Korean Journal of Pain最新文献

The power of data sharing: strengthening research integrity and advancing scientific discovery. 数据共享的力量：加强研究诚信，推进科学发现。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-06-18 DOI: 10.3344/kjp.25103

Jose Eric Mella Lacsa

引用次数: 0

Evaluation of the efficacy of the lumbar sympathetic ganglion block and the use of perfusion index as a predictor of its technical success: a prospective observational study. 评估腰交感神经节阻滞的疗效和使用灌注指数作为其技术成功的预测指标：一项前瞻性观察研究。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-06-18 DOI: 10.3344/kjp.24373

Seungpyo Nam, Shiback Lee, Soo Hyuk Yoon, Ho Jin Lee, Jee Youn Moon, Yongjae Yoo, Jeongsoo Kim

{"title":"Evaluation of the efficacy of the lumbar sympathetic ganglion block and the use of perfusion index as a predictor of its technical success: a prospective observational study.","authors":"Seungpyo Nam, Shiback Lee, Soo Hyuk Yoon, Ho Jin Lee, Jee Youn Moon, Yongjae Yoo, Jeongsoo Kim","doi":"10.3344/kjp.24373","DOIUrl":"https://doi.org/10.3344/kjp.24373","url":null,"abstract":"Background: This study aimed to evaluate the 4-week clinical efficacy of the lumbar sympathetic ganglion block (LSGB), assess the perfusion index (PI) as a marker for the LSGB's technical success, and examine the relationship between the PI change and post-procedure pain relief.Methods: In this prospective observational study, pain scores of 40 patients who underwent LSGB were measured using the Numeric Rating Scale (NRS) at pre-procedure, 20 minutes post-procedure, and at 1 and 4 weeks. The primary outcome was a positive LSGB response, defined as a reduction of ≥ 2 on the NRS at 20 minutes post-procedure. Skin temperature and PI were recorded every minute for 20 minutes post-procedure. The reliability of the PI was assessed using area under the curve (AUC) and receiver operating characteristic curves.Results: An immediate positive response to the LSGB was observed in 72.5% of patients, with 30.8% responding at 1 week and 17.9% responding at 4 weeks. NRS scores significantly decreased from baseline to 4.1 ± 2.5 immediately post-procedure and to 5.9 ± 2.7 at 4 weeks. A ΔPI of > 1.6% in the ipsilateral foot was a reliable indicator of technical success (sensitivity: 90.0%; specificity: 90.0%; AUC: 0.925; P < 0.001). However, neither temperature increase (R = 0.091, P = 0.577) nor PI increase (R = 0.029, P = 0.859) correlated significantly with pain reduction.Conclusions: Although the number of LSGB responders declined over 4 weeks, overall pain levels significantly decreased. The PI may serve as a quick and reliable indicator of technical success, but it does not correlate with post-procedure pain relief.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Balancing benefit and risk: clinical considerations in the use of acetaminophen, non-steroidal anti-inflammatory drugs, and dexamethasone for perioperative multimodal analgesia. 权衡利弊：对乙酰氨基酚、非甾体抗炎药和地塞米松围手术期多模式镇痛的临床考虑

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-06-18 DOI: 10.3344/kjp.25068

Boohwi Hong, Woosuk Chung, Chahyun Oh

{"title":"Balancing benefit and risk: clinical considerations in the use of acetaminophen, non-steroidal anti-inflammatory drugs, and dexamethasone for perioperative multimodal analgesia.","authors":"Boohwi Hong, Woosuk Chung, Chahyun Oh","doi":"10.3344/kjp.25068","DOIUrl":"https://doi.org/10.3344/kjp.25068","url":null,"abstract":"Multimodal analgesia, incorporating agents with diverse mechanisms of action, is a cornerstone of perioperative pain management, aiming to optimize analgesia while minimizing opioid-related adverse effects. Despite well-established guidelines, its adoption remains inconsistent due to entrenched practices and concerns about potential risks. This review focuses on the rationale and clinical considerations for foundational multimodal agents-acetaminophen, non-steroidal anti-inflammatory drugs, and dexamethasone-highlighting their benefits, contraindications, and controversies. Evidence regarding key concerns, including hepatotoxicity, nephrotoxicity, anastomotic leakage, bleeding, infection, and hyperglycemia, is comprehensively reviewed. While these concerns are not entirely unfounded, clear supporting data is often limited, highlighting the importance of a critical and thorough evaluation of the available evidence. Indiscriminate advocacy for or reluctance to adopt multimodal analgesia is equally undesirable; instead, a balanced, evidence-based approach is necessary. By refining the understanding of these agents, practitioners can support the broader implementation of multimodal analgesia in perioperative care, ultimately improving patient recovery and optimizing postoperative outcomes.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding pain in Parkinson's disease: types, predictors, and treatment approaches. 了解帕金森病的疼痛：类型、预测因素和治疗方法。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-06-10 DOI: 10.3344/kjp.25015

