Critical Reviews in Eukaryotic Gene Expression最新文献_第3页

Mechanism of Curcumin Inhibition of Malignant Progression of Lung Cancer Cells by Regulating Ferroptosis via the NRF2/HMOX1 Pathway. 姜黄素通过NRF2/HMOX1通路调控铁凋亡抑制肺癌细胞恶性进展的机制

IF 1.5 4区医学

Critical Reviews in Eukaryotic Gene Expression Pub Date : 2025-01-01 DOI: 10.1615/CritRevEukaryotGeneExpr.2025058526

Xiaoqi Guo, Tianci Han, Liang Zhang

{"title":"Mechanism of Curcumin Inhibition of Malignant Progression of Lung Cancer Cells by Regulating Ferroptosis via the NRF2/HMOX1 Pathway.","authors":"Xiaoqi Guo, Tianci Han, Liang Zhang","doi":"10.1615/CritRevEukaryotGeneExpr.2025058526","DOIUrl":"https://doi.org/10.1615/CritRevEukaryotGeneExpr.2025058526","url":null,"abstract":"Inducing ferroptosis has become a means of hindering lung cancer progression. Curcumin regulates ferroptosis and participates in lung cancer progression, yet its mechanism on ferroptosis remains unclear. Semaphorin-6A attenuates lung cancer cell migration through the nuclear factor erythroid-2-related factor 2 (NRF2)/heme oxygenase-1 gene (HMOX1) axis. Therefore, the study investigated the mechanism of curcumin inhibiting the malignant progression of lung cancer cells by regulating ferroptosis via the NRF2/HMOX1 pathway. A549 and H209 cell viability, proliferation, death, invasion and migration were assessed by CCK-8, colony formation, lactate dehydrogenase, and Transwell assays. Levels of reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), and Fe2+, glutathione peroxidase 4 (GPX4), nuclear NRF2, and HMOX1, and NRF2 nuclear translocation were measured by kits, Western blot and immunofluorescence. Cell viability, proliferation, invasion and migration were decreased after curcumin treatment, while cell death was significantly increased (all P < 0.01). Curcumin-treated cells showed elevated ROS, MDA and Fe2+ levels, decreased SOD, GSH and GPX4 levels (all P < 0.01), and increased nuclear NRF2 level and nuclear translocation, and HMOX1 expression (all P < 0.01), suggesting that curcumin activated the NRF2/HMOX1 pathway to promote ferroptosis, thereby inhibiting lung cancer cell malignant progression. Liproxstatin-1 or ML385 treatment reversed curcumin-induced anti-tumor effect and ferroptosis. Curcumin activates the NRF2/HMOX1 pathway to promote ferroptosis, thus repressing the malignant progression of lung cancer cells. These findings provide new insights into the mechanism of curcumin's anti-tumor effect and highlight its potential as a therapeutic drug for lung cancer.","PeriodicalId":56317,"journal":{"name":"Critical Reviews in Eukaryotic Gene Expression","volume":"35 5","pages":"39-51"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in the Levels of the Serum Markers Serum Amyloid A and Immunoglobulin M in Children with Mycoplasma pneumoniae Infection Complicated with Asthma and Their Clinical Significance. 肺炎支原体感染并发哮喘患儿血清标志物、血清淀粉样蛋白A和免疫球蛋白M的变化及其临床意义

IF 1.5 4区医学

Critical Reviews in Eukaryotic Gene Expression Pub Date : 2025-01-01 DOI: 10.1615/CritRevEukaryotGeneExpr.2025056739

