Journal of Flow Chemistry最新文献_第2页

Driving sustainability through adoption of hybrid manufacturing in small molecule API production 在小分子原料药生产中采用混合生产技术，推动可持续发展

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2024-03-22 DOI: 10.1007/s41981-024-00325-0

Svetlana Borukhova, Robert Sebastian Rönnback

{"title":"Driving sustainability through adoption of hybrid manufacturing in small molecule API production","authors":"Svetlana Borukhova, Robert Sebastian Rönnback","doi":"10.1007/s41981-024-00325-0","DOIUrl":"10.1007/s41981-024-00325-0","url":null,"abstract":"<div><p>Pharmaceutical industry is challenged by the rising development costs, strict regulatory and environmental requirements all while racing to deliver complex molecules to market. The need to be the first-in-class brings about shorter lifetime to the launched products in favor of better functioning followers. In addition, a shift from large volume blockbusters towards small volume production of complex molecules presents a unique opportunity to challenge the status quo in pharmaceutical manufacturing. Traditional batch manufacturing, while foundational, presents hurdles in scaling and efficiency, particularly for demanding reactions. Continuous manufacturing has emerged as a promising alternative, delivering better control and uniformity of operating conditions, mirroring the efficiencies found in small-scale batch reactors. However, continuous manufacturing is not universally applicable. As a solution, a combination of the two into hybrid manufacturing processes, appears to fill this gap effectively. While the concept of hybrid manufacturing is not new, the current perspective adds an additional angle to the integration of both technologies. Authors propose to sustain the continuity of the operation for batch mode processes by decreasing the reactor size and increasing the level of automation. Furthermore, modular fabrication of smaller-footprint technological platforms is expected to synergize other advancements in the field, such as digitalization, automation, and standardization. As a result, a leap towards the implementation of advanced manufacturing to drive sustainability in pharmaceutical industry is more tangible than ever.</p></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"14 1","pages":"303 - 312"},"PeriodicalIF":2.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140202863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient pinnick oxidation by a superheated micro-reaction process 通过过热微反应过程实现高效松脂氧化

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2024-03-20 DOI: 10.1007/s41981-024-00324-1

Jinpei Huang, Yongxiang Li, Yuanzheng Zhou, Yifu Yu, Jingyi Feng, Yongjun Zhang, Yifeng Zhou

{"title":"Efficient pinnick oxidation by a superheated micro-reaction process","authors":"Jinpei Huang, Yongxiang Li, Yuanzheng Zhou, Yifu Yu, Jingyi Feng, Yongjun Zhang, Yifeng Zhou","doi":"10.1007/s41981-024-00324-1","DOIUrl":"10.1007/s41981-024-00324-1","url":null,"abstract":"<p>The Pinnick oxidation, due to its tolerance for sensitive functional groups, is widely used in the process of oxidizing <i>α</i>,<i>β</i>-unsaturated aldehydes to corresponding carboxylic acids. The reaction reagents typically include sodium chlorite, buffer salts, and a scavenger. However, the controllability of Pinnick oxidation in the batch reaction process is poor due to the inherent limitations of the reactor’s performance. This leads to potential safety risks and necessitates the reaction to proceed slowly under conditions of low temperature and low concentration. In this work, we introduced a new continuous micro-reaction process to intensify the Pinnick oxidation. The water-soluble crotonic acid was selected as a typical object of study. Through the study of reaction parameters and the construction of a micro-reaction system, efficient continuous process was achieved under high-temperature and high-pressure conditions for the first time. Compared to the batch process, the reaction benefited from the superheated condition resulting in a significant acceleration of the reaction rate, efficient gas–liquid interphase mass transfer allowing for effective utilization of the generated chlorine dioxide, and the inherent safety of the microreactor enabling an increase in reaction concentration. In addition, the buffer salts used in the Pinnick oxidation has been successfully replaced by hydrochloric acid and applied to the continuous flow. This work shows the tremendous potential of microreactors in utilizing harsh reaction conditions to achieve process intensification.</p>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"14 3","pages":"529 - 537"},"PeriodicalIF":2.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140203177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid prototyping of a modular optical flow cell for image-based droplet size measurements in emulsification processes 用于乳化过程中基于图像的液滴粒度测量的模块化光学流动池的快速原型开发

