Canadian Journal of Neurological Sciences最新文献

{"title":"Movement Disorders in Central Nervous System Tuberculosis: A Systematic Review.","authors":"Ravindra Kumar Garg, Shweta Pandey, Raza Abbas Mahdi, Sanjay Singhal","doi":"10.1017/cjn.2025.10436","DOIUrl":"https://doi.org/10.1017/cjn.2025.10436","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-49"},"PeriodicalIF":2.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Myelopathy: Relieving Headache in Cervical Cord Lesions.","authors":"Jihad Yaqoob Ali Al Kharbooshi, Tommy Lik Hang Chan","doi":"10.1017/cjn.2025.10435","DOIUrl":"https://doi.org/10.1017/cjn.2025.10435","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-7"},"PeriodicalIF":2.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practice patterns of Canadian neurosurgeons in laparoscopic-assisted placement of ventriculoperitoneal shunts.","authors":"J M Heppner, B Ajlan, S Hart, M Ragulojan, M A Rizzuto, A Mastrolonardo, N Coote, M M Chow, M J Kim","doi":"10.1017/cjn.2025.10433","DOIUrl":"https://doi.org/10.1017/cjn.2025.10433","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-17"},"PeriodicalIF":2.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors and Outcomes of ASPECTS decay during inter-facility transfers in patients with large vessel occlusion.","authors":"Anas Alrohimi, Noman Ishaque, Amy Wagner, Thomas Jeerakathil, Brian Buck, Ashfaq Shuaib, Michael D Hill, Mohammed Almekhlafi, Sachin Mishra","doi":"10.1017/cjn.2025.10421","DOIUrl":"https://doi.org/10.1017/cjn.2025.10421","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-18"},"PeriodicalIF":2.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prodromal Association of Non-Motor Symptomatology in Adults With Neurodegenerative Diseases.","authors":"Leonel Villa-Villegas, Katia Carmina Farías-Moreno, Biagio David González-Ruffino, Carlos Zúñiga-Ramírez","doi":"10.1017/cjn.2025.10390","DOIUrl":"10.1017/cjn.2025.10390","url":null,"abstract":"<p><strong>Background: </strong>Early diagnosis of neurodegenerative diseases (NDs) is a priority with the advent of disease-modifying therapies. The study of prodromal non-motor symptoms (NMS) in ND could help guide early diagnosis, facilitating adequate treatment. The primary objective of this study was to determine the prodromal association between NMS and ND.</p><p><strong>Methods: </strong>A retrospective cohort study was planned. Records of subjects attending the movement disorders and NDs unit from Hospital Civil de Guadalajara \"Fray Antonio Alcalde,\" from 2012 to January 2025, were evaluated. Subjects with NMSQuest questionnaire in ND were included. Descriptive and inferential parametric statistics (Student's <i>t</i>-test for independent samples and ANOVA) were used, and odds ratios (OD) with 95% confidence interval were calculated using binary logistic regression. A <i>p</i> value < 0.05 was considered significant.</p><p><strong>Results: </strong>The most frequent prodromal NMS in ND were depression, constipation, insomnia, anxiety and pain. There was an average of 7.7 ± 7.6 years of prodromal NMS prior to the diagnosis of ND. Prodromal depression [OR 1.9 (1.1-3.5 <i>p</i> < 0.001) and confusion/delusional thoughts [OR 7.2 (1.3-39.2) <i>p</i> = 0.02] were associated with dementia (time onset prior to diagnosis 9.9 ± 12.2 and 5.5 ± 9.7 years, respectively). Prodromal restless legs syndrome was associated with movement disorders [OR 3.3 (1.1-9.7) <i>p</i> = 0.02] (time onset 4.7 ± 6.9 years prior to diagnosis).</p><p><strong>Conclusion: </strong>Evidence points to a potential association of prodromal NMS in ND. Prospective studies are required to confirm and characterize the association between prodromal NMS and ND, as their early identification may contribute to the timely diagnosis of ND.</p>","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-7"},"PeriodicalIF":2.2,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of Subcutaneous Immunoglobulin therapy as the Maintenance Therapy in Patients with Autoimmune Neuromuscular Disease - A Prospective Study.","authors":"Faraz S Hussain, Zaeem A Siddiqi","doi":"10.1017/cjn.2025.10428","DOIUrl":"https://doi.org/10.1017/cjn.2025.10428","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-9"},"PeriodicalIF":2.