John Patrick C Toledo

引用次数: 0

Effect of glucagon-like peptide-1 receptor agonist on paclitaxel induced neurotoxicity in dorsal root ganglion neuronal cells in vitro. 胰高血糖素样肽-1受体激动剂对紫杉醇诱导的背根神经节细胞体外神经毒性的影响。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-06-09 DOI: 10.3344/kjp.24419

Younghoon Jung, Seungbin Park, Won Yong Lim, Jeongmin Hong, Jiseok Baik, Hyeon Jeong Lee, Jae-Young Kwon, Eunsoo Kim

{"title":"Effect of glucagon-like peptide-1 receptor agonist on paclitaxel induced neurotoxicity in dorsal root ganglion neuronal cells in vitro.","authors":"Younghoon Jung, Seungbin Park, Won Yong Lim, Jeongmin Hong, Jiseok Baik, Hyeon Jeong Lee, Jae-Young Kwon, Eunsoo Kim","doi":"10.3344/kjp.24419","DOIUrl":"https://doi.org/10.3344/kjp.24419","url":null,"abstract":"Background: Chemotherapy is the basis of cancer treatment. Chemotherapy-induced peripheral neuropathy (CIPN) is a major adverse effect. CIPN has a high incidence rate and substantially affects the quality of life of cancer survivors. Despite this, no definitive treatment for persistent unmet medical needs is available. Glucagon-like peptide-1 receptor agonists (GLP-1RA), widely used to treat obesity and diabetes, have recently been reported to be efficacious in treating neuropathic pain. The authors aimed to confirm its effects on CIPN and elucidate its underlying mechanisms.Methods: After differentiation, 50B11 dorsal root ganglion cells were treated with paclitaxel and GLP-1RA to confirm changes in oxidative stress, neuroinflammation, and neuronal damage. Immunofluorescence, flow cytometry, Western blotting, quantitative reverse transcription-polymerase chain reaction, cytokine quantitation by ELISA, and assessments of axonal degeneration and regeneration were performed to evaluate the effect of GLP-1RA on CIPN and confirm the associated mechanisms.Results: After treatment with paclitaxel, the increased oxidative stress and inflammatory signals decreased with the administration of GLP-1RA. GLP-1RA also led to an increase in β-endorphin and μ-opioid receptors through IL-10. And administration of GLP-1RA had the effect of increasing neurite length. Additionally, the increased expression of the TRP family induced by paclitaxel treatment was restored with GLP-1RA administration.Conclusions: GLP-1RA reduces oxidative stress and neuroinflammation, thereby alleviating paclitaxel-induced neurotoxicity. Additionally, GLP-1RA increases β-endorphin and μ-opioid receptors and reduces TRP family expression and promotes neuroregeneration, suggesting its effectiveness in mitigating chemotherapy-induced neuropathic pain.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of unpredictable chronic mild stress of female rats before pregnancy on morphine-induced antinociceptive tolerance in offspring. 妊娠前雌性大鼠不可预测的慢性轻度应激对后代吗啡诱导的抗伤性耐受的影响。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-05-19 DOI: 10.3344/kjp.24403

Nastaran Roshd Rashidi, Nahid Khodayari, Mehdi Sadegh, Hadi Karami, Mahdi Khors Ghaffari, Masoumeh Gholami