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2024-03-19 DOI: 10.1007/s41981-024-00323-2

Inga Burke, Christina Assies, Norbert Kockmann

{"title":"Rapid prototyping of a modular optical flow cell for image-based droplet size measurements in emulsification processes","authors":"Inga Burke, Christina Assies, Norbert Kockmann","doi":"10.1007/s41981-024-00323-2","DOIUrl":"10.1007/s41981-024-00323-2","url":null,"abstract":"<div><p>Emulsification processes are often found in the process industry and their evaluation is crucial for product quality and safety. Numerous methods exist to analyze critical quality attributes (CQA) such as the droplet sizes and droplet size distribution (DSD) of an emulsification process. During the emulsification process, the optical process accessibility may be limited due to high disperse phase content of liquid-liquid systems. To overcome this challenge, a modular, optical measurement flow cell is presented to widen the application window of optical methods in emulsification processes. In this contribution, the channel geometry is subject of optimization to modify the flow characteristics and produce high optical quality. In terms of rapid prototyping, an iterative optimization procedure via SLA-3D printing was used to increase operability. The results demonstrated that the flow cell resulting from the optimization procedure provides a broad observation window for droplet detection.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"14 3","pages":"515 - 528"},"PeriodicalIF":2.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s41981-024-00323-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140166040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Investigators in Flow Chemistry 2023 2023 年流动化学领域的新兴研究人员

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2024-03-18 DOI: 10.1007/s41981-024-00322-3

Cecilia Bottecchia, Wu Jie, Luca Capaldo

引用次数: 0

Determination of micromixing times in commercially available continuous-flow mixers: evaluation of the incorporation and interaction by exchange with the mean model 确定市售连续流动混合器的微混合时间：通过与平均模型交换来评估混合和相互作用

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2024-03-06 DOI: 10.1007/s41981-024-00321-4

Jasper H. A. Schuurmans, Micha Peeters, Matthieu Dorbec, Koen P. L. Kuijpers

{"title":"Determination of micromixing times in commercially available continuous-flow mixers: evaluation of the incorporation and interaction by exchange with the mean model","authors":"Jasper H. A. Schuurmans, Micha Peeters, Matthieu Dorbec, Koen P. L. Kuijpers","doi":"10.1007/s41981-024-00321-4","DOIUrl":"10.1007/s41981-024-00321-4","url":null,"abstract":"<div><p>To understand and predict the effect of mixing in a mixer or reactor, characterization is essential. The Villermaux-Dushman system of competitive parallel reactions is one of the most frequently used methods to obtain details on the micromixing behavior in mixers and reactors. For quantitative information, a model can convert experimental data into a universal micromixing time, which can be used to compare set-ups and reaction conditions. Different modeling approaches have been developed over time and complicate the comparison of results with newfound micromixing times. In this work, these different modeling approaches are elaborated upon to show the significant differences that can arise between these models. Special attention goes out to a model for continuous-flow mixers, which operates differently and has different characteristics compared to mixing in conventional batch reactors. The volume fractions of the two phases being mixed are generally closer to one another in flow mixers, requiring adaptations in the experimental and modeling approach. Several models were tested, after which the interaction by exchange with the mean (IEM) model was selected. Using this model, micromixing times were determined for a variety of continuous-flow mixers under different operating conditions.</p></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"14 1","pages":"33 - 42"},"PeriodicalIF":2.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140046793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Access semi-stabilized and unstabilized diazo compounds using iodosylbenzene 利用碘代苯获得半稳定和非稳定重氮化合物

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2024-02-29 DOI: 10.1007/s41981-024-00320-5

