Korean Journal of Pain最新文献

{"title":"The power of data sharing: strengthening research integrity and advancing scientific discovery.","authors":"Jose Eric Mella Lacsa","doi":"10.3344/kjp.25103","DOIUrl":"10.3344/kjp.25103","url":null,"abstract":"","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"357-358"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucagon-like peptide-1 receptor agonists in neuropathic pain: hype or hope?","authors":"Jeong Il Choi","doi":"10.3344/kjp.25214","DOIUrl":"10.3344/kjp.25214","url":null,"abstract":"","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"38 3","pages":"219-221"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, mechanisms, and intervention of the polytrauma clinical triad in military pain medicine.","authors":"Qinghua Liu, Peipei Qiu, Tao Ma, Yali Zhao, Shihui Fu, Minglong Gao, Zeguo Feng, Long Feng","doi":"10.3344/kjp.24425","DOIUrl":"10.3344/kjp.24425","url":null,"abstract":"<p><p>This up-to-date review focused on the recent advances in the concept, interrelationship, and mechanisms of the polytrauma clinical triad (PCT), and intervention knowledge and approaches to its prevention and treatment from the perspective of military pain medicine, hoping to provide a scientific basis and reference of PCT. Many soldiers suffering from chronic pain coexist with post-traumatic stress disorder and traumatic brain injury. If the above three diseases exist, it is called PCT. Three diseases in this common triad are interrelated and reinforce each other. This triad is challenging to treat and often leads to chronic issues, especially if not adequately monitored and managed. Although each disease of this triad could occur in isolation, it is valuable to know whether the rest of PCT needs to be screened. Current treatment of this triad emphasizes accurate identification and assessment of each disease, the new interdisciplinary and multimodal system of care, individualized customization principles, and shared medical decisions. To maximize clinical success and military service, interdisciplinary providers may benefit from the joint development of complementary treatment and biopsychosocial approach supported by theoretical and empirical evidence. The management of the PCT should emphasize integrative medicine and new interdisciplinary, multimodal nursing. Furthermore, cognitive behavioral therapy, standard rehabilitation care, and integrated health therapy have yielded valuable efficacy. It also should encourage the establishment of harmonious treatment relationships, shared medical decisions, and individualized customization principles to care for military service members with these comorbidities.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"38 3","pages":"222-243"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the efficacy of the lumbar sympathetic ganglion block and the use of perfusion index as a predictor of its technical success: a prospective observational study.","authors":"Seungpyo Nam, Shiback Lee, Soo Hyuk Yoon, Ho Jin Lee, Jee Youn Moon, Yongjae Yoo, Jeongsoo Kim","doi":"10.3344/kjp.24373","DOIUrl":"10.3344/kjp.24373","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the 4-week clinical efficacy of the lumbar sympathetic ganglion block (LSGB), assess the perfusion index (PI) as a marker for the LSGB's technical success, and examine the relationship between the PI change and post-procedure pain relief.</p><p><strong>Methods: </strong>In this prospective observational study, pain scores of 40 patients who underwent LSGB were measured using the Numeric Rating Scale (NRS) at pre-procedure, 20 minutes post-procedure, and at 1 and 4 weeks. The primary outcome was a positive LSGB response, defined as a reduction of ≥ 2 on the NRS at 20 minutes post-procedure. Skin temperature and PI were recorded every minute for 20 minutes post-procedure. The reliability of the PI was assessed using area under the curve (AUC) and receiver operating characteristic curves.</p><p><strong>Results: </strong>An immediate positive response to the LSGB was observed in 72.5% of patients, with 30.8% responding at 1 week and 17.9% responding at 4 weeks. NRS scores significantly decreased from baseline to 4.1 ± 2.5 immediately post-procedure and to 5.9 ± 2.7 at 4 weeks. A Δ PI of > 1.6% in the ipsilateral foot was a reliable indicator of technical success (sensitivity: 90.0%; specificity: 90.0%; AUC: 0.925; <i>P</i> < 0.001). However, neither temperature increase (R = 0.091, <i>P</i> = 0.577) nor PI increase (R = 0.029, <i>P</i> = 0.859) correlated significantly with pain reduction.</p><p><strong>Conclusions: </strong>Although the number of LSGB responders declined over 4 weeks, overall pain levels significantly decreased. The PI may serve as a quick and reliable indicator of technical success, but it does not correlate with post-procedure pain relief.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"308-319"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MiR-298 suppresses astrocytic NF-κB activity and neuroinflammation <i>via</i> targeting MyD88 in bone cancer pain.","authors":"Ming Liu, Denggui Wang, Zhirong Yan, Min Zhou","doi":"10.3344/kjp.24386","DOIUrl":"10.3344/kjp.24386","url":null,"abstract":"<p><strong>Background: </strong>Bone cancer pain (BCP), a major symptom impairing quality of life and mobility in cancer patients, is linked to microRNAs dysregulation. This study investigates the role of miR-298 in a mouse BCP model established by implanting tumor cells into the femoral marrow cavity.