Pediatrics and Neonatology最新文献

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Targeting high-risk groups in the post-pandemic era: A focus on pediatric hematological malignancies 后流行病时代的高危人群:关注小儿血液恶性肿瘤。
IF 2.3 4区 医学
Pediatrics and Neonatology Pub Date : 2024-11-01 DOI: 10.1016/j.pedneo.2024.08.003
Nan-Chang Chiu, Hsin Chi, Chien-Yu Lin
{"title":"Targeting high-risk groups in the post-pandemic era: A focus on pediatric hematological malignancies","authors":"Nan-Chang Chiu, Hsin Chi, Chien-Yu Lin","doi":"10.1016/j.pedneo.2024.08.003","DOIUrl":"10.1016/j.pedneo.2024.08.003","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"65 6","pages":"Pages 525-526"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Level of knowledge about neonatal danger signs and associated factors among postpartum mothers in public hospitals, northeastern Ethiopia 埃塞俄比亚东北部公立医院产后母亲对新生儿危险征兆及相关因素的了解程度
IF 2.3 4区 医学
Pediatrics and Neonatology Pub Date : 2024-11-01 DOI: 10.1016/j.pedneo.2023.10.010
Muluken Amare Wudu , Yemane Eshetu Bekalu , Tarikua Afework Birehanu , Dagne Belete Gebrye , Molla Kassa Hailu
{"title":"Level of knowledge about neonatal danger signs and associated factors among postpartum mothers in public hospitals, northeastern Ethiopia","authors":"Muluken Amare Wudu ,&nbsp;Yemane Eshetu Bekalu ,&nbsp;Tarikua Afework Birehanu ,&nbsp;Dagne Belete Gebrye ,&nbsp;Molla Kassa Hailu","doi":"10.1016/j.pedneo.2023.10.010","DOIUrl":"10.1016/j.pedneo.2023.10.010","url":null,"abstract":"<div><h3>Background</h3><div>Knowing and seeking medical attention for neonatal danger signs has many benefits for reducing neonatal morbidity and death. Despite numerous interventions that have been made to raise mothers’ awareness about neonatal danger signs, the desired level of knowledge has not yet been reached in Ethiopia.</div></div><div><h3>Objective</h3><div>To assess the level of knowledge of neonatal danger signs and associated factors among postpartum mothers in public hospitals in the Eastern Amhara region, northeastern Ethiopia.</div></div><div><h3>Methods</h3><div>A hospital-based cross-sectional study was conducted in four government hospitals between January 10, 2023, and February 10, 2023.421 participants in the study were selected using a systematic random sampling technique. Face-to-face interviews, observation, and chart reviews were used to collect the data. The association was discovered through multivariate logistic regression analysis.</div></div><div><h3>Result</h3><div>Only 36.6% (154) of mothers were knowledgeable about newborn danger signs in this study. Mothers who had higher institution status [(adjusted odds ratio) AOR = 3.355, 95% CI (1.751, 6.428)]; who were civil servants or a private employer [AOR = 2.986, 95% CI (1.822, 4.892)] and [AOR = 2.544, 95% CI (1.269, 5.138)]; and who had counseling about breastfeeding [AOR = 2.614, 95% CI (1.695, 4.029)] were positive predictors of awareness of neonatal danger signs.</div></div><div><h3>Conclusion</h3><div>In this study, the level of mothers' awareness of newborn danger signs was low and required more effort. Moreover, mothers who were educated, worked as civil servants or private employers, had a family size of 4–6, and received breastfeeding counseling were linked to mothers’ good awareness of newborn danger signs. As a result, intensive community and facility-based health promotion activities on newborn danger signs should be strengthened, with special emphasis on uneducated and housewife mothers and breastfeeding counseling sessions.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"65 6","pages":"Pages 546-552"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140400633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive factors of progression to chronic glomerulonephritis in pediatric patients with post streptococcal acute glomerulonephritis 链球菌感染后急性肾小球肾炎儿科患者发展为慢性肾小球肾炎的预测因素。
IF 2.3 4区 医学
Pediatrics and Neonatology Pub Date : 2024-11-01 DOI: 10.1016/j.pedneo.2023.11.005
Ida Ayu Laksmi Arnita Utari , Surya Adhi , Kristia Hermawan , Eggi Arguni
