中华普通外科杂志最新文献_第8页

Diagnostic value of ultrasound-guided 14 gauge-core needle biopsy in breast nodules 超声引导下14号芯针活检对乳腺结节的诊断价值

中华普通外科杂志 Pub Date : 2019-10-25 DOI: 10.3760/CMA.J.ISSN.1007-631X.2019.10.013

Chun Zhang, Xuejuan Yu, Yonghui Zhang, Fenfen Fu, Dongjie Zhang, Lingduo Xie, Futao Chu, Chen Li, Qinqin Wang, Shuo Xu, Yuntao Xie

{"title":"Diagnostic value of ultrasound-guided 14 gauge-core needle biopsy in breast nodules","authors":"Chun Zhang, Xuejuan Yu, Yonghui Zhang, Fenfen Fu, Dongjie Zhang, Lingduo Xie, Futao Chu, Chen Li, Qinqin Wang, Shuo Xu, Yuntao Xie","doi":"10.3760/CMA.J.ISSN.1007-631X.2019.10.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2019.10.013","url":null,"abstract":"Objective \u0000To analyze the diagnostic value of ultrasound guided 14 gauge coreneedle biopsy (US-CNB) in breast nodules. \u0000 \u0000 \u0000Methods \u0000We retrospectively analyzed the pathological results of US-CNB and surgical excision from 373 breast nodules in Peking University International Hospital from Sep 2016 to Nov 2018 to evaluate the accuracy of 14g US-CNB. \u0000 \u0000 \u0000Results \u0000A total of 349 patients(373 nodules)underwent US-CNB. US-CNB reported 282 benign lesions(75.6%, 282/373), 20 high-risklesions(5.4%, 20/373), and 71 malignant lesions(19.0%, 71/373). For 282 CNB reported benign lesions, the surgical pathology confirmed 235 lesions , 46 for high-risk lesions and 1 for malignant lesion with a concordancy of 83.3%(235/282)and the underestimation rate was 16.7%(47/282). US-CNB identified 20 high-risk lesions. According to surgical results, 15 were high-risk lesions and 5 were malignant lesions with a concordancy of 75% (15/20)and the underestimation rate was 25%(5/20). When it comes to malignant lesions, the excision results showed that 70 were malignant lesions and 1was high-risk lesion with a concordancy of 98.6%(70/71)and the overestimation rate was 1.4%(1/71). The concordance of the histological type , calculated for 50 invasive carcinomas, was 92% (46/50) with a kappa value of 0.77.The concordance of the histological grade could be calculated for 38 invasive ductal carcinomas with the Elston-Elllis Method . It was 89.5% (34/38) with a kappa value of 0.57. \u0000 \u0000 \u0000Conclusions \u0000The pathology result of 14gUS-CNB is in good consistency with surgical excision for breast benign and malignant lesions. \u0000 \u0000 \u0000Key words: \u0000Breast neoplasms; Biopsy; Concordance","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":"34 1","pages":"867-870"},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45327919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction and evaluation of prognosis predictive nomogram for gastric cancer with peritoneal carcinomatosis treated by cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy 细胞减灭术加腹腔热疗治疗癌症腹膜癌预后预测列线图的构建与评价

