Korean Journal of Pain最新文献_第2页

The analgesic and anti-inflammatory effects of a combined preparation based on the blunt-nosed viper's venom and oregano essential oil. 基于钝鼻毒蛇毒液和牛至精油的联合制剂的镇痛和抗炎作用。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 Epub Date: 2025-03-26 DOI: 10.3344/kjp.24301

Lilya Mushegh Parsghyan, Armenuhi Vachagan Moghrovyan, Sona Samvel Poghosyan, Milena Ashot Babajanyan, Monica Armen Gaboyan, Armen Vaghinak Voskanyan, Anna Ashot Darbinyan

{"title":"The analgesic and anti-inflammatory effects of a combined preparation based on the blunt-nosed viper's venom and oregano essential oil.","authors":"Lilya Mushegh Parsghyan, Armenuhi Vachagan Moghrovyan, Sona Samvel Poghosyan, Milena Ashot Babajanyan, Monica Armen Gaboyan, Armen Vaghinak Voskanyan, Anna Ashot Darbinyan","doi":"10.3344/kjp.24301","DOIUrl":"10.3344/kjp.24301","url":null,"abstract":"Background: To relieve acute and inflammatory pain, preparations of plant and animal origin have been used. The present work aimed to study the analgesic and anti-inflammatory effectiveness of a combined preparation based on viper venom and essential oil. Determining effective routes of exposure, optimal doses, the duration of action of the preparation, and possible mechanisms of their action were the areas of interest.Methods: Experiments were carried out on murine. Essential oil content was determined by gas chromatography-mass spectrometry equipment. The formalin, carrageenan, and hot plate tests were used. Certain methods for determining side effects were used as well. To determine the participation of cannabinoid and opioid receptors in the antinociceptive action of combined preparation, SR144528 and naloxone were used.Results: The treatment of the ointment version of the preparation reduced inflammatory pain by more than 68% and decreased the volume of inflammatory edema by up to 36%. The involvement of cannabinoid receptors in the analgesic mechanism of the ointment was approximately 73%, and, for the opioid receptors, about 64%. Physiologically significant side effects were not observed.Conclusions: The active components of the ointment are principally different in their mechanism of action and make it possible to relieve pain and inflammation both through the blockade of pain receptors of afferent nociceptive neurons (venom) as well as via cannabinoid and opioid receptors (essential oil).","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"163-176"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of ultrasound-guided superior trunk block versus clavipectoral fascial plane block for clavicular surgery: a double-blind, randomized controlled trial. 超声引导下上干阻滞与锁骨筋膜平面阻滞在锁骨手术中的比较：一项双盲、随机对照试验。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 Epub Date: 2025-03-20 DOI: 10.3344/kjp.24343

Mohamed Gaber Mohamed, Ahmed Mohammad Fahmy, Marwa Mohamed Medhat

{"title":"Comparison of ultrasound-guided superior trunk block versus clavipectoral fascial plane block for clavicular surgery: a double-blind, randomized controlled trial.","authors":"Mohamed Gaber Mohamed, Ahmed Mohammad Fahmy, Marwa Mohamed Medhat","doi":"10.3344/kjp.24343","DOIUrl":"10.3344/kjp.24343","url":null,"abstract":"Background: This study compared the quality and duration of analgesia between the superior trunk (ST) and the clavipectoral fascial plane (CFP) blocks in conjunction with a selective supraclavicular nerve (SCN) block for clavicular surgeries.Methods: Fifty patients undergoing mid-third clavicular procedures were randomly assigned to the ST group (received an SCN block followed by blockage of the ST of the brachial plexus) and the CFP group (received an SCN block followed by the CFP block). The primary outcome was the time until the first rescue analgesia. Secondary outcomes included total nalbuphine dosage and numerical rating scale (NRS) scores within the first 24 hours, the onset of sensory block, as well as deltoid and biceps muscle function using the modified Bromage score (MBS), diaphragmatic excursion, along with satisfaction levels.Results: The ST group exhibited a more prolonged duration until the first request for rescue analgesia compared to the CFP group (18.76 ± 0.89 hours vs. 15.34 ± 1.38 hours), with a mean difference of 3.42 hours (95% confidence interval: 2.76 to 4.08, P < 0.001). The ST group consumed less nalbuphine and reported lower NRS scores at 6, 8, 12, 16, and 24 hours than the CFP group. Additionally, the ST group exhibited a lower MBS and diaphragmatic excursion than the CFP group. However, the differences in the onset of sensory block and satisfaction levels were not statistically significant.Conclusions: The ST group demonstrated superior outcomes in pain control with less favorable outcomes concerning diaphragmatic excursion and upper limb motor function.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"198-206"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Octanoic acid-rich diet alleviates breast cancer-induced bone pain via the acyl-ghrelin/NPY pathway. 富含辛酸的饮食通过酰基胃饥饿素/NPY途径缓解乳腺癌引起的骨痛。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 Epub Date: 2025-03-20 DOI: 10.3344/kjp.24388

