Korean Journal of Pain最新文献_第2页

Efficacy of intravenous acetaminophen as adjunct analgesia in patients undergoing cardiovascular surgery: a systematic review and meta-analysis. 静脉对乙酰氨基酚作为心血管手术患者辅助镇痛的疗效：一项系统综述和荟萃分析。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-07-01 Epub Date: 2025-06-25 DOI: 10.3344/kjp.25063

Soowon Lee, Chang-Hoon Koo, Yu Kyung Bae, Jung-Hee Ryu

{"title":"Efficacy of intravenous acetaminophen as adjunct analgesia in patients undergoing cardiovascular surgery: a systematic review and meta-analysis.","authors":"Soowon Lee, Chang-Hoon Koo, Yu Kyung Bae, Jung-Hee Ryu","doi":"10.3344/kjp.25063","DOIUrl":"10.3344/kjp.25063","url":null,"abstract":"Background: Although intravenous (IV) acetaminophen (AAP) may help reduce severe postoperative pain and opioid use after cardiovascular surgery, its effectiveness must be further validated. Therefore, the authors aimed to evaluate the analgesic efficacy of perioperative IV AAP in patients undergoing cardiovascular surgery by conducting this meta-analysis.Methods: A comprehensive literature search was conducted of PubMed, Embase, CENTRAL, CINAHL, Scopus, and Web of Science databases for studies published up to March 21, 2024. Six randomized controlled trials comparing IV AAP with a placebo in cardiovascular surgery were included. The mean difference (MD) was calculated to estimate pooled effect sizes. The primary outcome was opioid consumption, measured in morphine equivalent dose, and the secondary outcome was postoperative pain score.Results: Postoperative opioid consumption was significantly reduced with IV AAP than it was with a placebo (MD: -21.68, 95% confidence interval [CI]: -38.41 to -4.95, P = 0.011). Significant reductions in postoperative pain scores were observed at 6 hours (MD: -0.76, 95% CI: -1.43 to -0.10, P = 0.025) and 24 hours (MD: -0.63, 95% CI: -1.02 to -0.25, P = 0.001) after surgery. However, these reductions did not meet clinically meaningful thresholds. No significant differences were observed at 12, 18, and 48 hours postoperatively.Conclusions: IV AAP was more effective than a placebo for postoperative adjunct analgesia in patients who underwent cardiovascular surgery.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"320-331"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two-year prognosis of primary stabbing headache and its associated factors: a clinic-based study. 原发性刺痛性头痛的两年预后及其相关因素：一项临床研究。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-07-01 DOI: 10.3344/kjp.25081

Soohyun Cho, Byung-Kun Kim

{"title":"Two-year prognosis of primary stabbing headache and its associated factors: a clinic-based study.","authors":"Soohyun Cho, Byung-Kun Kim","doi":"10.3344/kjp.25081","DOIUrl":"10.3344/kjp.25081","url":null,"abstract":"Background: Primary stabbing headache (PSH) is commonly seen in headache clinics, yet its long-term course remains inadequately explored. This study aimed to determine the 2-year recurrence rate of PSH and to identify associated risk factors.Methods: Out of 1,756 patients who visited a specialized headache clinic due to headache complaints, 106 patients diagnosed with PSH were enrolled consecutively. Demographic and clinical information was collected, along with the time to achieve complete remission post-treatment. To evaluate the 2-year prognosis, all participants were contacted through telephone interviews. A total of 106 patients were interviewed by telephone at least 2 years after the onset of PSH. The authors examined the frequency and features of PSH recurrence and assessed clinical variables potentially linked to its recurrence.Results: A recurrence of PSH occurred in 36.3% of the patients. Patients with recurrent PSH had more prior history of stabbing headache (55.2% vs. 29.4%, P = 0.023), comorbid migraine (17.2% vs. 3.9%, P = 0.043) and severe intensity of stabbing headache (41.4% vs. 17.7%, P = 0.020) than those with non-recurrent PSH. Multivariable Cox regression analysis revealed that an independent effect of comorbid migraine on the recurrence of PSH (adjusted hazard ratio, 2.791; 95% confidence interval, 1.012-7.701; P = 0.047).Conclusions: Over one-third of individuals diagnosed with PSH experienced a recurrence within 2 years of the initial episode. Comorbid migraine was related to a recurrence of PSH, suggesting the potential role of shared pathophysiological mechanisms between migraine and PSH in influencing the prognosis of PSH.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"38 3","pages":"332-340"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rethinking nociplastic pain: implications for the Philippines and beyond. 重新思考致癌性疼痛：对菲律宾及其他地区的影响。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-07-01 Epub Date: 2025-06-25 DOI: 10.3344/kjp.25132