中华普通外科杂志 Pub Date : 2019-10-25 DOI: 10.3760/CMA.J.ISSN.1007-631X.2019.10.003

Z. Ji, Yang Yu, Gang Liu, Yanbin Zhang, Bing Li, S. An, Xinbao Li, Yan Li

{"title":"Construction and evaluation of prognosis predictive nomogram for gastric cancer with peritoneal carcinomatosis treated by cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy","authors":"Z. Ji, Yang Yu, Gang Liu, Yanbin Zhang, Bing Li, S. An, Xinbao Li, Yan Li","doi":"10.3760/CMA.J.ISSN.1007-631X.2019.10.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2019.10.003","url":null,"abstract":"Objectives \u0000To construct a prognosis predictive nomogram for gastric cancer with peritoneal carcinomatosis treated with cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy. \u0000 \u0000 \u0000Methods \u0000The clinical data and follow-up results of gastric cancer with peritoneal carcinomatosis patients treated by cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy at our center from 2005 to 2017 were collected for log-rank test and multivariate COX proportional regression model analysis. A prognostic predictive nomogram was constructed and internally validated. \u0000 \u0000 \u0000Results \u0000115 patients were included. The median overall survival was 13.1 months, and 1-, 2-, 3-, and 5-year survival rates being 56.5%, 25.3%, 12.6%, and 8.1% respectively. Univariate and the following multivariate analysis identified completeness of cytoreduction, temperature of hyperthermic intraperitoneal chemotherapy and type of adjuvant chemotherapy as independent prognostic factors on overall survival. The nomogram using these three factors showed a concordance index of 0.721 (95% CI: 0.669-0.773). The calibration curves for 1-, 2- and 3 -year survival probability showed a good consistency between actual observation and prediction. \u0000 \u0000 \u0000Conclusions \u0000The nomogram based on completeness of cytoreduction, temperature of hyperthermic intraperitoneal chemotherapy and type of adjuvant chemotherapy can effectively predict the survival probability for gastric cancer with peritoneal carcinomatosis patients treated with cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy. \u0000 \u0000 \u0000Key words: \u0000Stomach neoplasm; Neoplasm metastasis; Chemotherapy, regional perfusion; Prognosis","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":"34 1","pages":"833-836"},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46221857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognosis analysis and 21-gene recurrence score according to TAILORx standard in hormone receptor positive early-stage breast cancer 激素受体阳性早期乳腺癌预后分析及依TAILORx标准21基因复发评分

中华普通外科杂志 Pub Date : 2019-09-25 DOI: 10.3760/CMA.J.ISSN.1007-631X.2019.09.007

Yan-na Zhang, Yidong Zhou, F. Mao, Q. Sun

{"title":"Prognosis analysis and 21-gene recurrence score according to TAILORx standard in hormone receptor positive early-stage breast cancer","authors":"Yan-na Zhang, Yidong Zhou, F. Mao, Q. Sun","doi":"10.3760/CMA.J.ISSN.1007-631X.2019.09.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2019.09.007","url":null,"abstract":"Objective \u0000To explore the association of 21 gene recurrence score(RS)according to TAILORx standard and prognosis of hormone receptor(HR) positive, axillary lymph node negative breast cancer. \u0000 \u0000 \u0000Methods \u0000The clinicopathologic data of 558 early breast cancer patients who underwent 21 gene RS testing from May 2012 to Jan 2017 were retrospectively analyzed. RS was subgrouped according to TAILORx standard.Estimates of relapse free survival(RFS) were made from the Kaplan-Meier curves. \u0000 \u0000 \u0000Results \u0000In 558 patients, RS≤10, RS 11-25 and RS≥26 groups accounted for 23.1%, 63.6% and 13.3%.After a median follow-up of 38 months, the recurrence ratesin RS≤10, RS 11-25 and RS≥26 groups were 3.3%, 4.5% and 5.4%, respectively. Kaplan-Meier RFS curve showed no significant difference between the 3 groups(P=0.788). The recurrence ratesin RS≤15 group(3.0%) was significantly lower than that in RS≥16 group(5.9%)(P=0.041). \u0000 \u0000 \u0000Conclusions \u0000A significant association exists between RS and breast cancer prognosis.It is rational not to give chemotherapy to RS<18 low risk patients according to classical standard. \u0000 \u0000 \u0000Key words: \u0000Breast neoplasms; Prognosis; 21-gene assay; Recurrence score","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":"34 1","pages":"771-775"},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45156145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sentinel lymph node biopsy combined with preoperative ultrasonography in predicting axillary lymph node metastasis in early breast cancer 前哨淋巴结活检联合术前超声检查预测早期乳腺癌腋窝淋巴结转移

