Journal of Analytical Chemistry最新文献

{"title":"Erratum to: Ultrasound-Assisted Extraction Combined with Dispersive Liquid-Liquid Microextraction Using Low-Density Solvent—a Novel Approach to Determine Fenvalerate in Strawberry Samples","authors":"Mohammad Rezaee, Davood Ghoddocy Nejad","doi":"10.1134/S106193482504001X","DOIUrl":"10.1134/S106193482504001X","url":null,"abstract":"","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"80 4","pages":"784 - 784"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Organic Matter Content in Water and Sediments on the Recovery of Estrogenic Compounds Extracted by Solid-Phase Extraction and Ultrasound-Assisted Extraction","authors":"José Gustavo Ronderos-Lara,&nbsp;Hugo Saldarriaga-Noreña,&nbsp;Mario Alfonso Murillo-Tovar,&nbsp;Violeta Mugica-Álvarez,&nbsp;Iris J. Montoya-Balbás,&nbsp;Verónica Gisela López-Martínez,&nbsp;Khirbet López-Velázquez,&nbsp;Ernesto Sola-Pérez","doi":"10.1134/S1061934825700066","DOIUrl":"10.1134/S1061934825700066","url":null,"abstract":"<p>This work evaluates the effect of organic matter on the recovery of ibuprofen (<b>IBU</b>), naproxen (<b>NPX</b>), 4-<i>n</i>-nonylphenol (<b>4NP</b>), bisphenol A (<b>BPA</b>), 17β-estradiol (<b>E2</b>) and 17α-ethinylestradiol (<b>EE2</b>) in water and sediment samples. The best solid-phase extraction results were obtained with sample extractions at pH 7, and elution was performed using acetone–MeOH (3 : 2). Recoveries varied between 54.24 ± 0.86% (4NP) and 89.77 ± 5.40% (EE2). Repeatability and reproducibility were below 8.1 and 111.13% (EE2), respectively. The best ultrasound-assisted extraction results were obtained using acetone–MeOH (3 : 2) as the extraction solvent. Recoveries oscillated between 48.8 ± 8.4% (EE2) and 112.6 ± 4.3% (NPX). Repeatability and reproducibility were below 17.21 and 17.84% (BPA), respectively. The validated methods were applied to determine the effect of organic matter on recoveries in surface water and sediment samples impacted by different sources. As a result, in water samples with high organic matter content, recoveries for IBU, NPX, and EE2 increased up to 18, 11, and 22%, respectively. In sediment samples, the recovery of E2 increased up to 43%. Thus, due to the presence of organic matter in samples, it is recommended to explore organic matter content in samples before analysis to minimize errors in determined concentrations.</p>","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"80 4","pages":"634 - 646"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Separation and Preconcentration of Biologically Active Compounds by Capillary Electrophoresis Using Imidazolium-Based Modifiers","authors":"A. Sh. Ganieva,&nbsp;L. A. Kartsova","doi":"10.1134/S1061934825700170","DOIUrl":"10.1134/S1061934825700170","url":null,"abstract":"<p>A cationic covalent coating based on an imidazolium cation is synthesized for the inner walls of a fused silica capillary. The electroosmotic flow reproducibility, determined using dimethylformamide as a marker, was as high as 99%. The separation conditions for model systems of phenyl- and indolecarboxylic acids—phenylactic, phenylsuccinic, phenylbutanoic, indolelactic, indolepropionic, indoleacrylic, hydroxyindalmic, homogentisic, homovanillic, and hydroxyindoleacetic acids—were optimized for capillary electrophoresis. The optimal background electrolyte consisted of a 10 mM phosphate buffer solution of pH 4.2 with a 10 vol % acetonitrile additive. The resolution factors for adjacent analyte pairs ranged from 1.7 to 18.9. The synthesized coating enabled the in-capillary preconcentration of phenyl- and indolecarboxylic acids. Electrostacking increased analyte concentration factors to 106 to 512 and brought the limits of detection to 4 to 72 ng/mL.