Jose Eric Mella Lacsa

引用次数: 0

Pain assessment using the Analgesia Nociception Index in patients undergoing sedation: a systematic review and meta-analysis. 使用镇痛伤害感觉指数评估镇静患者的疼痛：一项系统回顾和荟萃分析。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-07-01 Epub Date: 2025-06-26 DOI: 10.3344/kjp.25105

Min Kyoung Kim, Oh Haeng Lee, Geun Joo Choi, Hyun Kang

{"title":"Pain assessment using the Analgesia Nociception Index in patients undergoing sedation: a systematic review and meta-analysis.","authors":"Min Kyoung Kim, Oh Haeng Lee, Geun Joo Choi, Hyun Kang","doi":"10.3344/kjp.25105","DOIUrl":"10.3344/kjp.25105","url":null,"abstract":"Background: This systematic review and meta-analysis analyzed the utility of the Analgesia Nociception Index (ANI) in detecting intraoperative and procedural pain in sedated patients.Methods: A comprehensive search of the Cochrane Central Register of Controlled Trials, Ovid-MEDLINE, Ovid-Embase, and Google Scholar databases was performed to identify relevant studies. The primary outcome was the diagnostic accuracy of ANI, assessed by pooled sensitivity, specificity, likelihood ratios, and diagnostic odds ratio (DOR). Secondary outcomes were the correlation between ANI and pain assessment scales, the effect of norepinephrine (NE) on ANI, and differences in opioid consumption between the ANI-guided and control groups.Results: Eleven studies were included in the systematic review, with ten studies incorporated into the meta-analysis. ANI demonstrated moderate sensitivity (0.746, 95% confidence interval [CI] = 0.683-0.803) and specificity (0.776, 95% CI = 0.741-0.808) for detecting intraoperative and procedural pain, with a pooled DOR of 10.491. ANI was lower in the pain state than that in the no-pain state (standardized mean difference [SMD] = -1.140, 95% CI = -1.239 to -1.041, I2 = 93.63%). ANI-guided analgesia was associated with a significant reduction in opioid consumption (SMD = -0.410, 95% CI = -0.643 to -0.178, I2 = 0.0%). There were no significant differences in ANI between the NE and control groups. ANI showed a negative correlation with pain scales (r = -0.110 to -0.470).Conclusions: ANI effectively differentiated between the pain and non-pain states in sedated patients with moderate diagnostic accuracy and helped reduce opioid consumption. However, the high heterogeneity suggests the need for cautious interpretation.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"341-354"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Balancing benefit and risk: clinical considerations in the use of acetaminophen, non-steroidal anti-inflammatory drugs, and dexamethasone for perioperative multimodal analgesia. 权衡利弊：对乙酰氨基酚、非甾体抗炎药和地塞米松围手术期多模式镇痛的临床考虑

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-06-18 DOI: 10.3344/kjp.25068

