 0.15 µg L⁻¹ and 0.26 µg L⁻¹ for naproxen and nabumetone were achieved, respectively. The sorption isotherm study illustrated that the experimental data of NAP fitted better to the Langmuir isotherm with a maximum monolayer sorption capacity of 76.92 mg g⁻¹, while the NAB data fitted to the Temkin isotherm model. The method was successfully applied to the determination of non-steroidal anti-inflammatory drug analytes in water and milk samples.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"22 2","pages":"349 - 361"},"PeriodicalIF":2.2,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143184866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of purification techniques for alpha-lipoic acid derivative, sodium zinc histidine dithiooctanamide using ethanol-based crystallization and suspension methods","authors":"Naoya Ohmori,&nbsp;Takamitsu Miyagi,&nbsp;Toshiaki Nakano,&nbsp;Simon Peter Bahau,&nbsp;Yohei Kono,&nbsp;Toshikazu Adachi,&nbsp;Satoshi Hiratsuka,&nbsp;Shigeru Goto,&nbsp;Masafumi Inomata,&nbsp;Takeshi Goto","doi":"10.1007/s13738-024-03151-2","DOIUrl":"10.1007/s13738-024-03151-2","url":null,"abstract":"<div><p>Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food. It is well defined as a therapy for preventing diabetic polyneuropathies, scavenges free radicals, chelates metals, and restores intracellular glutathione levels which otherwise decline with age.</p><p>Sodium zinc histidine dithiooctanamide (DHL-HisZn_Na) is a water-soluble substance, with strong antioxidant and anti-inflammatory properties, similar to α-lipoic acid with histidine bound to α-lipoic acid and zinc chelated with sulfur atoms. DHL-HisZn_Na slowly loses its stability under dry conditions in the dark and under refrigeration. Purification is essential for use after long-term storage. In this study, ethanol crystallization and suspension methods were utilized in development for the first time as purification methods for DHL-HisZn_Na.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"22 2","pages":"325 - 335"},"PeriodicalIF":2.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143184861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solvothermal method synthesized SnS nanoplates composites for electrochemical sensing of toxic ions Hg2+ and Pb2+","authors":"Vijaya Talapatadur,&nbsp;S. S. Hegde,&nbsp;N. Basavaraju,&nbsp;K. Ramesh","doi":"10.1007/s13738-024-03145-0","DOIUrl":"10.1007/s13738-024-03145-0","url":null,"abstract":"<div><p>Tin sulfide (SnS) semiconductors have become emerging sensor materials for the electrochemical sensing of heavy metals in trace amounts due to their supportive electrochemical properties. This study reports the synthesis, characterization of SnS/rGO composites and sensing of mercury and lead ions in an aqueous solution. SnS/rGO composites with the proper loading of rGO concentration were synthesized using simple solvothermal method and applied for sensing the heavy metals of mercury and lead ions. The synthesized samples were characterized by XRD, FE-SEM, TEM, FTIR and Raman spectroscopy to study the structure and morphology of the samples. Cyclic voltammetry and AC impedance were used to characterize the samples for electrochemical detection of toxic metals Hg and Pb ions. The XRD analysis reveals that the average crystallite of SnS/rGO nanoplates is in the range of 56–67 nm and was confirmed by TEM. FE-SEM analysis reveals the formation of nanoplates on rGO sheets. Raman spectroscopy and FTIR analysis confirm the presence of rGO and the composition of the prepared sample. The electrochemical sensing of SnS and SnS/rGO nanoplates with graphite powder in 0.1 M KOH solution showed good reversibility and was applied for sensing of HgCl₂ and PbCl₂ with a quick response time of 2 s. The LOD for Hg and Pb ions was found to be 47.3–65.3 ppm, respectively. All the prepared electrodes of SnS and SnS/rGO composites could be effectively supported by the electrochemical sensing response to HM ions in alkali medium.