Canadian Journal of Neurological Sciences最新文献_第4页

Left-Sided Neurological Symptoms and Negative Diffusion-Weighted MRI in Suspected Minor Stroke Patients. 疑似轻微脑卒中患者的左侧神经症状和阴性弥散加权MRI。

IF 2.2 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-06-27 DOI: 10.1017/cjn.2025.10125

Umberto Pensato, Nishita Singh, Raed A Joundi, Koji Tanaka, Andrew M William Penn, Kristine Votova, Maximilian Bibok, Robert Balshaw, Andrew M Demchuk, Michael D Hill, Shelagh B Coutts

{"title":"Left-Sided Neurological Symptoms and Negative Diffusion-Weighted MRI in Suspected Minor Stroke Patients.","authors":"Umberto Pensato, Nishita Singh, Raed A Joundi, Koji Tanaka, Andrew M William Penn, Kristine Votova, Maximilian Bibok, Robert Balshaw, Andrew M Demchuk, Michael D Hill, Shelagh B Coutts","doi":"10.1017/cjn.2025.10125","DOIUrl":"10.1017/cjn.2025.10125","url":null,"abstract":"Background: Historically, it has been proposed that functional neurological symptoms occur more frequently on the left side of the body due to a distinct body representation and emotional processing of the right hemisphere, yet objective imaging data to support this are lacking. We aimed to investigate whether patients with acute left-sided symptoms (right hemisphere) suspected of having a minor stroke are more likely to show negative diffusion-weighted imaging (DWI) compared to those with right-sided symptoms.Methods: Data are from the SpecTRA (Spectrometry for Transient Ischemic Attack Rapid Assessment) multicenter prospective cohort study conducted between 2013 and 2017. Patients with mild persistent unilateral hemiparesis and/or hemisensory symptoms (National Institute of Health Stroke Scale ≤ 3) and available DWI were included. The primary outcome was the proportion of patients with a negative DWI.Results: Of 1731 patients, 584 (30.8%) were included. Of these, 310 (53.1%) patients presented with left-sided symptoms and 274 (46.9%) with right-sided symptoms. Overall, 214 (36.6%) patients had a negative DWI, 126 (58.9%) with left-sided symptoms and 88 (41.1%) with right-sided symptoms: risk ratio (RR) 1.27 (95% CI = 1.02-1.57). Left-sided hemiparesis was associated with negative DWI (RR 1.42 [95% CI = 1.08-1.87]), while left-sided hemisensory symptoms were not (RR 1.11 [95% CI = 0.87-1.41]). There was no effect modification by age or sex on this association (Pinteraction 0.787 and 0.057, respectively).Conclusions: Unilateral left-sided neurological symptoms were more frequently associated with negative DWI compared to right-sided symptoms in suspected minor stroke patients. This observation is exploratory, as the final diagnosis in DWI-negative cases was not established.","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-6"},"PeriodicalIF":2.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and real-world effectiveness in the transition from Alteplase to Tenecteplase for stroke treatment. 卒中治疗从阿替普酶过渡到替奈替普酶的安全性和实际有效性。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-06-27 DOI: 10.1017/cjn.2025.10121

Mary-Lou Halabi, Jillian Stang, Bijoy K Menon, Brian H Buck, Christiane J McIntosh, Stephen B Wilton, Shelley Valaire, Balraj Mann, Lisa Collins, Colleen Taralson, Lindsay Beaulieu, Elaine Shand, Corinna Hartley, Chelsey Dalgleish, Anthony Nickonchuk, Shannon Erfle, Oje Imoukhuede, H Alejandro M Alzate, Katie Lin, Shelagh B Coutts, Thomas Jeerakathil, Ashfaq Shuaib, Andrew M Demchuk, Michael D Hill

引用次数: 0

Measuring migraine in Canada and the United States: An online survey of emergency room and smartphone application use. 测量加拿大和美国的偏头痛：一项关于急诊室和智能手机应用程序使用的在线调查。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-06-25 DOI: 10.1017/cjn.2025.10140

