Canadian Journal of Neurological Sciences最新文献

{"title":"Watch and Wait: Successful Conservative Management for a Traumatic Dural Defect at the Cervicomedullary Junction.","authors":"Matthew Redmond, Amparo Wolf, Stuart McGregor","doi":"10.1017/cjn.2025.10406","DOIUrl":"https://doi.org/10.1017/cjn.2025.10406","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-7"},"PeriodicalIF":2.2,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reframing Headache Education: A Call for Simulation-Based Headache Training.","authors":"Emilia Parsi","doi":"10.1017/cjn.2025.10393","DOIUrl":"10.1017/cjn.2025.10393","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1"},"PeriodicalIF":2.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive predictive value of CSF biomarker testing for a clinical diagnosis of Alzheimer's disease.","authors":"Adrian Budhram, Angela C Rutledge, Kamala Sangam, Stephen Pasternak, Elizabeth Finger, Michael J Borrie, Jaspreet Bhangu","doi":"10.1017/cjn.2025.10395","DOIUrl":"https://doi.org/10.1017/cjn.2025.10395","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-10"},"PeriodicalIF":2.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Susceptibility-Weighted Imaging: Another Technique to Unveil an Arteriovenous Shunt.","authors":"Mariana Duarte Gomes, Rita Coutinho, João Saraiva, Ângelo Carneiro, Miguel Quintas-Neves","doi":"10.1017/cjn.2025.10394","DOIUrl":"10.1017/cjn.2025.10394","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-2"},"PeriodicalIF":2.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lost and Found: A Brain Abscess and the Hidden Thumbtack.","authors":"Seunghun Lee, Farraminah Francis, Sarah Almas, Karina Top, Trina Rosaasen, Cameron Alistair Elliott","doi":"10.1017/cjn.2025.10396","DOIUrl":"10.1017/cjn.2025.10396","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-3"},"PeriodicalIF":2.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Progressive Painful Bilateral Medial Medullary Stroke Syndrome Accompanied by an Evolving and Ominous Air-Pod Sign.","authors":"Ryan T Muir, Madawi Ismail, Philippe Couillard, Julie Anne Kromm, Kathleen Jacobs, Muneer Eesa, Peter K Stys","doi":"10.1017/cjn.2025.10345","DOIUrl":"10.1017/cjn.2025.10345","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-3"},"PeriodicalIF":2.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Face, Content, Construct and Convergent Validity of a Surgical Spine Simulator for Pedicle Screw Insertions.","authors":"Trisha Tee, Noel Abboud, Bilal Tarabay, Abdulmajeed Albeloushi, Puja Pachchigar, Mohamed Alhantoobi, Nour Abou Hamdan, Recai Yilmaz, Ali Fazlollahi, Rolando F Del Maestro","doi":"10.1017/cjn.2025.10404","DOIUrl":"10.1017/cjn.2025.10404","url":null,"abstract":"<p><strong>Background: </strong>Spine simulators offer learners risk-free environments to develop psychomotor skills for pedicle screw insertions. The virtual reality TSYM simulator deconstructs and simulates pedicle screw insertions. This case series study investigates face, content, construct, and convergent validity of an L4-L5 bilateral pedicle screw insertion on the TSYM simulator.</p><p><strong>Methods: </strong>Neurosurgical-orthopedic residents, fellows, and spine surgeons performed an L4-L5 bilateral pedicle screw insertion on the TSYM simulator. Participants were classified a priori into skilled (postgraduate year (PGY) 5-6, fellows, and consultant neurosurgeons or orthopedic surgeons) or less skilled (PGY 1-4) groups. Face and content validity were assessed utilizing a 7-point Likert scale. Construct validity was determined by investigating group differences in simulation-derived performance metrics and the Objective Structured Assessment of Technical Skills (OSATS) ratings. Convergent validity was examined by correlating simulation-derived performance metrics and OSATS ratings.</p><p><strong>Results: </strong>Thirteen skilled and 14 less skilled participants were included in this study. Eight of nine face and content validity statements were rated a median ≥ 4. Significant differences between the groups were found for four simulation-derived performance metrics (<i>P</i> < 0.05) and all OSATS categories (<i>P</i> < 0.001). Three simulation-derived performance metrics (maximum force and tool contact using the simulated screwdriver and three-dimensional velocity using the tap) significantly correlated with OSATS ratings.</p><p><strong>Conclusion: </strong>The L4-L5 bilateral pedicle screw insertion simulation on the TSYM platform demonstrated mixed and variable evidence for face, content, construct and convergent validity, supporting its educational potential for spine surgery training, but improvements are needed to optimize learning.