中国地球物理学会年刊Pub Date : 2003-04-01DOI: 10.1109/IEMBS.2002.1106281
Toshiyuki Tanaka, M. Torikai
{"title":"Contour extraction of fetus' head from echocardiogram using Snakes","authors":"Toshiyuki Tanaka, M. Torikai","doi":"10.1109/IEMBS.2002.1106281","DOIUrl":"https://doi.org/10.1109/IEMBS.2002.1106281","url":null,"abstract":"Summary form only given. We extract a contour of the fetus head from an echocardiogram BPD (biparietal diameter) level at 15-25 pregnancy weeks, without being influenced by the lack of pixels and noise elements, for the diagnostic support of the doctor. As for the contour of the fetus head, it is effective for diagnosis of the pregnancy week and degree of deformity before birth. Various evaluation values were automatically calculated as features from the obtained contour. This research consists of preprocessing, contour extraction, and calculation of the evaluation value. First, as the preprocessing, the noise is reduced from the original image and an indistinct point has been improved by using the contrast emphasis and median filtering. Next, the contour of the fetus head was extracted by using the active contour model Snakes, more highly accurate than a general technique. Finally the OFD (occipitofrontal diameter), BPD, were automatically computed from the obtained contour. The improvement of the extraction accuracy was confirmed by setting the best energy parameters for Snakes in contour extraction. We succeeded in obtaining evaluation values with the same accuracy, compared with those calculated from the contour depicted by the doctor.","PeriodicalId":60385,"journal":{"name":"中国地球物理学会年刊","volume":"9 1","pages":"1070 vol.2-"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89819083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国地球物理学会年刊Pub Date : 2002-12-01DOI: 10.1109/IEMBS.2002.1053279
B. Pikkula, J. Tunnell, B. Anvari
{"title":"Methodology for estimating instantaneous heat removal from human skin in response to cryogen spray cooling","authors":"B. Pikkula, J. Tunnell, B. Anvari","doi":"10.1109/IEMBS.2002.1053279","DOIUrl":"https://doi.org/10.1109/IEMBS.2002.1053279","url":null,"abstract":"Cryogen spray cooling (CSC) reduces epidermal damage during laser treatment of various dermatoses. The goal of this study was to determine the instantaneous surface heat removal from skin by CSC. Thermocouples were imbedded in four substrates with a range of thermal diffusivities, greater than three orders of magnitude in difference, to measure internal temperature profiles in response to CSC. An inverse heat conduction model was subsequently used to quantify the instantaneous heat removal from the substrates using the measured temperatures. The ratio of the average values of the instantaneous heat removal among pairs of substrates was plotted as a function of the ratio of the thermal diffusivity among the pairs. The resulting correlation was then used to estimate the instantaneous heat removal from skin. This work will aid in the modeling of heat transfer in skin during laser irradiation in conjunction with CSC.","PeriodicalId":60385,"journal":{"name":"中国地球物理学会年刊","volume":"68 1","pages":"2275-2276 vol.3"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78209057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国地球物理学会年刊Pub Date : 2002-12-01DOI: 10.1109/IEMBS.2002.1134423
J. Choi, Myung-Whun Sung, K. Park
{"title":"New method in acoustic analysis for the diagnosis of the laryngeal functions","authors":"J. Choi, Myung-Whun Sung, K. Park","doi":"10.1109/IEMBS.2002.1134423","DOIUrl":"https://doi.org/10.1109/IEMBS.2002.1134423","url":null,"abstract":"Speech has been widely used for the diagnosis of the laryngeal function, and many methods have been developed in voice analysis. But, some methods cannot be applied in clinical cases. So, we present a scheme for the diagnosis of the voice using some parametric methods. We expect this scheme to be useful for the diagnosis of patients' voices.","PeriodicalId":60385,"journal":{"name":"中国地球物理学会年刊","volume":"58 1","pages":"135-136 vol.1"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80163001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study of polarization evolution in phantom tissues with ultrafast optics techniques: Monte Carlo simulations and experiments","authors":"Xueding Wang, L.V. Wang, Chia-Wei Sun, Hsiang-Shi Wang, C.C. Yang, Y. Kiang","doi":"10.1109/IEMBS.2002.1053303","DOIUrl":"https://doi.org/10.1109/IEMBS.2002.1053303","url":null,"abstract":"This paper presents our study results of polarized short pulse transmission through phantom tissues made of polystyrene particle solutions with various concentrations and particle sizes. To improve the quality of optical imaging using an ultrafast light source, study is required to fully understand the evolution of the polarization state in the sample, as well as the time- and polarization-dependent distributions of optical intensity exiting from samples. Temporal profiles of the Stokes vectors and the degree of polarization are measured experimentally. The results agree well with those resulting from Monte Carlo simulations. Analyses based on the