世界危重病急救学杂志(英文版)Pub Date : 2026-03-09DOI: 10.5492/wjccm.v15.i1.113252
Marco Sanvitti, Laurynas Kanapeckas, Federico Bilotta
{"title":"Minimizing hospital acquired intensive care unit infections: A focus on prevention.","authors":"Marco Sanvitti, Laurynas Kanapeckas, Federico Bilotta","doi":"10.5492/wjccm.v15.i1.113252","DOIUrl":"10.5492/wjccm.v15.i1.113252","url":null,"abstract":"<p><p>Hospital-acquired infections (HAIs) are a leading cause of morbidity and mortality in intensive care units (ICUs), largely driven by invasive devices, immunosuppression, and prolonged hospitalization. Despite available guidelines, prevention strategies remain inconsistently applied across settings. This narrative review synthesized evidence from PubMed (2020-2025) and key guideline documents (World Health Organization, Centers for Disease Control and Prevention, Infectious Diseases Society of America, Society for Healthcare Epidemiology of America), focusing on staff-level, patient-level, and systemic interventions for ICU infection prevention. Eligible sources included systematic reviews, clinical trials, consensus statements, and implementation studies. Effective staff-level strategies include strict hand hygiene, correct use of personal protective equipment, vaccination, and decontamination of personal devices, supported by audits and feedback. Patient-level care bundles targeting ventilator-associated pneumonia, central line-associated bloodstream infection, and catheter-associated urinary tract infection reduce device-related complications, though real-world adherence varies. Systemic measures such as closed ICU models, adequate nurse-to-patient ratios, triage protocols, and single-patient rooms, further mitigate infection risks. Implementation barriers include resource limitations, compliance gaps, and ethical considerations regarding futile care. Preventing ICU-acquired infections requires coordinated, multifaceted strategies embedded into daily practice. Sustained progress depends on leadership, continuous education, auditing, and adaptation of international frameworks to local contexts.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"15 1","pages":"113252"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
世界危重病急救学杂志(英文版)Pub Date : 2026-03-09DOI: 10.5492/wjccm.v15.i1.110552
Caleb Fisher, Stephen Warrillow
{"title":"Continuous renal replacement therapy in acute liver failure.","authors":"Caleb Fisher, Stephen Warrillow","doi":"10.5492/wjccm.v15.i1.110552","DOIUrl":"10.5492/wjccm.v15.i1.110552","url":null,"abstract":"<p><p>Acute liver failure (ALF) is a devastating condition that primarily affects young adults. This often-lethal condition involves a rapid loss of hepatic function, that then leads to multiple organ failure. The accumulation of numerous toxins, especially ammonia, causes cerebral oedema and intracranial hypertension. Continuous renal replacement therapy (CRRT) is increasingly recognized as having a key role in ammonia removal in ALF and current evidence suggesting that timing of initiation, dose, and duration of therapy may influence survival. In addition to this important role of toxin clearance, CRRT helps with other complications of ALF such as acid-base balance, prevention of fever and management of fluid balance. As such, we propose that CRRT in ALF should be viewed as an \"metabolic-toxin-fluid\" therapy as much as a treatment for renal failure. In this review article we will explore the mechanisms of benefit, indications and evidence to support this concept of CRRT in ALF.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"15 1","pages":"110552"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
世界危重病急救学杂志(英文版)Pub Date : 2026-03-09DOI: 10.5492/wjccm.v15.i1.112345
Apurva Aggarwal, Mohd Mustahsin, Piyush Shishir