</p>","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-10"},"PeriodicalIF":2.2,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updated Canadian Headache Society Migraine Prevention Guideline with Systematic Review and Meta-analysis - CORRIGENDUM.","authors":"Ioana Medrea, Paul Cooper, Ana Marissa Lagman-Bartolome, Claire H Sandoe, Farnaz Amoozegar, Wasif M Hussain, Ana C Bradi, Jessica Dawe, Meagan Guay, Francois Perreault, Stuart Reid, Candice Todd, Becky Skidmore, Suzanne N Christie","doi":"10.1017/cjn.2025.10381","DOIUrl":"https://doi.org/10.1017/cjn.2025.10381","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1"},"PeriodicalIF":2.2,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Microbiota and Short-Chain Fatty Acid Profiles in Facioscapulohumeral Dystrophy: Associations with Epigenetic Alterations.","authors":"Ceren Hangul, Ozlem Koyuncu Ozyurt, Simone Baldi, Dilek Colak, Oznur Tokta, Toygar Pekcan, Sara Bertorello, Marco Pallecchi, Filiz Koc, Cumali Dalokay, Hilmi Uysal, Kemal Hakan Gulkesen, Filiz Ozcan, Gianluca Bartolucci, Sibel Berker Karauzum, Amedeo Amedei","doi":"10.1017/cjn.2025.10388","DOIUrl":"10.1017/cjn.2025.10388","url":null,"abstract":"<p><strong>Background: </strong>Gut microbiota (GM) affects muscle homeostasis, and growing evidence indicates dysbiosis of GM may be a contributing factor in the pathogenesis of dystrophies. Furthermore, GM metabolites can interact with DNA methylation. Facioscapulohumeral muscular dystrophy (FSHD) is the second common dystrophy with hypomethylation of DR1 and 5P regions of D4Z4 repeat on 4qter.</p><p><strong>Objective: </strong>Considering alteration of GM may be a contributing factor, we investigated (i) GM alterations and (ii) the correlation of microbial-derived free fatty acids (FFAs) with methylation of DR1 and 5P regions in FSHD.</p><p><strong>Methods: </strong>Twenty-eight FSHD patients and 28 gender-age-matched controls were included. GM characterisation was performed through 16S-rRNA sequencing. Methylation levels of DR1 and 5P regions were assessed by bisulphite sequencing. Faecal and circulating FFAs including short-chain fatty acids (SCFAs), medium-chain fatty acids (MCFAs) and long-chain fatty acids (LCFAs) were analysed with gas chromatography-mass spectrometry.</p><p><strong>Results: </strong>Altered GM was observed in patients, along with distinct profiles of <i>faecal</i> and <i>circulating</i> SCFAs, MCFAs and LCFAs. DR1 and 5P regions exhibited significant hypomethylation in FSHD compared to control. Hypomethylation correlated with <i>faecal and circulating</i> FFAs in patients, while no correlation was identified in healthy controls. The severely affected patients exhibited a notable increase in the prevalence of Pasteurellaceae, while the FFA profile was similar among mild and severely affected patients. This is the first study revealing that FSHD patients showed compositional and functional GM dysbiosis. A strong association between proximal D4Z4 hypomethylation with microbial-derived SCFAs was identified.</p><p><strong>Conclusion: </strong>These findings suggest that GM modulation with its metabolites could be a promising strategy for interventions in FSHD management.</p>","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-12"},"PeriodicalIF":2.2,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Representation in Brain Imaging Research: A Quebec Demographic Overview.","authors":"Olujide Oyeniran, Tudor Sintu, Udunna Anazodo, Benjamin De Leener, Eva Alonso-Ortiz","doi":"10.1017/cjn.2025.10387","DOIUrl":"10.1017/cjn.2025.10387","url":null,"abstract":"<p><p>Neuroimaging research must reflect the diversity of the populations it aims to serve. This scoping review examines the demographic characteristics (age, sex, race and ethnicity, and geographic representation) of participants in brain MRI and positron-emission tomography studies conducted in Quebec, Canada, between 1992 and 2023. A total of 1,549 studies, representing 62,555 participants, were identified through searches of Medline, Embase and Google Scholar, following JBI methodology. The vast majority of studies (92.7%) were conducted in Montreal, with limited representation from other urban centers and almost none from rural areas. Reporting of demographic variables was inconsistent: 22.1% of studies failed to report participant age adequately, and 20.3% did not fully report sex. Race and ethnicity were the most poorly documented, with fewer than 4% of studies reporting this information. Among the 2,396 participants with recorded race and ethnicity, 94.2% were categorized as White, highlighting a significant mismatch with Quebec's population diversity. Healthy participant samples were largely concentrated in the 20-35 age range, while clinical populations generally aligned with the expected age of disease onset. These findings reveal major gaps in demographic representation and reporting in Quebec-based neuroimaging research. Improving diversity and transparency is essential to ensure that neuroimaging findings are generalizable, equitable and clinically meaningful. We recommend the adoption of standardized demographic reporting formats, such as the Brain Imaging Data Structure, and broader recruitment efforts to capture underrepresented groups, including rural residents and racial and ethnic minorities.</p>","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-11"},"PeriodicalIF":2.2,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}