Journal of Pharmaceutical Innovation最新文献

{"title":"Curcumin-loaded Niosomes Prepared by Microfluidic Mixing; Characterization and Cytotoxicity Evaluation","authors":"Saif Aldeen Jaber,&nbsp;Mohamed Saadh,&nbsp;Qamar Abuhassan,&nbsp;Mohammad A. Obeid","doi":"10.1007/s12247-025-10003-w","DOIUrl":"10.1007/s12247-025-10003-w","url":null,"abstract":"<div><p>Curcumin is a commonly used natural chemical compound that has several reported therapeutic applications. Derived from <i>Curcuma longa</i>, curcumin possesses several limitations, such as limited water solubility, low bioavailability, and rapid in vivo degradation. In this study, niosomes were proposed to overcome some of these limitations. Niosomes composed of Span 60 and cholesterol were prepared using microfluidic mixing at flow rate ratio of 3:1 between the aqueous and the lipid phase and a total flow rate of 12 ml/min. The prepared formulations were evaluated for their physicochemical characteristics, curcumin encapsulation efficiency (EE), and cytotoxicity. The prepared niosomes had an average particle size of 139.7 nm with a monodisperse distribution and a spherical shape. The curcumin EE was approximately 37%, and the half maximal inhibitory concentration (IC₅₀) of curcumin was significantly reduced by niosome loading compared to free curcumin for all the tested cell lines. Moreover, curcumin loaded niosomes demonstrated a higher ability to activate both caspase-3 and caspase-9 proteins, crucial for initiating cell apoptosis. These results demonstrate that niosomes could effectively carry and deliver curcumin to improve its therapeutic potential for clinical applications.</p></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145161368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Prednisolone-Loaded Layer-by-Layer Nanoparticles (LBL-NPs) for Rheumatoid Arthritis: Optimization and Therapeutic Evaluation","authors":"Jamal Moideen Muthu Mohamed,&nbsp;Durgaramani Sivadasan,&nbsp;Ahmad Salawi,&nbsp;Muhammad H. Sultan,&nbsp;Pooja Muralidharan,&nbsp;Krishnaraju Venkatesan,&nbsp;Yahya I. Asiri,&nbsp;Mona Qushawy,&nbsp;Gayathri Pandurangam,&nbsp;Farid Menaa","doi":"10.1007/s12247-025-10029-0","DOIUrl":"10.1007/s12247-025-10029-0","url":null,"abstract":"<div><h3>Purpose</h3><p>Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with bone erosion, inflammatory joint disease, and long-term disability. In spite of traditional treatment, currently available therapies are challenged with several limitations such as systemic side effects, poor drug bioavailability, and frequent dosing, and therefore lead to reduced patient compliance.</p><h3>Method</h3><p>To addresses these challenges; this investigation focused on developing an optimized layer-by-layer (LBL) system of prednisolone acetate (PRD)-loaded nanoparticles (NPs) (LBL-PRD NPs) using the Box-Behnken design (BBD). The optimised LBL-PRD NPs (F18) were evaluated for mean hydrodynamic diameter (nm), zeta potential (ZP), scanning electron microscopy (SEM), atomic force microscopy (AFM), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR), in vitro drug release, collagen-induced arthritis (CIA), and radiological examinations on male Wistar rats.</p><h3>Results</h3><p>The outcome on entrapment efficiency (%EE) of 56.78 ± 2.52% and burst release (%BR) of 30.57 ± 1.63%. The drug had been successfully loaded into the NPs, exhibiting a spherical shape and physicochemical compatibility without any chemical interaction with the used polymers.</p><h3>Conclusion</h3><p>The prepared LBL-PRD NPs showed a longer residence time at the bloodstream, resulting in a prolonged therapeutic effect and inhibition of bone erosion and soft tissue swelling in the treated animals, which did not express any allergic reactions and skin alterations. This pioneered LBL-PRD NPs appears to be a promising, alternative, and effective nanodrug delivery system (NDDS) to treat effectively RA.</p></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145161259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface-Decoration of Solid Lipid Nanoparticles (SLNs) Using 7D12 Nanobody for Targeted Delivery of 5-Fluorouracil to Colorectal cancer Cells: Preparation, Statistical Optimization and Cytotoxicity Studies","authors":"Zahra Salimi,&nbsp;Meysam Soleimani,&nbsp;Reza Mahjub","doi":"10.1007/s12247-025-10005-8","DOIUrl":"10.1007/s12247-025-10005-8","url":null,"abstract":"<div><h3>Purpose</h3><p>Colorectal cancer remains a significant concern, demanding innovative strategies for enhanced therapeutic outcomes. This study explores the potential of nanobodies as an EGFR-targeting ligand which were conjugated to the surface of 5-fluorouracil (5-FU)-containing solid lipid nanoparticles (SLNs) in treatment of colorectal cancer.