Longjie Xu, Lili Hou, Chun Cao, Xiaohua Li

{"title":"Octanoic acid-rich diet alleviates breast cancer-induced bone pain via the acyl-ghrelin/NPY pathway.","authors":"Longjie Xu, Lili Hou, Chun Cao, Xiaohua Li","doi":"10.3344/kjp.24388","DOIUrl":"10.3344/kjp.24388","url":null,"abstract":"Background: Breast cancer is a common malignant tumor that has a high tendency to metastasis to the bone, leading to cancer-induced bone pain (CIBP). Ghrelin can not only stimulate appetite and regulate energy balance, but also alleviate CIBP by inducing NPY expression. Octanoic acid (OA), a type of medium chain fatty acids, provides an energy substrate and promotes acylation of ghrelin. However, it remains to be elucidated whether an OA-rich diet can alleviate CIBP by activating the acyl-ghrelin/NPY pathway.Methods: First, thirty-six Sprague-Dawley rats were randomly divided into the sham, CIBP, CIBP + OA (20), CIBP + OA (40), CIBP + OA (60) and CIBP + OA (80) groups to investigate the effects of diets with different ratios of OA on CIBP and the acyl-ghrelin/NPY pathway. Next, a ghrelin O-acyltransferase (GOAT) inhibitor was exogenously administered to investigate whether an OA-rich diet alleviated CIBP through increasing the level of acyl-ghrelin and activating the acyl-ghrelin/NPY pathway.Results: An OA-rich diet significantly alleviated nociceptive behaviors and increased the levels of acyl-ghrelin and NPY in a dose-dependent manner in cancer-bearing rats. With the exogenous administration of the GOAT inhibitor, the beneficial effects of an OA-rich diet on the acyl-ghrelin/NPY pathway and its pain-relieving effects were attenuated.Conclusions: An OA-rich diet could alleviate CIBP through increasing the level of acyl-ghrelin and activating the acylghrelin/ NPY pathway.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"138-151"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author's response. 作者的回应。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 DOI: 10.3344/kjp.25057

Valdas Macionis

引用次数: 0

Effectiveness of intramuscular electrical stimulation using conventional and inverse electrode placement methods on pressure pain threshold and electromyographic activity of the upper trapezius muscle with myofascial trigger points: a randomized clinical trial. 采用常规和反向电极放置方法的肌内电刺激对带肌筋膜触发点的斜方肌上部压力痛阈值和肌电图活动的有效性：一项随机临床试验。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 Epub Date: 2025-03-20 DOI: 10.3344/kjp.24332

Sukumar Shanmugam, Fabio Vieira Dos Anjos, Arthur de Sá Ferreira, Ramprasad Muthukrishnan, Praveen Kumar Kandakurti, Satheeskumar Durairaj

{"title":"Effectiveness of intramuscular electrical stimulation using conventional and inverse electrode placement methods on pressure pain threshold and electromyographic activity of the upper trapezius muscle with myofascial trigger points: a randomized clinical trial.","authors":"Sukumar Shanmugam, Fabio Vieira Dos Anjos, Arthur de Sá Ferreira, Ramprasad Muthukrishnan, Praveen Kumar Kandakurti, Satheeskumar Durairaj","doi":"10.3344/kjp.24332","DOIUrl":"10.3344/kjp.24332","url":null,"abstract":"Background: This study investigates whether intramuscular electrical stimulation (IMES) with inverse electrode placement (IEP) or conventional electrode placement (CEP) more effectively modulates pain. The current study's aim was to compare the effects of IMES using IEP and CEP, and sham-IMES on the pressure pain threshold (PPT), EMG activity, upper trapezius (UT) muscle length and pain severity among adults with UT myofascial trigger points (MTrPs).Methods: Thirty-six male adults with UT-MTrPs were allocated into three groups. IEP, CEP and sham groups were respectively treated with a single IMES session using IEP, CEP, and sham-IMES. Pain intensity, PPT, EMG activity (root mean square, RMS) and UT muscle length were measured on day one before the treatment, day one post treatment and at a day three follow-up to determine the immediate and short-term effectiveness of IMES.Results: IMES using both IEP and CEP methods produced significant higher changes in UT-PPT (median, interquartile-interval, IEP group: 3.25, 2.56-3.50 and CEP group: 2.75, 1.75-3.00, vs. sham group: 1.07, 0.89-1.71 kg/cm2), RMS (IEP: 0.31, 0.26-0.35 and CEP: 0.36, 0.23-0.38, vs. sham: 0.21, 0.16-0.25 mV), and UT muscle length (IEP: 9.50, 8-12.75 and CEP: 8, 7-10, vs. 1.5. 1-2.75 degrees) and UT-pain severity (IEP: 3.00, 2.25-4 and CEP: 3, 3-3, vs. sham: 2, 2-2.75 points on VAS) compared to the score change in sham-IMES at day three follow up.Conclusions: Pain modulation can be effectively achieved using IMES regardless of electrode placement method, with different electrode configurations.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"187-197"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CT-guided extracranial radiofrequency of multiple groups of cranial nerves for the treatment of compound Meige's syndrome. ct引导下多组颅神经颅外射频治疗复合梅格综合征。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 DOI: 10.3344/kjp.24415

