Spray Angle Measurement in Pharmaceutical Sprays: Correct Methodology and Common Pitfalls

IF 2.7 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Adarsh Manjunath Hegde, Ayesha Syed, Preeti Karwa
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引用次数: 0

Abstract

Purpose

The primary purpose of this perspective article is to challenge the conventional approach of spray angle measurement in pharmaceutical sprays, which has long relied on the formula θ = \(\:{\text{tan}}^{-1}\frac{l}{r}\). This article introduces and justifies the use of the correct formula, θ =\(\:2{\text{tan}}^{-1}\frac{r}{l}\), which provides a more accurate method for calculating spray angles. Accurate spray angle measurement is crucial for determining drug dispersion and coverage, ensuring uniform deposition on target areas such as wounds and topical treatments,optimizing formulation and device performance. Inaccurate measurement may lead to under-dosing or over-dosing. Consistent spray patterns also guarantee reproducibility, which is essential for maintaining product quality and ensuring effective clinical outcomes.

Methods

A comprehensive review of existing literature was conducted to identify and analyse the use of the θ = \(\:{\text{tan}}^{-1}\frac{l}{r}\) formula in spray angle measurement. The mathematical and geometric principles underlying both formulas were examined and compared. Additionally, the implications of using the correct formula, θ =\(\:2{\text{tan}}^{-1}\frac{r}{l}\), were explored in the context of pharmaceutical spray performance.

Results

The analysis revealed that the traditional formula, θ = \(\:{\text{tan}}^{-1}\frac{l}{r}\), often leads to inaccuracies in determining the spray angle, which can result in suboptimal spray performance and drug delivery. The correct formula, θ =\(\:2{\text{tan}}^{-1}\frac{r}{l}\), addresses these inaccuracies, offering a more precise and reliable method for measuring spray angles ensuring accurate spray characterization.

Conclusion

This article advocates for the adoption of the θ = \(\:2{\text{tan}}^{-1}\frac{r}{l}\)formula as the standard for spray angle measurement in pharmaceutical sprays. By correcting the longstanding error in the methodology, this new approach enhances the accuracy of spray characterization, ultimately contributing to better drug delivery outcomes. Further research and validation are encouraged to solidify this method as the industry standard.

药物喷雾剂的喷雾角测量:正确的方法和常见的陷阱
这篇透视文章的主要目的是挑战传统的药物喷雾喷雾角测量方法,该方法长期依赖于公式θ = \(\:{\text{tan}}^{-1}\frac{l}{r}\)。本文介绍并论证了正确公式θ = \(\:2{\text{tan}}^{-1}\frac{r}{l}\)的使用,该公式为计算喷射角提供了更准确的方法。准确的喷雾角度测量对于确定药物分散和覆盖,确保均匀沉积在目标区域(如伤口和局部治疗),优化配方和设备性能至关重要。不准确的测量可能导致剂量不足或过量。一致的喷雾模式也保证了再现性,这对于保持产品质量和确保有效的临床结果至关重要。方法综合查阅已有文献,确定并分析θ = \(\:{\text{tan}}^{-1}\frac{l}{r}\)公式在喷雾角测量中的应用。对这两个公式背后的数学和几何原理进行了检验和比较。此外,在药物喷雾性能的背景下,探讨了使用正确的公式θ = \(\:2{\text{tan}}^{-1}\frac{r}{l}\)的影响。结果分析发现,传统公式θ = \(\:{\text{tan}}^{-1}\frac{l}{r}\)在确定喷雾角度时往往存在误差,导致喷雾效果和给药效果不理想。正确的公式,θ = \(\:2{\text{tan}}^{-1}\frac{r}{l}\),解决了这些不准确性,提供了一个更精确和可靠的方法来测量喷雾角,确保准确的喷雾特性。结论提倡采用θ = \(\:2{\text{tan}}^{-1}\frac{r}{l}\)公式作为药物喷雾中喷雾角测量的标准。通过纠正方法中长期存在的错误,这种新方法提高了喷雾表征的准确性,最终有助于更好的药物输送结果。鼓励进一步的研究和验证,以巩固该方法作为行业标准。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Pharmaceutical Innovation
Journal of Pharmaceutical Innovation PHARMACOLOGY & PHARMACY-
CiteScore
3.70
自引率
3.80%
发文量
90
审稿时长
>12 weeks
期刊介绍: The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories: Materials science, Product design, Process design, optimization, automation and control, Facilities; Information management, Regulatory policy and strategy, Supply chain developments , Education and professional development, Journal of Pharmaceutical Innovation publishes four issues a year.
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