中华普通外科杂志 Pub Date : 2019-09-25 DOI: 10.3760/CMA.J.ISSN.1007-631X.2019.09.009

W. Yanwei, Ping Xu, Zhao Lei, He Dongqiang, Tong Lei, Qiu Bin, Chi Dong, Song Ai-lin

{"title":"Sentinel lymph node biopsy combined with preoperative ultrasonography in predicting axillary lymph node metastasis in early breast cancer","authors":"W. Yanwei, Ping Xu, Zhao Lei, He Dongqiang, Tong Lei, Qiu Bin, Chi Dong, Song Ai-lin","doi":"10.3760/CMA.J.ISSN.1007-631X.2019.09.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2019.09.009","url":null,"abstract":"Objective \u0000To investigate the prediction of axillary lymph node metastasis in patients with early breast cancer by sentinel lymph node biopsy (SLNB) combined with preoperative ultrasound. \u0000 \u0000 \u0000Methods \u0000From Jun 2014 to Oct 2018, 340 patients with early breast cancer were enrolled in the 5th Department of General Surgery of Second Hospital of Lanzhou University. 113 cases were grouped into ultrasound examing, 75 patients in the SLNB, and 152 patients in the SLNB combined with preoperative ultrasound.Using the results of axillary lymph node dissection as gold standard, the 3 groups were compared. \u0000 \u0000 \u0000Results \u0000The sensitivity of SLNB, ultrasound and SLNB combined with ultrasound for suspicious axillary lymph node biopsy were 90.1%, 85.7%, and 96.4%, respectively. The specificity was 84.0%, 76.3%, and 100%, and the accuracy was 91.6%, 83.0%, and 97.4%, respectively. The false negative rates were 8.6%, 14.3%, and 3.6%, respectively. \u0000 \u0000 \u0000Conclusion \u0000Preoperative ultrasound diagnosis of axillary lymph node status combined with sentinel lymph node biopsy can significantly improve the diagnosis rate of axillary lymph node metastasis in early breast cancer. \u0000 \u0000 \u0000Key words: \u0000Breast neoplasms; Sentinel lymph node biopsy; Ultrasonography","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":"34 1","pages":"779-782"},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45350699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solid -papillary carcinoma of the breast, an analysis of 44 cases 乳腺实体乳头状癌44例分析

中华普通外科杂志 Pub Date : 2019-09-25 DOI: 10.3760/CMA.J.ISSN.1007-631X.2019.09.008

Lili Liu, Dingbao Chen, Si-qi Wang, D. Shen

{"title":"Solid -papillary carcinoma of the breast, an analysis of 44 cases","authors":"Lili Liu, Dingbao Chen, Si-qi Wang, D. Shen","doi":"10.3760/CMA.J.ISSN.1007-631X.2019.09.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2019.09.008","url":null,"abstract":"Objective \u0000To investigate the clinicopathological features of solid papillary carcinoma of the breast. \u0000 \u0000 \u0000Methods \u0000A retrospective study was performed to analyze the clinical and histopathologic manifestations in 44 cases of SPC in Peking University People′s Hospital from 2013.7 to 2017. 10. \u0000 \u0000 \u0000Results \u0000All the patients were female and mean age was 66.5 years. 17 cases complained of nipple discharge and 27 cases had breast mass .Pathologically tumors were of solid-papillary growth pattern. The tumor cells were polygonal or oval with mucin production and neuroendocrine differentiation. 22 cases were associated with invasive carcinoma, among which 15 cases were non-special invasive carcinomas. 7 cases were mucinous carcinoma.Six cases underwent modified radical mastectomy and axillary lymph nodes excision with two metastasis in an axillary lymph node.38 cases underwent breast conserving surgery or mastectomy. There were no local recurrence or distant metastasis during the follow-up periods of 12-48 months. \u0000 \u0000 \u0000Conclusion \u0000Solid papillary carcinoma of breast is a rare pathology type with predilection in older women. The postoperative prognosis is fair. \u0000 \u0000 \u0000Key words: \u0000Breast neoplasms; Pathology, clinical; Immunohistochemistry; Prognosis","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":"34 1","pages":"776-778"},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45907384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraoperative sac coiling embolization in type II endoleak high-risk population after endovascular aortic repair 术中囊圈栓塞在II型内溢高危人群血管内主动脉修复术后的应用

