W. Hu, F. Yoon, A. Crouch, Li Tao, H. Hillebrenner, J. S. Guthi, Moon J. Kim, Jinming Gao
{"title":"Surface energy induced patterning of polymer nanostructures for cancer diagnosis and therapy","authors":"W. Hu, F. Yoon, A. Crouch, Li Tao, H. Hillebrenner, J. S. Guthi, Moon J. Kim, Jinming Gao","doi":"10.1109/NANO.2007.4601193","DOIUrl":"https://doi.org/10.1109/NANO.2007.4601193","url":null,"abstract":"We have developed a new simple method to pattern discrete polymer micro and nanostructures. A Si template is patterned by lithography and selective surface treatment to have spatially different surface energies that induce microfluidic self-patterning of a spincoated polymer layer. Biocompatible diblock co-polymer and SU8 are patterned using this method to form monodisperse and shape specific microstructures. After patterning, these particles are lifted off the template surface into aqueous solution. The template is then cleaned and re-used. These freestanding polymer particles with uniform and precise spherical morphology can be used as carriers for drug and imaging agents for biomedical applications.","PeriodicalId":6415,"journal":{"name":"2007 7th IEEE Conference on Nanotechnology (IEEE NANO)","volume":"97 6 1","pages":"295-300"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87702739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Young's Modulus of High Aspect Ratio Si3N4 Nano-thickness Membrane","authors":"Ping-Hei Chen, Cheng-Hao Yang, Chien-Ying Tsai, Tien-Li Chang, W. Hsu, Tai-Chou Chen","doi":"10.1109/NANO.2007.4601367","DOIUrl":"https://doi.org/10.1109/NANO.2007.4601367","url":null,"abstract":"The physical properties of nano-thickness membrane are known to be different from those of bulk material. However, it requires a novel approach to measure the physical properties of nano-thickness membrane due to its nano-scale dimension. Currently, many potential applications for the nanoscale structures are not really practical because their mechanical properties have not been established. In this study, a suspended high aspect ratio silicon nitride nano-thickness membrane is fabricated by using silicon micro-machining. The membrane has a thickness of 30 nm and an area of 4 mm by 7 mm, as shown in Fig.1. Young's modulus of the silicon nitride nano-thickness membrane is determined from the deflection of the suspended membrane, which is resulted from the weight of membrane itself.","PeriodicalId":6415,"journal":{"name":"2007 7th IEEE Conference on Nanotechnology (IEEE NANO)","volume":"93 1","pages":"1341-1344"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76100533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hao-Yu Tseng, Chen-Yi Lee, Y. Shih, Xi-Zhang Lin, Gwo-Bin Lee
{"title":"Localized heating of tumor cells utilizing superparamagnetic nanoparticles","authors":"Hao-Yu Tseng, Chen-Yi Lee, Y. Shih, Xi-Zhang Lin, Gwo-Bin Lee","doi":"10.1109/NANO.2007.4601345","DOIUrl":"https://doi.org/10.1109/NANO.2007.4601345","url":null,"abstract":"This paper presents an investigation of hyperthermia cancer therapy utilizing high-frequency magnetic field to induce a localized temperature increase on tumors by using superparamagnetic nanoparticles. In-vitro and in-vivo experiments showed the feasibility of hyperthermia cancer therapy. The relationship between temperature rise and cell survival rate was also investigated. While CT-26 colon cancer cells were heated above 45degC, the survival rate of cancer cells would be greatly reduced. A temperature increase as high as 59.5degC can be successfully generated in rat livers. In-vivo tests also indicated that hyperthermia cancer therapy using this approach could significantly suppress the growth rate of tumors by utilizing concentrated magnetic nanoparticles and temperature-sensitive hydrogel, which was used to secure the nanoparticles in the target tumor tissue. Furthermore, a feedback temperature control system was successfully developed to keep the nanoparticles at a constant temperature to prevent overheating in the tumors such that a safer and more precise cancer therapy is feasible. The developed technique may be promising for the hyperthermia cancer therapy.","PeriodicalId":6415,"journal":{"name":"2007 7th IEEE Conference on Nanotechnology (IEEE NANO)","volume":"76 1","pages":"969-974"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90996448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quantum well nanomechanical actuators with atomic vertical resolution","authors":"J. D. Makowski, J. Talghader","doi":"10.1109/NANO.2007.4601158","DOIUrl":"https://doi.org/10.1109/NANO.2007.4601158","url":null,"abstract":"A novel continuously tunable vertical actuator with sub-nanometer resolution is presented. It consists of a heterostructure cantilever which has collapsed over a 125 nm thick nanogap. Its operating principle relies on the temperature dependence of the adhesion energy between two InGaAs surface quantum well surfaces. Deflections from -17 nm to 5 nm with a precision better than three atomic layers have been measured.","PeriodicalId":6415,"journal":{"name":"2007 7th IEEE Conference on