Journal of the Iranian Chemical Society最新文献

{"title":"Retention of the N-nitrosodiethanolamine by hydrophilic interaction liquid chromatography on different polar columns: mechanism study and optimization","authors":"Ghazaleh Abedi,&nbsp;Zahra Talebpour,&nbsp;Arezu Hosseiny","doi":"10.1007/s13738-024-03085-9","DOIUrl":"10.1007/s13738-024-03085-9","url":null,"abstract":"<div><p>To investigate the retention mechanism of N-nitrosodiethanolamine (NDELA) in liquid chromatography, the mobile phase composition was changed on five stationary phases including silica, diol, cyano, amino, and zwitterionic. Afterward, temperature, pH, and buffer concentration effects are studied. Results demonstrate a dual hydrophilic interaction liquid chromatography (HILIC)-reversed phase (RP) mechanism for the retention of NDELA. The transition between the HILIC and RP behavior on a different column, “U-turn” points, was observed between 43 and 68% of water in acetonitrile. The depiction of the natural logarithm of retention factor vs. inverse of the absolute temperature was linear for cyano, amino, and zwitterionic columns. In contrast, it was curvature for silica and diol columns. In each column, the positive slopes indicate a negative retention enthalpy, signifying an exothermic process of transferring analytes from the mobile phase to the stationary phases being examined. In the case of buffer pH and concentration, an ammonium acetate solution with a pH of 5.7 and a concentration of 10 mM was selected for further investigation. Finally, the selectivity of this method in optimal conditions for the analysis of NDELA in shampoo has been investigated. According to the well-obtained selectivity of NDELA in shampoo and the advantages of the HILIC method, this method seems to be a suitable alternative to RP methods.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 9","pages":"2477 - 2487"},"PeriodicalIF":2.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, characterization and anti-microbiological evaluation of 2-[(2,6-diaryl piperidin-4-yl)hydrazono]-2,3-dihydrothiazoles as a new class of antimicrobial agents","authors":"N. Sarathi,&nbsp;S. L. Ashok Kumar,&nbsp;C. Sankar","doi":"10.1007/s13738-024-03090-y","DOIUrl":"10.1007/s13738-024-03090-y","url":null,"abstract":"<div><p>A series of 2-[(2,6-diarylpiperidin-4-yl)hydrazono]-2,3-dihydrothiazoles (<b>25–40</b>) were synthesized by the reaction of respective thiosemicarbazones (<b>9–24</b>) with phenacyl bromide in the presence of sodium acetate-acetic acid buffer and refluxing in ethanol for 12–16 h. The newly synthesized target compounds were characterized by elemental analysis, mass, FT-IR, ¹H and ¹³C NMR spectroscopic methods. A Structure activity relationship study was carried out for the title compounds against a panel of bacterial strains viz<i> Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Pseudomonas aeruginosa</i>, <i>Salmonella typhi, Bacillus subtilis</i> and <i>Klebsiella pneumonia</i> and the fungal strains <i>Cryptococcus neoformans</i>, <i>Candida albicans</i>, <i>Rhizopus sp, Aspergillus niger and Aspergillus flavus</i>, respectively, using ciprofloxacin and amphotericin-B as standard drugs. These studies proved that compounds <b>26</b> and <b>34</b> against <i>Staphylococcus aureus</i>, <b>35</b> against <i>P. aeruginosa,</i> <b>38</b> against <i>B. subtilis</i>, and <b>27</b> against <i>K. pneumonia</i> showed maximum inhibitory potency at the lowest concentration (6.25 µg/mL), whereas <b>26</b>, <b>34</b> and <b>35</b> against <i>C. neoformans</i> and <b>26</b> and <b>27</b> against <i>Candida albicans</i> showed beneficial antifungal activity at a minimum concentration (MIC) of 6.25 µg/mL.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 9","pages":"2517 - 2529"},"PeriodicalIF":2.2,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, synthesis, biological evaluation and molecular docking studies of thiophene derivatives","authors":"Rashmi Shah,&nbsp;Prabhakar Kumar Verma,&nbsp;Manisha Shah,&nbsp;Satendra Kumar","doi":"10.1007/s13738-024-03088-6","DOIUrl":"10.1007/s13738-024-03088-6","url":null,"abstract":"<div><p>A series of 1-(2-amino-2,4,5,6,7,7a-hexahydrobenzo[<i>b</i>]-3-yl)-3-substitued-phenylpropane-1,3-dionederivatives were synthesized using the Gewald synthesis in first step which is followed by Baker−Venkataraman rearrangement to yield title compounds. The FTIR, MS and 1H NMR