Journal of Analytical Chemistry最新文献

Composition and Concentrations of Phenolic Compounds in Various Extracts from Stevia (Stevia rebaudiana Bertoni) 甜菊叶（Stevia reaudiana Bertoni）不同提取物中酚类化合物的组成及浓度

IF 1.5 4区化学

Journal of Analytical Chemistry Pub Date : 2026-08-22 DOI: 10.1134/S1061934826700668

Z. A. Temerdashev, T. K. Chubukina, N. V. Kiseleva, T. G. Tsyupko

{"title":"Composition and Concentrations of Phenolic Compounds in Various Extracts from Stevia (Stevia rebaudiana Bertoni)","authors":"Z. A. Temerdashev, T. K. Chubukina, N. V. Kiseleva, T. G. Tsyupko","doi":"10.1134/S1061934826700668","DOIUrl":"10.1134/S1061934826700668","url":null,"abstract":"The composition and concentrations of phenolic compounds (PCs) in aqueous and water–ethanol extracts from the leaves of stevia (Stevia rebaudiana Bertoni) obtained by various extraction methods (maceration, microwave and ultrasound assisted and subcritical extraction, and refluxing) are discussed. The efficiency of PC extraction was assessed by the concentrations of individual compounds and their total yield. The chromatographic identification of PCs in the extracts was studied. Chromatographic determination of PCs in the extracts was carried out in the reversed phase mode on a column with silica gel modified with octadecyl groups. Neochlorogenic and chlorogenic acids, rutin, quercetin glycosides I and II containing various sugar residues, two dicaffeoylquinic acid isomers, and apigenin-7-glucoside were identified by comparing the chromatographic retention parameters of the components and the absorption spectra and mass spectra with similar characteristics of standard reference compounds and with published data. The concentrations of individual PCs extracted into water–ethanol extracts by different methods and from different geographical areas varied greatly. The antioxidant activity of water–ethanol and aqueous extracts from the samples of stevia leaves from different vendors was evaluated, and this evaluation showed different contributions of individual PCs to the value of antioxidant activity.","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"81 :","pages":"1334 - 1346"},"PeriodicalIF":1.5,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rapid, Novel Colorimetric Method for Assessing Contamination of Glycerol with Toxic Diethylene Glycol 一种快速、新颖的比色法测定甘油被有毒二甘醇污染的方法

IF 1.5 4区化学

Journal of Analytical Chemistry Pub Date : 2026-08-22 DOI: 10.1134/S1061934826700735

Rajan Yadav, Dhruv Vishwakarma, Archana Upadhya

{"title":"A Rapid, Novel Colorimetric Method for Assessing Contamination of Glycerol with Toxic Diethylene Glycol","authors":"Rajan Yadav, Dhruv Vishwakarma, Archana Upadhya","doi":"10.1134/S1061934826700735","DOIUrl":"10.1134/S1061934826700735","url":null,"abstract":"Despite the stringency of the specifications of pharmaceutical glycerol to be used in oral syrups, diethylene glycol (DEG) contamination has been observed, leading to fatalities in young consumers. Formulations and glycerol raw materials in generic companies are not adequately tested due to the lack of sophisticated instrumentation and skilled manpower. The tests to determine glycerol purity according to recommended guidelines involve gas chromatographic techniques, which require expensive instruments and high technical skills. A rapid novel method for assessing glycerol purity is proposed, which can be used for screening glycerol raw material for DEG contamination. The colorimetric assay relies on the rapid reduction of chromium(VI) to chromium(III) by glycerol in the presence of excess sulfuric acid. The conversion of chromium(VI) to chromium(III) by DEG is much slower as compared to glycerol. Comparing both the analytes, a differential in the rate of reduction of chromium(VI) to chromium(III) was observed, which is exploited in the assay. The formation of chromium(III) product could be assessed by spectrophotometric analysis at 574 nm. The method is linearly sensitive to glycerol concentrations. The assay is simple, rapid, and can be used to screen glycerol consignments by comparing them with the readings obtained from standard pure pharmaceutical glycerol. DEG contamination greater than or equal to 5% (v/v) (~4.4%, m/m) can be indicated. However, confirmed analysis must be performed as per the recommended guidelines.","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"81 :","pages":"1428 - 1434"},"PeriodicalIF":1.5,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of Tin Species in Waters 水中锡的种类测定