Stokes-Mueller formalism show that the first scattering event determines the spatial patterns of the transmitted Stokes vectors. When a detected area at the output surface of the sample is symmetric about the incident beam, the temporal profile of transmittance is independent of the incident polarization state. The linear relationship between the average order of scatters and the light propagation time can be used to explain the exponential decay of the degree of polarization and the inversely proportional relationship between the FWHM of the degree of polarization and the scatterer concentration.","PeriodicalId":60385,"journal":{"name":"中国地球物理学会年刊","volume":"16 1","pages":"2323-2324 vol.3"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81502740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国地球物理学会年刊Pub Date : 2002-12-01DOI: 10.1109/IEMBS.2002.1136947
D. Ghosh, M. Barry
{"title":"Phage display of adenoviral HI loop for \"context-specific\" ligand selection","authors":"D. Ghosh, M. Barry","doi":"10.1109/IEMBS.2002.1136947","DOIUrl":"https://doi.org/10.1109/IEMBS.2002.1136947","url":null,"abstract":"Adenoviruses are used as delivery vectors in gene therapy mainly due to their ability to efficiently infect dividing and non-dividing cells. However, their success is hindered due to its tropism for non-targeted cell types. Adenoviruses can be genetically retargeted by ligand addition to confer specificity. Phage-presenting random peptide libraries have been used to select potential ligands. This approach does not require knowledge of the cell biology. However, selected peptides engineered into the adenovirus can reduce viral capsid function, and the adenovirus can impair targeting ability of the selected peptide. Our research focuses on the development of \"context-specific\" random libraries for ligand selection. By introducing a viral context, we hope to select a peptide that can be introduced into the virus without affecting function. In this paper, we report the phage display of biotin acceptor peptide within the adenoviral HI loop (denoted HI-BAP). HI-BAP is expressed and enzymatically biotinylated on the pIII minor coat protein of filamentous phage. This approach can improve targeting of viral vectors.","PeriodicalId":60385,"journal":{"name":"中国地球物理学会年刊","volume":"31 1","pages":"555-556 vol.1"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78497372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国地球物理学会年刊Pub Date : 2002-12-01DOI: 10.1109/IEMBS.2002.1053470
R. Linsenmeier, T. R. Harris, S. Olds
{"title":"The VaNTH Bioengineering Curriculum Project","authors":"R. Linsenmeier, T. R. Harris, S. Olds","doi":"10.1109/IEMBS.2002.1053470","DOIUrl":"https://doi.org/10.1109/IEMBS.2002.1053470","url":null,"abstract":"The NSF-sponsored VaNTH Engineering Research Center in Bioengineering Educational Technologies is developing a website, www.vanth.org/curriculum, to provide a forum for ideas about bioengineering curriculum. Two elements of that site are: 1) a listing of recommended core content, as opposed to core courses, for biomedical engineering undergraduate programs, and 2) recommendations for creation of curricula in terms of both content and pedagogy. This presentation addresses these two area. Our recommendations are intended to allow programs to meet a set of standard criteria that will allow industry, in particular, to understand what a biomedical engineer is, while allowing universities to meet local constraints and take advantage of their own strengths. Feedback from a broad cross-section of the bioengineering community is now needed to achieve agreement on core elements of a biomedical engineering curriculum.","PeriodicalId":60385,"journal":{"name":"中国地球物理学会年刊","volume":"29 1","pages":"2644-2645 vol.3"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79926989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国地球物理学会年刊Pub Date : 2002-12-01DOI: 10.1109/IEMBS.2002.1106416
Y. Hoi, H. Meng, B. Bendok, L. Guterman, L. Hopkins
{"title":"Effects of vessel curvature on intracranial aneurysmal flow","authors":"Y. Hoi, H. Meng, B. Bendok, L. Guterman, L. Hopkins","doi":"10.1109/IEMBS.2002.1106416","DOIUrl":"https://doi.org/10.1109/IEMBS.2002.1106416","url":null,"abstract":"The effects of parent vessel curvature on the hemodynamic forces for lateral saccular aneurysms are evaluated by using computational fluid dynamics (CFD). As the vessel curvature increases, flow impinges the distal neck and enters the aneurysm violently, causing both the pressure and shear stress at the distal neck to increase. High-pressure and high wall shear stress zones at the distal neck expand with the increasing of vessel curvature. The location of maximal wall shear stress implies that the growth or rupture of aneurysm may initiate in this region. Moreover, the effects of parent vessel curvature on aneurysm hemodynamics may eventually help to predict the risk of individual aneurysm rupture. Implantation of stents has the dual effect of disrupting the flow into the aneurysm and altering the radius of curvature. The study of the effects of vessel curvature effects on flow thus has new implications for stent design and implantation.","PeriodicalId":60385,"journal":{"name":"中国地球物理学会年刊","volume":"7 1","pages":"1337-1338 vol.2"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86120302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国地球物理学会年刊Pub Date : 2002-12-01DOI: 10.1109/IEMBS.2002.1053352