Huiling Peng, Chunxiao Wang, Binyue Xin, Bing Huang

引用次数: 0

Potential of histone deacetylase 6 inhibitors in alleviating chemotherapy-induced peripheral neuropathy. 组蛋白去乙酰化酶6抑制剂缓解化疗诱导的周围神经病变的潜力。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 DOI: 10.3344/kjp.24358

Su Jung Park, Soung-Min Lee, Seong Mook Kang, Hyun-Mo Yang, Su-Kil Seo, Ju-Hee Lee

{"title":"Potential of histone deacetylase 6 inhibitors in alleviating chemotherapy-induced peripheral neuropathy.","authors":"Su Jung Park, Soung-Min Lee, Seong Mook Kang, Hyun-Mo Yang, Su-Kil Seo, Ju-Hee Lee","doi":"10.3344/kjp.24358","DOIUrl":"10.3344/kjp.24358","url":null,"abstract":"Background: Histone deacetylase 6 (HDAC6), belonging to class IIb of histone deacetylases, regulates the acetylation of the cytoplasmic protein α-tubulin. The overexpression of HDAC6 is linked to the development of tumors, and inhibiting HDAC6 is known to trigger apoptosis in multiple myeloma cells. In addition to its application in cancer treatment, bortezomib, a proteasome inhibitor, is widely used in managing multiple myeloma and has shown effectiveness in patients with both newly diagnosed and relapsed disease. However, the treatment regimen may be delayed or discontinued due to the risk of peripheral neuropathy, a significant non-hematologic side effect.Methods: Animal models of peripheral neuropathy induced by various anti-cancer drugs were established, confirming the potential of HDAC6 inhibitors as a treatment for this condition. Six- to eight-week-old male Sprague Dawley rats were utilized to create these models. Mechanical allodynia and electron microscopy served as indicators of peripheral neuropathy. The HDAC6 inhibitor CKD-011 was administered at doses of 5, 10, 20, and 40 mg/kg.Results: In an animal model of bortezomib-induced peripheral neuropathy, CKD-011, an HDAC6 inhibitor, effectively ameliorated peripheral neuropathy. Similarly, CKD-011 administration demonstrated recovery from peripheral neuropathy in models induced with oxaliplatin, paclitaxel, and cisplatin.Conclusions: These findings suggest that HDAC6 inhibitors have the potential to mitigate peripheral neuropathy induced by chemotherapeutic agents.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"38 2","pages":"152-162"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genicular nerve radiofrequency ablation: proposal of a technical protocol for managing procedural pain. 膝神经射频消融术：处理程序性疼痛的技术方案建议。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-01-01 DOI: 10.3344/kjp.24312

Andrés Rocha-Romero, Tony Kwun Tung Ng, Guilherme Ferreira-Dos-Santos

引用次数: 0

Retraction: Comparison of the efficacy of genicular nerve phenol neurolysis and radiofrequency ablation for pain management in patients with knee osteoarthritis. 撤回：膝关节骨性关节炎患者膝神经苯酚神经溶解术和射频消融术止痛疗效比较。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-01-01 Epub Date: 2024-10-23 DOI: 10.3344/kjp.23220r

Gokhan Yildiz, Gevher Rabia Genc Perdecioglu, Damla Yuruk, Ezgi Can, Omer Taylan Akkaya

引用次数: 0

Ultrasound-guided pain management: pros, cons, and benefits for the Philippines. 超声引导下的疼痛治疗：利弊及对菲律宾的益处。