Korean Journal of Pain最新文献

{"title":"Hypoalgesic effects, safety, and feasibility of a 6-minute high-lung-volume static apnea intervention.","authors":"Cristian Mendoza-Arranz, Guillermo Miravet-Mingo, José Fierro-Marrero, Álvaro Reina-Varona, Jose Vicente León-Hernández, Asier Sagarribay-Villano, Hugo García-Del Arco, Francisco De Asís-Fernández","doi":"10.3344/kjp.25130","DOIUrl":"https://doi.org/10.3344/kjp.25130","url":null,"abstract":"<p><strong>Background: </strong>Repeated apneas may induce hypoalgesia, but the impact of high-lung-volume static apneas remains unexplored.</p><p><strong>Methods: </strong>Eighty-one healthy participants were randomized into an apnea group (AG) or control group (CG). The AG performed a 6-minute static intermittent apnea at high lung volume, while the CG breathed normally in supine. Pressure pain thresholds (PPTs) at the thumb, tibialis anterior and the 7^th cervical vertebra (C7), along with heart rate (HR), oxygen saturation (SpO₂), and systolic and diastolic blood pressure (SBP, DBP), were recorded. Qualitative analysis assessed sensations, emotions, and adverse effects.</p><p><strong>Results: </strong>ANCOVA showed no significant differences in PPT between groups in the thumb (mean difference [MD] = 0.306 kg/cm²; bias-corrected and accelerated [BCa] 95% confidence intervals [CI] = [-0.192, 0.775]; <i>P</i> = 0.215), tibialis (MD = 0.213 kg/cm²; BCa 95% CI = [-0.181, 0.629]; <i>P</i> = 0.303) and C7 (MD = 0.213 kg/cm²; BCa 95% CI = [-0.101, 0.543]; <i>P</i> = 0.190). No differences were found in SpO₂ (MD = 0.385%; <i>P</i> = 0.065). However, %HR_max (MD = 2.879%; <i>P</i> < 0.001), SBP (MD = 9.221 mmHg; <i>P</i> < 0.001) and DBP (MD = 6.604 mmHg; <i>P</i> < 0.001) were slightly higher in the AG. The AG presented greater distress-related sensations and emotions, while the CG reported more comfort-related experiences. AG presented with more, although mild, adverse effects.</p><p><strong>Conclusions: </strong>High-lung-volume static apneas showed no clear hypoalgesic effect and participants reported slightly greater discomfort. Further studies should explore the dose-effect relationships in healthy and clinical populations.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrodin alleviates bortezomib-induced peripheral neuropathy by inhibiting NF-κB/NLRP3 pathway-mediated microglial inflammation.","authors":"Long Gu, Xiaoli Lv, Song Cao, Yonghuai Feng","doi":"10.3344/kjp.25341","DOIUrl":"10.3344/kjp.25341","url":null,"abstract":"<p><strong>Background: </strong>Multiple chemotherapeutic agents exhibit neurotoxicity. For example, bortezomib (BTZ)-induced peripheral neuropathy (BIPN) is characterized by sensory abnormalities and pain, and effective treatment strategies are currently lacking. This study aimed to investigate the alleviating effects of gastrodin (GAS) on BIPN and its potential mechanisms.</p><p><strong>Methods: </strong>Behavioral tests were used to assess changes in pain thresholds across all groups of mice. Hematoxylin-eosin staining, transmission electron microscopy, and immunofluorescence were used to evaluate peripheral nerve injury and the activation of spinal glial cells. ELISA was used to measure the levels of inflammatory cytokines. Proteins associated with the NF-κB/NLRP3 pathway were examined using Western blot.</p><p><strong>Results: </strong>GAS significantly improved thermal and mechanical hyperalgesia in BIPN mice. Moreover, BTZ can cause loss of intraepidermal nerve fibers, microstructural damage to the dorsal root ganglia, a disorganized arrangement of sciatic nerve fibers, and demyelination, all of which were effectively reversed by GAS treatment. Further investigation revealed that GAS significantly suppressed the upregulation of IBA-1 and GFAP in the spinal cord of BIPN mice, and the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 were concurrently reduced. IBA-1/IL-1β and IBA-1/TNF-α double-labeled positive cells were significantly increased in BIPN mice, and GAS intervention reduced the number of these double-labeled cells. In addition, GAS significantly inhibited aberrant NF-κB signaling and upregulation of NLRP3 inflammasome-related proteins of BIPN mice.</p><p><strong>Conclusions: </strong>GAS may alleviate BIPN by suppressing microglia-mediated neuroinflammatory responses, and the NF-κB/NLRP3 inflammasome signaling pathway appears to be involved in this process.