Journal of Leather Science and Engineering最新文献

{"title":"Collagen-based biomaterials in organoid technology for reproductive medicine: composition, characteristics, and applications","authors":"Bo Feng,&nbsp;Hao Yang,&nbsp;Manman Zhu,&nbsp;Jinlin Li,&nbsp;Hsun-Ming Chang,&nbsp;Peter C. K. Leung,&nbsp;Junling Guo,&nbsp;Yaoyao Zhang","doi":"10.1186/s42825-023-00142-6","DOIUrl":"10.1186/s42825-023-00142-6","url":null,"abstract":"<div><p>Collagen-based biomaterials (CBB) are highly esteemed by researchers in materials science and biomedicine due to their extensive applications across various biomedical disciplines. In recent years, owing to advancements in developmental biology techniques, this superior biomaterial has seen increasing utilization in 3D in vitro tissue culture. Three-dimensional cell cultures, often referred to as organoids, have emerged in response to technological advancements in biomaterials and the growing need in the field of medical research. They serve as important models for simulating normal physiological activities in vivo, addressing limitations in experimental material sources, and resolving ethical issues. In this review, we discuss the material characteristics of CBBs commonly used for organoid culture, integrating aspects such as Matrigel and decellularized ECM as culture matrices. We also analyzed the development prospects and directions of various materials in the context of biology, clinical medicine, and particularly reproductive medicine. Currently, despite the FDA approval and clinical research incorporating numerous CBBs, existing challenges in multiple studies indicate a significant unmet need in the development of key tissue models for both medical research and clinical applications. In summary, CBBs are swiftly broadening their applicability in the realms of organoid nature and medical research, serving as a versatile and high-performing material for 3D in vitro tissue culture.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-023-00142-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138713681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyphenol-based antibacterial and antioxidative nanoparticles for improved peritonitis therapy","authors":"Jinhong Dong,&nbsp;Tianyou Wang,&nbsp;Haotian Li,&nbsp;Jianhua Zhang,&nbsp;Hengjie Zhang,&nbsp;Weijie Liu,&nbsp;Xinru You,&nbsp;Zhipeng Gu,&nbsp;Yiwen Li,&nbsp;Xianchun Chen,&nbsp;Qiang Fu","doi":"10.1186/s42825-023-00141-7","DOIUrl":"10.1186/s42825-023-00141-7","url":null,"abstract":"<div><p>The development of advanced sustainable biomedical materials with superior biosafety and bioactivity for clinical applications is highly desirable. In the present investigation, biomass-based nanoparticles (NPs) were assembled through the Mannich reaction between the plant polyphenols and the broad-spectrum antibiotic tigecycline (TG). The fabricated NPs with uniform size demonstrated excellent oxidative balance effects, pH-responsive release properties and antibacterial performances. Furthermore, the intracellular and in vivo studies confirmed that the NPs are capable of reducing oxidative damage to cells and significantly repairing tissue injury in mice with peritonitis. This work presents an effective method and idea for constructing biomass-based materials for the treatment of infection-induced diseases.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-023-00141-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138564641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in metal organic frameworks for the catalytic degradation of organic pollutants","authors":"Jinhui Wei,&nbsp;Min Yuan,&nbsp;Songtao Wang,&nbsp;Xuehu Wang,&nbsp;Nan An,&nbsp;Guangping Lv,&nbsp;Lina Wu","doi":"10.1186/s42825-023-00140-8","DOIUrl":"10.1186/s42825-023-00140-8","url":null,"abstract":"<div><p>Metal organic frameworks (MOFs) with their large surface area and numerous active sites have attracted significant research attention. Recently, the application of MOFs for the catalytic degradation of organic pollutants has provided effective solutions to address diverse environmental problems. In this review, the latest progress in MOF-based removal and degradation of organic pollutants is summarized according to the different roles of MOFs in the removal reaction systems, such as physical adsorbents, enzyme-immobilization carriers, nanozymes, catalysts for photocatalysis, photo-Fenton and sulfate radical based advanced oxidation processes (SR-AOPs). Finally, the opportunities and challenges of developing advanced MOFs for the removal of organic pollutants are discussed and anticipated.