2019 IEEE International Ultrasonics Symposium (IUS)最新文献_第5页

Image-guided doxorubicin delivery with ultrasound and microbubbles in a mouse model of hepatocellular carcinoma using a diagnostic ultrasound system 超声和微泡成像引导阿霉素给药肝细胞癌小鼠模型的超声诊断系统

2019 IEEE International Ultrasonics Symposium (IUS) Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925858

Sara B. Keller, Dingjie Suo, Yak-Nam Wang, H. Kenerson, Alexandra Sestero, R. Yeung, M. Averkiou

{"title":"Image-guided doxorubicin delivery with ultrasound and microbubbles in a mouse model of hepatocellular carcinoma using a diagnostic ultrasound system","authors":"Sara B. Keller, Dingjie Suo, Yak-Nam Wang, H. Kenerson, Alexandra Sestero, R. Yeung, M. Averkiou","doi":"10.1109/ULTSYM.2019.8925858","DOIUrl":"https://doi.org/10.1109/ULTSYM.2019.8925858","url":null,"abstract":"Despite advances in chemotherapeutic drug development, hepatocellular carcinoma (HCC) is still the third leading cause of cancer-related deaths worldwide with a <30% 5-year survival rate. This poor prognosis can be attributed to the fact that HCC most commonly occurs in patients with pre-existing liver conditions, rendering many systemic options too aggressive. Patient survival rates could be improved by a more targeted approach. Ultrasound and microbubbles can provide a means for overcoming traditional barriers defining drug uptake. The goal of this work was to evaluate preclinical efficacy of image-guided drug delivery of doxorubicin with ultrasound and microbubbles. To this end, therapy settings were created on a Philips EpiQ and S5-1 phased array probe to provide focused sound for treatment. Sonovue was chosen as a clinically approved microbubble. A genetically engineered mouse model was bred and used as a physiologically relevant preclinical analog to human HCC. It was observed that ultrasound and microbubble therapy resulted in enhanced doxorubicin distribution as seen in fluorescent microscopy. Further, immediate vascular shutdown was observed in treated animals. The combination of these effects may be exploited to treat a challenging malignancy.","PeriodicalId":6759,"journal":{"name":"2019 IEEE International Ultrasonics Symposium (IUS)","volume":"1 1","pages":"1527-1530"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87567506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNN Beamforming for High Contrast Targets in the Presence of Reverberation Clutter 混响杂波存在下高对比度目标的深度神经网络波束形成

2019 IEEE International Ultrasonics Symposium (IUS) Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925715

Adam C. Luchies, B. Byram

引用次数: 2

Real-Time Thermoacoustic Imaging and Thermometry during Focused Microwave Heating in Multilayer Breast Phantom 多层乳房幻影聚焦微波加热过程中的实时热声成像和测温

2019 IEEE International Ultrasonics Symposium (IUS) Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925833

Chandra Karunakaran, Srishti Saraswat, J. Tak, Hongbo Zhao, H. Xin, R. Witte

引用次数: 4

Coherent Multi-Transducer Ultrasound Imaging with Microbubble Contrast Agents 相干多换能器超声成像与微泡造影剂

2019 IEEE International Ultrasonics Symposium (IUS) Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8926265

K. Christensen-Jeffries, L. Peralta, M. Reinwald, J. Hajnal, R. Eckersley

引用次数: 4

Sputter Process Optimization for Al0.7Sc0.3N Piezoelectric Films Al0.7Sc0.3N压电薄膜溅射工艺优化

2019 IEEE International Ultrasonics Symposium (IUS) Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925576

V. Felmetsger, M. Mikhov, M. Ramezani, R. Tabrizian

引用次数: 12

Process and Design Challenge for SMR-type Bulk Acoustic Wave (BAW) Filters at Frequencies Above 5 GHz 频率高于5 GHz的smr型体声波(BAW)滤波器的工艺和设计挑战

2019 IEEE International Ultrasonics Symposium (IUS) Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925767

M. Schaefer, R. Rothemund, G. Fattinger

引用次数: 12

RU-Net: A refining segmentation network for 2D echocardiography RU-Net:二维超声心动图的细化分割网络

2019 IEEE International Ultrasonics Symposium (IUS) Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8926158

Sarah Leclerc, Pierre-Marc Jodoin, L. Løvstakken, O. Bernard, E. Smistad, T. Grenier, C. Lartizien, A. Ostvik, F. Cervenansky, F. Espinosa, T. Espeland, Erik Andreas Rye Berg

引用次数: 21

Microstructural evolution of the abnormal crystallite grains in sputtered ScAlN film for piezo-MEMS applications 用于压电mems的溅射ScAlN薄膜中异常晶粒的微观结构演变

2019 IEEE International Ultrasonics Symposium (IUS) Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8926009

Minghua Li, J. Xie, Bangtao Chen, Nan Wang, Yao Zhu

引用次数: 12

Side Lobe Reduction Using Centroid and Flatness in Passive Cavitation Imaging 被动空化成像中利用质心和平整度减少旁瓣

2019 IEEE International Ultrasonics Symposium (IUS) Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925582

M. Jeong, Sung Jae Kwon, M. Choi

{"title":"Side Lobe Reduction Using Centroid and Flatness in Passive Cavitation Imaging","authors":"M. Jeong, Sung Jae Kwon, M. Choi","doi":"10.1109/ULTSYM.2019.8925582","DOIUrl":"https://doi.org/10.1109/ULTSYM.2019.8925582","url":null,"abstract":"Cavitation bubbles generated by high-intensity focused ultrasound strongly collapse and emit ultrasound waves. Since passive cavitation imaging can be performed using only receive focusing, side lobes appear over a wide area of an image. The delay and sum beamforming technique used to construct passive cavitation images cannot effectively image the cavitation occurrence time and spatial distribution because a small cavitation signal is buried in the side lobe of a large cavitation signal when there are a large number of cavitation bubbles. The ultrasound wave emitted when the cavitation bubble collapses is a short duration pulse. After compensating for the focusing delay, the signals due to the main lobe (at the imaging point) received at each element of the transducer array are similar in magnitude, but those due to the side lobes (other than the imaging point) is significant only at some elements of the array. Using this characteristic of the received channel data, we propose both centroid and flatness as metrics to evaluate the effect of the main and side lobes at imaging points. If the centroid of the signal magnitude distribution of the entire receiving channel is positioned at the center of the array, the signal is considered to be due to the main lobe. However, if the centroid is computed to be located near both ends of the array, the signal is considered to be due to the side lobes. If the signals are found to be due to the side lobes in passive cavitation imaging, the pixel brightness is reduced by weighting using the centroid and flatness metrics. We computed the centroid and flatness metrics using computer simulation and experimental data, and confirmed the suppression of side lobes by multiplying the image by a weight using the centroid and flatness. The proposed method makes it easier to observe cavitation by effectively removing side lobes from passive cavitation images when the number of cavitation bubbles is not large.","PeriodicalId":6759,"journal":{"name":"2019 IEEE International Ultrasonics Symposium (IUS)","volume":"28 1","pages":"1455-1458"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90436899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wavefield focusing with reduced cranial invasiveness 波场聚焦降低颅骨侵入性

2019 IEEE International Ultrasonics Symposium (IUS) Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925565

G. Meles, J. van der Neut, K. V. van Dongen, K. Wapenaar

引用次数: 3