{"title":"Predictive factors of progression to chronic glomerulonephritis in pediatric patients with post streptococcal acute glomerulonephritis","authors":"Ida Ayu Laksmi Arnita Utari ,&nbsp;Surya Adhi ,&nbsp;Kristia Hermawan ,&nbsp;Eggi Arguni","doi":"10.1016/j.pedneo.2023.11.005","DOIUrl":"10.1016/j.pedneo.2023.11.005","url":null,"abstract":"<div><h3>Background</h3><div>Post streptococcal acute glomerulonephritis (PSAGN) patients have favorable prognosis, in which most patients showed full recovery in terms of kidney function. However, there is a slight chance ranging from 3 to 6% that PSAGN patients develop chronic kidney diseasewhich may progress into end-stage kidney disease in later life. It is important to identify the factors that can predict the development of chronic glomerulonephritis following PSAGN. Therefore, early intervention can be performed to halt the progression of chronic kidney disease. This study aimed to determine the predictive factors of chronic glomerulonephritis in pediatric patients with PSAGN.</div></div><div><h3>Methods</h3><div>This study was an analytical observational study with retrospective cohort design. The accessible population was children within the age of 2–18 years old who were admitted with PSAGN between January 2015 and December 2020 in Dr. Sardjito General Hospital Yogyakarta. All anonymized patient data were evaluated for demographic variables, clinical features, laboratory profiles and outcome. Multivariate analysis was performed with multivariate logistic regression method.</div></div><div><h3>Results</h3><div>A total of 124 patients with PSAGN were obtained from medical record data. There were 65 patients (52.4%) with chronic glomerulonephritis. Bivariate analysis was performed on assumed predictive factors with the results indicating massive proteinuria with hypoalbuminemia (OR 1.670, 95%CI 1.199–2.326; <em>p</em> = 0.003), oliguria (OR 1.517, 95%CI 1.101–2.089; <em>p</em> = 0.028) and macroscopic hematuria (OR 1.647, 95%CI:1.061–2.555; <em>p</em> = 0.013) were significantly higher in the PSAGN group with chronic glomerulonephritis compared to those without. Results of the multivariate logistic regression analysis showed massive proteinuria with hypoalbuminemia (OR 2.896, 95%CI 1.177–7.123, <em>p</em> = 0.021) and macroscopic hematuria (OR 2.457, 95%CI ,1.018–5.933, <em>p</em> = 0.046) would highly predict chronic glomerulonephritis in subjects with PSAGN.</div></div><div><h3>Conclusion</h3><div>We concluded that massive proteinuria with hypoalbuminemia and macroscopic hematuria are the predictive factors which highly predict chronic glomerulonephritis in PSAGN.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"65 6","pages":"Pages 571-575"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140784208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alport syndrome: Expanding diagnosis and treatment. 阿尔波特综合征:扩大诊断和治疗范围。
IF 2.3 4区 医学
Pediatrics and Neonatology Pub Date : 2024-10-30 DOI: 10.1016/j.pedneo.2024.10.005
Hou-Xuan Huang, I-Jung Tsai, Larry A Greenbaum
{"title":"Alport syndrome: Expanding diagnosis and treatment.","authors":"Hou-Xuan Huang, I-Jung Tsai, Larry A Greenbaum","doi":"10.1016/j.pedneo.2024.10.005","DOIUrl":"https://doi.org/10.1016/j.pedneo.2024.10.005","url":null,"abstract":"<p><p>Alport syndrome (AS) is the second common monogenic cause of end-stage kidney disease (ESKD) worldwide and is caused by defective type 4 collagen due to pathogenic variants of COL4A3, COL4A4, or COL4A5. Type 4 collagen also exists in the eyes and ears, and thus ocular defects and hearing loss occur in AS. The understanding of AS has expanded over the past two decades due to greater availability of genetic testing and research on genotype-phenotype correlation. Patients previously diagnosed with idiopathic steroid resistant nephrotic syndrome or ESKD of unknown etiology may now be diagnosed as AS if pathogenic COL4A3-5 variants are identified. Some carriers of heterozygous COL4A3-5 variants may now be classified into females with X-linked AS or autosomal dominant AS, if there are typical pathologic changes in the glomerular basement membrane or if there is proteinuria and progression of kidney disease. Lastly, it has been recommended that renin-angiotensin-aldosterone system inhibition be started as soon as possible for selected AS patients for its long-term protective effect against kidney function deterioration. The purpose of this review is to introduce these important concepts to general pediatricians and pediatric nephrologists.</p>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acid-base homeostasis in the neonate. 新生儿的酸碱平衡。
IF 2.3 4区 医学
Pediatrics and Neonatology Pub Date : 2024-10-30 DOI: 10.1016/j.pedneo.2024.10.004
Michael G Michalopulos, Raymond Quigley
{"title":"Acid-base homeostasis in the neonate.","authors":"Michael G Michalopulos, Raymond Quigley","doi":"10.1016/j.pedneo.2024.10.004","DOIUrl":"https://doi.org/10.1016/j.pedneo.2024.10.004","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advocacy for DOHaD research optimizing child kidney health. 倡导 DOHaD 研究优化儿童肾脏健康。
IF 2.3 4区 医学