Nanotechnology (IEEE NANO)","volume":"144 1","pages":"146-149"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76823066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study of nanopattern forming with chemical coatings for silicon-based stamp in nanoimprint process","authors":"Tien-Li Chang, Jung-Chang Wang","doi":"10.1109/NANO.2007.4601305","DOIUrl":"https://doi.org/10.1109/NANO.2007.4601305","url":null,"abstract":"The aim of this study is to present a silane molecule self-assembled monolayer (octadecyltrimethoxysilane (CH3(CH2)17Si(OCH3)3): OTS-SAM) as anti-adhesive coatings to improve of silicon-based stamps for the developed nanoimprint lithography (NIL). In this work, the nanostructures of stamps are fabricated by electron-beam lithography (EBL). The diameters of period pillar nanopatterns on the silicon-based stamps are 150 nm and 200 nm, receptively. The influence of silicon-based stamp substrate can be investigated by contact angle measurement after modifying the chemical coating treatment for imprinted thin polymethyl methacrylate (PMMA) films. To control the forming of fabricated nanopatterns, the simulation can be done to obtain the effects of patterning distortion during this NIL process. In addition, the study employs atomic force microscopy (AFM) to obtain a simultaneous observation for the morphologies of silicon-based and imprinted PMMA polymer nanostructures interface. The results indicate an over 95% improvement for silicon-based nanopatterns with the anti-adhesive properties in NIL process.","PeriodicalId":6415,"journal":{"name":"2007 7th IEEE Conference on Nanotechnology (IEEE NANO)","volume":"48 1","pages":"795-798"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85597142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Wen, L. Tsai, Chien-Wei Liu, Y. Tyan, S. Shy, B. Dai, P. Liao
{"title":"Investigation of effects attributed to spherical carbon nanomaterials in proteomic matrix-assisted laser desorption ionization-time of flight mass spectrometer","authors":"H. Wen, L. Tsai, Chien-Wei Liu, Y. Tyan, S. Shy, B. Dai, P. Liao","doi":"10.1109/NANO.2007.4601355","DOIUrl":"https://doi.org/10.1109/NANO.2007.4601355","url":null,"abstract":"The study presents the mass spectrometric application of carbon nanomaterials in proteomic research. We utilized two spherical carbon nanomaterials, C60 buckyball and iron-cored carbonball (Fe-C), in peptide sequence identification of a serum protein using matrix-assisted laser desorption ionization-time of flight mass spectrometer (MALDI-TOF-MS). The biological samples used in the experiments were enzymatically trypsinized bovine serum albumins (BSA) peptides instead of synthesized small peptide fragments. Experimental results were compared and noticeable improvements in mass spectrometric spectrum were obtained and quantified. In addition, we also utilized EDS and TEM to determine the chemical composition and morphology of nanostructure of iron-cored carbonball.","PeriodicalId":6415,"journal":{"name":"2007 7th IEEE Conference on Nanotechnology (IEEE NANO)","volume":"41 1","pages":"1015-1017"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89082998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Keng-Ming Liu, Wanqiang Chen, L. Register, S. Banerjee
{"title":"Schrödinger Equation Monte Carlo-3D for simulation of nanoscale MOSFETs","authors":"Keng-Ming Liu, Wanqiang Chen, L. Register, S. Banerjee","doi":"10.1109/NANO.2007.4601380","DOIUrl":"https://doi.org/10.1109/NANO.2007.4601380","url":null,"abstract":"A computational efficient quantum transport simulator, Schrodinger equation Monte Carlo in three dimensions (SEMC-3D), for simulating carrier quantum transport subject to scattering in 3D nanoscale MOSFETs is presented. SEMC-3D self-consistently solves (1) for the 2D-confined eigenstates across the channel as a function of position along the channel, (2) the quasi-1D quantum transport equations for injected carriers propagating through the simulation region within the each subband subject to a rigorous treatment of various intra- and inter-subband and valley scattering processes, and (3) the 3D Poisson equation. The technique, an extension of prior 1D and 2D versions of SEMC but subject to some significantly different computational considerations, is briefly described. SEMC-3D simulations of a Si omega-gate nano-scale nMOSFET are provided to illustrate the modeling capabilities and computational efficiency of SEMC-3D.","PeriodicalId":6415,"journal":{"name":"2007 7th IEEE Conference on Nanotechnology (IEEE NANO)","volume":"60 1","pages":"1120-1125"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75604204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Applications of magnetic nanoparticles in engineering and biomedical science","authors":"Tien-Li Chang, Ya-Wei Lee","doi":"10.1109/NANO.2007.4601275","DOIUrl":"https://doi.org/10.1109/NANO.2007.4601275","url":null,"abstract":"This study mainly employs magnetic nanoparticles (MNPs) for an amazing variety of engineering and biomedical applications. Herein MNPs are fabricated from fine ferromagnetic particles of iron ferrite