{"title":"Comparison of intubating laryngeal mask airway and video laryngoscope during emergency intubation in patients who are critically ill.","authors":"Apurva Aggarwal, Mohd Mustahsin, Piyush Shishir","doi":"10.5492/wjccm.v15.i1.112345","DOIUrl":"10.5492/wjccm.v15.i1.112345","url":null,"abstract":"<p><strong>Background: </strong>Emergency endotracheal intubation is a high-risk procedure in patients who are critically ill and associated with complications such as hypoxia, hemodynamic instability, and airway trauma. The intubating laryngeal mask airway (ILMA) and video laryngoscope (VL) are alternative devices to conventional direct laryngoscopy, but their comparative efficacy in emergency settings remains understudied.</p><p><strong>Aim: </strong>To compare the first-attempt success rate, intubation time, hemodynamic response, and complications between ILMA and VL in emergency intubations.</p><p><strong>Methods: </strong>A prospective randomized study was conducted on 64 patients who were critically ill and requiring emergency intubation. Patients were divided into the VL (<i>n</i> = 32) and ILMA (<i>n</i> = 32) groups. Primary outcomes included first-attempt success rate and intubation time. Secondary outcomes assessed hemodynamic changes (mean arterial pressure, heart rate, oxygen saturation) and complications (trauma, desaturation, sore throat).</p><p><strong>Results: </strong>The VL group had a significantly higher first-attempt success rate (87.5% <i>vs</i> 53.1%, <i>P</i> = 0.009) and shorter total intubation time (44.0 ± 19.7 seconds <i>vs</i> 82.5 ± 14.5 seconds, <i>P</i> < 0.001). Hemodynamic responses were comparable, but ILMA was associated with more complications (mouth damage: 26.9% <i>vs</i> 0%, <i>P</i> = 0.002; sore throat: 26.9% <i>vs</i> 3.1%, <i>P</i> = 0.009).</p><p><strong>Conclusion: </strong>VL is superior to ILMA for emergency intubation, offering higher first-pass success, faster intubation, and fewer complications. VL should be prioritized in critical care settings.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"15 1","pages":"112345"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
世界危重病急救学杂志(英文版)Pub Date : 2026-03-09DOI: 10.5492/wjccm.v15.i1.113889
Ecaterina Scarlatescu
{"title":"Viscoelastic testing: Transforming hemostasis management in patients in the medical intensive care unit.","authors":"Ecaterina Scarlatescu","doi":"10.5492/wjccm.v15.i1.113889","DOIUrl":"10.5492/wjccm.v15.i1.113889","url":null,"abstract":"<p><p>Viscoelastic testing (VET) has emerged as a groundbreaking method for assessing hemostasis, offering real-time evaluations of coagulation dynamics that exceed traditional tests. It provides immediate insights into the complex interplay among plasma coagulation factors, platelets, and cellular components that regulate hemostatic function, offering a continuous evaluation of the entire hemostatic process - from initial clot formation and stabilization to dissolution. Although often utilized in surgical settings such as liver transplants, trauma, or cardiac surgery, VET has also proven valuable in medical intensive care units (ICUs). In non-surgical patients in the ICU, coagulopathy is common, and timely decision-making is critical. VET offers distinct advantages over conventional coagulation tests by providing rapid, point-of-care results that can guide targeted therapeutic interventions. VET-guided transfusion algorithms have reduced allogeneic transfusion rates by 20%-40%, shortened time to intervention by 30%-50% compared to conventional coagulation tests, and improved ICU length of stay. This review discusses VET's principles, limitations, clinical applications in medical ICUs, and the challenges of its implementation. Incorporating VET into routine clinical practice signifies a shift toward advanced, individualized hemostatic care, significantly enhancing patient safety and clinical outcomes while optimizing resource utilization in modern medical ICUs.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"15 1","pages":"113889"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
世界危重病急救学杂志(英文版)Pub Date : 2026-03-09DOI: 10.5492/wjccm.v15.i1.115599
Mirza Kovacevic, Visnja Nesek-Adam, Semir Klokic, Mehmet Yilmaz