results of the produced derivatives were validated. The biological potential such as antimicrobial, antioxidant and antimycobacterial activity against a particularly virulent strain of MTB (MTB H37Ra) of the synthesized compounds were examined. Antimicrobial screening outcomes showed that compound <i>S</i>₁₇ turned to be the most effective antibacterial agent against Gram positive bacteria such as <i>Staphylococcus aureus</i> (MIC = 16.87 µM) and <i>Bacillus subtilis</i> (MIC = 9.45 µM) and Gram negative bacteria such as <i>Escherichia coli</i> (MIC = 16.87 µM) and compound <i>S</i>₇ against <i>Salmonella typhi</i> (MIC = 9.74 µM) and compound <i>S</i>₁₆ displayed remarkable antifungal activity toward each <i>Candida albicans</i> and <i>Aspergillus niger</i> (MIC = 15.23 µM). The standard drugs, cefadroxil (antibacterial), have MIC value against <i>S. aureus, B. subtilis, E. coli</i> and <i>S. Typhi are</i> 16.40 µM, 32.80 µM, 16.40 µM and 16.40 µM, respectively, and fluconazole (antifungal) has MIC value 20.40 µM against both the <i>C. albicans</i> and <i>A.niger</i> strain. In comparison with ascorbic acid, a standard drug (IC₅₀ 44.91 µg/mL), compound <i>S</i>₁₀ demonstrated good antioxidant activity, with an IC₅₀ value of 45.29 µg/mL, according to the results of the antioxidant screening. The results of the in vitro antituberculosis screening showed that compound <i>S</i>₂₃ was found to be effective with an MIC value of 78.125 µg/mL. Molecular docking study of an enzymatic active site of “<i>DprE1-decaprenylphosphoryl-β-D-ribose-2′-epimerase</i>” shows a comparable binding mode to the native ligand with better docking score which contributes in understanding and development of models for ligand–protein interactions. Compound <i>S</i>₂₃ showed better docking score of − 8.516 as compared to the Isoniazid with the docking score of − 6.315 which in future will create the fundamental structural framework for MTB inhibition.</p><h3>Graphic abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 9","pages":"2501 - 2515"},"PeriodicalIF":2.2,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mono-doped (X = S2−, Se2−, and Te2−) and co-doped (Zr4+-X) TiO2 monolayer nanosheet for water splitting: DFT modeling","authors":"Nasim Orangi,&nbsp;Hossein Farrokhpour","doi":"10.1007/s13738-024-03096-6","DOIUrl":"10.1007/s13738-024-03096-6","url":null,"abstract":"<div><p>The water splitting activity of (111) TiO₂ monolayer nanosheet and its mono and co-doped forms has been investigated by the periodic density functional theory (DFT) calculations. Upon Zr⁴⁺ mono-doping and even increasing the concentration of Zr⁴⁺ dopant, the band gap of the (111) TiO₂ monolayer becomes wider than that of the corresponding pure monolayer (3.9 eV), which reduces the photocatalytic efficiency. Fortunately, (S²⁻, Se²⁻, and Te²⁻) mono-doping and their increased concentration can effectively decrease the band gap by introducing midgap states above the valence band edge for the relevant monolayers. Moreover, the (Zr⁴⁺-S²⁻), (Zr⁴⁺-Se²⁻), and (Zr⁴⁺-Te²⁻) co-doping leads to a narrowed band gap and enhances the visible-light photoactivity of the (111) TiO₂ monolayer. Among considered monolayers, the Te²⁻-doped and (Zr⁴⁺-Te²⁻) co-doped (111) TiO₂ monolayers are the most desirable photocatalysts for hydrogen generation in this work.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 10","pages":"2643 - 2657"},"PeriodicalIF":2.2,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13738-024-03096-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel acidic deep eutectic solvents: synthesis, phase diagram, thermal behavior, physicochemical properties and application","authors":"Aso Kianpoor,&nbsp;Rahmat Sadeghi","doi":"10.1007/s13738-024-03077-9","DOIUrl":"10.1007/s13738-024-03077-9","url":null,"abstract":"<div><p>Three new binary acidic deep eutectic solvents (DESs) were derived from tetrabutylammonium bromide (TBAB) as a hydrogen bond acceptor (HBA) coupled with azelaic acid (AzA), benzilic acid (BeA) and boric acid (BoA) as hydrogen bond donors (HBD). In order to draw the complete phase diagram and find the molar ratios in which the DESs are formed, HBA and HBDs were mixed together in the full range of molar ratios and their thermal behavior (by differential scanning calorimetry method) and stability were investigated. The activity coefficient models including Wilson, NRTL and regular solution were applied to correlate the measured solid–liquid equilibrium data. FT–IR and NMR analysis were used to investigate the chemical structures, occurrence the hydrogen bond formation between the DESs constituents and purity of the prepared DESs. Physicochemical properties of these DESs including melting point, density, and speed of sound, conductivity and refractive index were measured at different temperatures. The performance of these new DESs were successfully evaluated for the dissolution of four metal oxides including PbO, CuO, Fe₂O₃ and ZnO and the obtained solubility values were compared with the reported literature data.