{"title":"Effects of unpredictable chronic mild stress of female rats before pregnancy on morphine-induced antinociceptive tolerance in offspring.","authors":"Nastaran Roshd Rashidi, Nahid Khodayari, Mehdi Sadegh, Hadi Karami, Mahdi Khors Ghaffari, Masoumeh Gholami","doi":"10.3344/kjp.24403","DOIUrl":"https://doi.org/10.3344/kjp.24403","url":null,"abstract":"Background: Prenatal chronic stress can impact pain sensitivity and analgesic responses in offspring. This study investigates oxidative stress markers in the ovaries of female rats that experienced unpredictable chronic mild stress (UCMS) before pregnancy and development of morphine analgesic tolerance in their offspring.Methods: In this experimental study, 23 adolescent Wistar rats, 22 female and one male (6-8 weeks), were used as breeding pairs. The rats were maintained in a controlled environment with a 12-hour light/dark cycle and had unrestricted access to food and water. For one month prior to mating, the female rats were subjected to UCMS. After this exposure, the females were mated with a single male rat. Following lactation, male offspring received a daily dose of 10 mg/kg morphine intraperitoneally for 7 days, and the analgesic effects of morphine were assessed using the hot plate test. Ovarian tissues from the female rats exposed to UCMS were analyzed for oxidative stress markers.Results: Pre-pregnancy UCMS significantly reduced morphine's antinociceptive potency, with the peak effect on day 1 being stronger in the stressed group (P < 0.0001). The cumulative antinociceptive effect over 7 days was significantly higher in the morphine-unstressed group (P < 0.01). UCMS increased malondialdehyde levels and decreased glutathione (P < 0.01), superoxide dismutase and catalase activities in maternal ovarian tissues (P < 0.05).Conclusions: Maternal UCMS increased oxidative stress markers in the ovaries and might relate to altered morphine antinociceptive potency in offspring, suggesting epigenetic effects of parental stress on pain management in future generations.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between knee pain and quadriceps condition in osteoarthritis rats treated with cog polydioxanone filaments. 骨关节炎大鼠膝关节疼痛与股四头肌状况的相关性。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-18 DOI: 10.3344/kjp.24364

Myeounghoon Cha, Guanghai Nan, Nari Kang, Sun Joon Bai, Ryo Ikeda, Bae Hwan Lee, Jun Ho Jang

{"title":"Correlation between knee pain and quadriceps condition in osteoarthritis rats treated with cog polydioxanone filaments.","authors":"Myeounghoon Cha, Guanghai Nan, Nari Kang, Sun Joon Bai, Ryo Ikeda, Bae Hwan Lee, Jun Ho Jang","doi":"10.3344/kjp.24364","DOIUrl":"https://doi.org/10.3344/kjp.24364","url":null,"abstract":"Background: Weakness in the quadriceps muscle significantly contributes to the development and progression of knee osteoarthritis (OA), characterized by pain and impaired function. This study aimed to assess structural and functional recovery in the quadriceps and its association with knee OA pain following treatment with the Muscle Enhancement and Support Therapy (MEST) device. MEST involves inserting cog polydioxanone filaments directly into muscle tissue to help alleviate OA pain.Methods: Knee OA was induced in Sprague-Dawley rats using monoiodoacetate injections, followed by MEST or a sham treatment. Five weeks post-MEST treatment, quadriceps recovery was evaluated by measuring entire muscle volume, hindlimb torque, tissue morphology, and key structural and functional biomarkers. Pain was assessed through paw withdrawal thresholds and weight-bearing distribution. Correlations between muscle measurements and pain levels were then analyzed.Results: MEST treatment resulted in significant increases in quadriceps volume, enhanced hindlimb torque, and elevated expression of α-actin, myosin, and the mitochondrial marker cytochrome c oxidase subunit 4, along with reductions in OA pain. These enhancements in muscle condition were closely associated with pain relief in OA.Conclusions: This study shows that MEST improves the quadriceps condition, including muscle volume, structure, function, and energy metabolism, and relieves knee OA pain, which are closely linked. These findings may suggest that promoting quadriceps recovery through MEST could be a promising approach for managing OA-related pain.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone marrow mesenchymal stem cells improve bone cancer pain by inhibiting p38MAPK phosphorylation and microglia activation. 骨髓间充质干细胞通过抑制p38MAPK磷酸化和小胶质细胞激活改善骨癌疼痛。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 Epub Date: 2025-03-11 DOI: 10.3344/kjp.24374

Houming Kan, Jinzhao Huang, Xiaodie Gui, Wendi Tian, Lijun Fan, Xuetai Chen, Xiaotong Ding, Liping Chen, Wen Shen