Shanshan Xiao, Xuejing Hou

{"title":"Changes in the Levels of the Serum Markers Serum Amyloid A and Immunoglobulin M in Children with Mycoplasma pneumoniae Infection Complicated with Asthma and Their Clinical Significance.","authors":"Shanshan Xiao, Xuejing Hou","doi":"10.1615/CritRevEukaryotGeneExpr.2025056739","DOIUrl":"https://doi.org/10.1615/CritRevEukaryotGeneExpr.2025056739","url":null,"abstract":"Asthma represents a chronic disorder with aberrant immunological and inflammatory responses. We analyzed the levels and clinical significance of serum markers serum amyloid A (SAA) and immunoglobulin M (IgM) in Mycoplasma pneumoniae (MP)-infected children with asthma. MP-infected children were allocated into the Asthma (n = 64) and N-Asthma (n = 104) groups, with baseline information collected. Levels of IgE, c-reactive protein, procalcitonin, lactate dehydrogenase, aspartate aminotransferase, interleukin-4/interferon-γ (IL-4/IFN-γ), transforming growth factor β1 (TGF-β1), SAA and IgM were determined by ELISA. Tidal breathing lung function [inspiratory time (TI), expiratory time (TE), inspiratory volume (V-TI), expiratory volume (V-TE), tidal volume (VT) and respiratory rate (RR)] was assessed using a pulmonary function instrument. The relationship of serum SAA and IgM with IgE, IL-4/IFN-γ, TGF-β1, and tidal breathing lung function in MP-infected asthmatic children, and their diagnostic value for asthma occurrence in MP-infected children were analyzed by Spearman analysis and receiver operating characteristic curve. IgE, V-TI, V-TE, VT, IL-4/IFN-γ, TGF-β1, SAA and IgM indexes in MP-infected asthmatic children surpassed those without asthma. Serum SAA and IgM significantly positively correlated with IgE, IL-4/IFN-γ, TGF-β1, V-TI, V-TE and VT, which had certain diagnostic value for asthma in MP-infected children. The incidence of asthma was higher in MP-infected children with high SAA and IgM expression levels. The diagnostic efficacy of SAA and IgM combined test surpassed single detection. Serum SAA and IgM were highly expressed in MP-infected asthmatic children, and their combined detection had high diagnostic value for asthma in MP-infected children.","PeriodicalId":56317,"journal":{"name":"Critical Reviews in Eukaryotic Gene Expression","volume":"35 4","pages":"27-37"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NEK6 Accelerates Hepatocellular Carcinoma Progression and Glycolysis through Ubiquitination of TCP10L. NEK6通过TCP10L泛素化加速肝细胞癌进展和糖酵解。

IF 1.5 4区医学

Critical Reviews in Eukaryotic Gene Expression Pub Date : 2025-01-01 DOI: 10.1615/CritRevEukaryotGeneExpr.2025057446

Ling Su, Dehong Zhao, Cheng Zhou, Biao Zhang

{"title":"NEK6 Accelerates Hepatocellular Carcinoma Progression and Glycolysis through Ubiquitination of TCP10L.","authors":"Ling Su, Dehong Zhao, Cheng Zhou, Biao Zhang","doi":"10.1615/CritRevEukaryotGeneExpr.2025057446","DOIUrl":"https://doi.org/10.1615/CritRevEukaryotGeneExpr.2025057446","url":null,"abstract":"Never in mitosis a related kinases 6 (NEK6) is a serine/threonine kinase, and dysregulation of NEK6 is associated with malignant progression of human cancers. Nonetheless, the biological function and molecular mechanism of NEK6 in hepatocellular carcinoma (HCC) are unknown. Our study found that NEK6 was obviously raised in HCC patient tissues and cells, and patients with high NEK6 expression had a worse prognosis. Silencing of NEK6 reduced the growth, metastasis, cell cycle, and glycolysis of HCC cells while facilitating apoptosis. In vivo experiments also showed that NEK6 knockdown dramatically hampered tumor growth, suggesting that NEK6 enhanced HCC progression in vivo and in vitro. Next, we proved that TCP10L was a target gene of NEK6, and NEK6 negatively regulated TCP10L expression. Mechanistically, we confirmed that NEK6 was bound to TCP10L, and NEK6 degraded TCP10L protein expression through ubiquitination. Rescue experiments also declared that TCP10L reversed the effect of NEK6 on HCC cells. Our results disclosed that NEK6 heightened HCC progression and glycolysis through ubiquitination of TCP10L. Our study may provide a new perspective for the treatment of HCC.","PeriodicalId":56317,"journal":{"name":"Critical Reviews in Eukaryotic Gene Expression","volume":"35 4","pages":"1-13"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure Analysis and Site-Directed Mutagenesis of the Glycosyltransferase UGT71B8 Leads to Increased Stability and Substrate Activity in Arabidopsis thaliana. 糖基转移酶UGT71B8的结构分析和定点诱变导致拟南芥稳定性和底物活性的提高。

IF 1.5 4区医学

Critical Reviews in Eukaryotic Gene Expression Pub Date : 2025-01-01 DOI: 10.1615/CritRevEukaryotGeneExpr.2024054550

Humara Naz Majeed, Sumera Shaheen, Sadaf Saleem, Sobia Aleem, Naila Sattar, Muhammad Kashif Zahoor, Aftab Ahmad

