中国地球物理学会年刊最新文献_第8页

A modified Neyman-Pearson technique for radiodense tissue estimation in digitized mammograms 一种改进的奈曼-皮尔逊技术用于数字化乳房x光片中放射性致密组织的估计

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1106243

J. Neyhart, R.E. Eckert, R. Polikar, S. Mandayam, M. Tseng

引用次数: 2

Application of multivariate analysis for optimizing & predicting hepatic function 多变量分析在肝功能优化预测中的应用

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1137038

C. Chan, D. Hwang, G. Stephanopoulous, G. Stephanopoulous, M. Yarmush

{"title":"Application of multivariate analysis for optimizing & predicting hepatic function","authors":"C. Chan, D. Hwang, G. Stephanopoulous, G. Stephanopoulous, M. Yarmush","doi":"10.1109/IEMBS.2002.1137038","DOIUrl":"https://doi.org/10.1109/IEMBS.2002.1137038","url":null,"abstract":"An optimization model based upon multivariate analysis was developed to capture hepatic specific function in relation to the environmental condition and the intracellular metabolic network and the flux information obtained from metabolic flux analysis (MFA). Fisher discriminant analysis (FDA) was applied to maximize the discrimination among groups thus permitting visualization of the sample separation between different conditions. FDA identified factors that contribute greatly to the separation of the groups. Mapping fluxes to a hepatic function permits an examination of the interrelationship of the fluxes and captures the hepatic function in terms of the metabolic profile. Partial least square (PLS) was the mapping technique applied to evaluate the effect of metabolic state on hepatic function, namely, the levels of intracellular triglyceride or urea production. This methodology identified fluxes most relevant to minimizing the accumulation of intracellular triglyceride and maximizing the production of urea, two important hepatic functions. In the study, 75 metabolic fluxes were mapped to measured levels of intracellular triglyceride or urea. Once a mapping model was constructed, analyzing the model parameters permitted the assessment of how the metabolic profile, in turn, pathways collectively regulate and control hepatic function by identifying pathways that are highly correlated with the hepatic function.","PeriodicalId":60385,"journal":{"name":"中国地球物理学会年刊","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84499925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-MEMS sensors for real-time shear stress on endothelial cell dynamics 生物mems传感器实时剪切应力内皮细胞动力学

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1053047

T. Hsiai, S. Cho, P. Wong, M. Ing, M. Navab, S. Reddy, L. Demer, C. Ho

引用次数: 10

Recurrent inhibition model of cat gastrocnemius muscle 猫腓肠肌复发性抑制模型

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1053128

T. Uchiyama, U. Windhorst, H. Johansson

引用次数: 0

Parameter estimation and multichannel fusion for classifying averaged ERPs 基于参数估计和多通道融合的平均erp分类

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1134437

L. Gupta, J. Phegley, D. Molfese

引用次数: 0

The Visible Heart/spl trade/: the collaborative development and use of this educational tool by the University of Minnesota and Medtronic 可见心脏/spl贸易/:明尼苏达大学和美敦力合作开发和使用这一教育工具

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1053460

P. Iaizzo, T. Laske

引用次数: 1

Directed attachment of Schwann cells on protein micropatterned degradable polymeric substrates 雪旺细胞在蛋白质微图案可降解聚合物基质上的定向附着

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1137020

K. Schmalenberg, H. Buettner, K. Uhrich

{"title":"Directed attachment of Schwann cells on protein micropatterned degradable polymeric substrates","authors":"K. Schmalenberg, H. Buettner, K. Uhrich","doi":"10.1109/IEMBS.2002.1137020","DOIUrl":"https://doi.org/10.1109/IEMBS.2002.1137020","url":null,"abstract":"After injury to the peripheral nervous system, axons from regenerating nerve cells must reach their innervation target to restore function. Polymeric substrates are currently being evaluated as nerve guides to enhance recovery after peripheral nerve injury. Degradable organic polymer substrates are highly suitable materials as matrices for tissue engineering because they can be specifically designed to serve as scaffolds then be absorbed by the body leaving only native tissue. Protein patterns on polymeric nerve guides may help maximize functional repair after injury because chemical cues can direct cellular components to their intended targets. Using microcontact printing techniques, protein stripes were patterned onto several different degradable polymeric substrates including poly(caprolactone), poly(caprolactam) and poly(3-hydroxybutyrate). The fluorescently tagged protein micro-patterns were visualized by confocal scanning laser fluorescence microscopy. The micropatterned polymer substrates were evaluated for their ability to direct attachment and alignment of Schwann cells (a cellular component of the peripheral nervous system).","PeriodicalId":60385,"journal":{"name":"中国地球物理学会年刊","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75713594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Comparative in vivo and ex vivo pacing and sensing performance study using isolated four-chamber working swine heart model 用离体四室工作猪心脏模型进行体内和离体起搏和传感性能的比较研究