Boohwi Hong, Woosuk Chung, Chahyun Oh

{"title":"Balancing benefit and risk: clinical considerations in the use of acetaminophen, non-steroidal anti-inflammatory drugs, and dexamethasone for perioperative multimodal analgesia.","authors":"Boohwi Hong, Woosuk Chung, Chahyun Oh","doi":"10.3344/kjp.25068","DOIUrl":"https://doi.org/10.3344/kjp.25068","url":null,"abstract":"Multimodal analgesia, incorporating agents with diverse mechanisms of action, is a cornerstone of perioperative pain management, aiming to optimize analgesia while minimizing opioid-related adverse effects. Despite well-established guidelines, its adoption remains inconsistent due to entrenched practices and concerns about potential risks. This review focuses on the rationale and clinical considerations for foundational multimodal agents-acetaminophen, non-steroidal anti-inflammatory drugs, and dexamethasone-highlighting their benefits, contraindications, and controversies. Evidence regarding key concerns, including hepatotoxicity, nephrotoxicity, anastomotic leakage, bleeding, infection, and hyperglycemia, is comprehensively reviewed. While these concerns are not entirely unfounded, clear supporting data is often limited, highlighting the importance of a critical and thorough evaluation of the available evidence. Indiscriminate advocacy for or reluctance to adopt multimodal analgesia is equally undesirable; instead, a balanced, evidence-based approach is necessary. By refining the understanding of these agents, practitioners can support the broader implementation of multimodal analgesia in perioperative care, ultimately improving patient recovery and optimizing postoperative outcomes.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone marrow mesenchymal stem cells improve bone cancer pain by inhibiting p38MAPK phosphorylation and microglia activation. 骨髓间充质干细胞通过抑制p38MAPK磷酸化和小胶质细胞激活改善骨癌疼痛。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 Epub Date: 2025-03-11 DOI: 10.3344/kjp.24374

Houming Kan, Jinzhao Huang, Xiaodie Gui, Wendi Tian, Lijun Fan, Xuetai Chen, Xiaotong Ding, Liping Chen, Wen Shen

{"title":"Bone marrow mesenchymal stem cells improve bone cancer pain by inhibiting p38MAPK phosphorylation and microglia activation.","authors":"Houming Kan, Jinzhao Huang, Xiaodie Gui, Wendi Tian, Lijun Fan, Xuetai Chen, Xiaotong Ding, Liping Chen, Wen Shen","doi":"10.3344/kjp.24374","DOIUrl":"10.3344/kjp.24374","url":null,"abstract":"Background: Bone cancer pain (BCP) is not adequately addressed by current treatment methods, making the exploration of effective management strategies a topic of significant interest. Bone marrow mesenchymal stem cells (BMSCs) seem to be a potential way for managing BCP, yet little is known about the mechanisms underlying the efficacy of this potential treatment.Methods: We established the male C57BL/6 mice BCP models. Behavioral tests, X-ray, bone histology, western blotting, and immunofluorescence were used to verify the analgesic effect of BMSCs.Results: Intramedullary injection of Lewis lung carcinoma cells into the femur successfully generated the mice BCP models. The number of c-Fos-positive neurons and phosphorylated mitogen-activated protein kinase (MAPK) proteins in the spinal dorsal horn of the BCP mice increased. Intrathecal injection of BMSCs temporarily improved the BCP mice's mechanical and thermal hyperalgesia without affecting motor function. This effect may be related to inhibiting spinal microglia and p-p38 MAPK activation. The analgesic effect of BMSCs may be related to the homing effect mediated by CXCR4.Conclusions: Intrathecal injection of BMSCs can temporarily inhibit mechanical and thermal hyperalgesia in BCP mice without affecting motor function. This effect may be related to the inhibition of p-p38 protein expression and the inhibition of microglia but not to p-ERK and p-JNK.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"116-127"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal association of obesity and chronic pain mediated by educational attainment and smoking: a mediation Mendelian randomization study. 受教育程度和吸烟介导的肥胖和慢性疼痛的因果关系：一项孟德尔随机研究。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 Epub Date: 2025-03-06 DOI: 10.3344/kjp.24331

Yunshu Lyu, Qingxing Lu, Yane Liu, Mengtong Xie, Lintong Jiang, Junnan Li, Ning Wang, Xianglong Dai, Yuqi Yang, Peiming Jiang, Qiong Yu