Andrea Portt, Christine Lay, Hong Chen, Erjia Ge, Peter Smith

引用次数: 0

Evaluating the Role of Post-Thrombectomy MRI in Predicting Functional Recovery in Basilar Artery Occlusion. 评价取栓后MRI在预测基底动脉闭塞患者功能恢复中的作用。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-06-24 DOI: 10.1017/cjn.2025.10347

Nahal Farhani, Marco Ayroso, Susan Alcock, Jai Shankar

引用次数: 0

Leptomeningeal Carcinomatosis from Triple-Negative Breast Cancer Presenting with Acute Bilateral Optic Neuropathy. 以急性双侧视神经病变为表现的三阴性乳腺癌轻脑膜癌。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-06-18 DOI: 10.1017/cjn.2025.10118

Arshia Eshtiaghi, Gary Yau, Rahul A Sharma, Edsel Ing, Matylda Machnowska, Arun Ne Sundaram

引用次数: 0

Primary Central Nervous System Melanoma with Bilateral Vestibular Lesions Mimicking Neurofibromatosis Type 2. 原发性中枢神经系统黑色素瘤伴双侧前庭病变，酷似2型神经纤维瘤病。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-06-16 DOI: 10.1017/cjn.2025.10343

Kenneth Ong, Celine Hounjet, Alexander D Rebchuk, Jeremy Kam, Nicolas Dea, Ian Mackenzie, Saba Vafaei-Nodeh, Ryojo Akagami, Steven Yip, Mostafa Fatehi

引用次数: 0

Using Titanium Clips to Close the Dura in Minimally Invasive Spinal Surgery: An Efficient and Easy-to-Use Technique. 微创脊柱手术中使用钛夹闭合硬脑膜：一种有效且易于使用的技术。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-06-16 DOI: 10.1017/cjn.2025.10344

Leonardo Olijnyk, Paul Kaseir, Tristan Brunette-Clément, Antoine Gennari, Daniel Shedid, Sung-Joo Yuh

引用次数: 0

First-Line Use of Higher-Efficacy Disease-Modifying Therapies in Multiple Sclerosis: Canadian Consensus Recommendations. 在多发性硬化症中一线使用更有效的疾病改善疗法：加拿大的共识建议。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-06-09 DOI: 10.1017/cjn.2025.10342

Mark S Freedman, Fraser Clift, Virginia Devonshire, François Émond, Catherine Larochelle, Michael C Levin, Heather MacLean, Sarah A Morrow, Alexandre Prat, Daniel Selchen, Penelope Smyth, Galina Vorobeychik

{"title":"First-Line Use of Higher-Efficacy Disease-Modifying Therapies in Multiple Sclerosis: Canadian Consensus Recommendations.","authors":"Mark S Freedman, Fraser Clift, Virginia Devonshire, François Émond, Catherine Larochelle, Michael C Levin, Heather MacLean, Sarah A Morrow, Alexandre Prat, Daniel Selchen, Penelope Smyth, Galina Vorobeychik","doi":"10.1017/cjn.2025.10342","DOIUrl":"10.1017/cjn.2025.10342","url":null,"abstract":"Multiple sclerosis (MS) is characterized by focal inflammatory activity in the central nervous system and a diffuse, compartmentalized inflammation that is the primary driver of neuroaxonal damage and worsening disability. It is now recognized that higher-efficacy disease-modifying therapies (HE-DMT) are often required to treat the complex neuropathological changes that occur during the disease course and improve long-term outcomes. The optimal use of HE-DMTs in practice was addressed by a Canadian panel of 12 MS experts who used the Delphi method to develop 27 consensus recommendations. The HE-DMTs that were considered were the monoclonal antibodies (natalizumab, ocrelizumab, ofatumumab) and the immune reconstitution agents (alemtuzumab, cladribine). The issues addressed included defining aggressive/severe disease, patient selection of the most appropriate candidates for HE-DMTs, baseline investigations and efficacy monitoring, defining suboptimal treatment response, use of serum neurofilament-light chain in evaluating treatment response, safety monitoring, aging and immunosenescence and when to consider de-escalating or discontinuing treatment. The goals of the consensus recommendations were to provide guidelines to clinicians on their use of HE-DMTs in practice and to improve long-term outcomes in persons with MS.","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-10"},"PeriodicalIF":2.9,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic review: mental health outcomes in Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy. 系统评价：格林-巴利综合征和慢性炎症性脱髓鞘多神经病变的心理健康结局。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-06-09 DOI: 10.1017/cjn.2025.10107

