生物mems传感器实时剪切应力内皮细胞动力学

中国地球物理学会年刊 Pub Date : 2002-12-01 DOI:10.1109/IEMBS.2002.1053047

T. Hsiai, S. Cho, P. Wong, M. Ing, M. Navab, S. Reddy, L. Demer, C. Ho

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引用次数: 10

摘要

动脉树剪应力的精确表征对于阐明时空剪应力梯度对内皮细胞(EC)生物活性的影响至关重要。我们开发了微电子机械系统(MEMS)传感器，其尺寸与EC (2 /spl倍/ 80 /spl mu/m)相当，可在频率响应> 100 Hz时提供所需的空间和时间分辨率。通过单核细胞趋化蛋白(MCP-1)的实时基因表达，我们首次在体外提供了实时壁剪切应力对EC偶联的影响。

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Bio-MEMS sensors for real-time shear stress on endothelial cell dynamics

Precise characterization of shear stress in the arterial trees is critical to elucidate the effects of spatial versus temporal shear stress gradients on the biological activities of endothelial cells (EC). We developed micro electrical mechanical systems (MEMS) sensors, comparable to the size of EC (2 /spl times/ 80 /spl mu/m), to deliver the spatial and temporal resolution necessary at a frequency response > 100 Hz. We provided the first in vitro evidence of real-time wall shear stress on EC couple with real-time gene expression of monocyte chemoattractant protein (MCP-1).

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来源期刊

中国地球物理学会年刊

自引率

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发文量

368