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-023-00140-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138564625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flake channels construction of hydroxyapatite/gelatin cryogel with excellent flame retardant properties for enhancing the capturing of iodine","authors":"Yanxia Wei,&nbsp;Bo Wang,&nbsp;Liyan Cao,&nbsp;Xin Cheng,&nbsp;Yuhan Qiao,&nbsp;Tao Duan,&nbsp;Guiqiang He,&nbsp;Pingping Ding,&nbsp;Yan Zhou,&nbsp;Jian Zhou","doi":"10.1186/s42825-023-00139-1","DOIUrl":"10.1186/s42825-023-00139-1","url":null,"abstract":"<div><p>Safe and efficient capturing of volatile radioiodine is of extremely important significance in the treatment of spent fuel. Herein, the flake channels in gelatin-hydroxyapatite (HAP@Ge) cryogel with excellent flame retardant properties were constructed by immobilizing hydroxyapatite nanorods (HAP) on Gelatin (Ge) cryogel for enhancing the capturing of iodine. The immobilization of HAP nanorods enhanced thermal stability, provided low rates of dynamic heat transfer and dissipation, and remarkably improved the flame retardant and smoke suppression properties of the Ge cryogel, which can effectively prevent the occurrence of safety incidents caused by further thermal degradation or combustion of this cryogel. More importantly, it was effective in improving the rapid enrichment of iodine, resulting in a high adsorption capacity. The maximum adsorption capacity of HAP@Ge cryogel for iodine vapor reached 2693 mg/g at equilibrium. The high adsorption capacity for iodine was attributed to the multi-scale porous structure in HAP@Ge cryogel, which offered effective channels for iodine diffusion, whereas the numerous complex and irregular flakes provided sufficient number of active sites for iodine capture. The adsorption process was chemical in nature and involved the -PO₄³⁻, –OH, –C=O, and –NHR groups on HAP@Ge cryogel. Moreover, the complex porous structure of HAP@Ge cryogel enhanced the physical capturing of iodine. These advantages, such as low-cost raw material, simple preparation method, good flame retardancy, and excellent capturing performance for iodine indicated that HAP@Ge cryogel is a potential candidate for the removal of radioactive iodine in the exhaust gas stream of post-treatment plants.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-023-00139-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138552835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent progresses of collagen dressings for chronic skin wound healing","authors":"Shuangni Shi,&nbsp;Lili Wang,&nbsp;Chen Song,&nbsp;Linyan Yao,&nbsp;Jianxi Xiao","doi":"10.1186/s42825-023-00136-4","DOIUrl":"10.1186/s42825-023-00136-4","url":null,"abstract":"<div><p>The skin plays a fundamental role in regulating the body’s internal balance and protecting against external traumas. A broad variety of environmental risk factors frequently result in acute skin wounds, whose inappropriate treatments would lead to chronic skin wounds that are difficult to heal. Traditional dressings have been widely used to repair chronic skin wounds, however their drawbacks such as insufficient hemostatic efficacy and non-moist environment have severely limited their clinical applications. As the principal component of skin, collagen has always been a research hotspot in the field of chronic skin wounds due to its advantages of low antigenicity, high biocompatibility and superior bioactivity. Collagen-based dressings have been increasingly developed to heal the chronic wounds during the past decades, arising from their capability in decreasing protein and electrolyte losses in wound exudate, preventing bacterial contamination, permitting less painful dressing changes, and improving the healing quality. This review overviews recent progress of collagen dressings for chronic skin wound healing. Various commonly used wound dressings for wound management have been first introduced. Collagen wound dressings have been categorized as films, sponges, hydrogels, nanofibers, and powders, and their efficacy has been compared. The critical functions of collagen dressings in wound healing, such as stopping bleeding, shortening inflammation, promoting angiogenesis, and stimulating tissue regeneration have been elaborated. The clinical applications of collagen dressings to repair different types of chronic wounds have been thoroughly summarized. A comprehensive list of commercialized collagen dressings has been updated, and an outlook of collagen dressings have been finally speculated.