IF 1.5 4区化学

Journal of Analytical Chemistry Pub Date : 2026-08-22 DOI: 10.1134/S1061934826700620

P. G. Abakumov, Z. A. Temerdashev, D. D. Abakumova, A. G. Abakumov, M. A. Bolshov

{"title":"Determination of Tin Species in Waters","authors":"P. G. Abakumov, Z. A. Temerdashev, D. D. Abakumova, A. G. Abakumov, M. A. Bolshov","doi":"10.1134/S1061934826700620","DOIUrl":"10.1134/S1061934826700620","url":null,"abstract":"This review presents a critical analysis of studies published in recent years on methods and analytical procedures for the determination of tin species in aquatic environments. The characteristics of determining inorganic and organotin species using various modern analytical methods are discussed. The determination of tin species in aquatic systems is complicated by the complexity of the sample matrix, particularly seawater, and by the low concentrations of the analyte, requiring the use of highly sensitive and selective analytical techniques combined with analyte preconcentration and separation procedures. The need to determine trace concentrations of tin is associated with the fact that the maximum permissible concentration (MPC) of tin ranges from 0.010 to 10.0 μg/L. Spectrometric methods predominate in the determination of inorganic tin and enable low limits of detection to be achieved; however, the possible presence of organotin compounds in samples complicates the analysis. In the analysis of waters with complex sample matrices, hyphenated methods that combine various approaches for separating tin species with subsequent spectrometric determination play an important role. The combination of chromatographic separation with ICP–AES/MS techniques appears to be the most effective approach, enabling the detection of tin compounds at the nanogram per liter level. However, the optimal analytical conditions are generally specific to a particular tin species and require the development of new analytical schemes for the comprehensive assessment of water contamination. Preliminary extraction-based separation of tin species followed by ICP determination of the analytes is also an effective approach.","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"81 :","pages":"1273 - 1285"},"PeriodicalIF":1.5,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Biosensing Methods for Lactate Detection 乳酸盐生物传感检测方法研究进展

IF 1.5 4区化学

Journal of Analytical Chemistry Pub Date : 2026-08-22 DOI: 10.1134/S106193482670070X

Haolin Xin, Yingkai Qin, Aili Wei, Tianhui Wang

引用次数: 0

Solid-Phase Colorimetric Determination of Yellow-Colored Substances Using Immobilized Sorption Microprobes 固定化吸附微探针固相比色法测定黄色物质

IF 1.5 4区化学

Journal of Analytical Chemistry Pub Date : 2026-08-22 DOI: 10.1134/S106193482670067X

T. I. Tikhomirova, V. V. Apyari, A. O. Sarkisyan

引用次数: 0

Separation of Selenium Forms and Their Determination Using Polyvinyl Formaldehyde Thiourea Sorbent 聚乙烯醇硫脲吸附剂对硒形态的分离及测定

IF 1.5 4区化学

Journal of Analytical Chemistry Pub Date : 2026-08-22 DOI: 10.1134/S1061934826700693

S. L. Didukh-Shadrina, D. I. Belyakovich, V. N. Losev, S. I. Metelitsa

引用次数: 0

Analytical Quantification of Tofacitinib Citrate in Bulk and Nanostructured Lipidic Formulations by HPLC Using a Quality by Design Approach Integrated with Monte Carlo Simulations 采用质量设计与蒙特卡罗模拟相结合的高效液相色谱法定量分析散装和纳米结构脂质制剂中的柠檬酸托法替尼

IF 1.5 4区化学

Journal of Analytical Chemistry Pub Date : 2026-08-22 DOI: 10.1134/S1061934826700747