{"title":"Determinants of fatal outcome in septic shock patients with euthyroid sick syndrome.","authors":"Mirza Kovacevic, Visnja Nesek-Adam, Semir Klokic, Mehmet Yilmaz","doi":"10.5492/wjccm.v15.i1.115599","DOIUrl":"10.5492/wjccm.v15.i1.115599","url":null,"abstract":"<p><strong>Background: </strong>Septic shock is a leading cause of mortality in intensive care, and euthyroid sick syndrome (ESS) may influence outcomes. Identifying predictors of fatal outcome in this population is crucial for guiding management.</p><p><strong>Aim: </strong>To identify clinical and laboratory predictors of 28-day mortality in patients with septic shock and ESS, and to evaluate the prognostic value of markers such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), prognostic index (PI), and modified Glasgow prognostic score (mGPS), the vasoactive drug-dependent index (VDI), and shock index (SI).</p><p><strong>Methods: </strong>In this prospective observational study, 95 patients with septic shock and ESS admitted between May 2024 and August 2025 were analyzed. Demographic, clinical, and laboratory data were collected at admission and on days 1, 3, and 7. Prognostic markers - NLR, PLR, PI, and mGPS, VDI, and SI were analyzed. Associations with 28-day mortality were evaluated using standard statistical tests.</p><p><strong>Results: </strong>Of the 95 patients (mean age 61 ± 14.6 years; female/male ratio 52/43), 53 (52%) died. Duration of mechanical ventilation (<i>P</i> = 0.013) and intensive care unit (ICU) length of stay (<i>P</i> = 0.005) were significantly associated with mortality. Acute Physiology and Chronic Health Evaluation II (<i>P</i> = 0.014) and Simplified Acute Physiology Score II (<i>P</i> = 0.001) scores correlated positively with fatal outcome. Predictive laboratory parameters included base excess and free thyroxine (FT4) at admission (<i>P</i> = 0.013, <i>P</i> < 0.001); free triiodothyronine and FT4 on day 1 (<i>P</i> = 0.007, <i>P</i> < 0.001); red blood cells (RBC) and lymphocytes on day 2 (<i>P</i> = 0.027, <i>P</i> = 0.049); and white blood cells, pO<sub>2</sub>, thyroid-stimulating hormone, and FT4 on day 3 (all <i>P</i> < 0.05). Variables positively correlated with mortality included neutrophils, lactate, C-reactive protein, and albumin, while pH, pO<sub>2</sub>, bicarbonate, RBC, platelets, and thyroid hormones were negatively correlated. SI on day 3 (<i>P</i> = 0.027) and mGPS on day 1 (<i>P</i> = 0.030) were significant prognostic indices.</p><p><strong>Conclusion: </strong>The 28-day mortality among patients with septic shock and ESS was 52%. Duration of mechanical ventilation, ICU stay, severity scores, laboratory parameters, and indices such as SI and mGPS were significantly associated with outcome. The presence of ESS may contribute to adverse prognosis, and combined evaluation of clinical and laboratory factors can improve risk stratification in this high-risk population.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"15 1","pages":"115599"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
世界危重病急救学杂志(英文版)Pub Date : 2026-03-09DOI: 10.5492/wjccm.v15.i1.114670
Arunkumaar Srinivasan, Ponnsusamy Dhivya
{"title":"Dysregulation of renin-angiotensin-aldosterone axis in septic shock: Emerging roles of angiotensin-(1-5) and alamandine.","authors":"Arunkumaar Srinivasan, Ponnsusamy Dhivya","doi":"10.5492/wjccm.v15.i1.114670","DOIUrl":"10.5492/wjccm.v15.i1.114670","url":null,"abstract":"<p><p>The renin-angiotensin-aldosterone system (RAAS) undergoes profound dysregulation during septic shock, defined by persistent hypotension requiring vasopressors to maintain mean arterial pressure ≥ 65 mmHg plus lactate > 2 mmol/L, with mortality exceeding 40%. The classical RAAS pathway becomes impaired with elevated renin but paradoxically low angiotensin (Ang) II levels, correlating with poor outcomes. The alternative Ang-converting enzyme 2-Ang-(1-7)-mas receptor axis provides counter-regulatory effects but represents a \"double-edged sword\" in sepsis. Elevated circulating Ang-converting enzyme 2 paradoxically predicts worse outcomes, possibly through excessive Ang II depletion contributing to vasoplegia. Downstream metabolites including Ang-(1-5) and alamandine show cardioprotective properties in experimental models. Ang-(1-5) may serve as a biomarker reflecting RAAS dysregulation severity. Elevated dipeptidyl peptidase 3 exacerbates dysfunction by degrading Ang II. Experimental Ang-(1-7) infusion prevented septic shock and reduced vasopressor requirements. However, human randomized trials remain limited. Future research should focus on biomarker-guided patient stratification and multicenter trials establishing clinical utility of alternative RAAS modulation.