</p>","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"80 4","pages":"748 - 755"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Separation of Oxidative Degradation Products of the Anti-Cancer Drug Gilteritinib Fumarate by Liquid Chromatography with Photodiode Array and Mass Spectrometric Detection","authors":"Pushpa Pilli,&nbsp;Sowmya Chaganti,&nbsp;Vijaya Madhyanapu Golla,&nbsp;Hema Sree Kommalapati,&nbsp;Bhukya Vijay Nayak,&nbsp;Gananadhamu Samanthula","doi":"10.1134/S106193482570011X","DOIUrl":"10.1134/S106193482570011X","url":null,"abstract":"<p>Gilteritinib (<b>GTB</b>) is used for the treatment of refractory or relapsed acute myeloid leukemia and inhibits several receptor tyrosine kinases, including FMS-like tyrosine kinase 3 and AXL. The main objective of the current study was to determine how GTB degrades under forced conditions (hydrolysis, oxidation, and photolysis) in accordance with ICH Q1A and Q1B criteria. Zeneth software was used to predict the in-silico deterioration profile of GTB before the study was carried out. GTB was found to be stable under hydrolytic (acidic, basic, and neutral) and photolytic degradation conditions, but it was labile under oxidative (H₂O₂) conditions, producing three novel degradation products. The degradation products were identified and separated using a Phenomenex Gemini C18 column (250 × 4.6 mm, 5 µm) in a reversed-phase high-performance liquid chromatography with a gradient program. Mobile phases consisted of 10 mM ammonium formate with 0.01% acetic acid (pH unadjusted, %A) and methanol (%B). High-resolution mass spectrometry was used for the structural elucidation of the degradation products. The resulting data enabled the proposal of a mechanism for the formation of the degradation products. Using in silico techniques (DEREK Nexus, SARAH Nexus, and ProTox-3.0), the toxicity and mutagenicity of GTB and its degradation products were predicted. In summary, this study highlights safety monitoring and storage conditions for GTB.</p>","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"80 4","pages":"684 - 692"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of an Immunochromatography Test System for Determining Okadaic Acid in Seafood","authors":"E. K. Singov,&nbsp;O. S. Morenkov,&nbsp;S. V. Sipin,&nbsp;V. V. Vrublevskaya","doi":"10.1134/S1061934825700169","DOIUrl":"10.1134/S1061934825700169","url":null,"abstract":"<p>Okadaic acid (OA) and its derivatives—dinophysistoxins—belong to the group of diarrhetic shellfish poison toxins (DSP toxins), which are produced by toxin-forming dinoflagellates. When mollusks ingest these algae, DSP toxins accumulate in their adipose tissue and can cause acute poisoning in humans upon consumption. We developed a simple, a sensitive, and a specific test system for the detection and semiquantitatively determination of okadaic acid and its derivatives in mollusks. This system is based on a direct competitive immunochromatographic analysis. The test strips contain three immunoreagent binding lines: a test line, a control line, and an internal reference line. The color intensity of the internal reference line remains independent of the OA concentration in the solution and is comparable to the color intensity of the test line. If DSP toxins are present in a sample, the color intensity of the test line decreases relative to the reference line, enabling toxin detection. Sample preparation involves the extraction of mollusk tissue homogenates with methanol, followed by the dilution of the extract with an analysis buffer. The test strips are manufactured in a dipstick format, and the analysis procedure consists of immersing part of the strip into a sample for a few seconds, with results processed after 30 min. The total analysis time, including sample preparation, is approximately 1 h. The test system reliably detects and semiquantitatively determines okadaic acid in various mollusks, including oysters, mussels, venus clams, whelks, and sea scallops, at toxin concentrations of up to 40 ng/g using visual result detection and up to 10 ng/g using instrumental registration. These limits of detection are significantly lower than the maximum permissible concentration for okadaic acid set by the World Health Organization and Rospotrebnadzor (160 ng/g). In addition to okadaic acid, the test system can also detect its derivatives, dinophysistoxin-1 and dinophysistoxin-2, in mollusks. The developed immunochromatographic test system can be used for monitoring OA-group toxin levels in mollusks in Russia.