美国分子生物学期刊(英文)最新文献_第2页

Identification and Characterization of Hepatitis B Virus Immune Escape Mutants in Kenya 肯尼亚乙型肝炎病毒免疫逃逸突变体的鉴定和表征

美国分子生物学期刊(英文) Pub Date : 2023-01-01 DOI: 10.4236/ajmb.2023.131001

Rhoda Elizabeth King, J. Kimotho, R. Macharia, Faith Ndung'u, S. Nzou, R. M. Irekwa

引用次数: 0

Molecular Profiling of Sugarcane Wine, a Traditional Fermented Beverage (Loungouila) from Madingou 马定沟传统发酵饮料甘蔗酒的分子特征分析

美国分子生物学期刊(英文) Pub Date : 2023-01-01 DOI: 10.4236/ajmb.2023.134014

Yannick Frédéric Okouakoua, N. Mokémiabeka, C. A. Kayath, Moïse Doria Kaya-Ongoto, S. A. Nzaou, Nkalla Lambi Ndelani, Etienne Nguimbi

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Ampelographic and Genetic Diversity Assessment of Some Local Grape Genotypes under Egyptian Conditions 埃及条件下一些地方葡萄基因型的气谱和遗传多样性评价

美国分子生物学期刊(英文) Pub Date : 2023-01-01 DOI: 10.4236/ajmb.2023.133013

R. Mahmoud, A. A. Dahab, Gehan Ahmed Mahmoud, M. El-Wahab, E. El-Bassel, E. Mahdy

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Use of Polyclonal Antibody for the Diagnosis of Human African Trypanosomiasis 多克隆抗体在非洲人锥虫病诊断中的应用

美国分子生物学期刊(英文) Pub Date : 2023-01-01 DOI: 10.4236/ajmb.2023.132009

Dawala Koromtili Oumar, Matthew Mutinda Munyao, A. Mwangi, R. Waihenya, Peter Kipkemboi Rotich, R. M. Irekwa, Tonny Teya Nyandwaro, C. W. Njoroge, J. Yego, Primrose Muthoni Ndungu, Sharlene Kerubo Mageto, Damaris Mutethya Kilei, Otilmoi Poul Stephen, Nicole Sian Tanchu, Grace Ng’endo Kanyita, Shingo Inoue, Lucy Gitau, S. Nzou

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Streptococcal Pyrogenic Exotoxin Genes SpeA and SpeB in Isolates of Streptococcus pyogenes from Children with Pharyngitis, Gezira State, Sudan 苏丹Gezira州儿童咽炎化脓性链球菌分离株的热原性外毒素基因SpeA和SpeB

美国分子生物学期刊(英文) Pub Date : 2022-01-01 DOI: 10.4236/ajmb.2022.124015

Minas Mohamed Balla, A. Mergani, Mohamed Elamin A. M. E. Medani, A. Abakar, A. Dafalla

{"title":"Streptococcal Pyrogenic Exotoxin Genes SpeA and SpeB in Isolates of <i>Streptococcus pyogenes</i> from Children with Pharyngitis, Gezira State, Sudan","authors":"Minas Mohamed Balla, A. Mergani, Mohamed Elamin A. M. E. Medani, A. Abakar, A. Dafalla","doi":"10.4236/ajmb.2022.124015","DOIUrl":"https://doi.org/10.4236/ajmb.2022.124015","url":null,"abstract":"Background: Streptococcus pyogenes (group A streptococcus, GAS) is an important human bacterial pathogen. This organism possesses many virulence factors, Streptococcal pyrogenic exotoxinone of these. Aim: Detection of Streptococcal pyrogenic exotoxin SpeA and SpeB in isolated Streptococcus pyogenes. Methods: Tow hundred throat swab samples were collected from children with pharyngitis referred to Pediatric Teaching hospital and ENT hospital Wad medani, Sudan, from January to November 2021. The ques-tionnaire was filled out to collect clinical and demographic data. Throat swabs were collected and processed with the standard microbiological pro-cedure to isolate Streptococcus pyogenes. Antimicrobial susceptibility testing was done on all GAS isolates using the Kirby Bauer disk diffusion method according to clinical laboratory standard institute (CLSI) guidelines. Detection of Spy 1258 gene and Streptococcal pyrogenic exotoxins SpeA and SpeB were done by using Multiplex PCR. Results: Amongst the Tow hundred collected samples fifty-one isolates (25.5%) were identified as S. pyogenes. Antibiotic susceptibility testing showed that all the GAS isolates were sensitive to Azithromycin and Penicillin. Sensitivity to Erythromycin, Gentamicin, Clarithromycin, Amoxicillin and Cephalexin were 88.2%, 86.3%, 45.1%, 41.2%, 13.7%, respectively. SpeA was detected in 17 (33.3%) and SpeB in 48 (94.1%). Conclusion: Streptococcal pyrogenic exotoxin genes SpeA and SpeB were detected in 17 (33.3%) and 48 (94.1%) respectively of Streptococcus pyogenes isolates.","PeriodicalId":65391,"journal":{"name":"美国分子生物学期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70513486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological, Cultural, Molecular and Pathogenic Variation of Bipolaris sorokiniana in Wheat 小麦褐飞蛾的形态、培养、分子和致病变异