</p><h3>Methods</h3><p>The 7D12 nanobody was successfully expressed in <i>E. coli</i> and was further purified. The SLNs were prepared and were statistically optimized using central composite response surface methodology. Then after, the purified nanobody was chemically attached to the surface of the nanoparticles and following lyophilization, their morphology determined using scanning electron microscopy (SEM). Then, the in vitro release of 5-FU from the targeted nanoparticles was examined and finally the cytotoxicity of the nanoparticles was evaluated in SW480 and HepG2 cells.</p><h3>Results</h3><p>The size, poly dispersity index (PdI), zeta potential, entrapment efficiency (EE%) and loading efficiency of the optimized nanoparticles were 169.8 ± 37.17 nm, 0.247 ± 0.062, -13.2 ± 2.18 mV, 82.9 ± 5.39% and 9.3 ± 1.06%, respectively. Although a burst release of 5-FU from nanoparticles were demonstrated in the first hours of incubation, but in further time intervals, the in vitro release profile revealed sustained release behavior. The cytotoxicity studies revealed a significant higher toxicity of targeted 5-FU-containing nanoparticles on SW480 as an EGFR- positive colorectal cancer cells in comparison with HepG2 as an EGFR-negative cell line.</p><h3>Conclusion</h3><p>This study paves the way for the development of an efficient, EGFR-targeted drug delivery system, with potential applications in treatment of colorectal cancer.</p></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145161280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Plasticizer on the Drug Supersaturation Maintenance by Polymer","authors":"Maryam Maghsoodi,&nbsp;Ahmadreza Shahidi,&nbsp;Ali Nokhodchi","doi":"10.1007/s12247-025-10014-7","DOIUrl":"10.1007/s12247-025-10014-7","url":null,"abstract":"<div><h3>Objective</h3><p>One of the widely used methods to inhibit precipitation and provide supersaturation stabilization of poorly water-soluble drugs in aqueous solution is the use of polymers. To enhance the precipitation inhibitory effect of a polymer, its fast dissolution is a prerequisite, while many polymers have extended-release profiles. The present study investigates the impact of four plasticizers, including glycerol (GLY), polyethylene glycol 400 (PEG), methylparaben (MP) and propylparaben (PP), on the supersaturation stabilization of cinnarizine (CNZ) as a poorly water-soluble drug using eudragit S100 (Eu) as a polymeric precipitation inhibitor.</p><h3>Methods</h3><p>The supersaturation behavior of CNZ in the presence of Eu, plasticizers, plasticizer/Eu physical mixtures, and plasticized Eu was evaluated and compared to identify the effect of plasticizers on the Eu-mediated supersaturation stabilization of CNZ.</p><h3>Results</h3><p>For MP, PP and PEG, when the plasticizers were physically blended with Eu, no significant improvement in CNZ supersaturation was found compared to Eu alone. However, plasticized Eu with each of these plasticizers resulted in much higher supersaturation stabilization of CNZ compared to polymer alone, which might be due to the higher dissolution rate of polymer with plasticizer. Contrarily, GLY, irrespective of the mode of addition to Eu, led to lower supersaturation stabilization of CNZ by Eu, which might be due to its interaction with Eu which impedes the preventing effect of Eu on the drug precipitation.</p><h3>Conclusion</h3><p>From these results, incorporating a suitable plasticizer into a polymer can have a strong advantage in further enhancing the drug supersaturation stabilization by the polymer.</p></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145161292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Assessment of Electrospun Nanofibrous Wound Dressing Containing Curcumin and Wedelolactone","authors":"Deepika Sharma,&nbsp;Shriyansh Srivastava,&nbsp;Sachin Kumar,&nbsp;Abdul Rahaman,&nbsp;Rupali Sharma,&nbsp;Vipin Kumar Garg,&nbsp;Sumel Ashique,&nbsp;Siva Prasad Panda,&nbsp;Uttam Prasad Panigrahy,&nbsp;Sabina Yasmin,&nbsp;Kumar Venkatesan,&nbsp;Mohammad Yousuf Ansari","doi":"10.1007/s12247-025-10001-y","DOIUrl":"10.1007/s12247-025-10001-y","url":null,"abstract":"<div><h3>Purpose</h3><p>Polyvinyl alcohol (PVA), widely used in scaffold fabrication, is valued for its permeability, softness, and transparency, making it ideal for wound-healing applications. This study aims to enhance wound healing by incorporating bioactive compounds, curcumin and wedelolactone, into electrospun PVA nanofibers, leveraging their antioxidant, antibacterial, anti-inflammatory, and analgesic properties.