An eco-friendly and very low catalyst loading continuous condensation of primary amines and 1,3 Di carbonyl compounds: Synthesis of enaminones and enaminoesters by microreactor technology

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Flow Chemistry Pub Date : 2023-03-01 DOI:10.1007/s41981-023-00263-3

Zahra Goodarzi, M. Sadegh Ramezani

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Abstract

Herein, an efficient eco-friendly protocol is reported for the continuous synthesis of enaminones using a microreactor device in the presence of a catalytic amount of cerium (III) trichloride (1 mol%) in Propylene carbonate (PC) as a non-toxic solvent. Moreover, continuous separation of the corresponding product, and recycling of the catalyst-solvent system with water is another promising advantage of this technique. Indeed, the separation of the product by water allows any required catalyst and solvent to be reapplied in the next run. In addition, this microfluidic system enabled turnover frequency (TOF) of up to 2940 h⁻¹ for the corresponding products. The employment of these environment friendly facilitates produce the products with an excellent isolated yield up to 98%. This method performs efficiently, and would extent future applications of continuous organic, inorganic and biochemical reactions in green chemistry.

Graphical Abstract

Abstract Image

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伯胺和1,3二羰基化合物连续缩合的环保低催化剂:微反应器技术合成胺酮和胺酯

本文报道了一种高效环保的方法，在碳酸丙烯酯(PC)作为无毒溶剂的催化量(1 mol%)的三氯化铈(III)存在下，利用微反应器装置连续合成胺酮。此外，相应产物的连续分离以及催化剂-溶剂系统与水的循环利用是该技术的另一个有前途的优点。事实上，通过水分离产品可以在下次运行中重新应用任何所需的催化剂和溶剂。此外，该微流体系统使相应产品的周转频率(TOF)高达2940 h−1。采用这些环保材料，产品分离收率可达98%。该方法具有良好的性能，将进一步扩大绿色化学中连续有机、无机和生化反应的应用范围。图形抽象

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来源期刊

Journal of Flow Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

6.40

自引率

3.70%

发文量

审稿时长

>12 weeks

期刊介绍： The main focus of the journal is flow chemistry in inorganic, organic, analytical and process chemistry in the academic research as well as in applied research and development in the pharmaceutical, agrochemical, fine-chemical, petro- chemical, fragrance industry.