美国分子生物学期刊(英文) Pub Date : 2022-01-01 DOI: 10.4236/ajmb.2022.124016

A. Sharmin, F. Aminuzzaman, T. H. Ansari, M. Ahmed

引用次数: 1

New Progress in Clinical Diagnosis, Treatment and Laboratory Testing of Acute Respiratory Infections in Children 儿童急性呼吸道感染的临床诊断、治疗和实验室检测新进展

美国分子生物学期刊(英文) Pub Date : 2022-01-01 DOI: 10.4236/ajmb.2022.121001

Huan Zhao, Xiaoyu Jiang, Ling-ling Lu, Qing Lin

引用次数: 0

M₃ Muscarinic Acetylcholine Receptor Antagonist Darifenacin Protects against Pulmonary Fibrosis through ERK/NF-κB/miR-21 Pathway M3毒蕈碱乙酰胆碱受体拮抗剂达利那新通过ERK/NF-κB/miR-21通路抑制肺纤维化

美国分子生物学期刊(英文) Pub Date : 2022-01-01 DOI: 10.4236/ajmb.2022.122002

Y. Liu, Yanan Jiang, Chao Wang, Haiying Zhang, Yan Liu

引用次数: 0

Identification of a Candida albicans Biofilm Inhibitor 白色念珠菌生物膜抑制剂的鉴定

美国分子生物学期刊(英文) Pub Date : 2022-01-01 DOI: 10.4236/ajmb.2022.122003

Keita Odanaka

{"title":"Identification of a <i>Candida albicans</i> Biofilm Inhibitor","authors":"Keita Odanaka","doi":"10.4236/ajmb.2022.122003","DOIUrl":"https://doi.org/10.4236/ajmb.2022.122003","url":null,"abstract":"Candida albicans proliferates in the skin and oral cavity and is the causative agent of candida dermatitis and oral candidiasis. C. albicans is known to form biofilms on oral mucosa and denture surfaces. Formation of biofilms deteri-orates the permeability of antifungal drugs, decreasing their effectiveness. Therefore, in this study, I identified a compound with inhibitory activity against C. albicans biofilm formation. Heat shock protein 90 was selected as the target protein, and a potential ligand for the same was extracted and identified as 2-(4-methylpiperazin-1-yl)cyclopentanol. C. albicans was then cultured with varying concentrations of this compound: 0 mmol/L, 0.63 mmol/l. 2.5 mmol/l, and 10 mmol/l, and biofilm formation was measured via crystal violet assay. The findings demonstrated that 2-(4-methylpiperazin-1-yl)cyclo-pentanol substantially inhibits biofilm formation when added at a concentration of 0.63 mmol/l or higher. It is suggested that C. albicans could be elimi-nated more efficiently using this compound in combination with the existing antifungal drug miconazole. Further, the compound may also be useful as a disinfectant for medical devices, such as catheters, to prevent the formation of C. albicans biofilms.","PeriodicalId":65391,"journal":{"name":"美国分子生物学期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70513223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of Oxa23 and Oxa51 Genes Associated with Bacterial Isolated from Patients with Urosepsis: Single Centre Prespective 尿脓毒症患者分离细菌相关Oxa23和Oxa51基因的发生率:单中心预测

美国分子生物学期刊(英文) Pub Date : 2022-01-01 DOI: 10.4236/ajmb.2022.123008

Salma Ibrahim, E. A. Mohammed, S. Taha, S. Yousif, H. Omer, O. Omer, Mirghani Seif-Elnasr, Seitelbanat Yassin, Y. Mohammed, O. A. Elhasan, Mohamed Taj-Eldin, A. Abakar, E. A. Ahmed, S. Elzaki

引用次数: 0