Laurent Vinet, Emmanuelle M. D. Allouche, Vanessa Kairouz, André B. Charette

引用次数: 0

3D-printed open-source sensor flow cells for microfluidic temperature, electrical conductivity, and pH value determination 用于测定微流控温度、电导率和 pH 值的 3D 打印开源传感器流动池

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2024-02-28 DOI: 10.1007/s41981-024-00319-y

Robin Dinter, Lennart Helwes, Stijn de Vries, Kausik Jegatheeswaran, Henning Jibben, Norbert Kockmann

{"title":"3D-printed open-source sensor flow cells for microfluidic temperature, electrical conductivity, and pH value determination","authors":"Robin Dinter, Lennart Helwes, Stijn de Vries, Kausik Jegatheeswaran, Henning Jibben, Norbert Kockmann","doi":"10.1007/s41981-024-00319-y","DOIUrl":"10.1007/s41981-024-00319-y","url":null,"abstract":"<div><p>Due to the miniaturization of equipment for flow chemistry and microprocess engineering, low-cost sensors and analytical devices are becoming increasingly important for automated inline process control and monitoring. The combination of 3D printing technology and open-source lab automation facilitates the creation of a microfluidic toolbox containing tailored actuators and sensors for flow chemistry, enabling a flexible and adaptable design and efficient processing and control based on the measured data. This contribution presents a set of 3D-printed microfluidic sensor flow cells for inline measurement of temperature, electrical conductivity (EC), and pH value, while compensating for the temperature dependence of EC and pH. The tailored sensor flow cells were tested using model reactions in a single-phase capillary flow system. They have an accuracy comparable to reference sensors in batch measurements. The sensor data can be used to monitor the reaction progress (conversion), determine the kinetic data (activation energy, pre-exponential factors) of saponification reactions, and identify titration characteristics (equivalence and isoelectric points) of neutralization reactions. Hence, the 3D-printed microfluidic sensor flow cells offer an attractive alternative to commercial analytical flow devices for open-source and low-cost lab automation.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"14 2","pages":"469 - 479"},"PeriodicalIF":2.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s41981-024-00319-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140008279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and structural parameter optimization of Venturi-type microbubble reactor for wastewater treatment by CFD simulation 通过 CFD 仿真优化用于废水处理的文丘里型微气泡反应器的设计和结构参数

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2024-02-27 DOI: 10.1007/s41981-024-00317-0

Hanfei Liu, Chao Li, Shuangfei Zhao, Hao Zhu, Yiping Huang, Wei He, Yue Zhao, Yuguang Li, Kai Guo

{"title":"Design and structural parameter optimization of Venturi-type microbubble reactor for wastewater treatment by CFD simulation","authors":"Hanfei Liu, Chao Li, Shuangfei Zhao, Hao Zhu, Yiping Huang, Wei He, Yue Zhao, Yuguang Li, Kai Guo","doi":"10.1007/s41981-024-00317-0","DOIUrl":"10.1007/s41981-024-00317-0","url":null,"abstract":"<div><p>Microbubble reactors play an important role in the development of gas-liquid reaction process enhancement. However, the urgent demand for high efficiency and low energy consumption in gas-liquid reaction processes, as well as the trend towards large-scale production, have put forward higher requirements for the design and optimization of microbubble reactors. In this study, a self-priming microbubble reactor was designed and its structure parameters were optimized by (computational fluid dynamics) CFD simulations. Based on the grid division method combining structured and unstructured grids, the most suitable mesh number is selected, and the simulation calculation time is saved on the premise of ensuring the accuracy. The effects of five structural parameters on the gas content and energy loss was discussed and the optimal structural parameters of the microbubble reactor were determined as follows: the diffusion section length is 75 mm, the contraction angle is 22°, the diffusion angle is 10.5°, the inlet diameter of the gas phase is 6 mm, the inlet diameter of the liquid phase flowing into the gas chamber is 3 mm, the diffusion section inlet diameter is 5 mm. Under the condition of the same inlet flow rate, the outlet gas content of the optimized gas-liquid reactor is increased by 42.9% compared with the initial structure. In the wastewater treatment experiment, the microbubble reactor reduced the chemical oxygen demand of wastewater by 61% within three hours. This study provides significant references for the design of the self-priming microbubble reactor.</p></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"14 1","pages":"161 - 176"},"PeriodicalIF":2.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140008173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lab-scale flow chemistry? Just do it yourself! 实验室规模的流动化学？自己动手

