世界危重病急救学杂志(英文版)最新文献

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Optic nerve sheath diameters in nontraumatic brain injury: A scoping review and role in the intensive care unit. 非创伤性脑损伤中的视神经鞘直径:范围综述及在重症监护室中的作用。
世界危重病急救学杂志(英文版) Pub Date : 2024-09-09 DOI: 10.5492/wjccm.v13.i3.97205
Madhura Bhide, Deven Juneja, Omender Singh, Shakya Mohanty
{"title":"Optic nerve sheath diameters in nontraumatic brain injury: A scoping review and role in the intensive care unit.","authors":"Madhura Bhide, Deven Juneja, Omender Singh, Shakya Mohanty","doi":"10.5492/wjccm.v13.i3.97205","DOIUrl":"https://doi.org/10.5492/wjccm.v13.i3.97205","url":null,"abstract":"<p><strong>Background: </strong>Neuromonitoring in medical intensive care units is challenging as most patients are unfit for invasive intracranial pressure (ICP) modalities or unstable to transport for imaging. Ultrasonography-based optic nerve sheath diameter (ONSD) is an attractive option as it is reliable, repeatable and easily performed at the bedside. It has been sufficiently validated in traumatic brain injury (TBI) to be incorporated into the guidelines. However, currently the data for non-TBI patients is inconsistent for a scientific recommendation to be made.</p><p><strong>Aim: </strong>To compile the existing evidence for understanding the scope of ONSD in measuring ICP in adult non-traumatic neuro-critical patients.</p><p><strong>Methods: </strong>PubMed, Google Scholar and research citation analysis databases were searched for studies in adult patients with non-traumatic causes of raised ICP. Studies from 2010 to 2024 in English languages were included.</p><p><strong>Results: </strong>We found 37 articles relevant to our search. The cutoff for ONSD in predicting ICP varied from 4.1 to 6.3 mm. Most of the articles used cerebrospinal fluid opening pressure followed by raised ICP on computed tomography/magnetic resonance imaging as the comparator parameter. ONSD was also found to be a reliable outcome measure in cases of acute ischaemic stroke, intracerebral bleeding and intracranial infection. However, ONSD is of doubtful utility in septic metabolic encephalopathy, dysnatremias and aneurysmal subarachnoid haemorrhage.</p><p><strong>Conclusion: </strong>ONSD is a useful tool for the diagnosis of raised ICP in non-traumatic neuro-critically ill patients and may also have a role in the prognostication of a subset of patients.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"13 3","pages":"97205"},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11372515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Remimazolam in intensive care unit: Potential applications and considerations. 重症监护室中的雷马唑仑:潜在应用和注意事项。
世界危重病急救学杂志(英文版) Pub Date : 2024-09-09 DOI: 10.5492/wjccm.v13.i3.96877
Praveen Reddy Elmati, Teja Nagaradona, Gowthami Sai Kogilathota Jagirdhar, Salim Surani
{"title":"Remimazolam in intensive care unit: Potential applications and considerations.","authors":"Praveen Reddy Elmati, Teja Nagaradona, Gowthami Sai Kogilathota Jagirdhar, Salim Surani","doi":"10.5492/wjccm.v13.i3.96877","DOIUrl":"https://doi.org/10.5492/wjccm.v13.i3.96877","url":null,"abstract":"<p><p>This manuscript explores the potential use of Remimazolam in the intensive care unit (ICU) and critical care units, considering its pharmacological characteristics, clinical applications, advantages, and comparative effectiveness over current sedatives and anesthetics. We reviewed existing PubMed and Google Scholar literature to find relevant studies on Remimazolam in ICU. We created search criteria using a combination of free text words, including Remimazolam, critical care, intensive care, sedation, anesthesia, pharmacokinetics, and pharmacodynamics. Relevant articles published in the English language were analyzed and incorporated. Remimazolam is an ultra-short-acting benzodiazepine derivative