Korean Journal of Pain最新文献_第4页

Bone marrow mesenchymal stem cells improve bone cancer pain by inhibiting p38MAPK phosphorylation and microglia activation. 骨髓间充质干细胞通过抑制p38MAPK磷酸化和小胶质细胞激活改善骨癌疼痛。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 Epub Date: 2025-03-11 DOI: 10.3344/kjp.24374

Houming Kan, Jinzhao Huang, Xiaodie Gui, Wendi Tian, Lijun Fan, Xuetai Chen, Xiaotong Ding, Liping Chen, Wen Shen

{"title":"Bone marrow mesenchymal stem cells improve bone cancer pain by inhibiting p38MAPK phosphorylation and microglia activation.","authors":"Houming Kan, Jinzhao Huang, Xiaodie Gui, Wendi Tian, Lijun Fan, Xuetai Chen, Xiaotong Ding, Liping Chen, Wen Shen","doi":"10.3344/kjp.24374","DOIUrl":"10.3344/kjp.24374","url":null,"abstract":"Background: Bone cancer pain (BCP) is not adequately addressed by current treatment methods, making the exploration of effective management strategies a topic of significant interest. Bone marrow mesenchymal stem cells (BMSCs) seem to be a potential way for managing BCP, yet little is known about the mechanisms underlying the efficacy of this potential treatment.Methods: We established the male C57BL/6 mice BCP models. Behavioral tests, X-ray, bone histology, western blotting, and immunofluorescence were used to verify the analgesic effect of BMSCs.Results: Intramedullary injection of Lewis lung carcinoma cells into the femur successfully generated the mice BCP models. The number of c-Fos-positive neurons and phosphorylated mitogen-activated protein kinase (MAPK) proteins in the spinal dorsal horn of the BCP mice increased. Intrathecal injection of BMSCs temporarily improved the BCP mice's mechanical and thermal hyperalgesia without affecting motor function. This effect may be related to inhibiting spinal microglia and p-p38 MAPK activation. The analgesic effect of BMSCs may be related to the homing effect mediated by CXCR4.Conclusions: Intrathecal injection of BMSCs can temporarily inhibit mechanical and thermal hyperalgesia in BCP mice without affecting motor function. This effect may be related to the inhibition of p-p38 protein expression and the inhibition of microglia but not to p-ERK and p-JNK.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"116-127"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal association of obesity and chronic pain mediated by educational attainment and smoking: a mediation Mendelian randomization study. 受教育程度和吸烟介导的肥胖和慢性疼痛的因果关系：一项孟德尔随机研究。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 Epub Date: 2025-03-06 DOI: 10.3344/kjp.24331

Yunshu Lyu, Qingxing Lu, Yane Liu, Mengtong Xie, Lintong Jiang, Junnan Li, Ning Wang, Xianglong Dai, Yuqi Yang, Peiming Jiang, Qiong Yu

{"title":"Causal association of obesity and chronic pain mediated by educational attainment and smoking: a mediation Mendelian randomization study.","authors":"Yunshu Lyu, Qingxing Lu, Yane Liu, Mengtong Xie, Lintong Jiang, Junnan Li, Ning Wang, Xianglong Dai, Yuqi Yang, Peiming Jiang, Qiong Yu","doi":"10.3344/kjp.24331","DOIUrl":"10.3344/kjp.24331","url":null,"abstract":"Background: Obesity and chronic pain are related in both directions, according to earlier observational research. This research aimed to analyze the causal association between obesity and chronic pain at the genetic level, as well as to assess whether common factors mediate this relationship.Methods: This study used bidirectional two sample Mendelian randomization (MR) technique to analyze the association between obesity and chronic pain. Obesity's summary genome-wide association data were obtained from European ancestry groups, as measured by body mass index (BMI), waist-to-hip ratio, waist circumference (WC), and hip circumference (HC), genome-wide association study data for chronic pain also came from the UK population, including chronic pain at three different sites (back, hip, and headache), chronic widespread pain (CWP), and multisite chronic pain (MCP). Secondly, a two-step MR and multivariate MR investigation was performed to evaluate the mediating effects of several proposed confounders.Results: The authors discovered a link between chronic pain and obesity. More specifically, a sensitivity analysis was done to confirm the associations between greater BMI, WC, and HC with an increased risk of CWP and MCP. Importantly, the intermediate MR results suggest that education levels and smoking initiation may mediate the causal relationship between BMI on CWP, with a mediation effect of 23.08% and 15.38%, respectively.Conclusions: The authors' findings demonstrate that the importance of education and smoking in understanding chronic pain's pathogenesis, which is important for the primary prevention and prognosis of chronic pain.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"177-186"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nociplastic pain: exploring the concept and ongoing discussions. 伤害性疼痛：探索概念和正在进行的讨论。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 DOI: 10.3344/kjp.25007