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2024-02-23 DOI: 10.1007/s41981-024-00312-5

Laura Y. Vázquez-Amaya, Guglielmo A. Coppola, Erik V. Van der Eycken, Upendra K. Sharma

{"title":"Lab-scale flow chemistry? Just do it yourself!","authors":"Laura Y. Vázquez-Amaya, Guglielmo A. Coppola, Erik V. Van der Eycken, Upendra K. Sharma","doi":"10.1007/s41981-024-00312-5","DOIUrl":"10.1007/s41981-024-00312-5","url":null,"abstract":"<div><p>In the realm of flow chemistry, Do-It-Yourself (DIY) flow setups represent a versatile and cost-effective alternative to expensive commercially available reactors. Not only they are budget friendly, but also unlock a world of possibilities for researchers to explore and create customized setups tailored to their specific needs. This minireview serves as a short compendium of DIY flow systems to assist flow researchers in the challenging task of finding a suitable setup for their experiments and facilitate the transition from batch to flow chemistry. Our goal is to demonstrate that flow chemistry can be affordable, easy-to-build, and reproducible at the same time. Therefore, herein we review and describe selected illustrative examples of easily assembled/constructed DIY flow setups, with a particular emphasis on how to select the most suitable one based on the specific chemistry of interest, ranging from simple homogeneous monophasic reactions to more complex systems for photo-, electrochemistry, and so on. In addition, we briefly comment on the significance of DIY approach on education, particularly its integration into the standard undergraduate curriculum as a key educational tool for young chemists. Ultimately, we hope this mini review will help and encourage the reader to go with the flow and get started with the fine art of flow chemistry.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"14 1","pages":"257 - 279"},"PeriodicalIF":2.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139956157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Practical synthesis of tetrahydrofolate by highly efficient catalytic hydrogenation in continuous flow 通过连续流高效催化加氢法合成四氢叶酸的实用方法

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2024-02-16 DOI: 10.1007/s41981-024-00310-7

Heng Pang, Junrong Huang, Juntao Wang, Gang Wang, Ana Xu, Lei Luo, Qunhui Yuan, Hengzhi You, Fen-Er Chen

{"title":"Practical synthesis of tetrahydrofolate by highly efficient catalytic hydrogenation in continuous flow","authors":"Heng Pang, Junrong Huang, Juntao Wang, Gang Wang, Ana Xu, Lei Luo, Qunhui Yuan, Hengzhi You, Fen-Er Chen","doi":"10.1007/s41981-024-00310-7","DOIUrl":"10.1007/s41981-024-00310-7","url":null,"abstract":"<div><p>Hundred-gram scale of highly selective catalytic hydrogenation of folic acid has been developed, which is adopted continuous-flow technology with Raney Ni as a catalyst. Through optimization of the reaction condition, a high conversion rate of folic acid (> 99%) and a high selectivity (99%) of tetrahydrofolate have been achieved. Additionally, a high-purity calcium-6<i>S</i>-5-methyltetrahydrofolate (6<i>S</i>-5-MTHF.Ca) has been synthesized from tetrahydrofolate obtained by continuous hydrogenation through chiral resolution, methylation, salting and recrystallization (purity: 99.5%, <i>de</i>: 97.6%). Compared to known methods, this method provides a feasible procedure using simple, inexpensive, and readily available reagents, making it a step-economical and cost-effective alternative strategy for production of tetrahydrofolate and its active derivatives.</p><h3>Graphical Abstract</h3><p>For Table of Contents Only</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"14 2","pages":"427 - 435"},"PeriodicalIF":2.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139756669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0