</p>","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"80 4","pages":"738 - 747"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Main Strategies of the Sample Preparation of Biological Samples Containing Nanoparticles for Their Subsequent Analysis by Single Particle Inductively Coupled Plasma Mass Spectrometry: A Mini-Review","authors":"O. N. Grebneva-Balyuk,&nbsp;M. S. Kiseleva,&nbsp;I. V. Kubrakova","doi":"10.1134/S1061934825700042","DOIUrl":"10.1134/S1061934825700042","url":null,"abstract":"<p>The characterization of highly dispersed materials and nanoparticles (NPs), as well as the investigation of their transformations in biological systems, constitute a critical aspect of research aimed at assessing the potential for active NP applications in biomedicine and pharmacology. A promising method for characterizing NPs involves single particle inductively coupled plasma mass spectrometry (SP ICP MS). This technique enables the determination of nanoparticle masses at the femtogram level and gives information on their distribution by the analyte form (soluble ionic or nanoscale), size, and quantity within the analyzed sample. Sample preparation for an SP ICP MS analysis is based on the quantitative extraction of NPs from a biological sample while preserving their characteristics. Liquid samples for analysis are prepared by dilutions, involving filtration, centrifugation, sedimentation, and various fractionation and separation techniques. Enzymatic and alkaline hydrolysis have been applied to the decomposition of biological tissues. The discussion addresses the capabilities and limitations of primary sample preparation methods, using biomaterials containing gold and silver NPs as examples. Particular attention is given to techniques that do not alter the analyte, such as dilution and filtration. A possibility of analyzing iron oxide-based materials, relevant to biomedical research, using SP ICP MS is noted, along with the challenges associated with such analyses. The combination of laser ablation (as a sampling method) with SP ICP MS is shown to be a promising approach to studying the spatial distribution of NPs in biological systems.</p>","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"80 4","pages":"608 - 622"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and Detection of Adulterations of Salmon Caviar by PCR, IR Spectrometry, and Digital Coloriometry","authors":"V. G. Amelin,&nbsp;O. E. Emel’yanov,&nbsp;A. V. Tret’yakov,&nbsp;M. A. Gergel’,&nbsp;E. V. Zaitseva","doi":"10.1134/S1061934825700194","DOIUrl":"10.1134/S1061934825700194","url":null,"abstract":"<p>A possibility of identifying and establishing adulterations of salmon caviar by a simple and an available method using PCR, Fourier transform IR spectrometry, digital colorimetry with the chemometric processing of the analysis results is shown. The PCR method is used to determine the species of salmon caviar. No salmon DNA in the studied caviar samples, as well as the presence of DNA of other fish, indicates the adulteration of the caviar products. Near- and mid-region Fourier transform infrared spectroscopy makes it possible to distinguish between the natural and imitation caviar after processing diffuse reflectance spectra by principal component analysis and hierarchical cluster analysis. The above methods are combined with a simpler and a cheaper colorimetric analysis method. Hand-made devices with LEDs emitting in the UV and IR regions are used. The analytical signal is recorded using smartphones with specialized applications. Chemometric processing of the spectral characteristics of the samples makes it possible to distinguish natural caviar from imitation and structured caviar: in the principal component analysis and hierarchical cluster analysis, points of the analyzed samples are located in different quadrants and clusters.</p>","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"80 4","pages":"772 - 783"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxythermography Method for Assessing Passive Adsorption of Organic Compounds on Surfaces of Solid Materials to Evaluate the 14C Contribution to the Background","authors":"M. Yu. Vorobyeva,&nbsp;B. K. Zuev,&nbsp;V. G. Filonenko,&nbsp;I. V. Rogovaya,&nbsp;D. V. Filosofov","doi":"10.1134/S1061934825700157","DOIUrl":"10.1134/S1061934825700157","url":null,"abstract":"<p>The method for investigating passive adsorption of organic compounds from the indoor air on surfaces of solids is proposed. The method is based on detecting organic matter on the surface of the material using oxythermography after keeping the material in the indoor air for a certain time. The method evaluates the total amount of carbon on the surface of the material and assesses the ¹⁴C contribution of organic substances adsorbed on the surface to the radiation background in low-background experiments. The method has been tested in laboratory rooms of two different institutions. The total amount of organic substances adsorbed on the surface of platinum, palladium, and fused silica has been evaluated after keeping the samples in the indoor air for 10 minutes to 34 days. The differences in adsorption have been observed, and they depend on the material composition of the surface and the class of the cleanrooms where the experiments were performed. The method allows examining the samples without transferring them elsewhere.