John Quintner, Asaf Weisman, Milton Cohen

引用次数: 0

Chrysin ameliorates pain through regulation of the serum metabolomics in the rats. 黄菊花素通过调节大鼠血清代谢组学改善疼痛。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 Epub Date: 2025-03-20 DOI: 10.3344/kjp.24355

Khadijeh Haghighat, Fariba Mahmoudi, Maryam Khoshkam, Homayoun Khazali

{"title":"Chrysin ameliorates pain through regulation of the serum metabolomics in the rats.","authors":"Khadijeh Haghighat, Fariba Mahmoudi, Maryam Khoshkam, Homayoun Khazali","doi":"10.3344/kjp.24355","DOIUrl":"10.3344/kjp.24355","url":null,"abstract":"Background: Chrysin is a natural flavonoid that exhibits various pharmacological activities including pain relief. However, the effects of chrysin on changes of metabolic profiles during pain remain unclear. The aim of this study was to analyze the biomarkers related to pain in serum and to evaluate the analgesic properties of chrysin in a rat model of pain.Methods: Male Wister rats were divided into four groups (n = 5). Pain was induced by injecting 50 μL of formalin into the hind paw. Chrysin and diclofenac (10 mg/kg, intraperitoneal injection) was administered to the intact and pain groups. All injections were given 30 minutes before pain induction. Immediately, the behavioral test was performed. Then the serum sample was separated for 1HNMR-based metabolite analysis.Results: Chrysin treatment alleviated the paw licking events, flinching response, and pain score. The integrated analyses further revealed three major metabolic changes including glycine-serine-threonine, taurine-hypotaurine, and arginine by comparing the serums from intact operated rats, pain rats, and pain rats treated with chrysin, and suggested that chrysin may improve pain by regulating the biosynthesis of these metabolic pathways.Conclusions: These findings provide insights into metabolic pathways involved in pain and the analgesic effects of chrysin and may help to identify potential targets for the anti-pain properties of chrysin.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"128-137"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nociplastic pain: conceptual and terminological considerations. 伤害性疼痛：概念和术语的考虑。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 DOI: 10.3344/kjp.25104

Kyung Hoon Kim

引用次数: 0

Physicochemical stability of mixtures of non-steroidal anti-inflammatory drugs such as ketorolac and diclofenac and antiemetics such as ondansetron and ramosetron: an in vitro study. 非甾体抗炎药如酮咯酸和双氯芬酸与止吐药如昂丹司琼和雷莫司琼混合物的物理化学稳定性：一项体外研究。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 DOI: 10.3344/kjp.24316