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"15 1","pages":"114670"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Burden and impact of acute kidney injury in acute liver failure: A systematic review.","authors":"Armin Ahmed, Medhavi Gautam, Afzal Azim, Banadana Chakravarti, Meenakshi Tiwari","doi":"10.5492/wjccm.v15.i1.111114","DOIUrl":"10.5492/wjccm.v15.i1.111114","url":null,"abstract":"<p><strong>Background: </strong>Acute kidney injury (AKI) affects 40%-80% of patients with acute liver failure (ALF) and arises from complex mechanisms, including hemodynamic instability, drug toxicity, and direct renal insults. Unlike chronic liver disease, AKI in ALF is poorly studied.</p><p><strong>Aim: </strong>To consolidate current evidence and guide future research and interventions to improve outcomes in ALF patients with AKI.</p><p><strong>Methods: </strong>This systematic review followed PRISMA guidelines, searching databases from 2000 to 2024 for studies on AKI in ALF. We included studies focused on adult, English-language, full-length epidemiological studies. Data were extracted on study design, patient demographics, risk factors, and outcomes. Methodological quality was assessed using a tailored 5-point tool. Data were summarized using descriptive statistics and analyzed with GraphPad Prism and MedCalc software.</p><p><strong>Results: </strong>This systematic review analyzed nine studies published between 2009 and 2024, encompassing 6031 patients with ALF, of whom 62.9% developed AKI. Most studies were retrospective and varied in methodology, setting, and population. Only three studies reported independent risk factors for the development of AKI among ALF patients, with significant variation in the risk factors studied. AKI in ALF patients significantly increased mortality, with hazard ratios ranging from 2.77 to 11.61. The review highlights the need for standardized diagnostic criteria and risk stratification to guide prevention and improve clinical outcomes in ALF.</p><p><strong>Conclusion: </strong>AKI is common in ALF, increasing morbidity and mortality; standardised diagnosis and targeted management strategies are urgently needed.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"15 1","pages":"111114"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
世界危重病急救学杂志(英文版)Pub Date : 2026-03-09DOI: 10.5492/wjccm.v15.i1.110763
Elizabeth Teo, Karon Kung, Sarah Chen, Kay C See
{"title":"Clinical scoring systems for diagnosing tuberculous meningitis: A systematic review.","authors":"Elizabeth Teo, Karon Kung, Sarah Chen, Kay C See","doi":"10.5492/wjccm.v15.i1.110763","DOIUrl":"10.5492/wjccm.v15.i1.110763","url":null,"abstract":"<p><strong>Background: </strong>Tuberculous meningitis (TBM) is a severe extrapulmonary complication of tuberculosis. Early diagnosis is crucial in improving patient outcomes, albeit difficult given the non-specific clinical presentation of early stage TBM. Numerical diagnostic scoring systems may be useful diagnostic tools for clinicians, particularly in resource-constrained settings.</p><p><strong>Aim: </strong>To describe existing TBM diagnostic scores with the primary focus being on scores with external validation.</p><p><strong>Methods: </strong>PubMed and EMBASE were searched from inception to 21 March 2024. Cross-sectional studies with numerical TBM scoring systems were included. Literature pertaining to non-human, non-live subjects, single diagnostic tests, papers with no gold standard diagnosis, and non-English papers were excluded.</p><p><strong>Results: </strong>We reviewed 21 unique scoring systems, of which 4 have been externally validated. Key features of the scores (clinical, laboratory, microbiological, histopathological and radiological criteria, interpretation), outcomes (sensitivity, specificity) and study population (location, demographics, subgroups) were described.</p><p><strong>Conclusion: </strong>We suggest Thwaites (2002) and Marais (2010) as first-line TBM screening tests due to high sensitivities and extensive external validation, however clinicians should consider scores specific to their patient population.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"15 1","pages":"110763"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
