Korean Journal of Pain最新文献

Effects of unpredictable chronic mild stress of female rats before pregnancy on morphine-induced antinociceptive tolerance in offspring. 妊娠前雌性大鼠不可预测的慢性轻度应激对后代吗啡诱导的抗伤性耐受的影响。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-05-19 DOI: 10.3344/kjp.24403

Nastaran Roshd Rashidi, Nahid Khodayari, Mehdi Sadegh, Hadi Karami, Mahdi Khors Ghaffari, Masoumeh Gholami

{"title":"Effects of unpredictable chronic mild stress of female rats before pregnancy on morphine-induced antinociceptive tolerance in offspring.","authors":"Nastaran Roshd Rashidi, Nahid Khodayari, Mehdi Sadegh, Hadi Karami, Mahdi Khors Ghaffari, Masoumeh Gholami","doi":"10.3344/kjp.24403","DOIUrl":"https://doi.org/10.3344/kjp.24403","url":null,"abstract":"Background: Prenatal chronic stress can impact pain sensitivity and analgesic responses in offspring. This study investigates oxidative stress markers in the ovaries of female rats that experienced unpredictable chronic mild stress (UCMS) before pregnancy and development of morphine analgesic tolerance in their offspring.Methods: In this experimental study, 23 adolescent Wistar rats, 22 female and one male (6-8 weeks), were used as breeding pairs. The rats were maintained in a controlled environment with a 12-hour light/dark cycle and had unrestricted access to food and water. For one month prior to mating, the female rats were subjected to UCMS. After this exposure, the females were mated with a single male rat. Following lactation, male offspring received a daily dose of 10 mg/kg morphine intraperitoneally for 7 days, and the analgesic effects of morphine were assessed using the hot plate test. Ovarian tissues from the female rats exposed to UCMS were analyzed for oxidative stress markers.Results: Pre-pregnancy UCMS significantly reduced morphine's antinociceptive potency, with the peak effect on day 1 being stronger in the stressed group (P < 0.0001). The cumulative antinociceptive effect over 7 days was significantly higher in the morphine-unstressed group (P < 0.01). UCMS increased malondialdehyde levels and decreased glutathione (P < 0.01), superoxide dismutase and catalase activities in maternal ovarian tissues (P < 0.05).Conclusions: Maternal UCMS increased oxidative stress markers in the ovaries and might relate to altered morphine antinociceptive potency in offspring, suggesting epigenetic effects of parental stress on pain management in future generations.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between knee pain and quadriceps condition in osteoarthritis rats treated with cog polydioxanone filaments. 骨关节炎大鼠膝关节疼痛与股四头肌状况的相关性。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-18 DOI: 10.3344/kjp.24364

Myeounghoon Cha, Guanghai Nan, Nari Kang, Sun Joon Bai, Ryo Ikeda, Bae Hwan Lee, Jun Ho Jang