promising for sedation and anesthesia. It is a safer option for hemodynamically unstable, elderly, or liver or kidney issues. It also has comparable deep sedation properties to propofol in the ICU. Furthermore, it reduces post-procedural delirium and patient comfort and reduces the need for additional sedatives in pediatric patients. In conclusion, Remimazolam is an excellent alternative to current sedatives and anesthetics in the ICU. Its cost is comparable to that of current medications. Further research on its long-term safety in the ICU and its broader application and incorporation into routine use is necessary.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"13 3","pages":"96877"},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11372519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial and synergistic effects of lemongrass and geranium essential oils against Streptococcus mutans, Staphylococcus aureus, and Candida spp. 柠檬草和天竺葵精油对变异链球菌、金黄色葡萄球菌和白色念珠菌的抗菌和协同作用
世界危重病急救学杂志(英文版) Pub Date : 2024-09-09 DOI: 10.5492/wjccm.v13.i3.92531
Patrícia Michelle Nagai de Lima, Thaís Cristine Pereira, Lara Steffany de Carvalho, Letícia Ferreira Dos Santos, Carlos Eduardo Rocha Oliveira, Lucas de Paula Ramos, Maria Cristina Marcucci, Amjad Abu Hasna, Luciane Dias de Oliveira
{"title":"Antimicrobial and synergistic effects of lemongrass and geranium essential oils against <i>Streptococcus mutans</i>, <i>Staphylococcus aureus</i>, and <i>Candida</i> spp.","authors":"Patrícia Michelle Nagai de Lima, Thaís Cristine Pereira, Lara Steffany de Carvalho, Letícia Ferreira Dos Santos, Carlos Eduardo Rocha Oliveira, Lucas de Paula Ramos, Maria Cristina Marcucci, Amjad Abu Hasna, Luciane Dias de Oliveira","doi":"10.5492/wjccm.v13.i3.92531","DOIUrl":"https://doi.org/10.5492/wjccm.v13.i3.92531","url":null,"abstract":"<p><strong>Background: </strong>The oral cavity harbors more than 700 species of bacteria, which play crucial roles in the development of various oral diseases including caries, endodontic infection, periodontal infection, and diverse oral diseases.</p><p><strong>Aim: </strong>To investigate the antimicrobial action of <i>Cymbopogon Schoenanthus</i> and <i>Pelargonium graveolens</i> essential oils against <i>Streptococcus mutans, Staphylococcus aureus, Candida albicans, Ca. dubliniensis</i>, and <i>Ca. krusei</i>.</p><p><strong>Methods: </strong>Minimum microbicidal concentration was determined following Clinical and Laboratory Standards Institute documents. The synergistic antimicrobial activity was evaluated using the Broth microdilution checkerboard method, and the antibiofilm activity was evaluated with the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay. Data were analyzed by one-way analysis of variance followed by the Tukey post-hoc test (<i>P</i> ≤ 0.05).</p><p><strong>Results: </strong><i>C. schoenanthus</i> and <i>P. graveolens</i> essential oils were as effective as 0.12% chlorhexidine against <i>S. mutans</i> and <i>St. aureus</i> monotypic biofilms after 24 h. After 24 h <i>P. graveolens</i> essential oil at 0.25% was more effective than the nystatin group, and <i>C. schoenanthus</i> essential oil at 0.25% was as effective as the nystatin group.</p><p><strong>Conclusion: </strong><i>C. schoenanthus</i> and <i>P. graveolens</i> essential oils are effective against <i>S. mutans, St. aureus, Ca. albicans, Ca. dubliniensis</i>, and <i>Ca. krusei</i> at different concentrations after 5 min and 24 h.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"13 3","pages":"92531"},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11372514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis and management of severe pulmonary and extrapulmonary tuberculosis in critically ill patients: A mini review for clinicians. 重症患者严重肺结核和肺外结核病的诊断与管理:临床医生小综述。
世界危重病急救学杂志(英文版) Pub Date : 2024-06-09 DOI: 10.5492/wjccm.v13.i2.91435