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 9","pages":"2385 - 2399"},"PeriodicalIF":2.2,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, fluorescence, enzymes effects, and evaluation of tetrahydroxy substituted zinc phthalocyanine as multitarget metabolic enzyme inhibitors with molecular docking: the biochemistry-oriented drug design","authors":"Derya Güngördü Solğun,&nbsp;Nastaran Sadeghian,&nbsp;Tugba Taskin-Tok,&nbsp;Mehmet Salih Ağirtaş,&nbsp;Parham Taslimi","doi":"10.1007/s13738-024-03079-7","DOIUrl":"10.1007/s13738-024-03079-7","url":null,"abstract":"<div><p>Synthesis and properties of tetrahydroxy substituted zinc phthalocyanine is reported. UV–Visible spectrum for the aggregation properties of the compound and fluorescence properties were examined by excitation, emission spectra. This complex was an inhibitor of butyrylcholinesterase (BChE), <i>α</i>-Gly, <i>α</i>-Amy, and acetylcholinesterase (AChE) enzymes for tetra- hydroxy phthalocyaninato zinc (II) 3 with IC50 values of 49.18 μM for <i>α</i>-Amy, 110.85 μM for BChE, 35.13 μM for <i>α</i>-glycosidase and 54.63 μM for AChE, respectively. On the otherside, within the scope of computational study, in vitro activity behavior and states of the related complex, which cannot be explained experimentally, were evaluated at atomic level. The pharmacodynamics properties of the complex (3) were elucidated by molecular docking against four target enzymes, AChE, BChE, <i>α</i>-Gly and <i>α</i>-Amy. After that, its potential drug candidate was investigated based on its pharmacokinetic properties with help of in silico-ADMET analysis. As a result of all the applications, a desired goal in medicinal chemistry was to develop new, reliable and safe cholinesterase and <i>α</i>-glycosidase inhibitors with high efficacy.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 9","pages":"2413 - 2424"},"PeriodicalIF":2.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of terminal halogen atom on the self-assembly of bisthienylethene-based rod-like molecules","authors":"Ying Pu,&nbsp;Yurun Liang,&nbsp;Xiuning Hu,&nbsp;Guoyi Li,&nbsp;Binli Deng,&nbsp;Xiaotong Liu,&nbsp;Yulong Xiao","doi":"10.1007/s13738-024-03087-7","DOIUrl":"10.1007/s13738-024-03087-7","url":null,"abstract":"<div><p>Three novel rod-like molecules containing a bisthienylethene as π-conjugate rigid core with a different type of terminal functional atom (H, Cl, Br) were constructed by using Suzuki coupling and Knoevenagel reactions. The effect of the terminal functional atom on self-assembly behaviors in both bulk state and solution states and solid structures was investigated by using differential scanning calorimetry, polarized optical microscopy, small-angle X-ray scattering diffraction, density functional theory calculations and field-emission scanning electron microscopy. The non-halogen substituted compound and chlorinated compound are non-mesogen, whereas the brominated compound can self-assemble into a monotropic single-layer smectic A phase. The non-halogen substituted compound cannot form organogel in the common organic solvents, the chlorinated compound can form yellow-green fluorescent oragnogels in ethyl acetate and acetone, with rod-like morphology and brominated compound can form yellow-green, yellow or orange fluorescent oragnogels in ethyl acetate, acetone, 1,4-dioxane and toluene with sheet-like morphology. In addition, the terminal halogen atom induced great changes in the orderliness of solid morphology. Therefore, tuning terminal halogen atom could well lead to the transition of self-assembly behaviors in bulk state and solution state, which provides a way to obtain different self-assembly materials.