Non-effervescent Polymeric Floating Tablets of Clarithromycin and Pantoprazole: Preparation and In-Vitro Evaluation for Improved Gastric Drug Retention

IF 2.7 4区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of Pharmaceutical Innovation Pub Date : 2025-01-02 DOI:10.1007/s12247-024-09917-8

Fahad Ashraf, Kifayat Ullah Shah, Muhammad Danish Saeed, Faiqa Falak Naz, Fahad Y. Sabei, Tahseen Ahmed, Syed Shafqat Ali Shah, Amir Badshah, Naeem Ur Rehman, Kausar Ali Mahsud

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引用次数: 0

Abstract

Purpose

The study intended to develop and investigate controlled release non-effervescent floating polymeric tablets of Clarithromycin and Pantoprazole to enhance their bioavailability by prolonging the gastrointestinal transit time of drugs, a system for Helicobacter pylori elimination.

Methods

The gastro-retentive tablets were prepared via direct compression method using different concentrations and combinations of hydroxypropyl methylcellulose (HPMC) K4M, Carbopol and guar gum as hydrophilic polymers and Avicel 102 as a filler. The pre-compression solid mixture was characterized for angle of repose and compressibility index, applying Hausner’s ratio to predict the flowability, as well as fourier transform infrared spectroscopy for drug-excipient interaction evaluation. The prepared tablets were investigated for dimension, hardness and friability, weight variation and content uniformity, swelling index, density, buoyancy and in-vitro drug release.

Results

All the formulations exhibited desired floating and flow attributes. Solid-state characterization revealed no chemical interaction between excipients and the drugs. With reference to in-vitro study results, all formulations, except F7, have displayed slow drug release and reduced burst effect (F6). The lowest lag buoyancy of 5 min was achieved in F2. This study develops a non-effervescent floating system for dual drug delivery to enhance gastric residence time, thereby optimizing local therapeutic effects. This innovative approach aims to reduce dosing frequency and associated side effects, improving patient compliance and treatment efficacy for gastric ulcer. This innovative approach can provide effective ulcer healing with shortened treatment time, reduced side effects and improved patient compliance.

Conclusion

This study also highlights the effectiveness of non-effervescent approach to improve dissolution and bioavailability.

Graphical Abstract

Abstract Image

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来源期刊

Journal of Pharmaceutical Innovation PHARMACOLOGY & PHARMACY-

CiteScore

3.70

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories: Materials science, Product design, Process design, optimization, automation and control, Facilities; Information management, Regulatory policy and strategy, Supply chain developments , Education and professional development, Journal of Pharmaceutical Innovation publishes four issues a year.