中华普通外科杂志 Pub Date : 2019-09-25 DOI: 10.3760/CMA.J.ISSN.1007-631X.2019.09.001

Xian-tao Li, Yanyan Huang, Ruiquan Chen, Meihong Guo, P. Guo

{"title":"Intraoperative sac coiling embolization in type II endoleak high-risk population after endovascular aortic repair","authors":"Xian-tao Li, Yanyan Huang, Ruiquan Chen, Meihong Guo, P. Guo","doi":"10.3760/CMA.J.ISSN.1007-631X.2019.09.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2019.09.001","url":null,"abstract":"Objective \u0000To investigate the effectiveness and safety of intraoperative sac coiling embolization among patients who are athigh-risk developing type-Ⅱ endoleak after endovascular aortic repair(EVAR). \u0000 \u0000 \u0000Methods \u0000From Jan 2014 to Jan 2018, one hundred and twelve consecutive patients with infra-renal AAA were enrolled for this study, There were 76 patients undergoing standard EVAR (standard-group)and 36 patients doing aneurysmal sac coiling embolization (embo-group). Baseline characteristics, aneurysmal sac parameters, radiological intervention details and follow up results were recorded. \u0000 \u0000 \u0000Results \u0000Mean follow-up time was 25.9 m for embo-group. During follow-up period, no coils-related complications were noted and no type-Ⅱ endoleak associated secondary interventions were reported. A mean of (2.72±1.16) coils (range 1-7) was used in the embo-group. The incidence of type Ⅱ endoleak was 30.3%(23/76) in standard-group and 11.1%(4/36) in embo-group(χ2=4.90, P=0.027). Logistic multivariate analysis revealed that the independent risk factors of type Ⅱ endoleak after endovascular aortic repair for high-risk patients were those EVAR without sac embolization and sac volume≥128 cm3. In the subgroup analysis (sac volume≥128 cm3), the incidence of type-Ⅱ endoleak was lower in embo-group compared to standard-group (χ2=6.07, P=0.014). \u0000 \u0000 \u0000Conclusion \u0000Intraoperative sac coiling embolization in high-risk patients is safe and effective in prevention of type Ⅱ endoleak. This preventive effect is more significant with large sac aneurysm compared to small sac aneurysm. \u0000 \u0000 \u0000Key words: \u0000Aortic aneurysm, abdominal; Radiology, interventional; Endoleak; Risk assessment","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":"34 1","pages":"745-749"},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46000321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Retrospective study on the risk factors related to intraabdominal infection after anatomical hepatectomy 解剖性肝切除术后腹腔感染危险因素的回顾性研究

中华普通外科杂志 Pub Date : 2019-09-25 DOI: 10.3760/CMA.J.ISSN.1007-631X.2019.09.005

Yali Tian, Lian Chen, Qing Sun, Xin-Long Cui, Shi-Teng Liu, L. Mao, Y. Qiu, Bingbing Li