Cathy Meng Fei Li, Stanley Wong, Nicholas Fabiano, Carol Li, Matthew McShane, Alla Iansavitchene, Michael W Nicolle

引用次数: 0

Assessing Motor Cortex Excitability and Its Relationship with Cortical Atrophy in Alzheimer's Dementia. 阿尔茨海默氏痴呆患者运动皮质兴奋性评估及其与皮质萎缩的关系。

IF 2.9 4区医学

Canadian Journal of Neurological Sciences Pub Date : 2025-06-09 DOI: 10.1017/cjn.2025.79

Renée P Lawson, Reza Zomorrodi, Michael Joseph, Hiba Alhabbal, Gifty Asare, Daniel M Blumberger, Zafiris J Daskalakis, Corinne E Fischer, Benoit H Mulsant, Bruce G Pollock, Tarek K Rajji, Aristotle N Voineskos, Sanjeev Kumar

{"title":"Assessing Motor Cortex Excitability and Its Relationship with Cortical Atrophy in Alzheimer's Dementia.","authors":"Renée P Lawson, Reza Zomorrodi, Michael Joseph, Hiba Alhabbal, Gifty Asare, Daniel M Blumberger, Zafiris J Daskalakis, Corinne E Fischer, Benoit H Mulsant, Bruce G Pollock, Tarek K Rajji, Aristotle N Voineskos, Sanjeev Kumar","doi":"10.1017/cjn.2025.79","DOIUrl":"https://doi.org/10.1017/cjn.2025.79","url":null,"abstract":"Background: Cortical excitability has been proposed as a novel neurophysiological marker of neurodegeneration in Alzheimer's dementia (AD). However, the link between cortical excitability and structural changes in AD is not well understood.Objective: To assess the relationship between cortical excitability and motor cortex thickness in AD.Methods: In 62 participants with AD (38 females, mean ± SD age = 74.6 ± 8.0) and 47 healthy control (HC) individuals (26 females, mean ± SD age = 71.0 ± 7.9), transcranial magnetic stimulation resting motor threshold (rMT) was determined, and T1-weighted MRI scans were obtained. Skull-to-cortex distance was obtained manually for each participant using MNI coordinates of the motor cortex (x = -40, y = -20, z = 52).Results: The mean skull-to-cortex distances did not differ significantly between participants with AD (22.9 ± 4.3 mm) and HC (21.7 ± 4.3 mm). Participants with AD had lower motor cortex thickness than healthy individuals (t(92) = -4.4, p = <0.001) and lower rMT (i.e., higher excitability) than HC (t(107) = -2.0, p = 0.045). In the combined sample, rMT was correlated positively with motor cortex thickness (r = 0.2, df = 92, p = 0.036); however, this association did not remain significant after controlling for age, sex and diagnosis.Conclusions: Patients with AD have decreased cortical thickness in the motor cortex and higher motor cortex excitability. This suggests that cortical excitability may be a marker of neurodegeneration in AD.","PeriodicalId":56134,"journal":{"name":"Canadian Journal of Neurological Sciences","volume":" ","pages":"1-8"},"PeriodicalIF":2.9,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0