by chemical co-precipitation technique, and their average size is about 27 nm via HR-TEM micrograph and XRD analysis to investigate. In this study, MNPs have been demonstrated their excellent properties of heat transfer, electric conductivity, magnetism within the applications for multi-loop pulsating heat pipe (MLPHP), switch-based nanodevice, microfluidic on-chip system and nanogap-based DNA sensor. Based on the effect of magnetic field for MNPs, MLPHP can enhance thermal performance itself at different heating power. In addition, the switch-based nanodevice with MNPs can efficiently add and remove an electrical function of electron charging with current shift. Furthermore, the microfluidic chip utilizing MNPs is demonstrated that can be suited for drug delivThis study mainly employs magnetic nanoparticles (MNPs) for an amazing variety of engineering and biomedical applications. Herein MNPs are fabricated from fine ferromagnetic particles of iron ferrite by chemical co-precipitation technique, and their average size is about 27 nm via HR-TEM micrograph and XRD analysis to investigate. In this study, MNPs have been demonstrated their excellent properties of heat transfer, electric conductivity, magnetism within the applications for multi-loop pulsating heat pipe (MLPHP), switch-based nanodevice, microfluidic on-chip system and nanogap-based DNA sensor. Based on the effect of magnetic field for MNPs, MLPHP can enhance thermal performance itself at different heating power. In addition, the switch-based nanodevice with MNPs can efficiently add and remove an electrical function of electron charging with current shift. Furthermore, the microfluidic chip utilizing MNPs is demonstrated that can be suited for drug delivery. Finally, we use MNPs to develop an electrical approach to detect femtomolar DNA that can amplify the low target DNA concentration for a clinical gene diagnostic system.ery. Finally, we use MNPs to develop an electrical approach to detect femtomolar DNA that can amplify the low target DNA concentration for a clinical gene diagnostic system.","PeriodicalId":6415,"journal":{"name":"2007 7th IEEE Conference on Nanotechnology (IEEE NANO)","volume":"14 1","pages":"656-659"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89531151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dong Ho Kim, H. Song, C. Roh, C. Hahn, Shi-Jong Leem, N. Tsurumachi, Tae Geun Kim
{"title":"Improved spectral response of an InAs QD RC-SACM-APD with Ta2O5/SiO2 DBRs","authors":"Dong Ho Kim, H. Song, C. Roh, C. Hahn, Shi-Jong Leem, N. Tsurumachi, Tae Geun Kim","doi":"10.1109/NANO.2007.4601281","DOIUrl":"https://doi.org/10.1109/NANO.2007.4601281","url":null,"abstract":"We report the improvement in the spectral response of an InAs QD resonant-cavity separate absorption, charge, and multiplication avalanche photodetector (RC-SACM-APD) by increasing the quantum efficiency (QE) using dielectric Ta2O5/SiO2 top distributed Bragg reflectors (DBRs). The reflectivities of the top and bottom DBRs were numerically designed to be 70 % and 99.1 %, respectively, in order to maximize the QE. The spectral response characteristics of the InAs QD RC-SACM-APD with enhanced top DBRs was remarkably improved at 1098 nm, which is close to the target wavelength of 1100 nm, and its full width at half-maximum (FWHM) was 19 nm. The photoluminescence (PL) spectra revealed an intense and narrow single-mode peak at 1101 nm. The FWHM of the PL peak was as narrow as 8 nm and the difference in wavelength between the spectrum and the PL peak was as small as 3 nm.","PeriodicalId":6415,"journal":{"name":"2007 7th IEEE Conference on Nanotechnology (IEEE NANO)","volume":"25 1","pages":"681-685"},"PeriodicalIF":0.0,"publicationDate":"2007-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73652425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The mechanisms of PAN electrospinning nanofibers based on the effect of surface charges","authors":"Xiao-hong Qin, Shanyuan Wang","doi":"10.1109/NANO.2007.4601238","DOIUrl":"https://doi.org/10.1109/NANO.2007.4601238","url":null,"abstract":"In electrospinning, the addition of salts results in a higher charge density on the surface of jet. The theoretical analysis shows that the relationship between radius r of jet and the axial distance z from nozzle follows an allometric law in the form r ~ z-0.5 in case of full surface charge, and the scaling exponent becomes larger when the jet has part surface charge. Theoretical analysis also showed that the electricity potential with high content of LiCl descends more sharply than low content LiCl during the charged fibers moving. LiCl was chosen to confirm the theory. The experimental data agreed very well with our theoretical analysis by a series of experiments. Moreover, the structures of nanofibers with LiCl were investigated.","PeriodicalId":6415,"journal":{"name":"2007 7th IEEE Conference on Nanotechnology (IEEE NANO)","volume":"22 1","pages":"489-493"},"PeriodicalIF":0.0,"publicationDate":"2007-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75202731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}