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"39 2","pages":"246-259"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"Comparison of ultrasound-guided superior trunk block <i>versus</i> clavipectoral fascial plane block for clavicular surgery\".","authors":"Pranjali Kurhekar, Srinidhi Narayanan, Raghuraman M Sethuraman, Buddhan Rajarathinam","doi":"10.3344/kjp.25328","DOIUrl":"10.3344/kjp.25328","url":null,"abstract":"","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"39 2","pages":"289-290"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical practice guidelines for the management of refractory postherpetic neuralgia by the Korean Pain Society.","authors":"Hee Yong Kang, Chung Hun Lee, Doo-Hwan Kim, Yeon-Dong Kim, Won-Joong Kim, Eunsoo Kim, Jae Hun Kim, Hyun Jung Kim, Yangki Minn, Kyungseung Yang, Jinyoung Oh, Yongjae Yoo, So Young Lim, Mihn-Sook Jue, Eun Joo Choi, Kunhee Han, Seong-Soo Choi","doi":"10.3344/kjp.25161","DOIUrl":"10.3344/kjp.25161","url":null,"abstract":"<p><p>Postherpetic neuralgia (PHN) is persistent pain that occurs after the resolution of skin lesions caused by the reactivation of the herpes zoster virus. Several first-line agents, including anticonvulsants, tricyclic antidepressants, and lidocaine patches, are used in treatment. However, systematic, evidence-based, multidisciplinary clinical practice guidelines (CPGs) addressing the use of opioids and pain interventions-such as nerve blocks-for patients with refractory PHN unresponsive to first-line agents have not yet been established. Therefore, the Korean Pain Society, in collaboration with relevant medical specialty societies, has developed <i>de novo</i> CPGs for the management of refractory PHN. The development process followed Cochrane's systematic literature review methodology and employed the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system to assess the certainty of evidence and strength of recommendations. Key questions, identified through a survey of experts treating patients with refractory PHN, were finalized by the CPGs development panel. A literature search was conducted in four electronic databases: PubMed (MEDLINE), Embase, Cochrane Library, and KoreaMed. Studies were selected based on predefined inclusion and exclusion criteria using the population, intervention, comparison, outcomes, and study design (PICOS) framework. The resulting recommendations integrate evidence from the literature with patient and clinician preferences and values. They also take into account the quality of evidence, the balance of benefits and harms, potential barriers to implementation, and feasibility within various healthcare settings. These evidence-based multidisciplinary CPGs are expected to assist physicians in safely and effectively treating patients with refractory PHN.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"171-190"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13061597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of menstrual pain intensity, menstrual symptoms, and catastrophization on cognitive function in young women with primary dysmenorrhea.","authors":"Esra Uzelpasaci, Özgü İnal Özün","doi":"10.3344/kjp.25326","DOIUrl":"10.3344/kjp.25326","url":null,"abstract":"<p><strong>Background: </strong>Cognitive function is negatively affected in different chronic painful conditions. This study aimed to examine the relationship between pain intensity, menstrual symptoms, catastrophization, and cognitive functions in young women with primary dysmenorrhea.</p><p><strong>Methods: </strong>This cross-sectional study comprised 132 nulliparous young women with primary dysmenorrhea. Sociodemographic characteristics and detailed medical, obstetric, and urogynecological history were recorded. Menstrual pain intensity was evaluated with the Visual Analogue Scale, symptoms experienced during the menstrual cycle with the Menstruation Symptom Questionnaire (MSQ), pain-related emotions with the Pain Catastrophizing Scale (PCS), and cognitive functions with the Montreal Cognitive Assessment (MoCA) and Stroop test. All evaluations were performed in the periovulatory phase.