Journal of Flow Chemistry最新文献_第10页

The applications of organozinc reagents in continuous flow chemistry: Negishi coupling 有机锌试剂在连续流化学中的应用:根岸耦合

IF 2.7 4区化学

Journal of Flow Chemistry Pub Date : 2023-01-12 DOI: 10.1007/s41981-022-00253-x

Roop Varghese Rubert, Rony Rajan Paul

{"title":"The applications of organozinc reagents in continuous flow chemistry: Negishi coupling","authors":"Roop Varghese Rubert, Rony Rajan Paul","doi":"10.1007/s41981-022-00253-x","DOIUrl":"10.1007/s41981-022-00253-x","url":null,"abstract":"<div><p>The design and implementation of flow technique helps organic chemists to resolve numerous challenges that are encountered during various catalytic reactions. Flow technologies, which offer solutions for technical and/or chemical issues, have gained popularity over the last two decades in the field of organic chemistry. The selectivity, efficiency, and safety of the entire process has been accelerated by flow reactors as they improve mass and heat transfer, speeds up the mixing of the reaction, and they offer exact control of the reaction parameters. This review mainly describes the utilization of flow chemistry in reactions involving organiozinc reagent, particularly Negishi coupling. The Negishi coupling of organozinc reagent is a valuable tool for the formation of C-C bond with functional group tolerance and are used extensively in total synthesis. This review also portrays a comparative study of organozinc reagents prepared using different procedures. A study of the effect of different catalysts over the same reaction is also carried out. An overview of different flow techniques that are employed has also been incorporated.</p></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"13 3","pages":"217 - 246"},"PeriodicalIF":2.7,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4496032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Electrophilic cyclization of reticuline-type alkaloids in flow via o-quinol intermediates 网状型生物碱通过邻喹啉中间体的亲电环化

IF 2.7 4区化学

Journal of Flow Chemistry Pub Date : 2023-01-12 DOI: 10.1007/s41981-022-00256-8

Bi Bali Judicaël Tra, Abollé Abollé, Killian Lucas, François-Xavier Felpin

引用次数: 0

Selective monosubstitution on a trichlorosilane with highly reactive organolithium compounds in a microflow reactor 微流反应器中高活性有机锂化合物对三氯硅烷的选择性单取代

IF 2.7 4区化学

Journal of Flow Chemistry Pub Date : 2022-12-27 DOI: 10.1007/s41981-022-00254-w

Moritz Achternbosch, Lukas Zibula, Annika Schmidt, Waldemar Krieger, Norbert Kockmann, Carsten Strohmann

引用次数: 0

Reactor performance estimation in microscale flow calorimeter for rapid characterization of exothermic reactions 用于放热反应快速表征的微尺度流动量热计反应器性能评估

IF 2.7 4区化学

Journal of Flow Chemistry Pub Date : 2022-12-12 DOI: 10.1007/s41981-022-00251-z

Timothy Aljoscha Frede, Nick Nikbin, Norbert Kockmann

引用次数: 0

TfOH-catalyzed three-component synthesis of Dithiocarbamates from α-Diazoesters under continuous flow conditions 连续流动条件下tfoh催化α-重氮酯合成三组分二硫代氨基甲酸酯

IF 2.7 4区化学

Journal of Flow Chemistry Pub Date : 2022-12-12 DOI: 10.1007/s41981-022-00249-7

Rui Wang, Hangli He, Qiongjiao Yan, Wei Wang, Haifeng Wang, Fener Chen

引用次数: 1

Minireview: recent efforts toward upgrading lignin-derived phenols in continuous flow 综述:木质素衍生酚类化合物在连续工艺中的最新进展

IF 2.7 4区化学

Journal of Flow Chemistry Pub Date : 2022-12-05 DOI: 10.1007/s41981-022-00248-8

Erin E. Brown

{"title":"Minireview: recent efforts toward upgrading lignin-derived phenols in continuous flow","authors":"Erin E. Brown","doi":"10.1007/s41981-022-00248-8","DOIUrl":"10.1007/s41981-022-00248-8","url":null,"abstract":"<div><p>Phenols are vital building blocks for manufactured goods, agrochemicals, and medicine. As the demand to circumvent fossil fuels intensifies, so does the need to establish alternate sources of chemical feedstock, with many researchers looking to biomass. Lignin, a complex biopolymer found in plants, represents a relatively untapped renewable source of phenolic compounds. Examples of aromatic compounds derived from lignin include phenol, guaiacol (2-methoxyphenol), and catechol (2-hydroxyphenol). The development of new technologies and chemistry to upgrade or modify these compounds is crucial to realizing the potential of biomass as chemical feedstock. Over the last two decades, continuous flow technology has become an established tool for chemists to expand the capabilities of reaction control and to provide a means to probe novel reactions that might otherwise be difficult to study or accomplish via conventional means. Flow also imparts many advantages, such as superior mixing capabilities for gas/liquid reactions, increased efficiency for photochemical transformations, and improved scalability. This mini review will highlight research efforts reported in the last half-decade (since 2016) toward <i>upgrading lignin-derived phenolic substrates using continuous flow technology</i>. Recent developments focus on reactions requiring oxygenation, oxidation, hydrogenation, and deoxygenation to name a few.</p><h3>Graphical abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"13 2","pages":"91 - 102"},"PeriodicalIF":2.7,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4204213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mediated formic acid flow fuel cell (MFAFFC) based on biomimetic electrolytes 仿生电解质介导甲酸流动燃料电池(MFAFFC)