{"title":"Retrospective study on the risk factors related to intraabdominal infection after anatomical hepatectomy","authors":"Yali Tian, Lian Chen, Qing Sun, Xin-Long Cui, Shi-Teng Liu, L. Mao, Y. Qiu, Bingbing Li","doi":"10.3760/CMA.J.ISSN.1007-631X.2019.09.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2019.09.005","url":null,"abstract":"Objective \u0000To assess the incidence and related risk factors of postoperative intraabdominal infection in patients undergoing anatomical hepatectomy. \u0000 \u0000 \u0000Methods \u0000The clinical data from 122 patients who underwent anatomical major hepatectomy in our institution were retrospectively analyzed. The electronic medical data were retrieved for further analysis including the amount of crystalloid and colloid fluid infused, intraoperative estimated blood loss, volume of blood transfusion, the dosage of vasoactive drugs, postoperative liver function, inflammation index, the incidence of intraabdominal infection and the length of hospital stay (LOS). \u0000 \u0000 \u0000Results \u0000Patients were divided into infection group (n=39) and non- infection group (n=83). Intraabdominal infection was correlated with preoperative cirrhosis, the elevated direct bilirubin and alanine aminotransferase, the duration of operation, bilioenteric anastomosis or cholangiotomy, the infusion volume of colloid and crystalloid fluid, transfusion volume, direct bilirubin level on the POD 1(post-operation on day 1) (P<0.05); Multivariate analysis showed the incidence of intraabdominal infection was highly correlated with the amount of intraoperative colloid fluid bilioenteric anastomosis(P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Intraoperative infused volume of synthetic colloid, along with bilioenteric anastomosis are independent risk factors for postoperative intraabdominal infection. \u0000 \u0000 \u0000Key words: \u0000Hepatectomy; Fluid management; Intraabdominal infection","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":"34 1","pages":"762-765"},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49040916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transvaginal pedicled omentum pull-through combined transanal colon pull-through for the treatment of vesicorectovaginal fistula 经阴道带蒂大网膜牵引联合经肛门结肠牵引治疗膀胱直肠阴道瘘

中华普通外科杂志 Pub Date : 2019-09-25 DOI: 10.3760/CMA.J.ISSN.1007-631X.2019.09.013

Yong Cheng, Gang-cheng Wang, G. Han, Y. Ren, Zhimeng Li, Jian Li, Yan-hui Gu, Shijia Zhang, M. Huo, Z. Run

{"title":"Transvaginal pedicled omentum pull-through combined transanal colon pull-through for the treatment of vesicorectovaginal fistula","authors":"Yong Cheng, Gang-cheng Wang, G. Han, Y. Ren, Zhimeng Li, Jian Li, Yan-hui Gu, Shijia Zhang, M. Huo, Z. Run","doi":"10.3760/CMA.J.ISSN.1007-631X.2019.09.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2019.09.013","url":null,"abstract":"Objective \u0000To evaluate surgical repair of vesicorectovaginal fistula using transvaginal pedicled omentum pull-through combined transanal colon pull-through. \u0000 \u0000 \u0000Methods \u0000A total of 11 patients with postoperative vesicorectovaginal fistulas complicating female reproductive system malignant tumors undergoing repairement from Aug 2013 to Aug 2018 were retrospectively analyzed. In order to isolate, protect the bladder and eliminate residual vaginal cavity using transvaginal pedicled omentum pull-through, combined transanal colon pull-through to repair vesicorectovaginal fistula. \u0000 \u0000 \u0000Results \u0000All the 11 patients in this group completed the operation successfully, and no air or stool passing from the vaginal after the operation. The fistula disappeared in five patients confirmed by cystography and enterograph. The average operation time was 115 min, the average blood loss was 260 ml.Incision fat liquefaction was found in two. Incision infection occurred in one. Urinary dysfunction in two. Anal stenosis was found in four patients which were healed by anal dilation. \u0000 \u0000 \u0000Conclusions \u0000Transvaginal pedicled omentum pull-through combined transanal colon pull-through can eliminate vesicorectovaginal fistula, improve life quality and avoid colostomy. \u0000 \u0000 \u0000Key words: \u0000Vesicovaginal fistula; Rectovaginal fistula; Omentum; Anal canal","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":"34 1","pages":"791-794"},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42997122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors associated with myocardial injury after non-cardiac major surgery in ICU admitted patients ICU住院患者非心脏大手术后心肌损伤的相关危险因素

