Journal of Analytical Chemistry最新文献_第10页

Oxythermography Method for Assessing Passive Adsorption of Organic Compounds on Surfaces of Solid Materials to Evaluate the 14C Contribution to the Background 固体材料表面有机化合物被动吸附的氧热成像法评价14C对背景的贡献

IF 1 4区化学

Journal of Analytical Chemistry Pub Date : 2025-05-14 DOI: 10.1134/S1061934825700157

M. Yu. Vorobyeva, B. K. Zuev, V. G. Filonenko, I. V. Rogovaya, D. V. Filosofov

{"title":"Oxythermography Method for Assessing Passive Adsorption of Organic Compounds on Surfaces of Solid Materials to Evaluate the 14C Contribution to the Background","authors":"M. Yu. Vorobyeva, B. K. Zuev, V. G. Filonenko, I. V. Rogovaya, D. V. Filosofov","doi":"10.1134/S1061934825700157","DOIUrl":"10.1134/S1061934825700157","url":null,"abstract":"The method for investigating passive adsorption of organic compounds from the indoor air on surfaces of solids is proposed. The method is based on detecting organic matter on the surface of the material using oxythermography after keeping the material in the indoor air for a certain time. The method evaluates the total amount of carbon on the surface of the material and assesses the 14C contribution of organic substances adsorbed on the surface to the radiation background in low-background experiments. The method has been tested in laboratory rooms of two different institutions. The total amount of organic substances adsorbed on the surface of platinum, palladium, and fused silica has been evaluated after keeping the samples in the indoor air for 10 minutes to 34 days. The differences in adsorption have been observed, and they depend on the material composition of the surface and the class of the cleanrooms where the experiments were performed. The method allows examining the samples without transferring them elsewhere.","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"80 4","pages":"731 - 737"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Innovative Membrane Approaches to Creating Horseradish Peroxidase-Based Conjugates for the Detection of Viral Infections 创新膜方法制备辣根过氧化物酶偶联物用于病毒感染检测

IF 1 4区化学

Journal of Analytical Chemistry Pub Date : 2025-05-14 DOI: 10.1134/S1061934825700078

V. M. Shkinev, V. F. Larichev, D. A. Trofimov

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Green Spectrophotometric Methods for the Determination of Ivermectin and Closantel in Veterinary Dosage Forms 绿分光光度法测定兽用制剂中伊维菌素和Closantel的含量

IF 1 4区化学

Journal of Analytical Chemistry Pub Date : 2025-05-14 DOI: 10.1134/S106193482570008X

Naglaa Ahmed, Ahmed Hemdan, Hala ZaaZaa, Maha Galal

{"title":"Green Spectrophotometric Methods for the Determination of Ivermectin and Closantel in Veterinary Dosage Forms","authors":"Naglaa Ahmed, Ahmed Hemdan,  Hala ZaaZaa, Maha Galal","doi":"10.1134/S106193482570008X","DOIUrl":"10.1134/S106193482570008X","url":null,"abstract":"Closaverm® is an injectable solution for cattle and sheep, containing 125.0 mg of closantel and 5.0 mg of ivermectin. It is effective against parasitic infestations and liver flukes. Spectrophotometric techniques were used to determine closantel and ivermectin in bulk powder and veterinary dosage forms. The techniques employed in this study consisted of univariate spectrophotometric methods that relied on mathematical calculations or graphical representations of data. Ivermectin was determined using several methods, including ratio subtraction, constant value, concentration value as well as constant multiplication followed by spectrum subtraction, while closantel was determined using the zero-order method. Three green analytical evaluation approaches were used to perform a quantitative and qualitative green performance evaluation of the suggested methods, namely the National Environmental Method Index, the Analytical Eco-Scale, and the Analytical GREEnness Metric tool. Different spectrophotometric methods were utilized to analyze the combination present in the veterinary dosage form of Closaverm®, with a linearity range of 8.0–75.0 µg/mL for closantel and 3.0–26.0 µg/mL for ivermectin. The suggested green analytical methods are eco-friendly and straightforward, providing an appropriate alternative for routine analysis of the mixture in quality control laboratories. The results obtained are precise and require minimal manipulation steps, thereby reducing the potential for errors and the time required for analysis. Additionally, these methods pose no adverse impacts on the health of the analyst or the environment. This study marks the first instance of a spectrophotometric method being utilized to determine the combination of ivermectin and closantel. The developed techniques exhibit exceptional green quality while upholding analytical standards.","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"80 4","pages":"657 - 665"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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State-of-the-Art Technologies in Explosives Detection 最新的爆炸物探测技术

IF 1 4区化学

Journal of Analytical Chemistry Pub Date : 2025-05-14 DOI: 10.1134/S1061934825700029

I. A. Buryakov, T. I. Buryakov

引用次数: 0

Quantification of the Anticancer Drug Avapritinib in Human Plasma Using 2,2-Dihydroxyindane-1,3-Dione: Application to a Pharmacokinetic Study 用2,2-二羟基茚-1,3-二酮定量测定人血浆中抗癌药物阿伐替尼：在药代动力学研究中的应用

