Control of mixing in a continuous-flow microreactor with an integrated bubble

IF 2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Dmitry Bratsun, Aleksey Mizev, Ramil Siraev, Elena Krasnyakova
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Abstract

Continuous-flow microreactors are increasingly used to replace batch reactors in fine organic synthesis. The interest of pharmaceutical production and similar industries in greater flexibility in reconfiguring synthesis systems motivates the design of increasingly miniature devices, in which mechanical mixing is difficult to apply, while the diffusion mechanism is inefficient. In this paper, using the example of a T-shaped continuous-flow microreactor, we propose to supplement the reaction chamber with a unit that rapidly mixes flowing solutions due to the concentration-capillary mechanism. Two syringe pumps supply a less dense isobutyric acid (\(\mathrm {C_{3}H_{7}COOH}\)) aqueous solution to the upper inlet and denser sodium hydroxide (\(\textrm{NaOH}\)) aqueous solution to the lower inlet, establishing a stably stratified two-layer system at the reaction chamber entrance. The contact between the solutions triggers a neutralization reaction. At a distance from the entrance, an additional inlet helps to form a gas bubble within the chamber. We show experimentally and numerically that the integration of an air bubble in a channel leads to the excitation of a self-oscillatory process near the air-liquid surface. The convective mixing process occurs in a pulsed mode, which includes a phase of rapid homogenization of the medium and subsequent restoration of heterogeneity by the base flow. We have determined the flow stability map on the plane of solution flow rates. We demonstrate that one can control the activation of convection, which enhances the mixing process, by manipulating the flow rates.

带集成气泡的连续流微反应器混合控制
连续流微反应器在精细有机合成中越来越多地用于取代间歇式反应器。制药生产和类似行业对更大灵活性重新配置合成系统的兴趣激发了越来越多的微型设备的设计,其中机械混合难以应用,而扩散机制效率低下。本文以t型连续流微反应器为例,提出利用浓度-毛细机制在反应室中增加一个快速混合流动溶液的装置。两台注射泵将密度较小的异丁酸(\(\mathrm {C_{3}H_{7}COOH}\))水溶液输送到上入口,将密度较大的氢氧化钠(\(\textrm{NaOH}\))水溶液输送到下入口,在反应室入口处建立稳定的分层两层体系。溶液之间的接触引起中和反应。在离入口一定距离处,一个额外的入口有助于在腔室内形成气泡。我们通过实验和数值证明了通道内气泡的积分会导致气液表面附近的自振荡过程的激发。对流混合过程以脉冲模式发生,其中包括介质的快速均匀化阶段和随后基流恢复非均匀性的阶段。我们确定了溶液流速平面上的流动稳定性图。我们证明可以通过控制流量来控制对流的激活,从而增强混合过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Flow Chemistry
Journal of Flow Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
6.40
自引率
3.70%
发文量
29
审稿时长
>12 weeks
期刊介绍: The main focus of the journal is flow chemistry in inorganic, organic, analytical and process chemistry in the academic research as well as in applied research and development in the pharmaceutical, agrochemical, fine-chemical, petro- chemical, fragrance industry.
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