中华普通外科杂志 Pub Date : 2019-09-25 DOI: 10.3760/CMA.J.ISSN.1007-631X.2019.09.015

Shu Li, F. Zhu, F. Guo, Lilei Jiang, Haiyan Xue, Xiujuan Zhao, Y. An

{"title":"Risk factors associated with myocardial injury after non-cardiac major surgery in ICU admitted patients","authors":"Shu Li, F. Zhu, F. Guo, Lilei Jiang, Haiyan Xue, Xiujuan Zhao, Y. An","doi":"10.3760/CMA.J.ISSN.1007-631X.2019.09.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2019.09.015","url":null,"abstract":"Objective \u0000To analyze the risk factors related to the myocardial injury after non-cardiac surgery (MINS) in patients who underwent major abdominal surgery. \u0000 \u0000 \u0000Methods \u0000The clinical data of all patients admitted in the surgical ICU of Peking University People′s Hospital from Jan 2016 to Dec 2018 were analyzed. Logistic multivariate analysis was performed to analyze the association of clinical characteristics with the incidence of MINS. \u0000 \u0000 \u0000Results \u0000A total of 322 patients were included, 48.4% (156/322) were diagnosed as with MINS. 97.4% (152/156) of MINS occurred during the first 72 h of admission. Multivariate analysis showed that independent predictive factors of MINS were age >65y (OR=1.747, P=0.021), body mass index (OR=1.085, P=0.008), acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ, OR=1.066; P=0.047), hypertension (OR=1.747, P=0.027), blood lactate (OR=1.393, P=0.001) and acute kidney injury (OR=2.065, P=0.047). \u0000 \u0000 \u0000Conclusions \u0000The incidence of MINS in patients who underwent major abdominal surgery was high. Age, body mass index, APACHE Ⅱ score, hypertension, blood lactate level and acute kidney injury after surgery were independent risk factors of MINS. \u0000 \u0000 \u0000Key words: \u0000Postoperative complications; Intensive care; Risk factors; Myocardial injury","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":"34 1","pages":"798-801"},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42523006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metformin improves oxaliplatin resistance in colorectal cancer cells by inhibiting EIF3G expression 二甲双胍通过抑制EIF3G表达改善结直肠癌细胞对奥沙利铂的耐药性

中华普通外科杂志 Pub Date : 2019-09-25 DOI: 10.3760/CMA.J.ISSN.1007-631X.2019.09.016

Xianli Meng, Hai-rong Jia, Dongsheng Yu, J. Zhi, Chao Zhang

{"title":"Metformin improves oxaliplatin resistance in colorectal cancer cells by inhibiting EIF3G expression","authors":"Xianli Meng, Hai-rong Jia, Dongsheng Yu, J. Zhi, Chao Zhang","doi":"10.3760/CMA.J.ISSN.1007-631X.2019.09.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2019.09.016","url":null,"abstract":"Objective \u0000To analyze the mechanism of metformin in improving oxaliplatin resistance of colorectal cancer cells. \u0000 \u0000 \u0000Methods \u0000The expression levels of EIF3G in 71 cases of colorectal cancer and adjacent tissues were detected by RT-qPCR. The survival curve was established by Kaplan-Meier method. The survival rate difference between the two groups was compared by Log-rank test.HCT-116 cells were infected with shEIF3G lentivirus, HCT-116 L-OHP-resistant cell line was constructed.After treated with metformin, sensitivity to L-OHP was detected by CCK-8 assay, RT-qPCR and Western blot were used to analyze the EIF3G mRNA and protein levels. The subcutaneous tumor model of nude mice was constructed to observe the effect of metformin on tumor growth. \u0000 \u0000 \u0000Results \u0000The expression level of EIF3G mRNA in colorectal cancer tissues was up-regulated by (3.24±0.43) times compared with paraneoplastic tissues (P<0.01). EIF3G level was significantly correlated with the prognosis of colon cancer patients. Knockdown EIF3G could enhance the L-OHP sensitivity of HCT116/L-OHP cells (P<0.05); Metformin can reduce the expression level of EIF3G and improve the drug resistance of HCT116/L-OHP cells (P<0.05), and inhibit the development of colorectal cancer in vivo (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Metformin can inhibit the expression of EIF3G and improve the L-OHP resistance of HCT-116 cells. \u0000 \u0000 \u0000Key words: \u0000Colorectal neoplasms; Metformin; Drug resistance, neoplasms","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":"34 1","pages":"802-805"},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47627495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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