IF 1 4区化学

Journal of Analytical Chemistry Pub Date : 2025-05-14 DOI: 10.1134/S1061934825700108

Baher I. Salman

{"title":"Quantification of the Anticancer Drug Avapritinib in Human Plasma Using 2,2-Dihydroxyindane-1,3-Dione: Application to a Pharmacokinetic Study","authors":"Baher I. Salman","doi":"10.1134/S1061934825700108","DOIUrl":"10.1134/S1061934825700108","url":null,"abstract":"The study examined the effectiveness of 2,2-dihydroxyindane-1,3-dione, commonly utilized as a derivatizing reagent for quantifying avapritinib (AVB) in pure form, pharmaceutical dosage formulations, and human plasma samples. In 2020, the United States Food and Drug Administration (US FDA) approved AVB, marking it as the inaugural precision therapy for individuals suffering from unresectable or metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis. Therefore, adjusting the AVB dose is essential for drug monitoring. Hence, the described spectrofluorimetric technique relies on a condensation reaction involving 2,2-dihydroxyindane-1,3-dione and the primary amine group found in AVB in the presence of phenylacetaldehyde. This reaction yields a highly fluorescent compound detectable at 468 nm (excitation wavelength of 395 nm). The calibration curve was established within a range of 0.4–4.0 µg/mL, demonstrating an excellent correlation coefficient of 0.9993 and a lower limit of quantification of 0.10 µg/mL. The methodology proved effective in estimating AVB in spiked plasma samples and assessing content uniformity. The research protocol was established and validated through bioanalytical methods by the ICH and US FDA guidelines. Additionally, this approach was employed to verify the drug concentration in each tablet, achieving a high recovery rate of 101.37% during the content uniformity test. This method was designed for pharmacokinetic analysis and easily applied in clinical laboratories.","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"80 4","pages":"675 - 683"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of an Eco-Friendly Liquid Chromatography Method for the Separation and Trace Determination of Caffeine in Beverages, Pharmaceuticals, and Environmental Water Samples Utilizing High-Temperature and Superheated Water: A Greenness Assessment 利用高温和过热水分离和痕量测定饮料、药品和环境水样中咖啡因的环保型液相色谱法的建立：绿色度评价

IF 1 4区化学

Journal of Analytical Chemistry Pub Date : 2025-05-14 DOI: 10.1134/S1061934825700121

Lateefa A. Al-Khateeb, Fatimah A. Dahas

{"title":"Development of an Eco-Friendly Liquid Chromatography Method for the Separation and Trace Determination of Caffeine in Beverages, Pharmaceuticals, and Environmental Water Samples Utilizing High-Temperature and Superheated Water: A Greenness Assessment","authors":"Lateefa A. Al-Khateeb, Fatimah A. Dahas","doi":"10.1134/S1061934825700121","DOIUrl":"10.1134/S1061934825700121","url":null,"abstract":"The retention behavior of the central nervous system stimulant caffeine (CAF) on the thermally stable Zir-Chrom-PBD column (5 μm, 150 × 4.6 mm) was investigated thermodynamically at various elevated temperatures utilizing high-temperature liquid chromatography (HTLC). The HTLC method was optimized for CAF analysis. The determination was performed using pure water or 20% acetonitrile in water as the mobile phase.The lower limit of detection for CAF was found to be 0.008 mg/mL, whereas the limit of quantification was 0.026 mg/mL. The developed HTLC method is the first HTLC method for this compound and has been used for multiple applications. It was applied for the assay of CAF in tablets and energy drinks, with acceptable mean recoveries ranging from 99.7 ± 0.3 to 100.0 ± 0.2% and 90.9 ± 1.9 to 103.6 ± 2.1%, respectively. Furthermore, the HTLC method was applied for monitoring of CAF in wastewater and groundwater. Multi-walled carbon nanotubes (MWCNTs) were applied for the efficient removal of CAF from water, and a mechanism of interaction between CAF and the MWCNTs was proposed. The method greenness was positively evaluated using two tools: the Analytical GREEnness metric and the Green Analytical Procedure Index.","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"80 4","pages":"693 - 706"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous Determination of Chiral Amino Acid Enantiomers by Liquid Chromatography–Mass Spectrometry Using (S)-2,5-Dioxypyrrolidine-1-yl-(5-(4-Methylpiperazin-1-yl)-2,4-Dinitrophenyl) Pyrrolidine-2-Carboxylate as a Chiral Derivatizing Reagent 以(S)-2,5-二氧吡咯烷-1-基-（5-（4-甲基哌嗪-1-基）-2,4-二硝基苯）吡咯烷-2-羧酸盐为手性衍生试剂的液相色谱-质谱同时测定手性氨基酸对映体

IF 1 4区化学

Journal of Analytical Chemistry Pub Date : 2025-05-14 DOI: 10.1134/S1061934825700145