</p><h3>Graphical Abstract</h3>\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 </div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-023-00136-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134797450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistically enhancing hydrogen bonding, hydrophobic interaction and electrostatic association of collagen fiber to flavonoid aglycones for their effective separation by polyethyleneimine modification","authors":"Qixian Zhang,&nbsp;Rui Wang,&nbsp;Bi Shi","doi":"10.1186/s42825-023-00138-2","DOIUrl":"10.1186/s42825-023-00138-2","url":null,"abstract":"<div><p>Compared with flavonoid glycosides, flavonoid aglycones are difficult to be separated since they have less hydroxyls. Collagen fiber (CF), a natural polymer, was once used as packing material for separation of kaempferol and quercetin (the typical flavonoid aglycones) after crosslinking by glutaraldehyde mainly based on hydrogen bonding and hydrophobic interaction in column length-diameter ratio of 60:1. Hydrophobic modification by grafting alkyl chains was then employed to enhance the hydrophobic interaction between CF and flavonoid aglycones, which can improve the separation efficiency and decrease column length-diameter ratio to 19:1. In order to further improve the adsorption capacity and separation efficiency, the strategy of simultaneously grafting hydrophobic alkyl chains (–CH₂–CH₂–) and alkali groups (–NH₂) was adopted in this work to enhance hydrophobic interaction, hydrogen bonding and electrostatic association to flavonoid aglycones at the same time through grafting polyethyleneimine (PEI). PEI modified CF (PEI-CF) maintained the fiber structure of CF, and had higher adsorption extent and rate to flavonoid aglycones through the enhanced synergetic effect of hydrophobic interaction, hydrogen bonding and electrostatic association. As a result, PEI-CF presented a satisfactory column separation efficiency for kaempferol and quercetin even the length-diameter ratio of column was decreased to 11:1, which was much better than previously developed glutaradehyde-crosslinked collagen fiber and isobutyl-grafted collagen fiber, as well as commonly used polyamide and Sephadex LH-20.</p><h3>Graphical abstract</h3>\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 </div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-023-00138-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134796864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-functional epoxides cross-linked collagen sponges for tissue engineering scaffolds","authors":"Yuanzhi Zhang,&nbsp;Changkai Yang,&nbsp;Min Gu,&nbsp;Xiaoxia Zhang,&nbsp;Xueqing Zhang,&nbsp;Guoying Li","doi":"10.1186/s42825-023-00137-3","DOIUrl":"10.1186/s42825-023-00137-3","url":null,"abstract":"<div><p>With the efficient cross-linking abilities and the flexible regulation abilities to the performances of cross-linked products, the multi-functional aliphatic epoxides were once widely used to cross-link the collagen-based materials in the last century. In present work, the multi-functional epoxides were used to construct and cross-link collagen sponges for tissue engineering scaffolds, which was hoped to board the theoretical system of epoxides and explore their potentials for modern applications. The bi- to tetra-functional epoxides were used to cross-link collagen solutions and establish the gel-like precursors, then using freeze-drying to form the final sponges. The SEM observed that the sponges had shown regular porous structures with a wide range of pore sizes from 160 to 440 μm. The sponges had presented the resistance to enzymatic degradation, shape-remaining ability, and reversible compressibility in aqueous environments, which all could be regulated through the functionalities of epoxides. The regulation abilities of multi-functional epoxides on the performances of sponges had been mainly achieved through the cross-linking degrees that the higher functionality of epoxides would bring higher cross-linking degree. Such higher cross-linking degrees could enhance the elastic behaviors of gel-like precursors, and improve the compressive strengths and thermal stabilities of sponges. Nevertheless, the multi-functional epoxides had barely affected the safety of collagen sponges at the cellular level according to the results of CCK8 assay and the SEM and CLSM images of L929 fibroblasts cultured on the cross-sections of sponges.