{"title":"Causal association of obesity and chronic pain mediated by educational attainment and smoking: a mediation Mendelian randomization study.","authors":"Yunshu Lyu, Qingxing Lu, Yane Liu, Mengtong Xie, Lintong Jiang, Junnan Li, Ning Wang, Xianglong Dai, Yuqi Yang, Peiming Jiang, Qiong Yu","doi":"10.3344/kjp.24331","DOIUrl":"10.3344/kjp.24331","url":null,"abstract":"Background: Obesity and chronic pain are related in both directions, according to earlier observational research. This research aimed to analyze the causal association between obesity and chronic pain at the genetic level, as well as to assess whether common factors mediate this relationship.Methods: This study used bidirectional two sample Mendelian randomization (MR) technique to analyze the association between obesity and chronic pain. Obesity's summary genome-wide association data were obtained from European ancestry groups, as measured by body mass index (BMI), waist-to-hip ratio, waist circumference (WC), and hip circumference (HC), genome-wide association study data for chronic pain also came from the UK population, including chronic pain at three different sites (back, hip, and headache), chronic widespread pain (CWP), and multisite chronic pain (MCP). Secondly, a two-step MR and multivariate MR investigation was performed to evaluate the mediating effects of several proposed confounders.Results: The authors discovered a link between chronic pain and obesity. More specifically, a sensitivity analysis was done to confirm the associations between greater BMI, WC, and HC with an increased risk of CWP and MCP. Importantly, the intermediate MR results suggest that education levels and smoking initiation may mediate the causal relationship between BMI on CWP, with a mediation effect of 23.08% and 15.38%, respectively.Conclusions: The authors' findings demonstrate that the importance of education and smoking in understanding chronic pain's pathogenesis, which is important for the primary prevention and prognosis of chronic pain.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"177-186"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nociplastic pain: exploring the concept and ongoing discussions. 伤害性疼痛：探索概念和正在进行的讨论。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 DOI: 10.3344/kjp.25007

John Quintner, Asaf Weisman, Milton Cohen

引用次数: 0

Chrysin ameliorates pain through regulation of the serum metabolomics in the rats. 黄菊花素通过调节大鼠血清代谢组学改善疼痛。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 Epub Date: 2025-03-20 DOI: 10.3344/kjp.24355

Khadijeh Haghighat, Fariba Mahmoudi, Maryam Khoshkam, Homayoun Khazali

{"title":"Chrysin ameliorates pain through regulation of the serum metabolomics in the rats.","authors":"Khadijeh Haghighat, Fariba Mahmoudi, Maryam Khoshkam, Homayoun Khazali","doi":"10.3344/kjp.24355","DOIUrl":"10.3344/kjp.24355","url":null,"abstract":"Background: Chrysin is a natural flavonoid that exhibits various pharmacological activities including pain relief. However, the effects of chrysin on changes of metabolic profiles during pain remain unclear. The aim of this study was to analyze the biomarkers related to pain in serum and to evaluate the analgesic properties of chrysin in a rat model of pain.Methods: Male Wister rats were divided into four groups (n = 5). Pain was induced by injecting 50 μL of formalin into the hind paw. Chrysin and diclofenac (10 mg/kg, intraperitoneal injection) was administered to the intact and pain groups. All injections were given 30 minutes before pain induction. Immediately, the behavioral test was performed. Then the serum sample was separated for 1HNMR-based metabolite analysis.Results: Chrysin treatment alleviated the paw licking events, flinching response, and pain score. The integrated analyses further revealed three major metabolic changes including glycine-serine-threonine, taurine-hypotaurine, and arginine by comparing the serums from intact operated rats, pain rats, and pain rats treated with chrysin, and suggested that chrysin may improve pain by regulating the biosynthesis of these metabolic pathways.Conclusions: These findings provide insights into metabolic pathways involved in pain and the analgesic effects of chrysin and may help to identify potential targets for the anti-pain properties of chrysin.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"128-137"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nociplastic pain: conceptual and terminological considerations. 伤害性疼痛：概念和术语的考虑。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 DOI: 10.3344/kjp.25104

Kyung Hoon Kim

引用次数: 0