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"22 1","pages":"231 - 242"},"PeriodicalIF":2.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142995296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simulation-based insights into Remdesivir coating on Ag nanoparticles for optimized COVID-19 drug delivery","authors":"Seyedeh Seddigheh Mousavian,&nbsp;Farhad Shirini,&nbsp;Hossein Taherpour Nahzomi","doi":"10.1007/s13738-024-03147-y","DOIUrl":"10.1007/s13738-024-03147-y","url":null,"abstract":"<div><p>Remdesivir (RDV) is a drug that exhibits broad-spectrum antiviral against RNA viruses, and so this drug could be an appropriate therapeutic candidate. To increase the therapeutic efficiency of Remdesivir, nanoparticles are employed to prolong bioavailability and facilitate targeted delivery in the body and the drug transportation. In this study, we employed classical atomistic molecular dynamics simulations to characterize the adsorption properties of this compound on Ag nanoparticles. The simulation results show that Remdesivir molecules adsorb onto the surface of Ag nanoparticles in a size-dependent manner, so that smaller AgNPs exhibit a higher degree of Remdesivir coating than larger ones. The results also show that the coating of Remdesivir molecules on nanoparticles can improve their pharmacokinetic properties in vivo studies. These findings provide a basis for designing nanoparticle-based drug delivery systems. </p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"22 2","pages":"271 - 281"},"PeriodicalIF":2.2,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143184742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer activity of new quinolinyl–benzothiazolyl clubbed with amino acids and their in-silico studies","authors":"S. Shashidhar Bharadwaj,&nbsp;Boja Poojary,&nbsp;Sathish Kumar Boda,&nbsp;T. Shubhavathi,&nbsp;Vinuta Kamat,&nbsp;Bhuvanesh Sukhlal Kalal","doi":"10.1007/s13738-024-03144-1","DOIUrl":"10.1007/s13738-024-03144-1","url":null,"abstract":"<div><p>A lot of research is focused on creating novel chemotherapeutic medicines since cancer is becoming a more serious concern. In the present investigation, we have developed some quinolinyl–benzothiazolyl linked with amino acids and their anticancer efficacy against melanoma and breast cancer cells evaluated. All the compounds evaluated for in silico studies towards the target protein Human estrogen receptor (PDB: 2IOK). Out of all the evaluated aminoacids conjugates four compounds <b>5b</b>, <b>5 k</b>, <b>5f</b>, and <b>5d</b> exhibited remarkable docking scores and were chosen for in vitro anticancer studies. Out of which <b>5 k</b>, and <b>5f</b> exhibited good anticancer properties with the IC₅₀[μg/mL] of 22.9 and 22.3 respectively against the melanoma cell line and <b>5b</b> exhibited good anticancer properties with the IC₅₀[μg/mL] of 61.0 against breast cancer cell.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"22 1","pages":"219 - 230"},"PeriodicalIF":2.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142994702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming theophylline-7-acetic acid into novel beta-lactam derivatives via an unstable ketene containing imidazole moiety and assessing their antibacterial efficacy","authors":"Parvaneh Agharezaei,&nbsp;Mohammad Reza Islami,&nbsp;Kazem Saidi,&nbsp;Payam Khazaeli","doi":"10.1007/s13738-024-03146-z","DOIUrl":"10.1007/s13738-024-03146-z","url":null,"abstract":"<div><p>New β-lactams was synthesized by reacting theophylline-7-acetic acid with various Schiff bases in dry CH₂Cl₂ under a nitrogen atmosphere, utilizing the Mukaiyama reagent. The resulting β-lactams featured the theophylline moiety situated at the one position of the four-membered β-lactam ring. This approach represents a formal [2 + 2] cycloaddition of an imine to a novel ketene containing a theophyllinyl group. Remarkably, this chemoselective reaction exclusively yielded the <i>cis</i>-isomer of the β-lactam compound as the sole product. Subsequently, the newly synthesized compounds were evaluated for their antibacterial properties. The findings revealed that compounds <b>5f</b> and <b>5g</b> exhibited noteworthy antibacterial effects among the tested β-lactams. Specifically, compound <b>5f</b> demonstrated activity against <i>Staphylococcus aureus</i> PTCC 2923, while compound <b>5g</b> displayed activity against both Gram-negative bacteria and <i>Staphylococcus epidermidis</i> PTCC 1435.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"22 2","pages":"263 - 270"},"PeriodicalIF":2.2,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143184729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and comparison of the drug delivery systems of pegylated doxorubicin loaded Zn-CP and Zn-CP-SO3H","authors":"Zeinab Bakhoda,&nbsp;Shayessteh Dadfarnia,&nbsp;Ali Mohammad Haji Shabani,&nbsp;Ali Dehshahri,&nbsp;Marzieh Baneshi,&nbsp;Delaram Moghadam","doi":"10.1007/s13738-024-03148-x","DOIUrl":"10.1007/s13738-024-03148-x","url":null,"abstract":"<div><p>In this investigation, a zinc coordination polymer of 5-aminoisophtalic acid [Zn(AIP)(DMSO)]_n called (Zn-CP) was employed as a drug delivery system. The surface of Zn-CP was modified with an acidic SO₃H group, and its capability for doxorubicin (Dox) delivery was compared to unmodified Zn-CP. The stability, specificity, cellular solubility, and loading/release process as well as the capability of inducing late apoptosis in MCF7 cells were improved through the pegylation of Dox-loaded carriers. The morphology of the designed carriers was evaluated using different analytical methods. Functionalizing the surface of Zn-CP with an acidic group increases its water solubility, drug loading, controlled release, and biocompatibility. The Dox loading and loading efficiency for Zn-CP@PEG were 28.8, and 40.6%, respectively, whereas, for Zn-CP-SO₃H@PEG were 33.0, and 51.2%, respectively. Zn-CP-SO₃H has a higher capacity of Dox loading than Zn-CP and Dox@Zn-CP-SO₃H@PEG has more control over the drug release as well as better specificity toward the cancerous cells of MCF7 than the surface unmodified carrier. The cytotoxicity study shows that modification of the Zn-CP surface with acidic groups of SO₃H decreases its cytotoxicity. The Dox@Zn-CP@PEG and Dox@Zn-CP-SO₃H@PEG exhibited high cytotoxic activity against cancer cells of MCF7, and remarkably low toxicity to normal breast cells of MCF10.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"22 2","pages":"283 - 295"},"PeriodicalIF":2.2,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143184764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and antimicrobial evaluation of some novel heterocyclic compounds based on azo chromene moiety","authors":"Asmaa Abd Elhaleem,&nbsp;Sawsan A. Fouad,&nbsp;Sadia A. Hessein,&nbsp;Nadia A. M. Shmiess,&nbsp;Ghada E. Ahmed","doi":"10.1007/s13738-024-03138-z","DOIUrl":"10.1007/s13738-024-03138-z","url":null,"abstract":"<div><p>Developing new agents for treating bacterial and fungal resistance remain a top priority in developing countries because the antibiotic resistance is one of the major threats to human health. Thus, the current work was designed to synthesize a new series of chromene and pyrazole derivatives based on 2-hydroxy-5-((4-nitrophenyl) diazenyl) benzaldehyde moiety. The structure of the designed derivatives was confirmed using different spectroscopic techniques (FT-IR and NMR) and elemental analysis. Most of the designed derivatives were evaluated against six standard microbial strains. Compounds <b>3</b>, <b>12</b>, <b>13</b> and <b>16</b> showed excellent antimicrobial activity against <i>S</i>. <i>faecalis</i> with MIC (3.91) µg/ml closed to Penicillin G and MBC values (15.6, 31.3) µg/ml. In addition, chromene <b>14</b> exhibited an inhibition effect better than the positive control <i>Penicillin G</i> with MIC (1.95) µg/ml and MBC value (31.3) µg/ml.