</p>","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"80 4","pages":"731 - 737"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative Membrane Approaches to Creating Horseradish Peroxidase-Based Conjugates for the Detection of Viral Infections","authors":"V. M. Shkinev,&nbsp;V. F. Larichev,&nbsp;D. A. Trofimov","doi":"10.1134/S1061934825700078","DOIUrl":"10.1134/S1061934825700078","url":null,"abstract":"<p>An approach is proposed to using membrane filtration in the development of methodologies for obtaining horseradish peroxidase-based conjugates for the detection of viral infections. This approach is significantly simpler, faster, and more cost-effective than chromatographic methods. Nearly no conjugate losses occur during the purification of the components. A procedure for the membrane purification of horseradish peroxidase and its analysis via capillary electrophoresis is proposed. The procedure also ensures the preparation of horseradish peroxidase conjugates with viral antigens for use in enzyme-linked immunosorbent assays (ELISA) for the detection of class M antibodies against a virus (in the M antibody capture modification). The practice of utilizing various diagnostic kits prepared with this approach is described, for example, in ELISA test systems, for diagnosing diseases caused by viruses like West Nile, Crimean–Congo hemorrhagic fever, tick-borne encephalitis, and others.</p>","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"80 4","pages":"647 - 656"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Spectrophotometric Methods for the Determination of Ivermectin and Closantel in Veterinary Dosage Forms","authors":"Naglaa Ahmed,&nbsp;Ahmed Hemdan,&nbsp; Hala ZaaZaa,&nbsp;Maha Galal","doi":"10.1134/S106193482570008X","DOIUrl":"10.1134/S106193482570008X","url":null,"abstract":"<p>Closaverm^® is an injectable solution for cattle and sheep, containing 125.0 mg of closantel and 5.0 mg of ivermectin. It is effective against parasitic infestations and liver flukes. Spectrophotometric techniques were used to determine closantel and ivermectin in bulk powder and veterinary dosage forms. The techniques employed in this study consisted of univariate spectrophotometric methods that relied on mathematical calculations or graphical representations of data. Ivermectin was determined using several methods, including ratio subtraction, constant value, concentration value as well as constant multiplication followed by spectrum subtraction, while closantel was determined using the zero-order method. Three green analytical evaluation approaches were used to perform a quantitative and qualitative green performance evaluation of the suggested methods, namely the National Environmental Method Index, the Analytical Eco-Scale, and the Analytical GREEnness Metric tool. Different spectrophotometric methods were utilized to analyze the combination present in the veterinary dosage form of Closaverm^®, with a linearity range of 8.0–75.0 µg/mL for closantel and 3.0–26.0 µg/mL for ivermectin. The suggested green analytical methods are eco-friendly and straightforward, providing an appropriate alternative for routine analysis of the mixture in quality control laboratories. The results obtained are precise and require minimal manipulation steps, thereby reducing the potential for errors and the time required for analysis. Additionally, these methods pose no adverse impacts on the health of the analyst or the environment. This study marks the first instance of a spectrophotometric method being utilized to determine the combination of ivermectin and closantel. The developed techniques exhibit exceptional green quality while upholding analytical standards.</p>","PeriodicalId":606,"journal":{"name":"Journal of Analytical Chemistry","volume":"80 4","pages":"657 - 665"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}