Canadian Journal of Neurological Sciences最新文献_第5页

Contrast-Induced Encephalopathy and the Blood-Brain Barrier. 造影剂诱发脑病与血脑屏障

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-01-01 Epub Date: 2024-03-08 DOI: 10.1017/cjn.2024.38

Mark A Maclean, Patrick S Rogers, Jamil H Muradov, Gwynedd E Pickett, Alon Friedman, Adrienne Weeks, Ryan Greene, David Volders

{"title":"Contrast-Induced Encephalopathy and the Blood-Brain Barrier.","authors":"Mark A Maclean, Patrick S Rogers, Jamil H Muradov, Gwynedd E Pickett, Alon Friedman, Adrienne Weeks, Ryan Greene, David Volders","doi":"10.1017/cjn.2024.38","DOIUrl":"10.1017/cjn.2024.38","url":null,"abstract":"Background: Contrast-induced encephalopathy (CIE) is an adverse event associated with diagnostic and therapeutic endovascular procedures. Decades of animal and human research support a mechanistic role for pathological blood-brain barrier dysfunction (BBBd). Here, we describe an institutional case series and review the literature supporting a mechanistic role for BBBd in CIE.Methods: A literature review was conducted by searching MEDLINE, Web of Science, Embase, CINAHL and Cochrane databases from inception to January 31, 2022. We searched our institutional neurovascular database for cases of CIE following endovascular treatment of cerebrovascular disease during a 6-month period. Informed consent was obtained in all cases.Results: Review of the literature revealed risk factors for BBBd and CIE, including microvascular disease, pathological neuroinflammation, severe procedural hypertension, iodinated contrast load and altered cerebral blood flow dynamics. In our institutional series, 6 of 52 (11.5%) of patients undergoing therapeutic neuroendovascular procedures developed CIE during the study period. Four patients were treated for ischemic stroke and two patients for recurrent cerebral aneurysms. Mechanical stenting or thrombectomy were utilized in all cases.Conclusion: In this institutional case series and literature review of animal and human data, we identified numerous shared risk factors for CIE and BBBd, including microvascular disease, increased procedure length, large contrast volumes, severe intraoperative hypertension and use of mechanical devices that may induce iatrogenic endothelial injury.","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"85-94"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140061381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PET Imaging in Dementia: Mini-Review and Canadian Perspective for Clinical Use. 痴呆症的 PET 成像：微型综述和加拿大的临床应用前景。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-01-01 Epub Date: 2024-03-04 DOI: 10.1017/cjn.2024.31

Freimut Juengling, Frank Wuest, Ralf Schirrmacher, Jonathan Abele, Alexander Thiel, Jean-Paul Soucy, Richard Camicioli, Valentina Garibotto

{"title":"PET Imaging in Dementia: Mini-Review and Canadian Perspective for Clinical Use.","authors":"Freimut Juengling, Frank Wuest, Ralf Schirrmacher, Jonathan Abele, Alexander Thiel, Jean-Paul Soucy, Richard Camicioli, Valentina Garibotto","doi":"10.1017/cjn.2024.31","DOIUrl":"10.1017/cjn.2024.31","url":null,"abstract":"PET imaging is increasingly recognized as an important diagnostic tool to investigate patients with cognitive disturbances of possible neurodegenerative origin. PET with 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG), assessing glucose metabolism, provides a measure of neurodegeneration and allows a precise differential diagnosis among the most common neurodegenerative diseases, such as Alzheimer's disease, frontotemporal dementia or dementia with Lewy bodies. PET tracers specific for the pathological deposits characteristic of different neurodegenerative processes, namely amyloid and tau deposits typical of Alzheimer's Disease, allow the visualization of these aggregates in vivo. [18F]FDG and amyloid PET imaging have reached a high level of clinical validity and are since 2022 investigations that can be offered to patients in standard clinical care in most of Canada.This article will briefly review and summarize the current knowledge on these diagnostic tools, their integration into diagnostic algorithms as well as perspectives for future developments.","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"26-38"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140023484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disparities In Drug-Resistant Epilepsy Care In Canada. 加拿大抗药性癫痫护理中的差异。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-01-01 Epub Date: 2024-04-11 DOI: 10.1017/cjn.2024.57

R Grace Couper, Tresah Antaya, Dang K Nguyen, Jorge G Burneo

引用次数: 0

Colpocephaly and Partial Agenesis of Corpus Callosum with High Neurodegenerative Marker Levels. 无头畸形和胼胝体部分缺失，神经退行性标志物水平较高。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-01-01 Epub Date: 2024-03-01 DOI: 10.1017/cjn.2024.22

Abrar Ahmed, Simrika Thapa, Anna Vasilevskaya, Paula Alcaide-Leon, Maria Carmela Tartaglia

引用次数: 0

Carotid Stenosis and Stroke: Historical Perspectives Leading to Current Challenges. 颈动脉狭窄与中风：从历史角度看当前面临的挑战。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-01-01 Epub Date: 2024-03-11 DOI: 10.1017/cjn.2024.40

David M Pelz, Allan J Fox, J David Spence, Stephen P Lownie

引用次数: 0

Does Self-Reported BMI Modify the Association Between Stroke and Depressive Symptoms? 自我报告的体重指数是否会改变中风与抑郁症状之间的关联？

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-01-01 Epub Date: 2024-03-25 DOI: 10.1017/cjn.2024.41

Shakila Meshkat, Vanessa K Tassone, Michelle Wu, Sophie F Duffy, Josheil K Boparai, Hyejung Jung, Wendy Lou, Manav V Vyas, Venkat Bhat