E. Delikanaki-Skaribas, H. Lim, H. Qureshy, S. Holmes, E. Protas, A. Sherwood
{"title":"Gait training in individuals with incomplete SCI: how are they different from healthy subjects?","authors":"E. Delikanaki-Skaribas, H. Lim, H. Qureshy, S. Holmes, E. Protas, A. Sherwood","doi":"10.1109/IEMBS.2002.1053352","DOIUrl":"https://doi.org/10.1109/IEMBS.2002.1053352","url":null,"abstract":"The purpose of this study was to examine the effects of 3-month gait training on mean gait oxygen consumption (VO2), gait speed (GS), distance covered in a 5-minutes walk, and gait cost (GC). In order to better explain the results, the data were compared to healthy subjects. Ten incomplete SCI patients with mean age 40/spl plusmn/14 years participated to the study. The results showed significant increases in mean walking VO2 (p<0.01), GS (p<0.01), and distance covered (p<0.01) during the 5-minute walking test. While GC did not improve significantly after training, there was a definite trend of lower VO2 consumption per meter walked. The relation between VO2 and GS was compared to data of a 5-minute walking test of healthy individuals. There was a significant positive correlation between VO2 and GS in healthy (r=0.68; p<0.01) and there was no correlation (r=0.10) between those variables in SCI individuals. There was no correlation between GC and GS in healthy (r=0.128) and there was a significant negative correlation in SCI individuals. There is evidence that SCI individuals benefit from gait training. While physiological responses during walking are different in individuals with SCI than healthy, gait training reduces that difference.","PeriodicalId":60385,"journal":{"name":"中国地球物理学会年刊","volume":"9 1","pages":"2416-2417 vol.3"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86105902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国地球物理学会年刊Pub Date : 2002-12-01DOI: 10.1109/IEMBS.2002.1136969
B. Sprague, C. Pearson, P. Maddox, E. Salmon, D. Odde
{"title":"Integrated modeling of yeast kinetochore microtubule dynamics and the imaging thereof by fluorescence microscopy","authors":"B. Sprague, C. Pearson, P. Maddox, E. Salmon, D. Odde","doi":"10.1109/IEMBS.2002.1136969","DOIUrl":"https://doi.org/10.1109/IEMBS.2002.1136969","url":null,"abstract":"We were interested in determining the mechanisms by which microtubules mediate the segregation of chromosomes during mitosis in S. cerevisiae. In metaphase each chromosome has a single kinetochore assembled on its kinetochore region and each yeast kinetochore is in turn associated with a single microtubule plus end. A yeast strain containing a GFP fusion to the kinetochore protein, Cse4p, was used to track kinetochore microtubule dynamics by fluorescence microscopy. However, the images were blurry as a result of diffraction, and so rather than deconvolve the experimental images, we instead convolved the model predictions with a model of the image formation process to generate simulated microscopic images. Using the latter approach, which we call \"model-convolution,\" it was impossible to mistakenly converge to a false reconstructed image, as can happen with the former approach, and it was computationally faster. The simulated images were compared statistically to the experimental images to determine that a simple dynamic instability model was unacceptable. However, a stable spatial gradient of microtubule catastrophe rate model provided reasonable agreement. These results show that the behaviors of proteins confined to subcellular compartments can be quantitatively analyzed, provided that both the intrinsic dynamics and the imaging of those dynamics are modeled.","PeriodicalId":60385,"journal":{"name":"中国地球物理学会年刊","volume":"25 1","pages":"596-597 vol.1"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82736829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中国地球物理学会年刊Pub Date : 2002-12-01DOI: 10.1109/IEMBS.2002.1106218
J. Zhang, R. Patterson, A. Korjenevsky
{"title":"Comparison and analysis of electrical impedance tomographic images reconstructed using two algorithms","authors":"J. Zhang, R. Patterson, A. Korjenevsky","doi":"10.1109/IEMBS.2002.1106218","DOIUrl":"https://doi.org/10.1109/IEMBS.2002.1106218","url":null,"abstract":"Dynamic electrical impedance tomographic (EIT) images are constructed based on the measurements from Sheffield system DAS01P-01 using two algorithms. One is to derive dynamic images from static images. Another is to reconstruct dynamic images using the back projection method. Changes of resistivity in region of interests (ROI) are determined and compared. The difference and possible reasons are discussed.","PeriodicalId":60385,"journal":{"name":"中国地球物理学会年刊","volume":"22 1","pages":"945-946 vol.2"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89084491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}