{"title":"Structure Analysis and Site-Directed Mutagenesis of the Glycosyltransferase UGT71B8 Leads to Increased Stability and Substrate Activity in Arabidopsis thaliana.","authors":"Humara Naz Majeed, Sumera Shaheen, Sadaf Saleem, Sobia Aleem, Naila Sattar, Muhammad Kashif Zahoor, Aftab Ahmad","doi":"10.1615/CritRevEukaryotGeneExpr.2024054550","DOIUrl":"10.1615/CritRevEukaryotGeneExpr.2024054550","url":null,"abstract":"The uridine diphosphate-glycosyltransferase (UGT) family catalyses the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (substrate), it serves as controlling reaction for bioactivity, storage and decrease toxicity of different compounds in living organisms. UGT71B8 belongs to 71B family of UGTs and its donor sugars are UDP glucose, UDP galactose and UDP 5S glucose, respectively. The current study was designed to induce site-directed mutagenesis (SDM) to investigate the activity in UGT71B8 enzyme. During first step, in silico conformational change through 3D structure model was drawn and it was found that all the amino acids of mutation site were found in allowed region. The relative surface accessibility (RSA) and absolute surface accessibility (ASA) of UGT71B8 were found as 0.042-0.037 and 7.424, respectively, which shows that UGT71B8 T138M remains stable after SDM. This prediction model thus led to the efficacious mutation of UGT71B8 enzyme. Mass spectrometric analysis of UGT71B8T138M showed reduced activity with its substrate UDP glucose and kaempherol as acceptor molecule. Moreover, no new substrate activity of UGT71B8 was found. This data would direct future endeavors to engineer more glycosyltransferases of plants to augment its activity with different substrates and provide a basis for more exploration of UGT71B8 as an active compound for potential anti-cancer therapeutics.","PeriodicalId":56317,"journal":{"name":"Critical Reviews in Eukaryotic Gene Expression","volume":"35 2","pages":"1-12"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DUBR/miR-17-3p/TFRC/HO-1 Axis Promotes the Chemosensitivity of Multiple Myeloma. DUBR/miR-17-3p/TFRC/HO-1轴促进多发性骨髓瘤的化疗敏感性

IF 1.5 4区医学

Critical Reviews in Eukaryotic Gene Expression Pub Date : 2025-01-01 DOI: 10.1615/CritRevEukaryotGeneExpr.2024056835

Tao Guo, Feng Zhang, Hongfang Wang, He Li, Meihua Xia, Xiaoxiao Niu

{"title":"DUBR/miR-17-3p/TFRC/HO-1 Axis Promotes the Chemosensitivity of Multiple Myeloma.","authors":"Tao Guo, Feng Zhang, Hongfang Wang, He Li, Meihua Xia, Xiaoxiao Niu","doi":"10.1615/CritRevEukaryotGeneExpr.2024056835","DOIUrl":"10.1615/CritRevEukaryotGeneExpr.2024056835","url":null,"abstract":"Long non-coding RNAs (lncRNAs) are intensively involved in the pathogenesis of multiple myeloma (MM). The purpose of this study was to investigate the potentials of DUBR in MM. Gene expression was determined using RT-qPCR and western blot. The release of ROS, MDA, ferrous iron, and GSH was detected with corresponding assays. Cell behavior was detected using CCK-8, colony formation, transwell, and PI staining assays. The binding sites between miR-17-3p and DUBR/TFRC was verified firmed by RIP, RNA pull-down, as well as luciferase assays. We found that low levels of DUBR predicted poor prognosis of MM patients. However, overexpressed DUBR enhanced the chemosensitivity of MM cells to bortezomib (BTZ), as well as promoted the ferroptosis of MM cells. DUBR sponged miR-17-3p to upregulate TFRC. However, TFRC knockdown abrogated the effects of overexpressed DUBR and promoted the aggressiveness of MM cells. In summary, DUBR promotes the chemosensitivity of MM cells to BTZ via regulating miR-17-3p/TFRC axis. Therefore, targeting DUBR may be a potential target for MM.","PeriodicalId":56317,"journal":{"name":"Critical Reviews in Eukaryotic Gene Expression","volume":"35 3","pages":"51-62"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NAT10-Mediated N4-Acetylcytidine Modification of GRB7 Promotes the Progression of Gastric Cancer. nat10介导的n4 -乙酰胞苷修饰GRB7促进胃癌的进展。

IF 1.5 4区医学

Critical Reviews in Eukaryotic Gene Expression Pub Date : 2025-01-01 DOI: 10.1615/CritRevEukaryotGeneExpr.2025058741