Biao Jin, Zhiyin Jin, Dongri Jin

{"title":"Simultaneous Determination of Chiral Amino Acid Enantiomers by Liquid Chromatography–Mass Spectrometry Using (S)-2,5-Dioxypyrrolidine-1-yl-(5-(4-Methylpiperazin-1-yl)-2,4-Dinitrophenyl) Pyrrolidine-2-Carboxylate as a Chiral Derivatizing Reagent","authors":"Biao Jin, Zhiyin Jin, Dongri Jin","doi":"10.1134/S1061934825700145","DOIUrl":"10.1134/S1061934825700145","url":null,"abstract":"(S)-2,5-Dioxypyrrolidine-1-yl-(5-(4-methylpiperazin-1-yl)-2,4-dinitrophenyl) pyrrolidine-2-carboxylate (PPZ-Pro-NHS) was used as the reagent for chiral derivatization to distinguish between amino acid enantiomers. PPZ-Pro-NHS, synthesized from (S)-1-(5-(4-methylpiperazin-1-yl)-2,4-dinitrophenyl) pyrrolidine-2-carboxylic acid, reacted with chiral amines under mild conditions to yield the corresponding organic derivatives. The optimal conditions for derivatization using PPZ-Pro-NHS were 25°C and 40 min in a medium containing triethylamine. A simple liquid chromatography–mass spectrometry (LC−MS) method was developed to separate chiral amino acids using reversed-phase chromatography. The amino acids were separated by isocratic or gradient elution on a Mightysil RP-18 GP column with a mobile phase containing H2O, methanol, and 0.1% (v/v) formic acid. The enantiomers of the amino acids were fully separated with high resolution (Rs = 1.20–5.30) and high sensitivity (limit of detection: 85–4546 fmol) using PPZ-Pro-NHS derivatization and LC–MS analysis with both isocratic and gradient elution. The enantiomers of 16 amino acid mixtures were simultaneously separated in a single chromatographic run using a gradient mobile phase system. Thus, PPz-Pro-NHS can be used for chiral amine screening and authentication.","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"80 4","pages":"718 - 730"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analytical Applications of Chemiluminescence in Flow-Injection Systems 化学发光在流动注射系统中的分析应用

IF 1 4区化学

Journal of Analytical Chemistry Pub Date : 2025-05-14 DOI: 10.1134/S1061934825700017

Muhammad Asghar, Mohammad Yaqoob, Masood Ahmed Siddiqui, Amir Waseem

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Improvement of the Selectivity and Sensitivity of Analysis of Tetracycline Antibiotics Based on the ESI-MS Method with a Single-Quadrupole Mass Analyzer 单四极杆质谱分析仪ESI-MS分析四环素类抗生素选择性和灵敏度的提高

IF 1 4区化学

Journal of Analytical Chemistry Pub Date : 2025-05-14 DOI: 10.1134/S1061934825700091

A. V. Streletskiy, N. S. Antropova

引用次数: 0

Determination of Volatile Compounds from Lavender Flowers Using Passive Sorption on Novel Monolithic Butadiene-Nitrile Rubber and Silicon Carbide Materials by Thermal Desorption Gas Chromatography–Mass Spectrometry 新型单片丁腈橡胶和碳化硅材料被动吸附测定薰衣草花中挥发性化合物的热解吸气相色谱-质谱法

IF 1 4区化学

Journal of Analytical Chemistry Pub Date : 2025-05-14 DOI: 10.1134/S1061934825700133

A. V. Pirogov, E. S. Chichkanova, A. S. Popov, V. V. Levkina, T. A. Bolotnik, M. V. Popik, A. A. Stepashkin, E. N. Grunina, O. M. Zolotilova

{"title":"Determination of Volatile Compounds from Lavender Flowers Using Passive Sorption on Novel Monolithic Butadiene-Nitrile Rubber and Silicon Carbide Materials by Thermal Desorption Gas Chromatography–Mass Spectrometry","authors":"A. V. Pirogov, E. S. Chichkanova, A. S. Popov, V. V. Levkina, T. A. Bolotnik, M. V. Popik, A. A. Stepashkin, E. N. Grunina, O. M. Zolotilova","doi":"10.1134/S1061934825700133","DOIUrl":"10.1134/S1061934825700133","url":null,"abstract":"A novel composite material based on butadiene-nitrile rubber and silicon carbide (BNR-SiC) was synthesized and used for the first time to determine volatile components of lavender flowers by passive sorption, followed by thermal desorption and gas chromatography−mass spectrometry (GC−MS) identification. This material was demonstrated to capture almost the full range of organic compounds, exhibiting similar sorption/desorption efficiency and better thermal stability compared to Tenax TA. The chromatograms of lavender constituents obtained by passive sorption on Tenax TA and BNR-SiC composite are quite similar. Classes of compounds identified on the chromatograms include mono- and sesquiterpenes, their oxygenated derivatives, terpene alcohols, aromatic hydrocarbons, heterocyclic compounds, phenols, glycerides, linalool, linalyl acetate, eucalyptol, caryophyllene, linalool oxides, 1,3-glyceryl diacetate, and fatty acids, totaling 60 compounds. The approach of passive sorption on a BNR-SiC sorbent followed by thermal desorption GC−MS fingerprint analysis can provide a rough estimation of the compositional diversity and proximity of multi-herbal samples containing various groups of volatile terpene compounds.","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"80 4","pages":"707 - 717"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0