Akanksha Mahajan, Om Prakash Katare, Asha Patel, Bhupinder Singh, Kamalinder K Singh

{"title":"Analytical Quantification of Tofacitinib Citrate in Bulk and Nanostructured Lipidic Formulations by HPLC Using a Quality by Design Approach Integrated with Monte Carlo Simulations","authors":"Akanksha Mahajan, Om Prakash Katare, Asha Patel, Bhupinder Singh, Kamalinder K Singh","doi":"10.1134/S1061934826700747","DOIUrl":"10.1134/S1061934826700747","url":null,"abstract":"A novel, robust, and stability-indicating high-performance liquid chromatography method was developed and validated for the quantification of tofacitinib citrate (TFC) using an integrated quality-by-design approach supported by appropriate chemometric tools. The analytical target profile was defined, and critical analytical attributes (CAAs), including peak area and tailing factor, were identified. Chromatographic separation was achieved on a C18 column with photodiode array detection at 287 nm using an isocratic elution of methanol, acetonitrile, and phosphate buffer (pH 5.0) in a 20 : 20 : 60 (v/v/v) ratio. An Ishikawa fishbone diagram was employed to identify potential sources of variability affecting CAAs. Taguchi design facilitated the screening of critical method parameters, followed by method optimization using a face-centered cubic design. The optimized method complied with the International Council for Harmonization Q2 (R1) guideline and Monte Carlo validation criteria, demonstrating excellent linearity (correlation coefficient = 0.9999), precision (coefficient of variation ≤ 0.04%), accuracy (100.1–101.5% recovery), and sensitivity (limit of detection = 150 ng/mL; limit of quantitation = 460 ng/mL). Robustness was confirmed within the method operable design region. Chemometric evaluation using principal component analysis and variance inflation factor effectively addressed multicollinearity. Forced degradation studies confirmed the stability-indicating capability of the method for TFC in topical nanolipidic formulations, establishing its suitability for routine pharmaceutical analysis.","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"81 :","pages":"1435 - 1453"},"PeriodicalIF":1.5,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coordination Chemistry of Al3+-Selective Colorimetric and Fluorescent Chemosensors: Advances, Challenges, and Future Directions Al3+选择性比色和荧光化学传感器的配位化学：进展、挑战和未来方向

IF 1.5 4区化学

Journal of Analytical Chemistry Pub Date : 2026-08-22 DOI: 10.1134/S1061934825604384

Duraisamy Udhayakumari, Dhayanithi Duraisamy, Nanthakumar A

{"title":"Coordination Chemistry of Al3+-Selective Colorimetric and Fluorescent Chemosensors: Advances, Challenges, and Future Directions","authors":"Duraisamy Udhayakumari, Dhayanithi Duraisamy, Nanthakumar A","doi":"10.1134/S1061934825604384","DOIUrl":"10.1134/S1061934825604384","url":null,"abstract":"The coordination chemistry of aluminum plays a pivotal role in shaping the design, performance, and applicability of Al3+-selective colorimetric and fluorescent chemosensors. Owing to the high charge density, strong oxophilicity, and kinetic inertness of Al3+, the development of selective molecular probes remains both scientifically challenging and technologically significant. This review provides a comprehensive and mechanism-driven analysis of recent advances in Al3+ detection, focusing on how ligand architecture, donor-atom arrangement, and coordination geometries govern sensing behaviors. Emphasis is placed on polycyclic aromatic frameworks, heterocyclic scaffolds, and Schiff-base-derived receptors whose coordination modes enable turn-on fluorescence, ratiometric responses, and visible color changes. By correlating coordination features with optical outputs, the review highlights insights into binding stoichiometry, chelation-enhanced fluorescence effects, and metal-induced structural rigidification. Current limitations—such as interference from competing metal ions, aqueous stability issues, and challenges in real-sample quantification—are critically examined. Finally, the review outlines emerging research directions, including multifunctional probes, bioimaging-compatible designs, solid-state sensors, and computationally guided ligand engineering, collectively offering a strategic roadmap for the next generation of Al3+-selective chemosensors.","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"81 :","pages":"1380 - 1393"},"PeriodicalIF":1.5,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multisensor Data Analysis 多传感器数据分析