{"title":"Correlation between knee pain and quadriceps condition in osteoarthritis rats treated with cog polydioxanone filaments.","authors":"Myeounghoon Cha, Guanghai Nan, Nari Kang, Sun Joon Bai, Ryo Ikeda, Bae Hwan Lee, Jun Ho Jang","doi":"10.3344/kjp.24364","DOIUrl":"https://doi.org/10.3344/kjp.24364","url":null,"abstract":"Background: Weakness in the quadriceps muscle significantly contributes to the development and progression of knee osteoarthritis (OA), characterized by pain and impaired function. This study aimed to assess structural and functional recovery in the quadriceps and its association with knee OA pain following treatment with the Muscle Enhancement and Support Therapy (MEST) device. MEST involves inserting cog polydioxanone filaments directly into muscle tissue to help alleviate OA pain.Methods: Knee OA was induced in Sprague-Dawley rats using monoiodoacetate injections, followed by MEST or a sham treatment. Five weeks post-MEST treatment, quadriceps recovery was evaluated by measuring entire muscle volume, hindlimb torque, tissue morphology, and key structural and functional biomarkers. Pain was assessed through paw withdrawal thresholds and weight-bearing distribution. Correlations between muscle measurements and pain levels were then analyzed.Results: MEST treatment resulted in significant increases in quadriceps volume, enhanced hindlimb torque, and elevated expression of α-actin, myosin, and the mitochondrial marker cytochrome c oxidase subunit 4, along with reductions in OA pain. These enhancements in muscle condition were closely associated with pain relief in OA.Conclusions: This study shows that MEST improves the quadriceps condition, including muscle volume, structure, function, and energy metabolism, and relieves knee OA pain, which are closely linked. These findings may suggest that promoting quadriceps recovery through MEST could be a promising approach for managing OA-related pain.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone marrow mesenchymal stem cells improve bone cancer pain by inhibiting p38MAPK phosphorylation and microglia activation. 骨髓间充质干细胞通过抑制p38MAPK磷酸化和小胶质细胞激活改善骨癌疼痛。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 Epub Date: 2025-03-11 DOI: 10.3344/kjp.24374

Houming Kan, Jinzhao Huang, Xiaodie Gui, Wendi Tian, Lijun Fan, Xuetai Chen, Xiaotong Ding, Liping Chen, Wen Shen

{"title":"Bone marrow mesenchymal stem cells improve bone cancer pain by inhibiting p38MAPK phosphorylation and microglia activation.","authors":"Houming Kan, Jinzhao Huang, Xiaodie Gui, Wendi Tian, Lijun Fan, Xuetai Chen, Xiaotong Ding, Liping Chen, Wen Shen","doi":"10.3344/kjp.24374","DOIUrl":"10.3344/kjp.24374","url":null,"abstract":"Background: Bone cancer pain (BCP) is not adequately addressed by current treatment methods, making the exploration of effective management strategies a topic of significant interest. Bone marrow mesenchymal stem cells (BMSCs) seem to be a potential way for managing BCP, yet little is known about the mechanisms underlying the efficacy of this potential treatment.Methods: We established the male C57BL/6 mice BCP models. Behavioral tests, X-ray, bone histology, western blotting, and immunofluorescence were used to verify the analgesic effect of BMSCs.Results: Intramedullary injection of Lewis lung carcinoma cells into the femur successfully generated the mice BCP models. The number of c-Fos-positive neurons and phosphorylated mitogen-activated protein kinase (MAPK) proteins in the spinal dorsal horn of the BCP mice increased. Intrathecal injection of BMSCs temporarily improved the BCP mice's mechanical and thermal hyperalgesia without affecting motor function. This effect may be related to inhibiting spinal microglia and p-p38 MAPK activation. The analgesic effect of BMSCs may be related to the homing effect mediated by CXCR4.Conclusions: Intrathecal injection of BMSCs can temporarily inhibit mechanical and thermal hyperalgesia in BCP mice without affecting motor function. This effect may be related to the inhibition of p-p38 protein expression and the inhibition of microglia but not to p-ERK and p-JNK.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"116-127"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal association of obesity and chronic pain mediated by educational attainment and smoking: a mediation Mendelian randomization study. 受教育程度和吸烟介导的肥胖和慢性疼痛的因果关系：一项孟德尔随机研究。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 Epub Date: 2025-03-06 DOI: 10.3344/kjp.24331

Yunshu Lyu, Qingxing Lu, Yane Liu, Mengtong Xie, Lintong Jiang, Junnan Li, Ning Wang, Xianglong Dai, Yuqi Yang, Peiming Jiang, Qiong Yu

