Korean Journal of Pain最新文献

{"title":"MiR-298 suppresses astrocytic NF-κB activity and neuroinflammation <i>via</i> targeting MyD88 in bone cancer pain.","authors":"Ming Liu, Denggui Wang, Zhirong Yan, Min Zhou","doi":"10.3344/kjp.24386","DOIUrl":"10.3344/kjp.24386","url":null,"abstract":"<p><strong>Background: </strong>Bone cancer pain (BCP), a major symptom impairing quality of life and mobility in cancer patients, is linked to microRNAs dysregulation. This study investigates the role of miR-298 in a mouse BCP model established by implanting tumor cells into the femoral marrow cavity.</p><p><strong>Methods: </strong>Forty-eight male C3H/HeJ mice were randomized into sham or tumor groups, receiving intrathecal miR- 298 agonist/antagonist or controls. Behavioral assessments (paw withdrawal mechanical threshold [PWMT] and number of spontaneous flinches [NSF]) were performed before and after surgery (days 0, 4, 7, 10, 14, 21, 28). Astrocyte activation, inflammatory cytokines, and pathway proteins (MyD88, TAK1, p-p65) were analyzed via quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR), Western blot, and immunofluorescence. Statistical analysis used one-way ANOVA with Tukey's test and independent t-tests (<i>P</i> < 0.05).</p><p><strong>Results: </strong>Tumor-implanted mice showed significant mechanical hypersensitivity in PWMT and NSF versus sham controls (<i>P</i> < 0.001). MiR-298 expression was markedly downregulated in BCP mice (<i>P</i> < 0.001), confirmed by fluorescence in situ hybridization and qRT-PCR. Overexpression of miR-298 suppressed astrocyte proliferation (<i>P</i> = 0.005) and pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-1β; <i>P</i> < 0.001), while enhancing apoptosis (<i>P</i> = 0.003). Luciferase assays confirmed MyD88 as a direct miR-298 target (<i>P</i> < 0.001). Intrathecal miR-298 agonist reduced NF-κB activation (phospho-p65, <i>P</i> < 0.001) and alleviated pain behaviors versus tumor controls (<i>P</i> < 0.001).</p><p><strong>Conclusions: </strong>MiR-298 reduces BCP in mice by inhibiting astrocyte-mediated neuroinflammation and blocking the MyD88/NF-κB pathway.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"292-307"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding pain in Parkinson's disease: types, predictors, and treatment approaches.","authors":"John Patrick C Toledo","doi":"10.3344/kjp.25015","DOIUrl":"10.3344/kjp.25015","url":null,"abstract":"","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"355-356"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of glucagon-like peptide-1 receptor agonist on paclitaxel induced neurotoxicity in dorsal root ganglion neuronal cells <i>in vitro</i>.","authors":"Younghoon Jung, Seungbin Park, Won Yong Lim, Jeongmin Hong, Jiseok Baik, Hyeon Jeong Lee, Jae-Young Kwon, Eunsoo Kim","doi":"10.3344/kjp.24419","DOIUrl":"10.3344/kjp.24419","url":null,"abstract":"<p><strong>Background: </strong>Chemotherapy is the basis of cancer treatment. Chemotherapy-induced peripheral neuropathy (CIPN) is a major adverse effect. CIPN has a high incidence rate and substantially affects the quality of life of cancer survivors. Despite this, no definitive treatment for persistent unmet medical needs is available. Glucagon-like peptide-1 receptor agonists (GLP-1RA), widely used to treat obesity and diabetes, have recently been reported to be efficacious in treating neuropathic pain. The authors aimed to confirm its effects on CIPN and elucidate its underlying mechanisms.</p><p><strong>Methods: </strong>After differentiation, 50B11 dorsal root ganglion cells were treated with paclitaxel and GLP-1RA to confirm changes in oxidative stress, neuroinflammation, and neuronal damage. Immunofluorescence, flow cytometry, Western blotting, quantitative reverse transcription-polymerase chain reaction, cytokine quantitation by ELISA, and assessments of axonal degeneration and regeneration were performed to evaluate the effect of GLP-1RA on CIPN and confirm the associated mechanisms.</p><p><strong>Results: </strong>After treatment with paclitaxel, the increased oxidative stress and inflammatory signals decreased with the administration of GLP-1RA. GLP-1RA also led to an increase in β-endorphin and μ-opioid receptors through IL-10. And administration of GLP-1RA had the effect of increasing neurite length. Additionally, the increased expression of the TRP family induced by paclitaxel treatment was restored with GLP-1RA administration.</p><p><strong>Conclusions: </strong>GLP-1RA reduces oxidative stress and neuroinflammation, thereby alleviating paclitaxel-induced neurotoxicity. Additionally, GLP-1RA increases β-endorphin and μ-opioid receptors and reduces TRP family expression and promotes neuroregeneration, suggesting its effectiveness in mitigating chemotherapy-induced neuropathic pain.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"267-281"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ratio of excitatory and inhibitory synaptic processes in periaqueductal gray matter of the brain activated by the raphe magnus nucleus in a model of Parkinson's disease with hydrocortisone protection.","authors":"Harutyun Stepanyan, Mikhail Poghosyan, Maia Hovsepyan, Rafik Sargsyan, Margarita Danielyan, Arsen Minasyan, Naira Hunanyan, Kristina Karapetyan, John Sarkissian","doi":"10.3344/kjp.24385","DOIUrl":"10.3344/kjp.24385","url":null,"abstract":"<p><strong>Background: </strong>The involvement of antinociceptive centers in neurodegeneration within the brain, particularly in Parkinson's disease (PD), which is accompanied by chronic pain, is not yet well understood.</p><p><strong>Methods: </strong>Electrophysiological recordings were conducted on 15 king albino rats across three experimental conditions: intact, a rotenone-induced PD model, and a PD model treated with hydrocortisone. Extracellular spike activity was recorded from 241 single neurons in the periaqueductal gray (PAG) in response to stimulation of the raphe magnus nucleus (RMG).</p><p><strong>Results: </strong>The PD model exhibited significant excitotoxicity in the recorded neurons, indicative of substantial neurodegeneration, which appeared to precede both depressor (tetanic depression [TD], post-tetanic depression [PTD]) and excitatory (tetanic potentiation [TP], post-tetanic potentiation [PTP]) post-stimulus effects. A mathematical analysis of pre- and post-stimulus activation frequencies revealed the following: in the PD model with hydrocortisone protection, compared to the unprotected PD model, the pre-stimulus activation frequency of PAG neurons during high-frequency stimulation of the RMG was reduced, bringing the values closer to normal levels. The post-stimulus activation frequency of PAG neurons in the treatment group also decreased, both in depressor (TD, PTD) and excitatory (TP, PTP) responses, approaching normal levels.</p><p><strong>Conclusions: </strong>These findings, in conjunction with the previous research on the protective role of hydrocortisone in depressive reactions, suggest that hydrocortisone effectively mitigates excitotoxicity and provides significant neuroprotection in the context of PD.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"282-291"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between knee pain and quadriceps condition in osteoarthritis rats treated with cog polydioxanone filaments.","authors":"Myeounghoon Cha, Guanghai Nan, Nari Kang, Sun Joon Bai, Ryo Ikeda, Bae Hwan Lee, Jun Ho Jang","doi":"10.3344/kjp.24364","DOIUrl":"10.3344/kjp.24364","url":null,"abstract":"<p><strong>Background: </strong>Weakness in the quadriceps muscle significantly contributes to the development and progression of knee osteoarthritis (OA), characterized by pain and impaired function. This study aimed to assess structural and functional recovery in the quadriceps and its association with knee OA pain following treatment with the Muscle Enhancement and Support Therapy (MEST) device. MEST involves inserting cog polydioxanone filaments directly into muscle tissue to help alleviate OA pain.</p><p><strong>Methods: </strong>Knee OA was induced in Sprague-Dawley rats using monoiodoacetate injections, followed by MEST or a sham treatment. Five weeks post-MEST treatment, quadriceps recovery was evaluated by measuring entire muscle volume, hindlimb torque, tissue morphology, and key structural and functional biomarkers. Pain was assessed through paw withdrawal thresholds and weight-bearing distribution. Correlations between muscle measurements and pain levels were then analyzed.</p><p><strong>Results: </strong>MEST treatment resulted in significant increases in quadriceps volume, enhanced hindlimb torque, and elevated expression of α-actin, myosin, and the mitochondrial marker cytochrome c oxidase subunit 4, along with reductions in OA pain. These enhancements in muscle condition were closely associated with pain relief in OA.</p><p><strong>Conclusions: </strong>This study shows that MEST improves the quadriceps condition, including muscle volume, structure, function, and energy metabolism, and relieves knee OA pain, which are closely linked. These findings may suggest that promoting quadriceps recovery through MEST could be a promising approach for managing OA-related pain.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"244-257"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of unpredictable chronic mild stress of female rats before pregnancy on morphine-induced antinociceptive tolerance in offspring.","authors":"Nastaran Roshd Rashidi, Nahid Khodayari, Mehdi Sadegh, Hadi Karami, Mahdi Khors Ghaffari, Masoumeh Gholami","doi":"10.3344/kjp.24403","DOIUrl":"10.3344/kjp.24403","url":null,"abstract":"<p><strong>Background: </strong>Prenatal chronic stress can impact pain sensitivity and analgesic responses in offspring. This study investigates oxidative stress markers in the ovaries of female rats that experienced unpredictable chronic mild stress (UCMS) before pregnancy and development of morphine analgesic tolerance in their offspring.</p><p><strong>Methods: </strong>In this experimental study, 23 adolescent Wistar rats, 22 female and one male (6-8 weeks), were used as breeding pairs. The rats were maintained in a controlled environment with a 12-hour light/dark cycle and had unrestricted access to food and water. For one month prior to mating, the female rats were subjected to UCMS. After this exposure, the females were mated with a single male rat. Following lactation, male offspring received a daily dose of 10 mg/kg morphine intraperitoneally for 7 days, and the analgesic effects of morphine were assessed using the hot plate test. Ovarian tissues from the female rats exposed to UCMS were analyzed for oxidative stress markers.</p><p><strong>Results: </strong>Pre-pregnancy UCMS significantly reduced morphine's antinociceptive potency, with the peak effect on day 1 being stronger in the stressed group (<i>P</i> < 0.0001). The cumulative antinociceptive effect over 7 days was significantly higher in the morphine-unstressed group (<i>P</i> < 0.01). UCMS increased malondialdehyde levels and decreased glutathione (<i>P</i> < 0.01), superoxide dismutase and catalase activities in maternal ovarian tissues (<i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>Maternal UCMS increased oxidative stress markers in the ovaries and might relate to altered morphine antinociceptive potency in offspring, suggesting epigenetic effects of parental stress on pain management in future generations.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"258-266"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of intravenous acetaminophen as adjunct analgesia in patients undergoing cardiovascular surgery: a systematic review and meta-analysis.","authors":"Soowon Lee, Chang-Hoon Koo, Yu Kyung Bae, Jung-Hee Ryu","doi":"10.3344/kjp.25063","DOIUrl":"10.3344/kjp.25063","url":null,"abstract":"<p><strong>Background: </strong>Although intravenous (IV) acetaminophen (AAP) may help reduce severe postoperative pain and opioid use after cardiovascular surgery, its effectiveness must be further validated. Therefore, the authors aimed to evaluate the analgesic efficacy of perioperative IV AAP in patients undergoing cardiovascular surgery by conducting this meta-analysis.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted of PubMed, Embase, CENTRAL, CINAHL, Scopus, and Web of Science databases for studies published up to March 21, 2024. Six randomized controlled trials comparing IV AAP with a placebo in cardiovascular surgery were included. The mean difference (MD) was calculated to estimate pooled effect sizes. The primary outcome was opioid consumption, measured in morphine equivalent dose, and the secondary outcome was postoperative pain score.</p><p><strong>Results: </strong>Postoperative opioid consumption was significantly reduced with IV AAP than it was with a placebo (MD: -21.68, 95% confidence interval [CI]: -38.41 to -4.95, <i>P</i> = 0.011). Significant reductions in postoperative pain scores were observed at 6 hours (MD: -0.76, 95% CI: -1.43 to -0.10, <i>P</i> = 0.025) and 24 hours (MD: -0.63, 95% CI: -1.02 to -0.25, <i>P</i> = 0.001) after surgery. However, these reductions did not meet clinically meaningful thresholds. No significant differences were observed at 12, 18, and 48 hours postoperatively.</p><p><strong>Conclusions: </strong>IV AAP was more effective than a placebo for postoperative adjunct analgesia in patients who underwent cardiovascular surgery.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"320-331"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-year prognosis of primary stabbing headache and its associated factors: a clinic-based study.","authors":"Soohyun Cho, Byung-Kun Kim","doi":"10.3344/kjp.25081","DOIUrl":"10.3344/kjp.25081","url":null,"abstract":"<p><strong>Background: </strong>Primary stabbing headache (PSH) is commonly seen in headache clinics, yet its long-term course remains inadequately explored. This study aimed to determine the 2-year recurrence rate of PSH and to identify associated risk factors.</p><p><strong>Methods: </strong>Out of 1,756 patients who visited a specialized headache clinic due to headache complaints, 106 patients diagnosed with PSH were enrolled consecutively. Demographic and clinical information was collected, along with the time to achieve complete remission post-treatment. To evaluate the 2-year prognosis, all participants were contacted through telephone interviews. A total of 106 patients were interviewed by telephone at least 2 years after the onset of PSH. The authors examined the frequency and features of PSH recurrence and assessed clinical variables potentially linked to its recurrence.</p><p><strong>Results: </strong>A recurrence of PSH occurred in 36.3% of the patients. Patients with recurrent PSH had more prior history of stabbing headache (55.2% vs. 29.4%, <i>P</i> = 0.023), comorbid migraine (17.2% vs. 3.9%, <i>P</i> = 0.043) and severe intensity of stabbing headache (41.4% vs. 17.7%, <i>P</i> = 0.020) than those with non-recurrent PSH. Multivariable Cox regression analysis revealed that an independent effect of comorbid migraine on the recurrence of PSH (adjusted hazard ratio, 2.791; 95% confidence interval, 1.012-7.701; <i>P</i> = 0.047).</p><p><strong>Conclusions: </strong>Over one-third of individuals diagnosed with PSH experienced a recurrence within 2 years of the initial episode. Comorbid migraine was related to a recurrence of PSH, suggesting the potential role of shared pathophysiological mechanisms between migraine and PSH in influencing the prognosis of PSH.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"38 3","pages":"332-340"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking nociplastic pain: implications for the Philippines and beyond.","authors":"Jose Eric Mella Lacsa","doi":"10.3344/kjp.25132","DOIUrl":"10.3344/kjp.25132","url":null,"abstract":"","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"359-360"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain assessment using the Analgesia Nociception Index in patients undergoing sedation: a systematic review and meta-analysis.","authors":"Min Kyoung Kim, Oh Haeng Lee, Geun Joo Choi, Hyun Kang","doi":"10.3344/kjp.25105","DOIUrl":"10.3344/kjp.25105","url":null,"abstract":"<p><strong>Background: </strong>This systematic review and meta-analysis analyzed the utility of the Analgesia Nociception Index (ANI) in detecting intraoperative and procedural pain in sedated patients.</p><p><strong>Methods: </strong>A comprehensive search of the Cochrane Central Register of Controlled Trials, Ovid-MEDLINE, Ovid-Embase, and Google Scholar databases was performed to identify relevant studies. The primary outcome was the diagnostic accuracy of ANI, assessed by pooled sensitivity, specificity, likelihood ratios, and diagnostic odds ratio (DOR). Secondary outcomes were the correlation between ANI and pain assessment scales, the effect of norepinephrine (NE) on ANI, and differences in opioid consumption between the ANI-guided and control groups.</p><p><strong>Results: </strong>Eleven studies were included in the systematic review, with ten studies incorporated into the meta-analysis. ANI demonstrated moderate sensitivity (0.746, 95% confidence interval [CI] = 0.683-0.803) and specificity (0.776, 95% CI = 0.741-0.808) for detecting intraoperative and procedural pain, with a pooled DOR of 10.491. ANI was lower in the pain state than that in the no-pain state (standardized mean difference [SMD] = -1.140, 95% CI = -1.239 to -1.041, I² = 93.63%). ANI-guided analgesia was associated with a significant reduction in opioid consumption (SMD = -0.410, 95% CI = -0.643 to -0.178, I² = 0.0%). There were no significant differences in ANI between the NE and control groups. ANI showed a negative correlation with pain scales (<i>r</i> = -0.110 to -0.470).</p><p><strong>Conclusions: </strong>ANI effectively differentiated between the pain and non-pain states in sedated patients with moderate diagnostic accuracy and helped reduce opioid consumption. However, the high heterogeneity suggests the need for cautious interpretation.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"341-354"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}