{"title":"Bone marrow mesenchymal stem cells improve bone cancer pain by inhibiting p38MAPK phosphorylation and microglia activation.","authors":"Houming Kan, Jinzhao Huang, Xiaodie Gui, Wendi Tian, Lijun Fan, Xuetai Chen, Xiaotong Ding, Liping Chen, Wen Shen","doi":"10.3344/kjp.24374","DOIUrl":"10.3344/kjp.24374","url":null,"abstract":"Background: Bone cancer pain (BCP) is not adequately addressed by current treatment methods, making the exploration of effective management strategies a topic of significant interest. Bone marrow mesenchymal stem cells (BMSCs) seem to be a potential way for managing BCP, yet little is known about the mechanisms underlying the efficacy of this potential treatment.Methods: We established the male C57BL/6 mice BCP models. Behavioral tests, X-ray, bone histology, western blotting, and immunofluorescence were used to verify the analgesic effect of BMSCs.Results: Intramedullary injection of Lewis lung carcinoma cells into the femur successfully generated the mice BCP models. The number of c-Fos-positive neurons and phosphorylated mitogen-activated protein kinase (MAPK) proteins in the spinal dorsal horn of the BCP mice increased. Intrathecal injection of BMSCs temporarily improved the BCP mice's mechanical and thermal hyperalgesia without affecting motor function. This effect may be related to inhibiting spinal microglia and p-p38 MAPK activation. The analgesic effect of BMSCs may be related to the homing effect mediated by CXCR4.Conclusions: Intrathecal injection of BMSCs can temporarily inhibit mechanical and thermal hyperalgesia in BCP mice without affecting motor function. This effect may be related to the inhibition of p-p38 protein expression and the inhibition of microglia but not to p-ERK and p-JNK.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"116-127"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal association of obesity and chronic pain mediated by educational attainment and smoking: a mediation Mendelian randomization study. 受教育程度和吸烟介导的肥胖和慢性疼痛的因果关系：一项孟德尔随机研究。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 Epub Date: 2025-03-06 DOI: 10.3344/kjp.24331

Yunshu Lyu, Qingxing Lu, Yane Liu, Mengtong Xie, Lintong Jiang, Junnan Li, Ning Wang, Xianglong Dai, Yuqi Yang, Peiming Jiang, Qiong Yu

{"title":"Causal association of obesity and chronic pain mediated by educational attainment and smoking: a mediation Mendelian randomization study.","authors":"Yunshu Lyu, Qingxing Lu, Yane Liu, Mengtong Xie, Lintong Jiang, Junnan Li, Ning Wang, Xianglong Dai, Yuqi Yang, Peiming Jiang, Qiong Yu","doi":"10.3344/kjp.24331","DOIUrl":"10.3344/kjp.24331","url":null,"abstract":"Background: Obesity and chronic pain are related in both directions, according to earlier observational research. This research aimed to analyze the causal association between obesity and chronic pain at the genetic level, as well as to assess whether common factors mediate this relationship.Methods: This study used bidirectional two sample Mendelian randomization (MR) technique to analyze the association between obesity and chronic pain. Obesity's summary genome-wide association data were obtained from European ancestry groups, as measured by body mass index (BMI), waist-to-hip ratio, waist circumference (WC), and hip circumference (HC), genome-wide association study data for chronic pain also came from the UK population, including chronic pain at three different sites (back, hip, and headache), chronic widespread pain (CWP), and multisite chronic pain (MCP). Secondly, a two-step MR and multivariate MR investigation was performed to evaluate the mediating effects of several proposed confounders.Results: The authors discovered a link between chronic pain and obesity. More specifically, a sensitivity analysis was done to confirm the associations between greater BMI, WC, and HC with an increased risk of CWP and MCP. Importantly, the intermediate MR results suggest that education levels and smoking initiation may mediate the causal relationship between BMI on CWP, with a mediation effect of 23.08% and 15.38%, respectively.Conclusions: The authors' findings demonstrate that the importance of education and smoking in understanding chronic pain's pathogenesis, which is important for the primary prevention and prognosis of chronic pain.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"177-186"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nociplastic pain: exploring the concept and ongoing discussions. 伤害性疼痛：探索概念和正在进行的讨论。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 DOI: 10.3344/kjp.25007

John Quintner, Asaf Weisman, Milton Cohen

引用次数: 0