IF 1.5 4区化学

Journal of Analytical Chemistry Pub Date : 2026-08-22 DOI: 10.1134/S1061934826700632

A. Yu. Bogomolov, V. P. Korneev, E. A. Ignatiev

{"title":"Multisensor Data Analysis","authors":"A. Yu. Bogomolov, V. P. Korneev, E. A. Ignatiev","doi":"10.1134/S1061934826700632","DOIUrl":"10.1134/S1061934826700632","url":null,"abstract":"A promising area of development in modern analytical chemistry is the design of inexpensive and compact analyzers, usually specialized ones. Such devices include optical multisensor systems (OMSs), which possess a number of features distinguishing them from traditional laboratory spectrometers. A distinctive feature of the new multisensor technology is the significant simplification of the analyzer due to its optimization for solving a specific applied problem. As a consequence, the nature of the data obtained changes: in OMSs, the data are represented by a small number of spectral variables. This paper presents a critical review of traditional requirements for the spectrometer design, as well as approaches to the collection, preprocessing, visualization, and the subsequent analysis of the data of OMS measurements. The problems generated by the development of multisensor technologies are considered, and methods of their solution are proposed in the context of current and future tasks of qualitative and quantitative analysis. The main trends and prospects for the development of the necessary algorithms and software for the analysis of multivariate OMS data are considered.","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"81 :","pages":"1286 - 1301"},"PeriodicalIF":1.5,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assemblable Paper-Based Microfluidic Devices Functionalized with Silver Nanoparticles: Advances and Prospects in Solid‑Phase Spectroscopy and Digital Colorimetry 用纳米银功能化的可组装纸基微流控装置：固相光谱和数字比色法的进展和前景

IF 1.5 4区化学

Journal of Analytical Chemistry Pub Date : 2026-08-22 DOI: 10.1134/S1061934826700656

A. A. Furletov, V. V. Apyari, S. G. Dmitrienko

{"title":"Assemblable Paper-Based Microfluidic Devices Functionalized with Silver Nanoparticles: Advances and Prospects in Solid‑Phase Spectroscopy and Digital Colorimetry","authors":"A. A. Furletov, V. V. Apyari, S. G. Dmitrienko","doi":"10.1134/S1061934826700656","DOIUrl":"10.1134/S1061934826700656","url":null,"abstract":"This paper discusses the opportunities and prospects for apassemblable plying assemblable paper-based microfluidic systems modified with silver nanoparticles of various morphologies to the determination of biologically active compounds by diffuse reflectance spectroscopy and digital colorimetry. The combination of the adsorption properties of cellulose with the unique optical properties of silver nanoparticles, arising from the phenomenon of localized surface plasmon resonance, within a single analytical device, is shown to offer a promising platform for the development of resource-efficient and rapid chemical analysis test systems. The applicability of the developed paper-based microfluidic systems was demonstrated for the determination of biologically active compounds representing three priority classes: peroxides (using hydrogen peroxide as a model analyte), organic sulfur-containing compounds (using cysteamine as a model analyte), and flavonoids (using rutin as a model analyte). The morphology of the silver nanoparticles was found to influence the sensitivity and selectivity of the colorimetric determination of the target compounds. The feasibility of recording the analytical signal using a smartphone camera was also demonstrated. The achieved limits of detection ranged from 0.2 to 2.3 μg for diffuse reflectance spectroscopy and from 0.4 to 2.0 μg for digital colorimetry, depending on the nature of the analyte. The proposed approach was successfully applied to the determination of peroxides, biologically active organic sulfur-containing compounds, and flavonoids in pharmaceutical products and dosage forms, dietary supplement samples, as well as cosmetic products.","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"81 :","pages":"1321 - 1333"},"PeriodicalIF":1.5,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0