</p><h3>Method</h3><p>Innovative polymeric nanofibrous scaffolds crafted from PVA, curcumin, and wedelolactone have been expertly developed through advanced electrospinning techniques, showcasing their potential in various applications. Scanning Electron Microscopy (SEM), UV–visible spectroscopy, FTIR spectroscopy, X-ray diffraction (XRD), folding endurance tests, and in vitro drug release kinetics were among the methods used to characterize the scaffolds. The scaffolds' ability to promote wound healing was evaluated in vivo using a Wistar albino rat model with excision and incision wound models.</p><h3>Results</h3><p>Characterization techniques confirmed the successful incorporation of curcumin and wedelolactone into the PVA nanofibers. Rats with full-thickness wounds showed in vivo that PVA/Cur/Wed nanofibers healed the wounds on the 13th day compared to the 15th day for the control group, which received commercial povidone ointment. On the 12th day, NS had 18.33 ± 2.19(96.32%) mm2, whereas the control group had 274.16 ± 2.36 (44.65%)mm2, significantly more effective than the control group.</p><h3>Conclusion</h3><p>The results demonstrate that combining curcumin and wedelolactone in PVA nanofibrous scaffolds enhances wound healing, suggesting a potential therapeutic strategy for improving wound care and accelerating recovery in clinical settings.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145161293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rutin-Loaded Nanocapsules Mitigate Vancomycin-Induced Hepatotoxicity: Development, Characterization, Optimization, and In Vivo Evaluation","authors":"Mohamed Ibrahim,&nbsp;Mohamed Fouad Mansour,&nbsp;Mahran Mohamed Abd El-Emam,&nbsp;Tarek khamis,&nbsp;Maha S. Kilany,&nbsp;Amira Ebrahim Alsemeh,&nbsp;Asmaa Monir Eltaweel,&nbsp;Milad Reda Qelliny,&nbsp;Mahmoud Mostafa,&nbsp;Marwa Mohamed El Sayed","doi":"10.1007/s12247-025-10026-3","DOIUrl":"10.1007/s12247-025-10026-3","url":null,"abstract":"<div>\u0000 \u0000 <span>AbstractSection</span>\u0000 Background\u0000 <p>Vancomycin (VCM)-induced hepatotoxicity is a significant clinical concern due to its association with oxidative stress, apoptosis, and inflammatory responses. This study investigated the formulation and potential preclinical application of rutin-loaded nanocapsules (RUT-NC) as a hepatoprotective agent against VCM-induced liver injury.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Methods\u0000 <p>Hepatotoxicity was induced in rats through VCM administration, followed by oral treatment with RUT-NC. Liver function, oxidative stress markers, apoptotic proteins, lipid metabolism regulators, and inflammatory cytokines were subsequently evaluated.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Results\u0000 <p>RUT-NC treatment significantly improved liver function parameters, attenuated oxidative stress, and modulated apoptotic pathways by downregulating the expression of <i>p38</i>,<i> p53</i>,<i> caspase-8</i>,<i> miR-122</i>,<i> miR-7</i>, and <i>beclin-1.</i> Furthermore, RUT-NC restored lipid metabolism homeostasis by regulating the expression of PPAR-α, FASN, and SREBP-1. Notably, it exerted potent anti-inflammatory effects by suppressing <i>NF-κB</i>,<i> TNF-α</i>,<i> IL-1β</i>,<i> IL-6</i>,<i> IL-17</i>, and <i>Gasdermin-D</i>, thereby mitigating chronic liver inflammation. The pathological effects of VCM administration on hepatocytes were effectively counteracted by RUT-NC.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Conclusion\u0000 <p>RUT-NC demonstrates promising hepatoprotective properties by enhancing antioxidant defenses, inhibiting apoptosis, regulating lipid metabolism, and reducing inflammation. These findings highlight its potential as a therapeutic intervention for drug-induced liver injury (DILI) and warrant further investigation for clinical application.