</p><p><strong>Results: </strong>The mean MoCA total score was 24.31 ± 4.86 in young women with primary dysmenorrhea. The MoCA visuospatial/executive subscale showed negative correlations with menstrual pain intensity, pain duration, complaint duration, MSQ coping strategies, PCS rumination, PCS helplessness, and PCS total scores (r = -0.191 to -0.291, <i>P</i> < 0.05). In addition, Stroop 4-time showed a weak positive correlation with complaint duration (r = 0.236, <i>P</i> = 0.016) and PCS rumination scores (r = 0.222, <i>P</i> = 0.024).</p><p><strong>Conclusions: </strong>Young women with primary dysmenorrhea had low MoCA scores. In primary dysmenorrhea, visuospatial/executive cognitive function and selective attention were impaired, especially in relation to the severity of menstrual pain, pain duration, some menstrual symptoms, and pain catastrophization. Cognitive training, especially to improve visuospatial/executive cognitive function and selective attention, should be included in pain management programs applied to women with primary dysmenorrhea.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"39 2","pages":"272-283"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"More rigorously and more transparently: recommendations for reporting statistical methods.","authors":"Sang Gyu Kwak, Yong-Eun Park, Min Cheol Chang","doi":"10.3344/kjp.25242","DOIUrl":"10.3344/kjp.25242","url":null,"abstract":"","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"284-286"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145703198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manipulation therapy alleviates neuropathic pain <i>via</i> the SOCS1 m⁶A epigenetic loop.","authors":"Liping Wu, Xiang Wang, Peng Yang, Xiongjiang Wang, Yujiao Zheng, Yeni Tang, Haoxin Zheng, Peng Ning, Hongliang Tang","doi":"10.3344/kjp.25124","DOIUrl":"10.3344/kjp.25124","url":null,"abstract":"<p><strong>Background: </strong>Manipulation therapy (MT) relieves pain in nervous system disorders by reducing inflammation. Although evidence suggests MT is beneficial for neuropathic pain (NP), its molecular mechanisms remain unclear. This study investigated whether MT could reverse NP-related epigenetic changes and elucidated the potential mechanisms of NP.</p><p><strong>Methods: </strong>An NP model was established <i>via</i> spinal nerve ligation (SNL), and MT was administered at acupoints Jumping Round (GB30), Yang Mound Spring (GB34), and Suspended Bell (GB39) for 14 days. Mechanical and thermal pain in rats were evaluated using the mechanical paw withdrawal threshold and thermal paw withdrawal latency tests. Inflammatory cytokine levels in spinal cord neurons were quantified using enzyme-linked immunosorbent assay. Total N⁶-methyladenosine (m⁶A) levels were assessed by colorimetric analysis, while target genes were validated using methylated RNA immunoprecipitation succeeded by quantitative polymerase chain reaction, immunofluorescence, Western blotting, and quantitative real-time polymerase chain reaction.</p><p><strong>Results: </strong>The outcomes indicated that MT significantly attenuated SNL-induced pain hypersensitivity. The therapeutic effects of MT were correlated with global m⁶A methylation in spinal cord neurons. Moreover, MT affected the toll-like receptor 4 (TLR4) signaling pathway's expression by modulating suppressor of cytokine signaling 1 protein (SOCS1) mRNA m⁶A methylation levels, consequently reducing the secretion of neuroinflammatory cytokines interleukin-1 beta (IL-1β), IL-6, and tumor necrosis factor-alpha (TNF-α), thereby alleviating NP.</p><p><strong>Conclusions: </strong>This study provides evidence that MT effectively ameliorates NP by modulating inflammation and RNA m⁶A methylation in the spinal cord <i>via</i> the SOCS1/TLR4 pathway.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"191-206"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concordance of cortical morphological anomalies with genetic predisposition to multisite chronic pain in females.","authors":"Aihui Liu, Shinan Li, Yu Wang, Xiuwen Wang, Shuaijie Ding, Shiyi Wu, Zhi Ye, Ruitian Ma, Yixin Zhou, Sheng Qiu, Qiang Gao, Zhenhua Ying, Hongyang Jiang","doi":"10.3344/kjp.25253","DOIUrl":"10.3344/kjp.25253","url":null,"abstract":"<p><strong>Background: </strong>Multisite chronic pain (MCP) is a debilitating condition disproportionately affecting females, yet its underlying biological basis, particularly the connection to brain structure and the specific role of genetic factors, remains incompletely understood.