</p><h3>Graphical abstract</h3>\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 </div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-023-00137-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134796242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Composite nanofiltration membrane with tannic acid coordinated collagen fibers for enhanced molecule separation","authors":"Yinshan Xie,&nbsp;Zihao Ge,&nbsp;Xin Li,&nbsp;Yi Wang,&nbsp;Fei Liu,&nbsp;Jian Li","doi":"10.1186/s42825-023-00133-7","DOIUrl":"10.1186/s42825-023-00133-7","url":null,"abstract":"<div><p>Biomass-based membranes have attracted increasing attentions due to their cheap and sustainable advantages. In this work, a novel thin-film composite (TFC) nanofiltration (NF) membrane was fabricated through a facial interfacial polymerization (IP) process by initiate the crosslinking reaction between collagen fibers (CFs) and tannic acid (TA). The increased TA concentrations endowed the TFC membrane with a higher crosslinking degree, a thicker active layer and a rougher top surface. At optimized condition with 0.60 mg TA decoration, the TFC-3 membrane exhibited a high water permeability of 23.49 L m⁻² h⁻¹ bar⁻¹ with high rejections above 98.0% for congo red, reactive blue 19, coomassie blue G-250, and methyl blue. Furthermore, the membrane preserved remarkable salt retentions (93.3% for Na₂SO₄, 83.4% for MgSO₄, 36.2% for MgCl₂, and 26.4% for NaCl) and satisfying operation stability. This facial fabrication method offered a new insight to employ biomass for molecular precise separation.</p><h3>Graphical abstract</h3>\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 </div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-023-00133-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134796229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of bactericide–protease interactions on the protease-assisted soaking performance","authors":"Hao Liu,&nbsp;Yahang Pan,&nbsp;Bi Shi,&nbsp;Yunhang Zeng","doi":"10.1186/s42825-023-00135-5","DOIUrl":"10.1186/s42825-023-00135-5","url":null,"abstract":"<div><p>Protease-assisted soaking has received increasing attention in recent years. However, few reports have elaborated on the effect of bactericides, which are used to protect raw hides from microbial damage in the soaking process, on the performance of protease-assisted soaking. Here we investigate the effects of three bactericides, namely, 2-methyl-4-isothiazolin-3-one (MIT), sodium propyl 4-hydroxybenzoate (SPHB) and cetyl trimethyl ammonium bromide (CTAB), on the catalytic activity of protease. MIT and SPHB have little effect on the proteolytic activity, whilst CTAB has a negative effect. Fluorescence spectroscopy, synchronous fluorescence spectroscopy, molecular docking and molecular dynamics simulation were used to analyse the bactericide–protease interaction. The data reveal that MIT and SPHB are bound to the non-catalytic sites of protease, whilst CTAB affects the catalytic triad of protease. Furthermore, the protease and bactericides were used alone, simultaneously and sequentially in the soaking process, and their soaking performances were evaluated. The evaluation shows that the use of protease increases the microorganisms in the soaking float, and MIT exhibits the best bactericidal effect. The simultaneous use of protease and MIT effectively inhibits bacteria and scarcely affects the removal of unstructured proteins from hides and the attack on epidermis by protease. These findings contribute to a better understanding of the scientific use of protease with other auxiliaries in soaking.</p><h3>Graphical Abstract</h3>\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 </div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-023-00135-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134797783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developments for collagen hydrolysates as a multifunctional antioxidant in biomedical domains","authors":"Guiya Deng,&nbsp;Ke Huang,&nbsp;Xianchao Jiang,&nbsp;Kun Wang,&nbsp;Zihao Song,&nbsp;Yuchen Su,&nbsp;Chengming Li,&nbsp;Shuai Zhang,&nbsp;Shiqi Wang,&nbsp;Yaqin Huang","doi":"10.1186/s42825-023-00131-9","DOIUrl":"10.1186/s42825-023-00131-9","url":null,"abstract":"<div><p>Antioxidant collagen hydrolysates refers to the peptides mixture with antioxidant properties identified from hydrolyzed collagen. Due to its specific structural, biological and physicochemical properties, collagen hydrolysates have been explored as a multifunctional antioxidant in the biomedical field. In this review, we summarize recent advances in antioxidant collagen hydrolysates development. Initially, the preparation process of antioxidant collagen hydrolysates is introduced, including the production and separation methods. Then the effects and the mechanisms of amino acid composition and collagen peptide structure on the antioxidant activity of collagen hydrolysates are reviewed. Finally, the applications of antioxidant collagen hydrolysates in biomedical domains are summarized, with critical discussions about the advantages, current limitations and challenges to be resolved in the future.</p><h3>Graphical abstract</h3>\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 </div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-023-00131-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134797597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}