世界危重病急救学杂志(英文版)Pub Date : 2026-03-09DOI: 10.5492/wjccm.v15.i1.117127
Gemechu Dereje Feyissa
{"title":"Advancing emergency airway management: Video laryngoscope <i>vs</i> intubating laryngeal mask airway in critical care.","authors":"Gemechu Dereje Feyissa","doi":"10.5492/wjccm.v15.i1.117127","DOIUrl":"10.5492/wjccm.v15.i1.117127","url":null,"abstract":"<p><p>This editorial comments on the randomized controlled trial by Aggarwal <i>et al</i>, which demonstrates video laryngoscope (VL) superiority over intubating laryngeal mask airway (ILMA) for emergency intubation in critically ill patients-first-pass success (87.5% <i>vs</i> 53.1%), intubation times (44.0 ± 19.7 seconds <i>vs</i> 82.5 ± 14.5 seconds), and reduced complications including oral trauma (0% <i>vs</i> 26.9%) and sore throat (3.1% <i>vs</i> 26.9%). VL's camera-enhanced visualization ensures precise navigation in high-stakes scenarios where patients have limited physiological reserve, positioning it as the frontline device per updated Difficult Airway Society guidelines. ILMA retains value as rescue ventilation during failed VL attempts despite its longer procedure times and tissue trauma risks, warranting availability in all emergency airway algorithms. These rigorous findings guide intensivists toward protocol revisions prioritizing VL training, resource allocation, and simulation drills-particularly in resource-limited intensive care units. Future multicenter trials should validate performance across difficult airways and evaluate cost-effectiveness to optimize implementation globally.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"15 1","pages":"117127"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Myoclonus associated with tranexamic acid administration in a patient on veno-arterial extracorporeal membrane oxygenation support: A case report.","authors":"Fotios Dimitriadis, Theodoros Pitsolis, Kyriaki Kolovou, Sissy Maragoulia, Evangelia Theodorou, Giorgos Konstantinou, Theodora Soulele, Ioannis Vlahodimitris, Michail Zervos, Paraskevi Salata, Dimitrios Elaiopoulos, Stergios Gatzonis, Stavros Dimopoulos","doi":"10.5492/wjccm.v15.i1.115620","DOIUrl":"10.5492/wjccm.v15.i1.115620","url":null,"abstract":"<p><strong>Background: </strong>Tranexamic acid (TXA) is widely used as an antifibrinolytic agent to reduce bleeding in cardiac and extracorporeal circulation settings. Neurological adverse effects, including seizures and myoclonus, are rare and not well documented in patients supported by extracorporeal membrane oxygenation (ECMO).</p><p><strong>Case summary: </strong>We report the case of a 52-year-old male with ST-elevation myocardial infarction and severe left ventricular dysfunction, who was transferred to our intensive care unit department under veno-arterial (VA)-ECMO support and continuous renal replacement therapy (CRRT). To maintain ECMO oxygenator function and due to decreasing fibrinogen levels, endovenous one gram TXA twice a day was administered and within hours after the second dose, the patient developed generalized myoclonic jerks. A non-contrast brain computed tomography revealed no acute or chronic abnormalities, and neurological evaluation attributed the findings to TXA as the most likely cause due to TXA overdose. Following discontinuation of TXA, the symptoms resolved within 48 hours.</p><p><strong>Conclusion: </strong>This case highlights a rare neurological complication associated with TXA overdose, occurring in patient with VA-ECMO and CRRT. Clinicians should remain vigilant for such adverse effects in this context.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"15 1","pages":"115620"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}