超声辐照下用氨基甲酰化和酰化反应连续一锅合成新的螺体融合吲哚

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Flow Chemistry Pub Date : 2023-02-15 DOI:10.1007/s41981-023-00261-5

Milene M. Hornink, Beatriz G. Rodrigues, Caroline S. Santos, Leandro H. Andrade

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引用次数: 0

摘要

超声辐照下流动反应器的应用，实现了一锅法快速合成新型螺熔吲哚。利用生物基构建块的反应性，包括丙烯酸和甲酰胺，对于实现这种高度功能化的分子目标至关重要。该工艺为四步法，停留时间2-3分钟，无需水处理，可合成螺[吲哚-琥珀酰亚胺]、螺[吲哚-吡咯-琥珀酰亚胺]和螺[吲哚-吡咯-琥珀酰亚胺]，总收率高。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Continuous one-pot synthesis of new spiro-fused indoles from biobased building blocks using carbamoylation and imidation reactions under ultrasonic irradiation

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Continuous one-pot synthesis of new spiro-fused indoles from biobased building blocks using carbamoylation and imidation reactions under ultrasonic irradiation

The application of a flow reactor under ultrasonic irradiation enabled the fast synthesis of new spiro-fused indoles in a one-pot methodology. The exploitation of the reactivity of biobased building blocks, including acrylic acids and formamides, was essential to achieve such highly functionalized molecular targets. A four-step process with a 2–3 min residence time, and no aqueous work-up, created spiro[indoline-succinimides], spiro[indole-pyrrolo-succinimides] and spiro[indole-pyrido-succinimides] with high overall yields.

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来源期刊

Journal of Flow Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

6.40

自引率

3.70%

发文量

审稿时长

>12 weeks

期刊介绍： The main focus of the journal is flow chemistry in inorganic, organic, analytical and process chemistry in the academic research as well as in applied research and development in the pharmaceutical, agrochemical, fine-chemical, petro- chemical, fragrance industry.