Min Huang, Zhengrong Zhang, Wenwu Yan, Zhengwu Cheng, Jinguo Wang

{"title":"NAT10-Mediated N4-Acetylcytidine Modification of GRB7 Promotes the Progression of Gastric Cancer.","authors":"Min Huang, Zhengrong Zhang, Wenwu Yan, Zhengwu Cheng, Jinguo Wang","doi":"10.1615/CritRevEukaryotGeneExpr.2025058741","DOIUrl":"https://doi.org/10.1615/CritRevEukaryotGeneExpr.2025058741","url":null,"abstract":"Gastric cancer (GC) is a highly prevalent malignancy with significant morbidity and mortality rates. N4-acetylcytidine (ac4C), an emerging RNA modification, has been implicated in tumorigenesis of GC. NAT10, an enzyme responsible for ac4C modification, has garnered attention for its potential role in cancer progression. This study investigates the role of NAT10 in GC. We analyzed NAT10 expression in GC tissues and cell lines using Rt-qPCR, immunohistochemistry and Western blotting. Functional studies were conducted using shRNA and overexpression models in vitro and in vivo. The molecular mechanisms underlying NAT10-mediated GRB7 regulation were elucidated through ac4C modification assays. Our findings revealed that NAT10 is overexpressed in GC tissues and cells and predicted poor prognosis of GC patients. Inhibition of NAT10 suppressed the proliferation, migration, and invasion of GC cells. Mechanistically, NAT10-mediated ac4C modification enhanced expression of GRB7 by promoting its mRNA stability. Overexpression of GRB7 antagonized the effects of NAT10 shRNA and promoted the malignant behaviors of GC. In vivo studies showed that NAT10 knockdown reduced tumor growth. Collectively, our study highlights the crucial roles of NAT10 and ac4C modification in GC progression through the regulation of GRB7. Therefore, targeting NAT10/GRB7 axis may be a novel strategy for GC.","PeriodicalId":56317,"journal":{"name":"Critical Reviews in Eukaryotic Gene Expression","volume":"35 5","pages":"59-68"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell Division, Life, and Cancer: Novel Fundamental Insights. 细胞分裂、生命和癌症：新的基本见解。

IF 1.5 4区医学

Critical Reviews in Eukaryotic Gene Expression Pub Date : 2025-01-01 DOI: 10.1615/CritRevEukaryotGeneExpr.2025059382

Michael May

{"title":"Cell Division, Life, and Cancer: Novel Fundamental Insights.","authors":"Michael May","doi":"10.1615/CritRevEukaryotGeneExpr.2025059382","DOIUrl":"https://doi.org/10.1615/CritRevEukaryotGeneExpr.2025059382","url":null,"abstract":"Cell division, the fundamental mechanism of reproduction, is the basis of life. In highly evolved organisms, particularly in humans exposed to abnormal chronical endogen and exogen stress-factors, uncontrolled cell division can occur. Consideration of the space-wise uncontrolled cell division and an increased level of human chorionic gonadotropin (hCG) as the decisive initial abnormalities of cancer has induced this study. A correlation between these two abnormalities could not be excluded. Cell division, namely cell division of eukaryotic cells, is subject of numerous publications. Interestingly, the decisive agonist that activates and governs this most important and most complex biological process is unknown. So, it is also unknown whether hCG in its organism specific form is only one among a multitude of known promotors, or if it is possibly even the decisive agonist of controlled and uncontrolled cell division. A higher-than-normal hCG level might overrule healthy cells' growth control. Identification of the decisive agonist of controlled and uncontrolled cell division appeared of fundamental importance and became the main object of this paper. To evaluate the potential of hCG as the decisive agonist of cell division, hCG's first and most important accomplishments for the genesis of a human life were analyzed. Combinations and deductions of interconnected facts expose a higher-than-normal hCG level via the nuclear super receptor family as the decisive agonist of the first cell division of the first human cell, the zygote, and by consanguinity for the cell divisions of its daughter cells, including cancer cells.","PeriodicalId":56317,"journal":{"name":"Critical Reviews in Eukaryotic Gene Expression","volume":"35 5","pages":"33-38"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomal circ_001860 promotes colorectal cancer progression through miR-582-5p/ZEB1 axis 外泌体circ_001860通过miR-582-5p/ZEB1轴促进结直肠癌进展

IF 1.6 4区医学

Critical Reviews in Eukaryotic Gene Expression Pub Date : 2024-09-01 DOI: 10.1615/critreveukaryotgeneexpr.2024054404