{"title":"Does Self-Reported BMI Modify the Association Between Stroke and Depressive Symptoms?","authors":"Shakila Meshkat, Vanessa K Tassone, Michelle Wu, Sophie F Duffy, Josheil K Boparai, Hyejung Jung, Wendy Lou, Manav V Vyas, Venkat Bhat","doi":"10.1017/cjn.2024.41","DOIUrl":"10.1017/cjn.2024.41","url":null,"abstract":"Background: Depressive symptoms are common in stroke survivors. While obesity has been associated with stroke and depression, its influence on the association between stroke and depressive symptoms is unknown.Methods: Cross-sectional data from 2015 to 2016 Canadian Community Health Survey was used. History of stroke was self-reported and our outcome of interest was depressive symptoms in the prior 2 weeks, measured using the 9-item Patient Health Questionnaire. Self-reported body mass index (BMI) was modeled as cubic spline terms to allow for nonlinear associations. We used multivariable logistic regression to evaluate the association between stroke and depressive symptoms and added an interaction term to evaluate the modifying effect of BMI.Results: Of the 47,521 participants, 694 (1.0%) had a stroke and 3314 (6.5%) had depressive symptoms. Those with stroke had a higher odds of depressive symptoms than those without (aOR = 3.13, 95% CI 2.48, 3.93). BMI did not modify the stroke-depressive symptoms association (P interaction = 0.242) despite the observed variation in stroke-depressive symptoms association across BMI categories,: normal BMI [18.5-25 kg/m2] (aOR† = 3.91, 95% CI 2.45, 6.11), overweight [25-30 kg/m2] (aOR† = 2.63, 95% CI 1.58, 4.20), and obese [>30 kg/m2] (aOR† = 2.76, 95% CI 1.92, 3.94). Similar results were found when depressive symptoms were modeled as a continuous measure.Conclusion: The association between stroke and depressive symptoms is not modified by BMI, needing additional work to understand the role of obesity on depression after stroke.","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"68-74"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140208366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Botulinum Toxin Injection of the Flexor Digitorum Profundus: Are We Forgetting Something? 肉毒杆菌毒素注射深屈肌：我们是否遗忘了什么？

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-01-01 Epub Date: 2024-04-24 DOI: 10.1017/cjn.2024.59

Ahmad J Abdulsalam, Murat Kara, Bayram Kaymak

引用次数: 0

Migraine Association with Alzheimer's Disease Risk: Evidence from the UK Biobank Cohort Study and Mendelian Randomization. 偏头痛与阿尔茨海默病风险的关系：英国生物库队列研究和孟德尔随机化的证据。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-01-01 Epub Date: 2024-03-13 DOI: 10.1017/cjn.2024.35

Chaofan Geng, Chen Chen

{"title":"Migraine Association with Alzheimer's Disease Risk: Evidence from the UK Biobank Cohort Study and Mendelian Randomization.","authors":"Chaofan Geng, Chen Chen","doi":"10.1017/cjn.2024.35","DOIUrl":"10.1017/cjn.2024.35","url":null,"abstract":"Background: Epidemiological studies on the association between migraine and Alzheimer's disease (AD) risk have yielded inconsistent conclusions. We aimed to characterize the phenotypic and genetic relationships between migraine and AD.Methods: To investigate the association between migraine and the risk of AD by analyzing data from a large sample of 404,318 individuals who were initially free from all-cause dementia or cognitive impairment, utilizing the UK Biobank dataset. We employed Cox regression modeling and propensity score matching techniques to examine the relationship between migraine and subsequent occurrences of AD. Additionally, the study utilized Mendelian randomization (MR) analysis to identify the genetic relationship between migraine and the risk of AD.Results: Migraine patients had a significantly increased risk of developing AD, compared to non-migraine patients (adjusted hazard ratio (HR) = 2.34, 95% confidence interval (CI) = 2.01-0.74, P < 0.001). Moreover, the propensity scores matching analyses found that migraine patients had a significantly higher risk of developing AD compared to non-migraine patients (HR = 1.85, 95%CI = 1,68-2.05, P < 0.001). Additionally, the MR suggested that significant causal effects of migraine on AD risks were observed [odds ratio (OR) = 2.315; 95% confidence interval (CI) = 1.029-5.234; P = 0.002]. Moreover, no evidence supported the causal effects of AD on migraine (OR = 1.000; 95%CI = 0.999-1.006; P = 0.971).Conclusion: The present study concludes that migraine patients, compared to a matched control group, exhibit an increased risk of developing AD. Moreover, migraine patients exhibit an increased predisposition of genetic susceptibility to AD. These findings hold significant clinical value for early intervention and treatment of migraines to reduce the risk of AD.","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"44-52"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140112312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frontal Lobe Status Epilepticus Related to CAR T-Cell Therapy Responsive to Anakinra. 对 Anakinra 有反应的 CAR T 细胞疗法相关额叶状态癫痫。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-01-01 Epub Date: 2024-01-18 DOI: 10.1017/cjn.2024.7

Umberto Pensato, Chiara de Philippis, Daniele Mannina, Daniela Taurino, Barbara Sarina, Jacopo Mariotti, Federico Villa, Elena Costantini, Simona Marcheselli, Stefania Bramanti

引用次数: 0

Limb Temperature in Parkinson's Disease: Is It Symmetric? 帕金森病患者的肢体温度：是否对称？

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-01-01 Epub Date: 2024-02-01 DOI: 10.1017/cjn.2024.9

Rebecca George, Kimberley P Good, Heather Rigby

引用次数: 0