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"22 1","pages":"161 - 176"},"PeriodicalIF":2.2,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142994698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and characterization of Fe3O4@TiO2@Zeolite nanocomposite adsorbent for the removal of Levoflaxin antibiotic from environmental water matrices","authors":"Denga Ramutshatsha-Makhwedzha,&nbsp;Mapula Lucey Mavhungu,&nbsp;Jeffrey Baloyi,&nbsp;Richard Mbaya","doi":"10.1007/s13738-024-03135-2","DOIUrl":"10.1007/s13738-024-03135-2","url":null,"abstract":"<div><p>The presence of pharmaceuticals in water matrices has been a major problem because of its expected adverse consequences on oceanic biological systems and human well-being. Levofloxacin (Levo), a persistent and widely used antibiotic, has emerged as a significant pollutant in water samples. Its resistance to conventional water treatment processes poses challenges for its removal. This work focuses on preparing and characterizing a magnetic nanocomposite adsorbent (Fe₃O₄@TiO₂@Zeolite) designed to efficiently remove levofloxacin from the water samples, leveraging the Fe₃O₄ properties for easy separation and recovery of the adsorbent, TiO₂ for its adsorption capacity, while zeolite’s porous structure and high ion-exchange capacity improve adsorption efficiency. Together, these materials create a robust, multifunctional composite with promising applications for pollutant removal from aqueous environments. The adsorption of Levo antibiotic exhibited excellent fitting to both the pseudo-second-order model (<i>R</i>² = 1) and the Langmuir isotherm (<i>R</i>² = 0.9240) together with the Freundlich isotherm (<i>R</i>² = 0.999). Furthermore, the thermodynamic analysis indicated that the adsorption process of Levo was spontaneous and endothermic. This implies that the interaction between Levo and the Fe₃O₄@TiO₂@Zeolite nanocomposite, developed in this study, is favourable and requires energy input. The Fe₃O₄@TiO₂@Zeolite nanocomposite demonstrated a promising efficacy in the removal of Levo from wastewater samples, with removal percentage ranging between 92.43 and 96.95%. The prepared Fe₃O₄@TiO₂@Zeolite composite material could be regenerated up to the 5th cycle. This highlights the potential of the nanocomposite as an effective remedy for the purification of wastewater contaminated with Levo.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"22 1","pages":"113 - 128"},"PeriodicalIF":2.2,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13738-024-03135-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142994512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decarboxylative Cross-Coupling of Aryl Carboxylic Acids with Arylboronic Acids Using Ag/ZnO Catalyst under Aerobic Conditions in Aqueous Medium","authors":"Fatemeh Zeraatpisheh,&nbsp;Zahra Bazyar","doi":"10.1007/s13738-024-03131-6","DOIUrl":"10.1007/s13738-024-03131-6","url":null,"abstract":"<div><p>Recently, transition metal-catalyzed decarboxylative cross-coupling reactions have become a novel and crucial category of organic transformations. These reactions have practical applications in constructing carbon–carbon bonds. This study presents the efficient catalytic activity of Ag/ZnO nanoparticles that were synthesized and used as a heterogeneous catalyst in the carbon–carbon bond formation starting from carboxylic acids. By utilizing the heterogeneous Ag catalyst system, the Suzuki–Miyaura coupling reaction was effectively carried out in an aqueous environment, resulting in the formation of coupling products with high yields in a relatively short period of time. The Ag/ZnO nanoparticles were thoroughly characterized using various techniques, and inductively coupled plasma. The findings affirm that the prepared catalyst, comprising Ag/ZnO nanoparticles, exhibits exceptional efficiency and selectivity, with the added advantage of being recyclable multiple times without a significant decline in catalytic activity.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"22 1","pages":"83 - 89"},"PeriodicalIF":2.2,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142994561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}