Dominic Ti Ming Tan, Kay Choong See
{"title":"Diagnosis and management of severe pulmonary and extrapulmonary tuberculosis in critically ill patients: A mini review for clinicians.","authors":"Dominic Ti Ming Tan, Kay Choong See","doi":"10.5492/wjccm.v13.i2.91435","DOIUrl":"10.5492/wjccm.v13.i2.91435","url":null,"abstract":"<p><p>Among critically ill patients, severe pulmonary and extrapulmonary tuberculosis has high morbidity and mortality. Yet, it is a diagnostic challenge given its nonspecific clinical symptoms and signs in early stages of the disease. In addition, management of severe pulmonary and extrapulmonary tuberculosis is complicated given the high risk of drug-drug interactions, drug-disease interactions, and adverse drug reactions. To help clinicians acquire an up-to-date approach to severe tuberculosis, this paper will provide a narrative review of contemporary diagnosis and management of severe pulmonary and extrapulmonary tuberculosis in critically ill patients.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"13 2","pages":"91435"},"PeriodicalIF":0.0,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11155508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Future of neurocritical care: Integrating neurophysics, multimodal monitoring, and machine learning. 神经重症监护的未来:整合神经物理学、多模态监测和机器学习。
世界危重病急救学杂志(英文版) Pub Date : 2024-06-09 DOI: 10.5492/wjccm.v13.i2.91397
Bahadar S Srichawla
{"title":"Future of neurocritical care: Integrating neurophysics, multimodal monitoring, and machine learning.","authors":"Bahadar S Srichawla","doi":"10.5492/wjccm.v13.i2.91397","DOIUrl":"10.5492/wjccm.v13.i2.91397","url":null,"abstract":"<p><p>Multimodal monitoring (MMM) in the intensive care unit (ICU) has become increasingly sophisticated with the integration of neurophysical principles. However, the challenge remains to select and interpret the most appropriate combination of neuromonitoring modalities to optimize patient outcomes. This manuscript reviewed current neuromonitoring tools, focusing on intracranial pressure, cerebral electrical activity, metabolism, and invasive and noninvasive autoregulation monitoring. In addition, the integration of advanced machine learning and data science tools within the ICU were discussed. Invasive monitoring includes analysis of intracranial pressure waveforms, jugular venous oximetry, monitoring of brain tissue oxygenation, thermal diffusion flowmetry, electrocorticography, depth electroencephalography, and cerebral microdialysis. Noninvasive measures include transcranial Doppler, tympanic membrane displacement, near-infrared spectroscopy, optic nerve sheath diameter, positron emission tomography, and systemic hemodynamic monitoring including heart rate variability analysis. The neurophysical basis and clinical relevance of each method within the ICU setting were examined. Machine learning algorithms have shown promise by helping to analyze and interpret data in real time from continuous MMM tools, helping clinicians make more accurate and timely decisions. These algorithms can integrate diverse data streams to generate predictive models for patient outcomes and optimize treatment strategies. MMM, grounded in neurophysics, offers a more nuanced understanding of cerebral physiology and disease in the ICU. Although each modality has its strengths and limitations, its integrated use, especially in combination with machine learning algorithms, can offer invaluable information for individualized patient care.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"13 2","pages":"91397"},"PeriodicalIF":0.0,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11155497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Point-of-care ultrasonography spotlight: Could venous excess ultrasound serve as a shared language for internists and intensivists? 护理点超声聚焦:静脉过度超声检查能否成为内科医生和重症监护医生的共同语言?
