单四极杆质谱分析仪ESI-MS分析四环素类抗生素选择性和灵敏度的提高

IF 1 4区化学 Q4 CHEMISTRY, ANALYTICAL

Journal of Analytical Chemistry Pub Date : 2025-05-14 DOI:10.1134/S1061934825700091

A. V. Streletskiy, N. S. Antropova

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引用次数: 0

摘要

本文以四环素类抗生素为例，介绍了可用于改进单四极杆质量分析仪的性能特征的方法学方法。为了提高分析的选择性，建议在源中使用最优的电子光学参数（碎片器上的电压）以获得高的产物离子收率。结果表明，将所有形成产物离子的信号相加可以提高分析的灵敏度。

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Improvement of the Selectivity and Sensitivity of Analysis of Tetracycline Antibiotics Based on the ESI-MS Method with a Single-Quadrupole Mass Analyzer

The article describes methodological approaches that can be used to improve the performance characteristics of a single-quadrupole mass analyzer for studying the residual content of small organic substances in an aqueous medium using tetracycline antibiotics as an example. To improve the selectivity of the analysis, it is proposed to use optimal parameters of electron optics in the source (voltage across the fragmentor) in order to achieve a high yield of product ions. It is shown that the sensitivity of the analysis can be improved by summing the signals of all the formed product ions.

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来源期刊

Journal of Analytical Chemistry 化学-分析化学

CiteScore

2.10

自引率

9.10%

发文量

146

审稿时长

13 months

期刊介绍： The Journal of Analytical Chemistry is an international peer reviewed journal that covers theoretical and applied aspects of analytical chemistry; it informs the reader about new achievements in analytical methods, instruments and reagents. Ample space is devoted to problems arising in the analysis of vital media such as water and air. Consideration is given to the detection and determination of metal ions, anions, and various organic substances. The journal welcomes manuscripts from all countries in the English or Russian language.