Role of the Transcription Factor FoxO in Type 2 Diabetes and Its Complications.

IF 1.5 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Critical Reviews in Eukaryotic Gene Expression Pub Date : 2025-01-01 DOI:10.1615/CritRevEukaryotGeneExpr.2025057309

Jing Hui Shi, Yi Biao Shi, Si Tian Qiu, Ying Song

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Abstract

FoxO proteins represent a subfamily of the forkhead box family (Fox) superfamily of proteins. It is involved in cell proliferation, differentiation, oxidative stress, apoptosis as well as tumors and metabolic disorders by regulating cellular functions. This paper aims to summarize the role of the transcription factor FoxO in type 2 diabetes and its complications, which may add to the potential of FoxO as a therapeutic target for future research. The transcription factor FoxO is expressed in various tissues and participates in various bodily functions including cell proliferation, differentiation, apoptosis, tumor therapy, and metabolic processes, playing a crucial role in the human body. FoxO plays a positive role in attenuating oxidative stress, inflammation, and metabolic disorders, which are the main causes of type 2 diabetes and its complications. FoxO plays an important role in the regulation of type 2 diabetes and its complications, and more precise targeting studies of FoxO will help to prevent, regulate, and treat diabetes-related diseases.

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转录因子FoxO在2型糖尿病及其并发症中的作用

FoxO蛋白是叉头盒蛋白家族（Fox）超家族的一个亚家族。它通过调节细胞功能参与细胞增殖、分化、氧化应激、凋亡以及肿瘤和代谢紊乱。本文旨在总结转录因子FoxO在2型糖尿病及其并发症中的作用，为今后FoxO作为治疗靶点的研究提供可能。转录因子FoxO在多种组织中表达，参与细胞增殖、分化、凋亡、肿瘤治疗、代谢过程等多种机体功能，在人体中起着至关重要的作用。FoxO在减轻氧化应激、炎症和代谢紊乱方面发挥积极作用，这些是2型糖尿病及其并发症的主要原因。FoxO在2型糖尿病及其并发症的调控中发挥着重要作用，对FoxO进行更精确的靶向研究将有助于预防、调节和治疗糖尿病相关疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Eukaryotic Gene Expression 生物-生物工程与应用微生物

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource. Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered.