Korean Journal of Pain最新文献

{"title":"Muscimol as a treatment for nerve injury-related neuropathic pain: a systematic review and meta-analysis of preclinical studies.","authors":"Hamzah Adel Ramawad,&nbsp;Parsa Paridari,&nbsp;Sajjad Jabermoradi,&nbsp;Pantea Gharin,&nbsp;Amirmohammad Toloui,&nbsp;Saeed Safari,&nbsp;Mahmoud Yousefifard","doi":"10.3344/kjp.23161","DOIUrl":"https://doi.org/10.3344/kjp.23161","url":null,"abstract":"<p><strong>Background: </strong>: Muscimol's quick onset and GABAergic properties make it a promising candidate for the treatment of pain. This systematic review and meta-analysis of preclinical studies aimed at summarizing the evidence regarding the efficacy of muscimol administration in the amelioration of nerve injury-related neuropathic pain.</p><p><strong>Methods: </strong>: Two independent researchers performed the screening process in Medline, Embase, Scopus and Web of Science extracting data were extracted into a checklist designed according to the PRISMA guideline. A standardized mean difference (SMD [95% confidence interval]) was calculated for each. To assess the heterogeneity between studies, I² and chi-square tests were utilized. In the case of heterogeneity, meta-regression and subgroup analyses were performed to identify the potential source.</p><p><strong>Results: </strong>: Twenty-two articles met the inclusion criteria. Pooled data analysis showed that the administration of muscimol during the peak effect causes a significant reduction in mechanical allodynia (SMD = 1.78 [1.45-2.11]; <i>P</i> < 0.0001; I² = 72.70%), mechanical hyperalgesia (SMD = 1.62 [1.28-1.96]; <i>P</i> < 0.0001; I² = 40.66%), and thermal hyperalgesia (SMD = 2.59 [1.79-3.39]; <i>P</i> < 0.0001; I² = 80.33%). This significant amendment of pain was observed at a declining rate from 15 minutes to at least 180 minutes post-treatment in mechanical allodynia and mechanical hyperalgesia, and up to 30 minutes in thermal hyperalgesia (<i>P</i> < 0 .0001).</p><p><strong>Conclusions: </strong>: Muscimol is effective in the amelioration of mechanical allodynia, mechanical hyperalgesia, and thermal hyperalgesia, exerting its analgesic effects 15 minutes after administration for up to at least 3 hours.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"36 4","pages":"425-440"},"PeriodicalIF":2.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/67/kjp-36-4-425.PMC10551397.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41155296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Predictive factors associated with successful response to ultrasound guided genicular radiofrequency ablation.","authors":"Selin Guven Kose,&nbsp;Halil Cihan Kose,&nbsp;Feyza Celikel,&nbsp;Omer Taylan Akkaya","doi":"10.3344/kjp.22109e","DOIUrl":"https://doi.org/10.3344/kjp.22109e","url":null,"abstract":"","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"36 4","pages":"481"},"PeriodicalIF":2.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/27/57/kjp-36-4-481.PMC10551401.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41171456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Involvement of the spinal γ-aminobutyric acid receptor in the analgesic effects of intrathecally injected hypertonic saline in spinal nerve-ligated rats.","authors":"Myong-Hwan Karm,&nbsp;Hyun-Jung Kwon,&nbsp;Euiyong Shin,&nbsp;Honggyoon Bae,&nbsp;Young Ki Kim,&nbsp;Seong-Soo Choi","doi":"10.3344/kjp.23162","DOIUrl":"10.3344/kjp.23162","url":null,"abstract":"<p><strong>Background: </strong>: Hypertonic saline is used for treating chronic pain; however, clinical studies that aid in optimizing therapeutic protocols are lacking. We aimed to determine the concentration of intrathecally injected hypertonic saline at which the effect reaches its peak as well as the underlying γ-aminobutyric acid (GABA) receptor-related antinociceptive mechanism.</p><p><strong>Methods: </strong>: Spinal nerve ligation (SNL; left L5 and L6) was performed to induce neuropathic pain in rats weighing 250-300 g. Experiment 1: one week after implanting the intrathecal catheter, 60 rats were assigned randomly to intrathecal injection with 0.45%, 0.9%, 2.5%, 5%, 10%, and 20% NaCl, followed by behavioral testing at baseline and after 30 minutes, 2 hours, 1 day, and 1 week to determine the minimal concentration which produced maximal analgesia. Experiment 2: after determining the optimal intrathecal hypertonic saline concentration, 60 rats were randomly divided into four groups: Sham, hypertonic saline without pretreatment, and hypertonic saline after pretreatment with one of two GABA receptor antagonists (GABA_A [bicuculline], or GABA_B [phaclofen]). Behavioral tests were performed at weeks 1 and 3 following each treatment.</p><p><strong>Results: </strong>: Hypertonic saline at concentrations greater than 5% alleviated SNL-induced mechanical allodynia and had a significant therapeutic effect, while showing a partial time- and dose-dependent antinociceptive effect on thermal and cold hyperalgesia. However, pretreatment with GABA receptor antagonists inhibited the antinociceptive effect of 5% NaCl.</p><p><strong>Conclusions: </strong>: This study indicates that the optimal concentration of hypertonic saline for controlling mechanical allodynia in neuropathic pain is 5%, and that its analgesic effect is related to GABA_A and GABA_B receptors.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"441-449"},"PeriodicalIF":2.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/47/d4/kjp-36-4-441.PMC10551396.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10362048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New insight into the mandibular nerve at the foramen ovale level for percutaneous radiofrequency thermocoagulation.","authors":"Peng-Bo Zhu,&nbsp;Yeon-Dong Kim,&nbsp;Ha Yeong Jeong,&nbsp;Miyoung Yang,&nbsp;Hyung-Sun Won","doi":"10.3344/kjp.23186","DOIUrl":"https://doi.org/10.3344/kjp.23186","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous radiofrequency thermocoagulation (RFTC) has been widely utilized in the management of trigeminal neuralgia. Despite using image guidance, accurate needle positioning into the target area still remains a critical element for achieving a successful outcome. This study was performed to precisely clarify the anatomical information required to ensure that the electrode tip is placed on the sensory component of the mandibular nerve (MN) at the foramen ovale (FO) level.</p><p><strong>Methods: </strong>The study used 50 hemi-half heads from 26 South Korean adult cadavers.</p><p><strong>Results: </strong>The cross-sectioned anterior and posterior divisions of the MN at the FO level could be distinguished based on an irregular boundary and color difference. The anterior division was clearly brighter than the posterior one. The anterior division of the MN at the FO level was located at the whole anterior (38.0%), anteromedial (6.0%), anterior center (8.0%), and anterolateral (22.0%) parts. The posterior division was often located at the whole posterior or posterolateral parts of the MN at the FO level. The anterior divisions covered the whole MN except for the medial half of the posterolateral part in the overwrapped images of the cross-sectional areas of the MN at the FO level. The cross-sectional areas of the anterior divisions were similar in males and females, whereas those of the posterior divisions were significantly larger in males (<i>P</i> = 0.004).</p><p><strong>Conclusions: </strong>The obtained anatomical information is expected to help physicians reduce unwanted side effects after percutaneous RFTC within the FO for the MN.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"36 4","pages":"465-472"},"PeriodicalIF":2.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c1/91/kjp-36-4-465.PMC10551399.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41156639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing analgesic efficacy of different local blocks after laparoscopic cholecystectomy: author's reply.","authors":"Ho-Jin Lee","doi":"10.3344/kjp.23233","DOIUrl":"https://doi.org/10.3344/kjp.23233","url":null,"abstract":"We express our gratitude to the authors for their valuable comments on our recent study comparing the analgesic effects of modified thoracoabdominal nerve block through the perichondral approach (M-TAPA) and subcostal transversus abdominis plane block (TAPB) [1]. They have raised several questions concerning the study design and results. First, they addressed concerns regarding our analgesic protocol, which did not involve the routine use of nonopioid analgesics such as acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) after surgery. As the authors rightfully mentioned, non-opioid analgesics like acetaminophen and NSAIDs are widely used for postoperative pain management. We administered these non-opioid analgesics intraoperatively, and, considering the short surgery duration, we believe that their effects sufficiently covered postoperative pain during the fasting period (approximately 6 hours). Additionally, for laparoscopic cholecystectomy, we followed our institution's standard analgesic protocol by administering 40 mg of intravenous nefopam during the first 8 hours postoperatively. Notably, we recently reported on the opioid-sparing and analgesic effects of intravenous nefopam during thoracic surgery [2]. Moreover, 6 hours post-surgery, when patients' pain had significantly decreased and they resumed oral intake, we administered an oral tramadol/ acetaminophen combination tablet as a rescue analgesic. Second, the authors expressed concerns that our study participants may have received insufficient postoperative pain control based on the pain intensity results. Although we administered non-opioid analgesics and performed nerve blockade in both groups, we observed high pain scores immediately after surgery. It is plausible that the participants' responses to the pain assessment might have influenced these results. According to a recent prospective study on the cutoff pain scores for mild, moderate, and severe pain in adult Korean patients, the cutoff score between mild and moderate pain was 5.5 on the numeric rating scale [3]. Our previous prospective study conducted in a post-anesthesia care unit yielded similar results [4]. Since we did not provide specific guidance beyond the numeric rating scale (with 0 indicating no pain and 10 indicating the worst pain imaginable), the participants tended to respond with scores closer to the midpoint of 5 when their consciousness was not entirely clear immediately after surgery. Third, the authors highlighted the high occurrence rate of postoperative nausea and vomiting (PONV) among","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"36 4","pages":"476-477"},"PeriodicalIF":2.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9e/29/kjp-36-4-476.PMC10551400.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41175103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of modified thoracoabdominal nerve block through perichondral approach and subcostal transversus abdominis plane block for pain management in laparoscopic cholecystectomy: a randomized-controlled trial.","authors":"Hye-Yeon Cho,&nbsp;In Eob Hwang,&nbsp;Mirang Lee,&nbsp;Wooil Kwon,&nbsp;Won Ho Kim,&nbsp;Ho-Jin Lee","doi":"10.3344/kjp.23114","DOIUrl":"https://doi.org/10.3344/kjp.23114","url":null,"abstract":"<p><strong>Background: </strong>The modified thoracoabdominal nerve block through the perichondral approach (M-TAPA) is a novel regional analgesic technique that can provide analgesia for both the lateral and anterior abdominal walls. This study aimed to compare the analgesic effect of M-TAPA with that of the subcostal transversus abdominis plane block (TAPB) in patients undergoing laparoscopic cholecystectomy (LC).</p><p><strong>Methods: </strong>Sixty patients scheduled to undergo elective LC were randomly assigned to receive either M-TAPA or subcostal TAPB during anesthesia induction. The primary outcome was the maximum pain intensity during movement within the first 12 hours postoperatively, measured using an 11-point numeric rating scale (NRS). Secondary outcomes included changes in NRS scores during rest, coughing, and movement, which were assessed at 1, 2, 4, 6, and 12 hours postoperatively and immediately before discharge. Additionally, postoperative nausea and vomiting, and patient satisfaction were recorded as secondary outcomes.</p><p><strong>Results: </strong>Data from 56 patients were analyzed, and no significant difference was observed in the primary outcome between the two groups (M-TAPA: 5.5 [interquartile range (IQR): 5-7] vs . subcostal TAPB: 5 [IQR: 4-7], median difference: 0, 95% confidence interval: -1 to 1, <i>P</i> = 0.580). Furthermore, no significant differences in secondary outcomes were observed between the two groups.</p><p><strong>Conclusions: </strong>No significant difference was observed in the analgesic effect between the two techniques. Consequently, further research is necessary to compare the efficacy of M-TAPA with other well-established regional analgesic techniques.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"36 3","pages":"382-391"},"PeriodicalIF":2.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7e/d8/kjp-36-3-382.PMC10322655.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9763369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial therapies for chronic pain (part 1): analgesic mechanisms.","authors":"Eric J Wang,&nbsp;Jay Karri,&nbsp;Nuj Tontisirin,&nbsp;Steven P Cohen","doi":"10.3344/kjp.23129","DOIUrl":"https://doi.org/10.3344/kjp.23129","url":null,"abstract":"There is increasing evidence that the relationship between chronic pain and infections is complex and intertwined. Bacterial and viral infections can cause pain through numerous mechanisms such as direct tissue damage and inflammation, the induction of excessive immunologic activity, and the development of peripheral or central sensitization. Treating infections might relieve pain by attenuating these processes, but a growing body of literature suggests that some antimicrobial therapies confer analgesic effects, including for nociceptive and neuropathic pain symptoms, and affective components of pain. The analgesic mechanisms of antimicrobials are indirect, but might be conceptualized into two broad categories: 1) the reduction of the infectious burden and associated pro-inflammatory processes; and 2) the inhibition of signaling processes (e.g., enzymatic and cytokine activity) necessary for nociception and maladaptive neuroplastic changes via off-target effects (unintended binding sites). For the former, there is evidence that symptoms of chronic low back pain (when associated with Modic type 1 changes), irritable bowel syndrome, inflammatory bowel disease, chronic pelvic pain, and functional dyspepsia might be improved after antibiotic treatment, though significant questions remain regarding specific regimens and dose, and which subpopulations are most likely to benefit. For the latter, there is evidence that several antimicrobial classes and medications exert analgesic effects independent of their reduction of infectious burden, and these include cephalosporins, ribavirin, chloroquine derivatives, rapalogues, minocycline, dapsone, and piscidin-1. This article aims to comprehensively review the existing literature for antimicrobial agents that have demonstrated analgesic efficacy in preclinical or clinical studies.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"36 3","pages":"281-298"},"PeriodicalIF":2.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0e/2a/kjp-36-3-281.PMC10322662.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10119125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial therapies for chronic pain (part 2): the prevention and treatment of chronic pain.","authors":"Eric J Wang,&nbsp;Edward Dolomisiewicz,&nbsp;Jay Karri,&nbsp;Nuj Tontisirin,&nbsp;Steven P Cohen","doi":"10.3344/kjp.23130","DOIUrl":"https://doi.org/10.3344/kjp.23130","url":null,"abstract":"<p><p>The discovery and development of antimicrobial therapies represents one of the most significant advancements in modern medicine. Although the primary therapeutic intent of antimicrobials is to eliminate their target pathogens, several antimicrobials have been shown to provide analgesia as a secondary benefit. Antimicrobials have demonstrated analgesic effects in conditions that involve dysbiosis or potential subclinical infection (<i>e.g .</i>, chronic low back pain with Modic type 1 changes; chronic prostatitis/chronic pelvic pain; irritable bowel syndrome; inflammatory bowel disease; functional gastrointestinal disorders/dyspepsia; myalgic encephalomyelitis/chronic fatigue syndrome), and might even prevent the chronification of pain after acute infections that are associated with excessive systemic inflammation (<i>e.g .</i>, post COVID-19 condition/long Covid, rheumatic fever). Clinical studies often assess the analgesic effects of antimicrobial therapies in an observational manner, without the ability to identify causative relationships, and significant gaps in the understanding remain regarding the analgesic potential of antimicrobials. Numerous interrelated patient-specific, antimicrobial-specific, and disease-specific factors altogether contribute to the perception and experience of pain, and each of these requires further study. Given worldwide concerns regarding antimicrobial resistance, antimicrobials must continue to be used judiciously and are unlikely to be repurposed as primary analgesic medications. However, when equipoise exists among several antimicrobial treatment options, the potential analgesic benefits of certain antimicrobial agents might be a valuable aspect to consider in clinical decision-making. This article (the second in a two-part series) aims to comprehensively review the evidence on the prevention and treatment of chronic pain using antimicrobial therapies and suggest a framework for future studies on this topic.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"36 3","pages":"299-315"},"PeriodicalIF":2.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/56/57/kjp-36-3-299.PMC10322666.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10119126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perampanel ameliorates nitroglycerin-induced migraine through inhibition of the cAMP/PKA/CREB signaling pathway in the trigeminal ganglion in rats.","authors":"QingLing Zhai,&nbsp;KaiXin Wang,&nbsp;Defu Zhang,&nbsp;Jinbo Chen,&nbsp;XiaoMeng Dong,&nbsp;Yonghui Pan","doi":"10.3344/kjp.23039","DOIUrl":"https://doi.org/10.3344/kjp.23039","url":null,"abstract":"<p><strong>Background: </strong>Perampanel, a highly selective glutamate AMPA receptor antagonist, is widely used to treat epilepsy. Since the existence of common pathophysiological features between epilepsy and migraine, the aim of this study was to investigate whether perampanel could exert an antimigraine effect.</p><p><strong>Methods: </strong>Nitroglycerin (NTG) was used to induce a migraine model in rats, and the model animals were pretreatment with 50 μg/kg and 100 μg/kg perampanel. The expression of pituitary adenylate-cyclase-activating polypeptide (PACAP) was quantified by western blot and quantitative real-time PCR in the trigeminal ganglion, and rat-specific enzyme-linked immunosorbent assay in serum. Western blot was also conducted to explore the effects of perampanel treatment on the phospholipase C (PLC)/protein kinase C (PKC) and protein kinase A (PKA)/cAMP-responsive-element-binding protein (CREB) signaling pathways. Moreover, the cAMP/PKA/CREB-dependent mechanism was evaluated <i>via</i> <i>in vitro</i> stimulation of hippocampal neurons. The cells were treated with perampanel, antagonists and agonists for 24 hours and cell lysates were prepared for western blot analysis.</p><p><strong>Results: </strong>Perampanel treatment notably increased the mechanical withdrawal threshold and decreased head grooming and light-aversive behaviors in NTG-treated rats. It also decreased PACAP expression and affected cAMP/PKA/CREB signaling pathway. However, PLC/PKC signaling pathway may not be involved in this treatment. In <i>in vitro</i> studies, perampanel notably decreased PACAP expression by inhibiting cAMP/PKA/CREB signaling pathway.</p><p><strong>Conclusions: </strong>This study shows that perampanel inhibits the migraine-like pain response and that this beneficial effect might be attributable to regulation of the cAMP/PKA/CREB signaling pathway.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"36 3","pages":"335-346"},"PeriodicalIF":2.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d3/f8/kjp-36-3-335.PMC10322658.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10119123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of graded motor imagery training on pain, functional performance, motor imagery skills, and kinesiophobia after total knee arthroplasty: randomized controlled trial.","authors":"Busra Candiri,&nbsp;Burcu Talu,&nbsp;Emre Guner,&nbsp;Metehan Ozen","doi":"10.3344/kjp.23020","DOIUrl":"https://doi.org/10.3344/kjp.23020","url":null,"abstract":"<p><strong>Background: </strong>The aim was to investigate the effect of graded motor imagery (GMI) added to rehabilitation on pain, functional performance, motor imagery ability, and kinesiophobia in individuals with total knee arthroplasty (TKA).</p><p><strong>Methods: </strong>Individuals scheduled for unilateral TKA were randomized to one of two groups: control (traditional rehabilitation, n = 9) and GMI (traditional rehabilitation + GMI, n = 9) groups. The primary outcome measures were the visual analogue scale and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Secondary outcome measures were knee range of motion, muscle strength, the timed up and go test, mental chronometer, Movement Imagery Questionnaire-3, lateralization performance, Central Sensitization Inventory, Pain Catastrophizing Scale, and Tampa Kinesiophobia Scale. Evaluations were made before and 6 weeks after surgery.</p><p><strong>Results: </strong>Activity and resting pain were significantly reduced in the GMI group compared to the control group (<i>P</i> < 0.001 and <i>P</i> = 0.004, respectively). Movement Imagery Questionnaire-3 scores and accuracy of lateralization performance also showed significant improvement (<i>P</i> = 0.037 and <i>P</i> = 0.015, respectively). The Pain Catastrophizing Scale and Tampa Kinesiophobia Scale scores were also significantly decreased in the GMI group compared to the control group (<i>P</i> = 0.039 and <i>P</i> = 0.009, respectively). However, GMI did not differ significantly in WOMAC scores, range of motion, muscle strength, timed up and go test and Central Sensitization Inventory scores compared to the control group (<i>P</i> > 0.05).</p><p><strong>Conclusions: </strong>GMI improved pain, motor imagery ability, pain catastrophizing, and kinesiophobia in the acute period after TKA.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"36 3","pages":"369-381"},"PeriodicalIF":2.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a3/15/kjp-36-3-369.PMC10322664.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9760335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}