Weizhen Huang, Jun Li, Siwei Zhou, Yi Li, Xia Yuan

{"title":"Exosomal circ_001860 promotes colorectal cancer progression through miR-582-5p/ZEB1 axis","authors":"Weizhen Huang, Jun Li, Siwei Zhou, Yi Li, Xia Yuan","doi":"10.1615/critreveukaryotgeneexpr.2024054404","DOIUrl":"https://doi.org/10.1615/critreveukaryotgeneexpr.2024054404","url":null,"abstract":"Extensive research has recently been conducted to investigate the regulating impact of exosomal circular RNAs (circRNAs) in throughout the development of multiple malignancies. Nevertheless, there is still much to learn about the biological roles and underlying mechanisms of exosomal circRNAs in colorectal cancer (CRC). Exosomes (exo) were isolated from blood samples and CRC cells by differential centrifugation. In addition, the competitive endogenous RNA (ceRNA) mechanism of circ_001860 in CRC was determined through Starbase and dual-luciferase reporter gene experiments. Gain and loss of function experiments verified the regulatory effect of circ_001860/miR-582-5p/ZEB1 on the malignant phenotype of CRC cells. The therapeutic effect of circ_001860 on CRC xenograft tumor model was explored through mouse experiment. Circ_001860 was significantly enriched in exo isolated from CRC blood samples and CRC cells. Circ_001860 can be transported into CRC cells via exo. Through competitive binding to miR-582-5p, circ_001860 increased ZEB1, thereby facilitating tumor formation in vivo as well as stimulating CRC cell proliferation and metastasis in vitro. Through the miR-582-5p/ZEB1 axis, exosomal circ_001860 enhanced the advancement of CRC. This finding may offer non-invasive biomarkers for clinical screening and diagnosis of CRC patients.","PeriodicalId":56317,"journal":{"name":"Critical Reviews in Eukaryotic Gene Expression","volume":"2 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142190734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glycosaminoglycans (GAGs) adenogenesis factors: immunohistochemical espression in endometriosis tissues compared to the endometrium 糖胺聚糖（GAGs）腺生成因子：与子宫内膜相比，在子宫内膜异位症组织中的免疫组化表达

IF 1.6 4区医学

Critical Reviews in Eukaryotic Gene Expression Pub Date : 2024-09-01 DOI: 10.1615/critreveukaryotgeneexpr.2024054273

Pietro G Signorile, Alfonso Baldi, Rosa Viceconte, Emma Carraturo, Maria Rosaria Boccellino, Mario Fordellone, Marco Montella

{"title":"Glycosaminoglycans (GAGs) adenogenesis factors: immunohistochemical espression in endometriosis tissues compared to the endometrium","authors":"Pietro G Signorile, Alfonso Baldi, Rosa Viceconte, Emma Carraturo, Maria Rosaria Boccellino, Mario Fordellone, Marco Montella","doi":"10.1615/critreveukaryotgeneexpr.2024054273","DOIUrl":"https://doi.org/10.1615/critreveukaryotgeneexpr.2024054273","url":null,"abstract":"Endometriosis is a chronic inflammatory pathology estrogen-dependent. It is a condition affecting 5%–10% of women of reproductive age worldwide. Recent evidence indicating an embryological origin of endometriosis has provided new insights into its pathogenesis and potential therapeutic approaches. In this study, we compared the immunohistochemical expression of extracellular matrix molecules involved in the interaction between epithelium and stroma in endometriotic lesions and normal endometrial tissue.\u0000A total of 41 cases were analyzed. We examined the immunohistochemical expression of Chondroitin sulfate proteoglycan 4 (CSPG4), Keratan sulfate, Chondroitin sulfate (CS-56), Hyaluronic acid, and Heparan sulfate (HEP).\u0000Our results showed higher expression of CSPG4 and CS-56 in epithelial endometriosis samples compared to normal endometrial tissue, while HEP, Keratan sulfate, and Hyaluronic acid showed decreased expression in epithelial endometriosis samples relative to normal endometrial tissue. Additionally, endometriotic stroma exhibited more frequent low intensity of Hyaluronic acid and HEP compared to normal endometrial stroma.\u0000Investigating the levels of these molecules in eutopic and ectopic endometrial tissues enables the identification of potential therapeutic targets and the development of novel treatments aimed at disrupting the adhesive and invasive properties of endometriotic lesions.","PeriodicalId":56317,"journal":{"name":"Critical Reviews in Eukaryotic Gene Expression","volume":"10 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142224865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curcumin-carbon dots suppress periodontitis via regulating METTL3/IRE1α signaling 姜黄素碳点通过调节 METTL3/IRE1α 信号抑制牙周炎

IF 1.6 4区医学

Critical Reviews in Eukaryotic Gene Expression Pub Date : 2024-08-01 DOI: 10.1615/critreveukaryotgeneexpr.2024054463

Ling Li, Yueyan Wang, Lang Gao, Shunying Wu, Ying Jin

引用次数: 0