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Graphical Abstract\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 \u0000 </div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12247-025-10026-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Sesamol Loaded-Polymer-Lipid Blend Nanoparticles: Statistical Optimization, In-Vitro, and Preclinical Assessment","authors":"Ameeduzzafar Zafar,&nbsp;Mohd Yasir,&nbsp;Md Ali Mujtaba,&nbsp;Mohammad Khalid,&nbsp;Dibya Sundar Panda,&nbsp;Lubhan Singh,&nbsp;Omar Awad Alsaidan,&nbsp;Anwarulabedin Mohsin Quazi","doi":"10.1007/s12247-025-10016-5","DOIUrl":"10.1007/s12247-025-10016-5","url":null,"abstract":"<div><h3>Background</h3><p>The oral route is the most preferred drug delivery method for treating both chronic and acute diseases due to its ease of administration and high patient compliance. However, sesamol (SM), a natural bioactive compound, exhibits promising antioxidant and anticancer activity but suffers from poor water solubility, inconsistent absorption, and low bioavailability, limiting its therapeutic potential. This study aimed to develop SM-loaded hybrid nanoparticles (HNP) composed of a polymer-lipid matrix to enhance bioavailability and therapeutic efficacy for its antioxidant potential and anticancer activity.</p><h3>Method</h3><p>SMHNP were formulated using homogenization and ionotropic gelation techniques and optimized by Box-Behnken design using design expert software. The SMHNP were evaluated through in-vitro and in vivo studies using the albino Wistar rat model.</p><h3>Results</h3><p>The optimized SMHNP formulation (SMHNP13) exhibits a particle size of 177.6 ± 4.7 nm, a polydispersity index of 0.179, and a zeta potential of 27.2 mV. Scanning electron microscopy (SEM) confirmed that the particles were spherical and non-aggregated. FTIR and X-ray diffraction (XRD) analyses indicated successful drug encapsulation within the HNP matrix. The SMHNP13 formulation exhibited a sustained drug release profile, with 92.81 ± 3.76% release over 24 h, attributed to its nanosize and encapsulation. It displayed 2.45-fold higher ex-vivo intestinal permeation and significantly higher in-vitro antioxidant activity (<i>P</i> &lt; 0.05) at all tested concentrations than pure SM. It also increased cytotoxicity against SK-LU-1 cells (IC50 = 590.23 µM) compared to pure SM (IC50 = 1510.12 µM) and demonstrated a 3.33-fold higher relative bioavailability than pure SM.</p><h3>Conclusion</h3><p>The results indicate that HNP are a promising strategy for enhancing the oral bioavailability and therapeutic potential of sesamol. Further preclinical investigations are needed to confirm their clinical applicability.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Berberine–Carrageenan Complexation: Preparation, Characterization and Employment of the Complex in a Gastric-Floating Matrix","authors":"Rana Z. Al-Sukhun,&nbsp;Ahmad Bani-Jaber","doi":"10.1007/s12247-025-10022-7","DOIUrl":"10.1007/s12247-025-10022-7","url":null,"abstract":"<div><h3>Purpose</h3><p>The efficient clinical utilization of Berberine (BRB), a natural alkaloid, could be hampered by its poor dissolution performance in the gastric fluid and by the intestinal glycoprotein mediated efflux. Therefore, formulations that enhance BRB dissolution with prolonged gastric retention may be beneficial. In this work, we sought to improve the dissolution performance of BRB by its complexation with carrageenan (CRG), a hydrophilic polyelectrolyte.</p><h3>Methods</h3><p>The optimum ratios of the complexation using λ and κ-CRG were studied by viscosity measurements. The release of BRB from the complexes was assessed in simulated gastric fluid (SGF). The complex with enhanced BRB release, namely BRB-κ-CRG complex, was formulated as hydroxypropyl-methylcellulose floating matrix.</p><h3>Results</h3><p>Compared to BRB-λ-CRG complex and neat BRB, BRB-κ-CRG complex showed a higher and faster rate of BRB release in SGF. Relative to that of BRB, the floating matrix of BRB-κ-CRG complex was shown to release twice as much BRB in a sustained-release zero-order pattern throughout the course of 8 h of dissolution in SGF.</p><h3>Conclusion</h3><p>The outcomes of the work are highly beneficial for further investigation of natural alternatives that target gastric related conditions.