Chung Hun Lee

{"title":"Physicochemical stability of mixtures of non-steroidal anti-inflammatory drugs such as ketorolac and diclofenac and antiemetics such as ondansetron and ramosetron: an in vitro study.","authors":"Chung Hun Lee","doi":"10.3344/kjp.24316","DOIUrl":"10.3344/kjp.24316","url":null,"abstract":"Background: Drugs administered intravenously during the postoperative period can mix before entering the bloodstream. This study assessed the stability of mixtures of non-steroidal anti-inflammatory drugs (ketorolac and diclofenac) and antiemetics (ondansetron and ramosetron) to determine their suitability for concurrent administration.Methods: Ketorolac or diclofenac was combined with ondansetron or ramosetron at a 1:1 volume ratio. Each mixture was stored in a propylene syringe at 24°C for 2 hours. The mixtures were assessed visually, and the pH was measured. Additionally, the drug concentrations were determined using high-performance liquid chromatography (HPLC).Results: Mixtures of ketorolac or diclofenac and ramosetron showed no crystal formation or pH changes, and HPLC analysis confirmed that the drug concentrations remained stable. In contrast, mixtures of ketorolac or diclofenac and ondansetron exhibited the visible formation of 10-50 μm crystals under a microscope. However, there were no changes in the pH levels, and HPLC analysis indicated that the drug concentrations remained stable for both the mixtures.Conclusions: Mixtures of ketorolac or diclofenac and ramosetron demonstrated physical and chemical stability for up to 2 hours, indicating that their concurrent use is feasible. Conversely, mixtures of ketorolac or diclofenac and ondansetron should be avoided due to the formation of crystals, even though the concentration of each drug remained stable.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"38 2","pages":"103-115"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leave me alone! When does social support become a menace to pain management? 别烦我！什么时候社会支持成为疼痛管理的威胁？

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 DOI: 10.3344/kjp.24299

Dalmacito Cordero

引用次数: 0

Neuroplasticity in chronic pain: insights into diagnosis and treatment. 慢性疼痛的神经可塑性：诊断和治疗的见解。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 DOI: 10.3344/kjp.24393

Sahar M Jaffal

{"title":"Neuroplasticity in chronic pain: insights into diagnosis and treatment.","authors":"Sahar M Jaffal","doi":"10.3344/kjp.24393","DOIUrl":"10.3344/kjp.24393","url":null,"abstract":"Chronic pain is a universal problem that directly evolves the central nervous system, altering both its structure and function. This review discusses neuroplastic alterations in critical areas in the brain like the anterior cingulate cortex, insula, prefrontal cortex, primary (S1) and secondary (S2) somatosensory cortices, and thalamus. These regions exhibit gray matter decrease and changes in connectivity during chronic pain. Several cortical networks, mainly the central executive network, the default mode network, and the salience network exhibit neuroplasticity which reallocates cognitive and emotional resources to pain processing. Thus, it was reported that sensitivity to pain enhances emotional suffering, indicating that altered connectivity and functional reorganization of these networks support maladaptive pain processing and underpin chronic pain persistence. Neuroplasticity-focused treatments such as brain stimulation, neuro-feedback, and exercise-based therapies constitute potential interventions for preventing such negative changes. Further, innovative neuroimaging biomarkers are effective in demonstrating precise neural changes and in providing information about the diagnosis of chronic pain syndromes. This review highlights neuro-plastic changes in chronically painful patients and acknowledges the brain's plasticity as a target for chronic pain treatment. It, also, points to the diagnostic strategies and practical interventions that address these alterations.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":"38 2","pages":"89-102"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The analgesic and anti-inflammatory effects of a combined preparation based on the blunt-nosed viper's venom and oregano essential oil. 基于钝鼻毒蛇毒液和牛至精油的联合制剂的镇痛和抗炎作用。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 Epub Date: 2025-03-26 DOI: 10.3344/kjp.24301

Lilya Mushegh Parsghyan, Armenuhi Vachagan Moghrovyan, Sona Samvel Poghosyan, Milena Ashot Babajanyan, Monica Armen Gaboyan, Armen Vaghinak Voskanyan, Anna Ashot Darbinyan