世界危重病急救学杂志(英文版) Pub Date : 2024-06-09 DOI: 10.5492/wjccm.v13.i2.93206
Anosh Aslam Khan, Hasham Saeed, Ibtehaj Ul Haque, Ayman Iqbal, Doantrang Du, Abhilash Koratala
{"title":"Point-of-care ultrasonography spotlight: Could venous excess ultrasound serve as a shared language for internists and intensivists?","authors":"Anosh Aslam Khan, Hasham Saeed, Ibtehaj Ul Haque, Ayman Iqbal, Doantrang Du, Abhilash Koratala","doi":"10.5492/wjccm.v13.i2.93206","DOIUrl":"10.5492/wjccm.v13.i2.93206","url":null,"abstract":"<p><p>Point-of-care ultrasonography (POCUS), particularly venous excess ultrasound (VExUS) is emerging as a valuable bedside tool to gain real-time hemodynamic insights. This modality, derived from hepatic vein, portal vein, and intrarenal vessel Doppler patterns, offers a scoring system for dynamic venous congestion assessment. Such an assessment can be crucial in effective management of patients with heart failure exacerbation. It facilitates diagnosis, quantification of congestion, prognostication, and monitoring the efficacy of decongestive therapy. As such, it can effectively help to manage cardiorenal syndromes in various clinical settings. Extended or eVExUS explores additional veins, potentially broadening its applications. While VExUS demonstrates promising outcomes, challenges persist, particularly in cases involving renal and liver parenchymal disease, arrhythmias, and situations of pressure and volume overload overlap. Proficiency in utilizing spectral Doppler is pivotal for clinicians to effectively employ this tool. Hence, the integration of POCUS, especially advanced applications like VExUS, into routine clinical practice necessitates enhanced training across medical specialties.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"13 2","pages":"93206"},"PeriodicalIF":0.0,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11155496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ten misconceptions regarding decision-making in critical care. 关于重症监护决策的十大误解。
世界危重病急救学杂志(英文版) Pub Date : 2024-06-09 DOI: 10.5492/wjccm.v13.i2.89644
Tara Ramaswamy, Jamie L Sparling, Marvin G Chang, Edward A Bittner
{"title":"Ten misconceptions regarding decision-making in critical care.","authors":"Tara Ramaswamy, Jamie L Sparling, Marvin G Chang, Edward A Bittner","doi":"10.5492/wjccm.v13.i2.89644","DOIUrl":"10.5492/wjccm.v13.i2.89644","url":null,"abstract":"<p><p>Diagnostic errors are prevalent in critical care practice and are associated with patient harm and costs for providers and the healthcare system. Patient complexity, illness severity, and the urgency in initiating proper treatment all contribute to decision-making errors. Clinician-related factors such as fatigue, cognitive overload, and inexperience further interfere with effective decision-making. Cognitive science has provided insight into the clinical decision-making process that can be used to reduce error. This evidence-based review discusses ten common misconceptions regarding critical care decision-making. By understanding how practitioners make clinical decisions and examining how errors occur, strategies may be developed and implemented to decrease errors in Decision-making and improve patient outcomes.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"13 2","pages":"89644"},"PeriodicalIF":0.0,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11155500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Critical care specialists, the missing link in organ procurement for transplantation. 重症监护专家是器官移植中缺失的一环。
世界危重病急救学杂志(英文版) Pub Date : 2024-06-09 DOI: 10.5492/wjccm.v13.i2.90274
Francisca Del Rocio Gonzalez Cohens, Fernando M Gonzalez
{"title":"Critical care specialists, the missing link in organ procurement for transplantation.","authors":"Francisca Del Rocio Gonzalez Cohens, Fernando M Gonzalez","doi":"10.5492/wjccm.v13.i2.90274","DOIUrl":"10.5492/wjccm.v13.i2.90274","url":null,"abstract":"<p><p>The procurement process for organ donation begins with the identification of potential organ donors in emergency or critical care units (CCU), followed by their clinical evaluation, diagnostic procedures, and therapeutic interventions, mostly conducted in CCUs. It concludes with the request for organ donation and, if accepted, the retrieval of organs. Despite most interventions occurring in detection units, there has been a neglect of the strategic role played by critical care specialists (CCS) in managing and caring for brain-dead or near-brain-death patients. Questions arise: Are they willing to undertake this responsibility? Do they fully comprehend the nature of organ procurement? Are they aware of the specific interventions required to maintain possible organ donors in optimal physiological condition? Our objective is to examine the role of CCS in organ procurement and propose ways to enhance it, ultimately aiming to increase and enhance organ donation rates.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"13 2","pages":"90274"},"PeriodicalIF":0.0,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11155502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Driving pressure decoded: Precision strategies in adult respiratory distress syndrome management. 驱动压力解码:成人呼吸窘迫综合征管理的精准策略。