IF 2.7 4区化学

Journal of Flow Chemistry Pub Date : 2022-12-02 DOI: 10.1007/s41981-022-00245-x

Katerina Bretosh, Mathieu Beaucamp, Florine Toulotte, Jinyi Yuan, Philippe Hapiot, Maël Penhoat

引用次数: 0

Continuous flow synthesis of HMF from glucose using gadolinium (III) trifluoromethanesulfonate in Brønsted acidic ionic liquid as a catalytic system Brønsted酸性离子液体中三氟甲烷磺酸钆催化葡萄糖连续流合成HMF的研究

IF 2.7 4区化学

Journal of Flow Chemistry Pub Date : 2022-11-29 DOI: 10.1007/s41981-022-00250-0

Ha Bich Phan, Trinh Hao Nguyen, Diep Dinh Le, Nhi Hoang Nguyen, Tan Van Nguyen, Phuong Hoang Tran

{"title":"Continuous flow synthesis of HMF from glucose using gadolinium (III) trifluoromethanesulfonate in Brønsted acidic ionic liquid as a catalytic system","authors":"Ha Bich Phan, Trinh Hao Nguyen, Diep Dinh Le, Nhi Hoang Nguyen, Tan Van Nguyen, Phuong Hoang Tran","doi":"10.1007/s41981-022-00250-0","DOIUrl":"10.1007/s41981-022-00250-0","url":null,"abstract":"<div><p>The direct conversion of glucose to 5-(hydroxymethyl)furfural (HMF) has been considered a challenging process. In this study, we developed a new method using gadolinium(III) trifluoromethanesulfonate (Gd(OTf)<sub>3</sub>) in combination with Brønsted acidic ionic liquids as a catalytic system to search possibly more environmentally benign process. The reaction was carried out under a continuous-flow system. The one-step isomerization/dehydration of glucose to give the highest HMF with Gd(OTf)<sub>3</sub> together with DBU-based Brønsted acidic ionic liquid in a low-cost home-built continuous system. The plausible mechanism was proposed with the Lewis acidic sites of Gd(OTf)<sub>3</sub> for the isomerization step and DBU-based Brønsted acidic ionic liquid sites for the dehydration step. The recycling of catalytic system Gd(OTf)<sub>3</sub>/DBU-based Brønsted acidic ionic liquid in DMSO was examined. Our findings provided a safe and environmental process for the continuous conversion of glucose into HMF. The use of continuous flow for HMF synthesis ensures that the current method can be applied to the large-scale process.</p></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"13 2","pages":"121 - 132"},"PeriodicalIF":2.7,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5133123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A perspective on automated advanced continuous flow manufacturing units for the upgrading of biobased chemicals toward pharmaceuticals 生物基化学品向药品升级的自动化先进连续流生产装置的展望

IF 2.7 4区化学

Journal of Flow Chemistry Pub Date : 2022-11-29 DOI: 10.1007/s41981-022-00247-9

Geoffroy Kaisin, Loïc Bovy, Yoann Joyard, Nicolas Maindron, Vincent Tadino, Jean-Christophe M. Monbaliu

{"title":"A perspective on automated advanced continuous flow manufacturing units for the upgrading of biobased chemicals toward pharmaceuticals","authors":"Geoffroy Kaisin, Loïc Bovy, Yoann Joyard, Nicolas Maindron, Vincent Tadino, Jean-Christophe M. Monbaliu","doi":"10.1007/s41981-022-00247-9","DOIUrl":"10.1007/s41981-022-00247-9","url":null,"abstract":"<div><p>Biomass is a renewable, almost infinite reservoir of a large diversity of highly functionalized chemicals. The conversion of biomass toward biobased platform molecules through biorefineries generally still lacks economic viability. Profitability could be enhanced through the development of new market opportunities for these biobased platform chemicals. The fine chemical industry, and more specifically the manufacturing of pharmaceuticals is one of the sectors bearing significant potential for these biobased building blocks to rapidly emerge and make a difference. There are, however, still many challenges to be dealt with before this market can thrive. Continuous flow technology and its integration for the upgrading of biobased platform molecules for the manufacturing of pharmaceuticals is foreseen as a game-changer. This perspective reflects on the main challenges relative to chemical, process, regulatory and supply chain-related burdens still to be addressed. The implementation of integrated continuous flow processes and their automation into modular units will help for tackling with these challenges.</p><h3>Graphical abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"13 2","pages":"77 - 90"},"PeriodicalIF":2.7,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s41981-022-00247-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5133518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemoselective borylation of bromoiodoarene in continuous flow: synthesis of bromoarylboronic acids 连续流动中溴碘芳烃的化学选择性硼化反应:溴芳基硼酸的合成

IF 2.7 4区化学

Journal of Flow Chemistry Pub Date : 2022-11-23 DOI: 10.1007/s41981-022-00246-w

Guillaume Reynard, Eric Wimmer, Jérémi Richelet, Jean-Marie Fourquez, Hélène Lebel

引用次数: 1