</p><p><strong>Methods: </strong>Forty-eight male C3H/HeJ mice were randomized into sham or tumor groups, receiving intrathecal miR- 298 agonist/antagonist or controls. Behavioral assessments (paw withdrawal mechanical threshold [PWMT] and number of spontaneous flinches [NSF]) were performed before and after surgery (days 0, 4, 7, 10, 14, 21, 28). Astrocyte activation, inflammatory cytokines, and pathway proteins (MyD88, TAK1, p-p65) were analyzed via quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR), Western blot, and immunofluorescence. Statistical analysis used one-way ANOVA with Tukey's test and independent t-tests (<i>P</i> < 0.05).</p><p><strong>Results: </strong>Tumor-implanted mice showed significant mechanical hypersensitivity in PWMT and NSF versus sham controls (<i>P</i> < 0.001). MiR-298 expression was markedly downregulated in BCP mice (<i>P</i> < 0.001), confirmed by fluorescence in situ hybridization and qRT-PCR. Overexpression of miR-298 suppressed astrocyte proliferation (<i>P</i> = 0.005) and pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-1β; <i>P</i> < 0.001), while enhancing apoptosis (<i>P</i> = 0.003). Luciferase assays confirmed MyD88 as a direct miR-298 target (<i>P</i> < 0.001). Intrathecal miR-298 agonist reduced NF-κB activation (phospho-p65, <i>P</i> < 0.001) and alleviated pain behaviors versus tumor controls (<i>P</i> < 0.001).</p><p><strong>Conclusions: </strong>MiR-298 reduces BCP in mice by inhibiting astrocyte-mediated neuroinflammation and blocking the MyD88/NF-κB pathway.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"292-307"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding pain in Parkinson's disease: types, predictors, and treatment approaches.","authors":"John Patrick C Toledo","doi":"10.3344/kjp.25015","DOIUrl":"10.3344/kjp.25015","url":null,"abstract":"","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"355-356"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of glucagon-like peptide-1 receptor agonist on paclitaxel induced neurotoxicity in dorsal root ganglion neuronal cells <i>in vitro</i>.","authors":"Younghoon Jung, Seungbin Park, Won Yong Lim, Jeongmin Hong, Jiseok Baik, Hyeon Jeong Lee, Jae-Young Kwon, Eunsoo Kim","doi":"10.3344/kjp.24419","DOIUrl":"10.3344/kjp.24419","url":null,"abstract":"<p><strong>Background: </strong>Chemotherapy is the basis of cancer treatment. Chemotherapy-induced peripheral neuropathy (CIPN) is a major adverse effect. CIPN has a high incidence rate and substantially affects the quality of life of cancer survivors. Despite this, no definitive treatment for persistent unmet medical needs is available. Glucagon-like peptide-1 receptor agonists (GLP-1RA), widely used to treat obesity and diabetes, have recently been reported to be efficacious in treating neuropathic pain. The authors aimed to confirm its effects on CIPN and elucidate its underlying mechanisms.</p><p><strong>Methods: </strong>After differentiation, 50B11 dorsal root ganglion cells were treated with paclitaxel and GLP-1RA to confirm changes in oxidative stress, neuroinflammation, and neuronal damage. Immunofluorescence, flow cytometry, Western blotting, quantitative reverse transcription-polymerase chain reaction, cytokine quantitation by ELISA, and assessments of axonal degeneration and regeneration were performed to evaluate the effect of GLP-1RA on CIPN and confirm the associated mechanisms.</p><p><strong>Results: </strong>After treatment with paclitaxel, the increased oxidative stress and inflammatory signals decreased with the administration of GLP-1RA. GLP-1RA also led to an increase in β-endorphin and μ-opioid receptors through IL-10. And administration of GLP-1RA had the effect of increasing neurite length. Additionally, the increased expression of the TRP family induced by paclitaxel treatment was restored with GLP-1RA administration.</p><p><strong>Conclusions: </strong>GLP-1RA reduces oxidative stress and neuroinflammation, thereby alleviating paclitaxel-induced neurotoxicity. Additionally, GLP-1RA increases β-endorphin and μ-opioid receptors and reduces TRP family expression and promotes neuroregeneration, suggesting its effectiveness in mitigating chemotherapy-induced neuropathic pain.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"267-281"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ratio of excitatory and inhibitory synaptic processes in periaqueductal gray matter of the brain activated by the raphe magnus nucleus in a model of Parkinson's disease with hydrocortisone protection.","authors":"Harutyun Stepanyan, Mikhail Poghosyan, Maia Hovsepyan, Rafik Sargsyan, Margarita Danielyan, Arsen Minasyan, Naira Hunanyan, Kristina Karapetyan, John Sarkissian","doi":"10.3344/kjp.24385","DOIUrl":"10.3344/kjp.24385","url":null,"abstract":"<p><strong>Background: </strong>The involvement of antinociceptive centers in neurodegeneration within the brain, particularly in Parkinson's disease (PD), which is accompanied by chronic pain, is not yet well understood.</p><p><strong>Methods: </strong>Electrophysiological recordings were conducted on 15 king albino rats across three experimental conditions: intact, a rotenone-induced PD model, and a PD model treated with hydrocortisone. Extracellular spike activity was recorded from 241 single neurons in the periaqueductal gray (PAG) in response to stimulation of the raphe magnus nucleus (RMG).