</p><p><strong>Methods: </strong>This study delves into the genetic correlation between MCP in females and cerebral cortical morphology, specifically concentrating on cortical thickness (CT) and surface area (SA). Leveraging genome-wide association study (GWAS) data, the investigation establishes significant genetic correlations between female MCP and diverse cerebral cortical regions.</p><p><strong>Results: </strong>The outcomes underscored that diminished CT in the frontal pole, increased CT in the rostral middle frontal cortex, and reduced SA in the superior frontal cortex exhibited nominal associations with increased susceptibility to MCP in females (<i>P</i> < 0.05). Conversely, MCP susceptibility demonstrated a nominal causal association with reduced CT in the parahippocampal gyrus and postcentral gyrus. Gene enrichment analysis suggests potential correlations between these genetic loci and biological pathways related to body mass index and pain phenotypes.</p><p><strong>Conclusions: </strong>This study provided exploratory evidence of potential shared genetic pathways influencing both MCP susceptibility and cerebral cortex structure. The results suggested that alterations in brain morphology in females may have a bidirectional relationship with susceptibility to chronic pain.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"39 2","pages":"260-271"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13061599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL-27-Ucp2-FoxO3 axis mediating the polarization of alternatively activated macrophages and ameliorating inflammatory pain.","authors":"Yi Ma, Shuyuan Gan, Yueying Zheng, Xianhui Kang, Shengmei Zhu","doi":"10.3344/kjp.25307","DOIUrl":"10.3344/kjp.25307","url":null,"abstract":"<p><strong>Background: </strong>The signaling pathways of inflammatory pain are widely explored, but practical clinical approaches to ameliorate pain remain inadequate.</p><p><strong>Methods: </strong>Quantitative PCR (qPCR) and ELISA methods were applied to measure the concentration of interleukin (IL)-27 in the inflammatory pain mouse model. Flow cytometry was conducted to identify the source of IL-27. Bone marrow-derived macrophages were stimulated by IL-27, IL-4, lipopolysaccharide, and/or interferon-gamma, followed by qPCR to assess pro-inflammatory and pro-resolving markers' dynamic expression. Then, the molecule profiling of IL-27-primed macrophages was determined using transcriptomic and proteomic sequencing. The Agilent Seahorse XF analyzer calculated energy metabolism indicators. The adoptive cell transfer method was used to verify that forkhead box class O3 (FoxO3) mediates alternatively activated macrophage differentiation induced by IL-27-Ucp2, contributing to alleviating pain sensation in mice.</p><p><strong>Results: </strong>IL-27 is highly expressed centrally and peripherally in rodent pain models. Selective downregulation of IL-27 intensifies pain sensitivity in mice. In macrophages, IL-27 promotes the secretion of anti-inflammatory molecules, such as Arginase-1. Further, transcriptome, energy metabolic examination, and proteome analyses identified that IL-27 restructures the metabolism in macrophages, which is mediated by uncoupling protein 2 (Ucp2) and subsequently activates transcription factor FoxO3. Conditional knockdown of FoxO3 (si-FoxO3) in macrophages refrains the production of anti-inflammatory genes <i>in vitro</i>; meanwhile, adoptive transfer of macrophages with si-FoxO3 but no wild-type macrophages (or IL-27 primed macrophages) prolongs mechanical hyperalgesia in mice.</p><p><strong>Conclusions: </strong>These findings reveal that the IL-27-Ucp2-FoxO3 axis regulates macrophage plasticity distinct from the canonical IL-4-mediated pathway through metabolic rewiring and facilitates alleviating Inflammatory pain.</p>","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"39 2","pages":"221-245"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13061598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suzetrigine: a novel allosteric voltage-gated sodium 1.8 channel inhibitor, thereby stabilizing the closed state of the channel.","authors":"Kyung-Hoon Kim","doi":"10.3344/kjp.26057","DOIUrl":"10.3344/kjp.26057","url":null,"abstract":"","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"39 2","pages":"151-155"},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}