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1106379

T. Laske, N. Skadsberg, P. Iaizzo

{"title":"Comparative in vivo and ex vivo pacing and sensing performance study using isolated four-chamber working swine heart model","authors":"T. Laske, N. Skadsberg, P. Iaizzo","doi":"10.1109/IEMBS.2002.1106379","DOIUrl":"https://doi.org/10.1109/IEMBS.2002.1106379","url":null,"abstract":"A study was conducted comparing the pacing and sensing performance of an endocardial pacing lead (5076, Medtronic, Inc., Minneapolis, MN) in vivo to an ex vivo isolated heart model designed to work all four chambers under simulated in vivo physiologic conditions. The lead was implanted in vivo using fluoroscopic guidance. Standard stimulation and sensing parameters were recorded. Using standard cardiac surgical techniques, 8 porcine hearts were excised and reperfused in a working heart model retaining their original lead placement. Following stabilization, the electrical measurements were repeated. Ex vivo electrical values were significantly decreased relative to the in vivo measurements: R-wave amplitude by 39%, P-wave amplitude by 39%, slew rate by 62%, and pacing impedance by 34%. Pacing threshold values were similar in vivo and ex vivo. Variations in performance were in part attributed to local tissue deformation in the isolated heart preparation leading to differences in lead slack and orientation. This comparative study substantiated the value of utilizing the isolated heart model to visualize and simultaneously evaluate lead pacing and sensing performance in comparison with in vivo experimental procedures.","PeriodicalId":60385,"journal":{"name":"中国地球物理学会年刊","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73612374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Left ventricular volume changes after defibrillation 除颤后左室容积变化

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1106470

A. de Jongh, B.S. Sheals, D. K. Chau, B. Hoffmeister, R. Malkin

引用次数: 1

Hepatocellular engineering via acellular cadherin-derived microinterfaces 通过脱细胞钙粘蛋白衍生的微界面进行肝细胞工程

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1137067

T. Brieva, P. Moghe

{"title":"Hepatocellular engineering via acellular cadherin-derived microinterfaces","authors":"T. Brieva, P. Moghe","doi":"10.1109/IEMBS.2002.1137067","DOIUrl":"https://doi.org/10.1109/IEMBS.2002.1137067","url":null,"abstract":"The development of cell-based therapies for liver failure relies on the availability of scaffolds that support high levels of cellular function. In this work, we functionalize biomaterial surfaces using a novel cell-based ligand as an alternative to traditional extracellular matrix-derived ligands. Initial studies in a model coculture system indicate that E-cadherin, a key cell-cell adhesion molecule present on hepatocytes, enhances liver-specific function when presented by chaperone cells. We then investigate the behavior of hepatocytes on acellular cadherin-presenting immobilized microparticle-based biomaterials. Biological activity of acellular cadherins is ensured by appending to the extracellular domain of E-cadherin an immunoglobulin Fc region, which induces dimerization and specifically adheres to a Protein A coating on the microbeads. Hepatocellular function was elevated on these surfaces as compared to the control, Fc presenting surfaces. Both surfaces exhibited similar cell adhesion and morphogenesis, suggesting that induction of hepatocyte function by cadherins was due to signaling activities rather than adhesive activities. Overall, we have demonstrated that functionalization of biomaterials with acellular cadherins is a powerful way to induce hepatocyte function.","PeriodicalId":60385,"journal":{"name":"中国地球物理学会年刊","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77541746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0