</p><p><strong>Results: </strong>The PD model exhibited significant excitotoxicity in the recorded neurons, indicative of substantial neurodegeneration, which appeared to precede both depressor (tetanic depression [TD], post-tetanic depression [PTD]) and excitatory (tetanic potentiation [TP], post-tetanic potentiation [PTP]) post-stimulus effects. A mathematical analysis of pre- and post-stimulus activation frequencies revealed the following: in the PD model with hydrocortisone protection, compared to the unprotected PD model, the pre-stimulus activation frequency of PAG neurons during high-frequency stimulation of the RMG was reduced, bringing the values closer to normal levels. The post-stimulus activation frequency of PAG neurons in the treatment group also decreased, both in depressor (TD, PTD) and excitatory (TP, PTP) responses, approaching normal levels.</p><p><strong>Conclusions: </strong>These findings, in conjunction with the previous research on the protective role of hydrocortisone in depressive reactions, suggest that hydrocortisone effectively mitigates excitotoxicity and provides significant neuroprotection in the context of PD.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"282-291"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between knee pain and quadriceps condition in osteoarthritis rats treated with cog polydioxanone filaments.","authors":"Myeounghoon Cha, Guanghai Nan, Nari Kang, Sun Joon Bai, Ryo Ikeda, Bae Hwan Lee, Jun Ho Jang","doi":"10.3344/kjp.24364","DOIUrl":"10.3344/kjp.24364","url":null,"abstract":"<p><strong>Background: </strong>Weakness in the quadriceps muscle significantly contributes to the development and progression of knee osteoarthritis (OA), characterized by pain and impaired function. This study aimed to assess structural and functional recovery in the quadriceps and its association with knee OA pain following treatment with the Muscle Enhancement and Support Therapy (MEST) device. MEST involves inserting cog polydioxanone filaments directly into muscle tissue to help alleviate OA pain.</p><p><strong>Methods: </strong>Knee OA was induced in Sprague-Dawley rats using monoiodoacetate injections, followed by MEST or a sham treatment. Five weeks post-MEST treatment, quadriceps recovery was evaluated by measuring entire muscle volume, hindlimb torque, tissue morphology, and key structural and functional biomarkers. Pain was assessed through paw withdrawal thresholds and weight-bearing distribution. Correlations between muscle measurements and pain levels were then analyzed.</p><p><strong>Results: </strong>MEST treatment resulted in significant increases in quadriceps volume, enhanced hindlimb torque, and elevated expression of α-actin, myosin, and the mitochondrial marker cytochrome c oxidase subunit 4, along with reductions in OA pain. These enhancements in muscle condition were closely associated with pain relief in OA.</p><p><strong>Conclusions: </strong>This study shows that MEST improves the quadriceps condition, including muscle volume, structure, function, and energy metabolism, and relieves knee OA pain, which are closely linked. These findings may suggest that promoting quadriceps recovery through MEST could be a promising approach for managing OA-related pain.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"244-257"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of unpredictable chronic mild stress of female rats before pregnancy on morphine-induced antinociceptive tolerance in offspring.","authors":"Nastaran Roshd Rashidi, Nahid Khodayari, Mehdi Sadegh, Hadi Karami, Mahdi Khors Ghaffari, Masoumeh Gholami","doi":"10.3344/kjp.24403","DOIUrl":"10.3344/kjp.24403","url":null,"abstract":"<p><strong>Background: </strong>Prenatal chronic stress can impact pain sensitivity and analgesic responses in offspring. This study investigates oxidative stress markers in the ovaries of female rats that experienced unpredictable chronic mild stress (UCMS) before pregnancy and development of morphine analgesic tolerance in their offspring.</p><p><strong>Methods: </strong>In this experimental study, 23 adolescent Wistar rats, 22 female and one male (6-8 weeks), were used as breeding pairs. The rats were maintained in a controlled environment with a 12-hour light/dark cycle and had unrestricted access to food and water. For one month prior to mating, the female rats were subjected to UCMS. After this exposure, the females were mated with a single male rat. Following lactation, male offspring received a daily dose of 10 mg/kg morphine intraperitoneally for 7 days, and the analgesic effects of morphine were assessed using the hot plate test. Ovarian tissues from the female rats exposed to UCMS were analyzed for oxidative stress markers.</p><p><strong>Results: </strong>Pre-pregnancy UCMS significantly reduced morphine's antinociceptive potency, with the peak effect on day 1 being stronger in the stressed group (<i>P</i> < 0.0001). The cumulative antinociceptive effect over 7 days was significantly higher in the morphine-unstressed group (<i>P</i> < 0.01). UCMS increased malondialdehyde levels and decreased glutathione (<i>P</i> < 0.01), superoxide dismutase and catalase activities in maternal ovarian tissues (<i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>Maternal UCMS increased oxidative stress markers in the ovaries and might relate to altered morphine antinociceptive potency in offspring, suggesting epigenetic effects of parental stress on pain management in future generations.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"258-266"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}