{"title":"Causal association of obesity and chronic pain mediated by educational attainment and smoking: a mediation Mendelian randomization study.","authors":"Yunshu Lyu, Qingxing Lu, Yane Liu, Mengtong Xie, Lintong Jiang, Junnan Li, Ning Wang, Xianglong Dai, Yuqi Yang, Peiming Jiang, Qiong Yu","doi":"10.3344/kjp.24331","DOIUrl":"10.3344/kjp.24331","url":null,"abstract":"Background: Obesity and chronic pain are related in both directions, according to earlier observational research. This research aimed to analyze the causal association between obesity and chronic pain at the genetic level, as well as to assess whether common factors mediate this relationship.Methods: This study used bidirectional two sample Mendelian randomization (MR) technique to analyze the association between obesity and chronic pain. Obesity's summary genome-wide association data were obtained from European ancestry groups, as measured by body mass index (BMI), waist-to-hip ratio, waist circumference (WC), and hip circumference (HC), genome-wide association study data for chronic pain also came from the UK population, including chronic pain at three different sites (back, hip, and headache), chronic widespread pain (CWP), and multisite chronic pain (MCP). Secondly, a two-step MR and multivariate MR investigation was performed to evaluate the mediating effects of several proposed confounders.Results: The authors discovered a link between chronic pain and obesity. More specifically, a sensitivity analysis was done to confirm the associations between greater BMI, WC, and HC with an increased risk of CWP and MCP. Importantly, the intermediate MR results suggest that education levels and smoking initiation may mediate the causal relationship between BMI on CWP, with a mediation effect of 23.08% and 15.38%, respectively.Conclusions: The authors' findings demonstrate that the importance of education and smoking in understanding chronic pain's pathogenesis, which is important for the primary prevention and prognosis of chronic pain.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"177-186"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nociplastic pain: exploring the concept and ongoing discussions. 伤害性疼痛：探索概念和正在进行的讨论。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 DOI: 10.3344/kjp.25007

John Quintner, Asaf Weisman, Milton Cohen

引用次数: 0

Chrysin ameliorates pain through regulation of the serum metabolomics in the rats. 黄菊花素通过调节大鼠血清代谢组学改善疼痛。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 Epub Date: 2025-03-20 DOI: 10.3344/kjp.24355

Khadijeh Haghighat, Fariba Mahmoudi, Maryam Khoshkam, Homayoun Khazali

{"title":"Chrysin ameliorates pain through regulation of the serum metabolomics in the rats.","authors":"Khadijeh Haghighat, Fariba Mahmoudi, Maryam Khoshkam, Homayoun Khazali","doi":"10.3344/kjp.24355","DOIUrl":"10.3344/kjp.24355","url":null,"abstract":"Background: Chrysin is a natural flavonoid that exhibits various pharmacological activities including pain relief. However, the effects of chrysin on changes of metabolic profiles during pain remain unclear. The aim of this study was to analyze the biomarkers related to pain in serum and to evaluate the analgesic properties of chrysin in a rat model of pain.Methods: Male Wister rats were divided into four groups (n = 5). Pain was induced by injecting 50 μL of formalin into the hind paw. Chrysin and diclofenac (10 mg/kg, intraperitoneal injection) was administered to the intact and pain groups. All injections were given 30 minutes before pain induction. Immediately, the behavioral test was performed. Then the serum sample was separated for 1HNMR-based metabolite analysis.Results: Chrysin treatment alleviated the paw licking events, flinching response, and pain score. The integrated analyses further revealed three major metabolic changes including glycine-serine-threonine, taurine-hypotaurine, and arginine by comparing the serums from intact operated rats, pain rats, and pain rats treated with chrysin, and suggested that chrysin may improve pain by regulating the biosynthesis of these metabolic pathways.Conclusions: These findings provide insights into metabolic pathways involved in pain and the analgesic effects of chrysin and may help to identify potential targets for the anti-pain properties of chrysin.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"128-137"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nociplastic pain: conceptual and terminological considerations. 伤害性疼痛：概念和术语的考虑。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 DOI: 10.3344/kjp.25104