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 9","pages":"2489 - 2499"},"PeriodicalIF":2.2,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response surface method Box-Behnken design-based optimization of organic fertilizer enrichment using bat guano","authors":"Jülide Erkmen","doi":"10.1007/s13738-024-03083-x","DOIUrl":"10.1007/s13738-024-03083-x","url":null,"abstract":"<div><p>Agricultural environmental pollution needs to be reduced in our future. The biggest obstacles to preventing this situation are that agricultural inputs such as synthetic fertilizers increase product yield and scattered agricultural areas. This study involves the optimization of the production process of an easy-to-apply organic fertilizer with high nutritional value by subjecting bat guano, one of the valuable organic fertilizers, to anaerobic digestion together with cattle manure. Response surface method Box-Behnken design, a statistical model, was used for process optimization. The process input parameters were temperature, cattle manure, and bat manure, and the response value was considered as 2% total nitrogen. As a result of the optimization for a total nitrogen value of 2%, the optimum mixture ratio was determined as cattle manure 77.0448%, bat manure 12%, and temperature 40 °C. Analysis results showed that the addition of bat manure increased the N, P, K, and humic and fulvic acid values in the fertilizer. The study revealed that strong organic fertilizers can be used to increase the value of cattle manure organically. It also offers very promising results based on reducing agricultural pollution and ensuring agricultural sustainability.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 9","pages":"2459 - 2468"},"PeriodicalIF":2.2,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of novel quinazolinone-triheterocyclic hybrides as dual inhibition of urease and ache","authors":"Emre Menteşe,&nbsp;Yeter Ünal Güzel,&nbsp;Gülay Akyüz,&nbsp;Nesrin Ünal Karaali","doi":"10.1007/s13738-024-03080-0","DOIUrl":"10.1007/s13738-024-03080-0","url":null,"abstract":"<div><p>New triheteroyclic compounds containing quinazolinone, thiophene, andthiadiazole /thiazolidinone structureswere synthesized and characterized by FT-IR, ¹H–NMR, and¹³C–NMRspectral data. The new compounds’ inhibitory activities on urease and acetylcholinesterase were assessed. All triheterocyclic compounds with thiadiazole ring have urease and acetylcholinesteraseinhibitory activities.Especially compound 5a; 3-[(5-(phenylamino)-1,3,4-thiadiazol-2-yl]methyl-2-(thiophen-3-ylmethyl)quinazolin-4(3<i>H</i>)-onehas the best urease inhibition result with 13.30 ± 0.15 µg/mL IC₅₀ value, and it also has the best acetylcholinesterase inhibition with 20.30 ± 0.15 µg/mL IC₅₀ value.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 9","pages":"2425 - 2431"},"PeriodicalIF":2.2,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on Eu3+-doped MgAl-LDH as carrier of chlorogenic acid and their fluorescent property","authors":"Xiaoqiang Shang,&nbsp;Tingting Li,&nbsp;Fang Guo,&nbsp;Yijun Liu,&nbsp;Yufeng Chen","doi":"10.1007/s13738-024-03081-z","DOIUrl":"10.1007/s13738-024-03081-z","url":null,"abstract":"<div><p>Since drug release behavior depends on the interaction between the drugs and carriers, the present work is to study the drug delivery system based on magnesium aluminum layered double hydroxides containing europium (MgAl-Eu-LDH) for chlorogenic acid (CGA). Various characterizations, including X-ray diffraction (XRD), infrared spectrum, zeta potentials, UV–Vis absorption spectrum, scanning electron scanning electron microscope equipped with energy-dispersive X-ray spectroscopy (SEM–EDS), CHN elemental analysis, and fluorescent spectra, were employed to investigate the drug delivery system. Results revealed that the CGA was loaded into MgAl-Eu-LDH. The drug delivery system based on MgAl-Eu-LDH exhibited more slow and sustained release of CGA compared with that of the previous methotrexate or 5-fluorouracil, and the drug release experiment can be reproducible. Moreover, the MgAl-Eu-LDH showed different fluorescence before loading CGA, during loading CGA, and after releasing CGA. These results may provide a reference for the development of CGA drug delivery systems with slow and sustained release.</p></div>","PeriodicalId":676,"journal":{"name":"Journal of the Iranian Chemical Society","volume":"21 9","pages":"2433 - 2442"},"PeriodicalIF":2.2,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}