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease Modifying Therapies in Amyotrophic Lateral Sclerosis: A Network Meta-Analysis of Randomized Clinical Trials.","authors":"Mario B Prado, Karen Joy Adiao","doi":"10.1017/cjn.2025.10429","DOIUrl":"https://doi.org/10.1017/cjn.2025.10429","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-34"},"PeriodicalIF":2.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting 1-year stroke recurrence and mortality in stable outpatients following ischemic stroke and transient ischemic attack.","authors":"Alisia Southwell, Anne Marie Liddy, Anna Chu, Bing Yu, Jiming Fang, Susan E Bronskill, Moira K Kapral, Peter C Austin, Lusine Abrahamyan, Richard H Swartz","doi":"10.1017/cjn.2025.10405","DOIUrl":"https://doi.org/10.1017/cjn.2025.10405","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-20"},"PeriodicalIF":2.2,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropathic arthropathy of the shoulder secondary to syringomyelia.","authors":"Jordi Pérez-Bovet","doi":"10.1017/cjn.2025.10427","DOIUrl":"https://doi.org/10.1017/cjn.2025.10427","url":null,"abstract":"","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-2"},"PeriodicalIF":2.2,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefits of First Pass Recanalization by Initial Infarct Burden for Basilar Artery Strokes.","authors":"Maria Fahmy, Vincent Brissette, Danielle Roy, Joyce Beshara, Cyril Dargazanli, Isabelle Mourand, Mehdi Mahmoudi, Julien Labreuche, David Weisenburger-Lile, Benjamin Gory, Sébastien Richard, Célina Ducroux, Michel Piotin, Raphaël Blanc, Ludovic Lucas, Gaultier Marnat, Mathilde Aubertin, Caroline Arquizan, Romain Bourcier, Lili Detraz, Stéphane Vannier, Maud Guillen, François Eugene, Arturo Consoli, Vincent Costalat, Bertrand Lapergue, Benjamin Maïer, Adrien Guenego, Dar Dowlatshahi, Michel Shamy, Robert Fahed","doi":"10.1017/cjn.2025.10425","DOIUrl":"10.1017/cjn.2025.10425","url":null,"abstract":"<p><strong>Background and aims: </strong>Achieving a first pass recanalization (FPR) improves clinical outcomes in patients with basilar artery strokes, but its association with initial infarct burden is unknown. We aimed to study the benefits of FPR for basilar artery strokes by initial infarct burden using the Posterior Circulation Alberta Stroke Program Early CT score (pc-ASPECTS).</p><p><strong>Methods: </strong>We retrospectively analyzed the prospective multicentric Endovascular Treatment of Ischemic Stroke registry and included 194 patients diagnosed with an acute basilar artery occlusion who were treated with thrombectomy. Our primary outcome was a modified Rankin Scale (mRS) of 0-3 at 90 days, and our secondary outcomes were an mRS of 4-6 and mortality. We compared the 90-day clinical outcomes of achieving an FPR versus multiple thrombectomy passes based on patients' initial infarct size on pretreatment MRI: small (pc-ASPECTS = 9-10), medium (pc-ASPECTS = 6-8) and large (pc-ASPECTS <6).</p><p><strong>Results: </strong>Patients with a medium or large infarct size had significantly better outcomes (mRS 0-3 at 3 months) if FPR was achieved than if multiple passes were required (RR = 1.61, 95% CI: 1.16, 2.24; <i>p</i>-value = 0.005; and RR = 3.41, 95% CI: 1.54-7.57; <i>p</i>-value = 0.003, respectively). No similar difference was seen among patients with small infarcts. Achieving an FPR was also associated with a significantly lower mortality risk among patients with a moderate infarct size (RR = 0.36, 95% CI: 0.17-0.79; <i>p</i>-value = 0.010) but not with those with small or large infarcts.</p><p><strong>Conclusions: </strong>Achieving an FPR significantly improves clinical outcomes in acute stroke patients with basilar artery occlusions undergoing thrombectomy when their infarcts are medium or large. Ongoing research to develop surgical techniques to achieve FPR is crucial to improving patients' prognoses.</p>","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-7"},"PeriodicalIF":2.2,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}