</p></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statistical Formulation Optimization of Naproxen Microsponges with Eudragit RS100 for Sustained Drug Release","authors":"Sonia Gupta,&nbsp;Himanshu Chopra,&nbsp;Prabhjot Singh bajwa,&nbsp;Dinesh Kumar","doi":"10.1007/s12247-025-09994-3","DOIUrl":"10.1007/s12247-025-09994-3","url":null,"abstract":"<div><h3>Background and Objective</h3><p>This study aims to address the solubility, stability, and bioavailability challenges of Naproxen, a widely used nonsteroidal anti-inflammatory drug (NSAID), by formulating Naproxen-loaded microsponges with controlled release properties. The ultimate objective is to achieve enhanced drug concentration in the bloodstream while ensuring prolonged therapeutic efficacy. Naproxen was specifically chosen for this study due to its frequent clinical use in managing musculoskeletal disorders, arthritis, and inflammatory conditions, along with its poor aqueous solubility (BCS Class II) and gastrointestinal side effects upon oral administration. While other NSAIDs, such as ibuprofen, diclofenac, and celecoxib, face similar biopharmaceutical limitations, Naproxen’s longer half-life and strong anti-inflammatory efficacy make it a suitable candidate for a controlled topical delivery system to enhance localized action, reduce systemic toxicity, and improve patient compliance.</p><h3>Methods</h3><p>Naproxen microsponges were developed using the quasi-emulsion solvent diffusion technique. Eudragit RS100 (ERS100) was employed as the polymer, polyvinyl alcohol (PVA) as the stabilizing emulsifier, and dichloromethane (DCM) as the organic solvent. To systematically optimize the formulation, a Box-Behnken design was utilized, enabling the evaluation of critical formulation and process parameters. The independent variables included ERS100 amount (X₁), PVA concentration (X₂), and stirring speed (X₃). Response factors were defined as particle size, percentage yield, and entrapment efficiency (%EE).</p><h3>Results</h3><p>All prepared microsponge batches demonstrated an initial burst release of more than 40% of Naproxen within the first hour, followed by a sustained drug release profile over 8 h. The optimized batch, identified through desirability-based software optimization, exhibited a particle size of 22.32 µm, a percentage yield of 85.14%, and an entrapment efficiency of 69.11%. Drug release from the optimized formulation (NXMF2) was found to follow the Korsmeyer-Peppas model, indicating a diffusion-controlled release mechanism.</p><p>This study demonstrates the potential of microsponge technology as an effective strategy to enhance the bioavailability and therapeutic performance of Naproxen, with the optimized formulation offering controlled release and improved pharmacokinetic properties.</p><h3>Conclusion</h3><p>The Naproxen-loaded microsponges achieved sustained drug release, improved bioavailability, and enhanced stability, demonstrating their potential for effective controlled drug delivery.</p></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Radioiodinated Silica-Coated Magnetic Nanoparticles as SPECT/MR Dual-Modality Probe for Bone Imaging","authors":"Noha A. Bayoumi","doi":"10.1007/s12247-025-10011-w","DOIUrl":"10.1007/s12247-025-10011-w","url":null,"abstract":"<div><h3>Purpose</h3><p>A reliable imaging probe is essential for the accurate diagnosis of diseases and to support effective therapeutic decision-making. Different nanoparticles based multimodal probes have been studied for bone imaging. This work focuses on synthesizing of radiolabeled iron oxide magnetic nanoparticles as a promising dual modality bioprobe (SPECT/MR) for bone imaging.</p><h3>Methods</h3><p>In this work, silica coated magnetic nanoparticles (SiO₂@MNPs) were synthesized. Radioiodination of SiO₂@MNPs with iodine − 131 was performed via the Finkelstein reaction to produce a prospective radioiodinated MNPs for bone targeting.</p><h3>Results</h3><p>The radioiodinated NPs were obtained in high radiochemical purity (about 98.5 ± 0.5%) by magnet separation. The aqueous dispersion of the radioiodinated silica coated MNPs (¹³¹I-SiO₂@MNPs) exhibited adequate in-vitro stability and biocompatibility. Biodistribution study results after intravenous injection of (¹³¹I-SiO₂@MNPs) in normal mice revealed the high bone targeting efficiency of the radiolabeled NPs (C_max= 6± 0.5% ID/g at t_max= 2 h post injection). Magnetization properties measurements proved the preservation of the magnetic properties of SiO₂@MNPs after the iodination process retaining its effectiveness as MRI contrast agent.</p><h3>Conclusion</h3><p>Based on to the results of this study, ¹³¹I-SiO₂@MNPs could be considered as a promising candidate for SPECT/MR dual bone imaging.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12247-025-10011-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145167063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}