Kyung Hoon Kim

引用次数: 0

Physicochemical stability of mixtures of non-steroidal anti-inflammatory drugs such as ketorolac and diclofenac and antiemetics such as ondansetron and ramosetron: an in vitro study. 非甾体抗炎药如酮咯酸和双氯芬酸与止吐药如昂丹司琼和雷莫司琼混合物的物理化学稳定性：一项体外研究。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 DOI: 10.3344/kjp.24316

Chung Hun Lee

{"title":"Physicochemical stability of mixtures of non-steroidal anti-inflammatory drugs such as ketorolac and diclofenac and antiemetics such as ondansetron and ramosetron: an in vitro study.","authors":"Chung Hun Lee","doi":"10.3344/kjp.24316","DOIUrl":"10.3344/kjp.24316","url":null,"abstract":"Background: Drugs administered intravenously during the postoperative period can mix before entering the bloodstream. This study assessed the stability of mixtures of non-steroidal anti-inflammatory drugs (ketorolac and diclofenac) and antiemetics (ondansetron and ramosetron) to determine their suitability for concurrent administration.Methods: Ketorolac or diclofenac was combined with ondansetron or ramosetron at a 1:1 volume ratio. Each mixture was stored in a propylene syringe at 24°C for 2 hours. The mixtures were assessed visually, and the pH was measured. Additionally, the drug concentrations were determined using high-performance liquid chromatography (HPLC).Results: Mixtures of ketorolac or diclofenac and ramosetron showed no crystal formation or pH changes, and HPLC analysis confirmed that the drug concentrations remained stable. In contrast, mixtures of ketorolac or diclofenac and ondansetron exhibited the visible formation of 10-50 μm crystals under a microscope. However, there were no changes in the pH levels, and HPLC analysis indicated that the drug concentrations remained stable for both the mixtures.Conclusions: Mixtures of ketorolac or diclofenac and ramosetron demonstrated physical and chemical stability for up to 2 hours, indicating that their concurrent use is feasible. Conversely, mixtures of ketorolac or diclofenac and ondansetron should be avoided due to the formation of crystals, even though the concentration of each drug remained stable.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"38 2","pages":"103-115"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leave me alone! When does social support become a menace to pain management? 别烦我！什么时候社会支持成为疼痛管理的威胁？

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 DOI: 10.3344/kjp.24299

Dalmacito Cordero

引用次数: 0

Neuroplasticity in chronic pain: insights into diagnosis and treatment. 慢性疼痛的神经可塑性：诊断和治疗的见解。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 DOI: 10.3344/kjp.24393

Sahar M Jaffal

{"title":"Neuroplasticity in chronic pain: insights into diagnosis and treatment.","authors":"Sahar M Jaffal","doi":"10.3344/kjp.24393","DOIUrl":"10.3344/kjp.24393","url":null,"abstract":"Chronic pain is a universal problem that directly evolves the central nervous system, altering both its structure and function. This review discusses neuroplastic alterations in critical areas in the brain like the anterior cingulate cortex, insula, prefrontal cortex, primary (S1) and secondary (S2) somatosensory cortices, and thalamus. These regions exhibit gray matter decrease and changes in connectivity during chronic pain. Several cortical networks, mainly the central executive network, the default mode network, and the salience network exhibit neuroplasticity which reallocates cognitive and emotional resources to pain processing. Thus, it was reported that sensitivity to pain enhances emotional suffering, indicating that altered connectivity and functional reorganization of these networks support maladaptive pain processing and underpin chronic pain persistence. Neuroplasticity-focused treatments such as brain stimulation, neuro-feedback, and exercise-based therapies constitute potential interventions for preventing such negative changes. Further, innovative neuroimaging biomarkers are effective in demonstrating precise neural changes and in providing information about the diagnosis of chronic pain syndromes. This review highlights neuro-plastic changes in chronically painful patients and acknowledges the brain's plasticity as a target for chronic pain treatment. It, also, points to the diagnostic strategies and practical interventions that address these alterations.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"38 2","pages":"89-102"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0