{"title":"The analgesic and anti-inflammatory effects of a combined preparation based on the blunt-nosed viper's venom and oregano essential oil.","authors":"Lilya Mushegh Parsghyan, Armenuhi Vachagan Moghrovyan, Sona Samvel Poghosyan, Milena Ashot Babajanyan, Monica Armen Gaboyan, Armen Vaghinak Voskanyan, Anna Ashot Darbinyan","doi":"10.3344/kjp.24301","DOIUrl":"10.3344/kjp.24301","url":null,"abstract":"Background: To relieve acute and inflammatory pain, preparations of plant and animal origin have been used. The present work aimed to study the analgesic and anti-inflammatory effectiveness of a combined preparation based on viper venom and essential oil. Determining effective routes of exposure, optimal doses, the duration of action of the preparation, and possible mechanisms of their action were the areas of interest.Methods: Experiments were carried out on murine. Essential oil content was determined by gas chromatography-mass spectrometry equipment. The formalin, carrageenan, and hot plate tests were used. Certain methods for determining side effects were used as well. To determine the participation of cannabinoid and opioid receptors in the antinociceptive action of combined preparation, SR144528 and naloxone were used.Results: The treatment of the ointment version of the preparation reduced inflammatory pain by more than 68% and decreased the volume of inflammatory edema by up to 36%. The involvement of cannabinoid receptors in the analgesic mechanism of the ointment was approximately 73%, and, for the opioid receptors, about 64%. Physiologically significant side effects were not observed.Conclusions: The active components of the ointment are principally different in their mechanism of action and make it possible to relieve pain and inflammation both through the blockade of pain receptors of afferent nociceptive neurons (venom) as well as via cannabinoid and opioid receptors (essential oil).","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"163-176"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of ultrasound-guided superior trunk block versus clavipectoral fascial plane block for clavicular surgery: a double-blind, randomized controlled trial. 超声引导下上干阻滞与锁骨筋膜平面阻滞在锁骨手术中的比较：一项双盲、随机对照试验。

IF 3.4 3区医学

Korean Journal of Pain Pub Date : 2025-04-01 Epub Date: 2025-03-20 DOI: 10.3344/kjp.24343

Mohamed Gaber Mohamed, Ahmed Mohammad Fahmy, Marwa Mohamed Medhat

{"title":"Comparison of ultrasound-guided superior trunk block versus clavipectoral fascial plane block for clavicular surgery: a double-blind, randomized controlled trial.","authors":"Mohamed Gaber Mohamed, Ahmed Mohammad Fahmy, Marwa Mohamed Medhat","doi":"10.3344/kjp.24343","DOIUrl":"10.3344/kjp.24343","url":null,"abstract":"Background: This study compared the quality and duration of analgesia between the superior trunk (ST) and the clavipectoral fascial plane (CFP) blocks in conjunction with a selective supraclavicular nerve (SCN) block for clavicular surgeries.Methods: Fifty patients undergoing mid-third clavicular procedures were randomly assigned to the ST group (received an SCN block followed by blockage of the ST of the brachial plexus) and the CFP group (received an SCN block followed by the CFP block). The primary outcome was the time until the first rescue analgesia. Secondary outcomes included total nalbuphine dosage and numerical rating scale (NRS) scores within the first 24 hours, the onset of sensory block, as well as deltoid and biceps muscle function using the modified Bromage score (MBS), diaphragmatic excursion, along with satisfaction levels.Results: The ST group exhibited a more prolonged duration until the first request for rescue analgesia compared to the CFP group (18.76 ± 0.89 hours vs. 15.34 ± 1.38 hours), with a mean difference of 3.42 hours (95% confidence interval: 2.76 to 4.08, P < 0.001). The ST group consumed less nalbuphine and reported lower NRS scores at 6, 8, 12, 16, and 24 hours than the CFP group. Additionally, the ST group exhibited a lower MBS and diaphragmatic excursion than the CFP group. However, the differences in the onset of sensory block and satisfaction levels were not statistically significant.Conclusions: The ST group demonstrated superior outcomes in pain control with less favorable outcomes concerning diaphragmatic excursion and upper limb motor function.","PeriodicalId":56252,"journal":{"name":"Korean Journal of Pain","volume":" ","pages":"198-206"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0