世界危重病急救学杂志(英文版) Pub Date : 2024-06-09 DOI: 10.5492/wjccm.v13.i2.92441
Muhammad Adrish, Sai Doppalapudi, Dmitry Lvovsky
{"title":"Driving pressure decoded: Precision strategies in adult respiratory distress syndrome management.","authors":"Muhammad Adrish, Sai Doppalapudi, Dmitry Lvovsky","doi":"10.5492/wjccm.v13.i2.92441","DOIUrl":"10.5492/wjccm.v13.i2.92441","url":null,"abstract":"<p><p>Mechanical ventilation (MV) is an important strategy for improving the survival of patients with respiratory failure. However, MV is associated with aggravation of lung injury, with ventilator-induced lung injury (VILI) becoming a major concern. Thus, ventilation protection strategies have been developed to minimize complications from MV, with the goal of relieving excessive breathing workload, improving gas exchange, and minimizing VILI. By opting for lower tidal volumes, clinicians seek to strike a balance between providing adequate ventilation to support gas exchange and preventing overdistension of the alveoli, which can contribute to lung injury. Additionally, other factors play a role in optimizing lung protection during MV, including adequate positive end-expiratory pressure levels, to maintain alveolar recruitment and prevent atelectasis as well as careful consideration of plateau pressures to avoid excessive stress on the lung parenchyma.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"13 2","pages":"92441"},"PeriodicalIF":0.0,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11155505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Major liver resections, perioperative issues and posthepatectomy liver failure: A comprehensive update for the anesthesiologist. 肝脏大部切除术、围手术期问题和肝切除术后肝功能衰竭:麻醉医师的全面更新。
世界危重病急救学杂志(英文版) Pub Date : 2024-06-09 DOI: 10.5492/wjccm.v13.i2.92751
Andrea De Gasperi, Laura Petrò, Ombretta Amici, Ilenia Scaffidi, Pietro Molinari, Caterina Barbaglio, Eva Cibelli, Beatrice Penzo, Elena Roselli, Andrea Brunetti, Maxim Neganov, Alessandro Giacomoni, Paolo Aseni, Elena Guffanti
{"title":"Major liver resections, perioperative issues and posthepatectomy liver failure: A comprehensive update for the anesthesiologist.","authors":"Andrea De Gasperi, Laura Petrò, Ombretta Amici, Ilenia Scaffidi, Pietro Molinari, Caterina Barbaglio, Eva Cibelli, Beatrice Penzo, Elena Roselli, Andrea Brunetti, Maxim Neganov, Alessandro Giacomoni, Paolo Aseni, Elena Guffanti","doi":"10.5492/wjccm.v13.i2.92751","DOIUrl":"10.5492/wjccm.v13.i2.92751","url":null,"abstract":"<p><p>Significant advances in surgical techniques and relevant medium- and long-term outcomes over the past two decades have led to a substantial expansion in the indications for major liver resections. To support these outstanding results and to reduce perioperative complications, anesthesiologists must address and master key perioperative issues (preoperative assessment, proactive intraoperative anesthesia strategies, and implementation of the Enhanced Recovery After Surgery approach). Intensive care unit monitoring immediately following liver surgery remains a subject of active and often unresolved debate. Among postoperative complications, posthepatectomy liver failure (PHLF) occurs in different grades of severity (A-C) and frequency (9%-30%), and it is the main cause of 90-d postoperative mortality. PHLF, recently redefined with pragmatic clinical criteria and perioperative scores, can be predicted, prevented, or anticipated. This review highlights: (1) The systemic consequences of surgical manipulations anesthesiologists must respond to or prevent, to positively impact PHLF (a proactive approach); and (2) the maximal intensive treatment of PHLF, including artificial options, mainly based, so far, on Acute Liver Failure treatment(s), to buy time waiting for the recovery of the native liver or, when appropriate and in very selected cases, toward liver transplant. Such a clinical context requires a strong commitment to surgeons, anesthesiologists, and intensivists to work together, for a fruitful collaboration in a mandatory clinical continuum.</p>","PeriodicalId":66959,"journal":{"name":"世界危重病急救学杂志(英文版)","volume":"13 2","pages":"92751"},"PeriodicalIF":0.0,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11155507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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