Pediatrics and Neonatology Pub Date : 2024-10-29 DOI: 10.1016/j.pedneo.2024.10.006
You-Lin Tain
{"title":"Advocacy for DOHaD research optimizing child kidney health.","authors":"You-Lin Tain","doi":"10.1016/j.pedneo.2024.10.006","DOIUrl":"https://doi.org/10.1016/j.pedneo.2024.10.006","url":null,"abstract":"<p><p>Emerging antenatal risk factors have been associated with an increased risk of kidney disease throughout the offspring's life course. However, the intricate kidney programming mechanisms underlying these risks remain complex and are incompletely understood, but they are rooted in structural and functional alterations within the kidneys. The Developmental Origins of Health and Disease (DOHaD) theory underscores the significance of elucidating core mechanisms initiated through the maternal-fetal interface, which trigger kidney programming. Furthermore, it offers a promising avenue for preventing kidney disease at its earliest stages through a process known as reprogramming. This concise review aims to synthesize existing knowledge regarding the impact of kidney programming on offspring kidney disease and to provide an overview of documented reprogramming strategies as observed in animal models of kidney programming. By consolidating this information, we aim to expedite the translation of research breakthroughs into practical clinical solutions, ultimately resulting in enhanced outcomes for children facing kidney-related issues.</p>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut dysbiosis as a susceptibility factor in childhood idiopathic nephrotic syndrome. 肠道菌群失调是儿童特发性肾病综合征的易感因素。
IF 2.3 4区 医学
Pediatrics and Neonatology Pub Date : 2024-10-29 DOI: 10.1016/j.pedneo.2024.10.003
Kazunari Kaneko
{"title":"Gut dysbiosis as a susceptibility factor in childhood idiopathic nephrotic syndrome.","authors":"Kazunari Kaneko","doi":"10.1016/j.pedneo.2024.10.003","DOIUrl":"https://doi.org/10.1016/j.pedneo.2024.10.003","url":null,"abstract":"<p><p>Idiopathic nephrotic syndrome (INS) is a relatively common renal disorder of childhood characterized by severe proteinuria and associated hypoproteinemia and edema. Although the pathogenesis of INS remains unknown, the prevailing theory of its pathogenesis is as follows. Antigenic stimulation, such as viral infections or vaccines, in children with susceptibility factors for INS triggers abnormal immune responses, resulting in production of pathogenic substances that injure podocytes (renal glomerular epithelial cells). The injured podocytes then change their function and morphology, resulting in increased permeability of plasma proteins. Consequently, plasma proteins, especially albumin, are leaked into urine and massive proteinuria ensues. Research on susceptibility factors for INS has focused on polymorphisms in several genes including human leukocyte antigen class II genes. However, we propose that dysbiosis of the intestinal microbiota could be a susceptibility factor for relapse. This proposal is based on our research group finding that children with INS and frequent relapses have gut dysbiosis characterized by a decreased proportion of beneficial bacteria such as short-chain fatty acid-producing bacteria. Dysbiosis from the neonatal period to infancy may result from environmental factors, such as cesarean section delivery and antibiotic administration, which prevent the establishment of a normal intestinal microbiota. Dysbiosis leads to aberrant gut immunity and is characterized by a decreased ratio of T helper 1 cells/T helper 2 cells and an increased ratio of T helper 17 cells/regulatory T-cells. Therefore, relapse occurs when immunologically pathogenic factors that injure podocytes are produced in response to trigger events in children with INS and gut dysbiosis. Our recent clinical trial suggested that long-term oral administration of butyric acid-producing bacterium as a probiotic is promising for suppressing relapse. Therefore, studying the causal relationship between dysbiosis and relapses in patients with INS in a larger number of patients is necessary.</p>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exome re-analysis increases the diagnostic yield of monogenic diseases in children. 外显子组再分析提高了儿童单基因疾病的诊断率。
IF 2.3 4区 医学
Pediatrics and Neonatology Pub Date : 2024-10-23 DOI: 10.1016/j.pedneo.2024.10.001
Atanu Kumar Dutta, Niladri Sekhar Bhunia, Rohit Bhowmik, Nihar Ranjan Mishra, Rimjhim Sonowal, Nibedita Sarma, Sumit Mukherjee, Kalyan Goswami
{"title":"Exome re-analysis increases the diagnostic yield of monogenic diseases in children.","authors":"Atanu Kumar Dutta, Niladri Sekhar Bhunia, Rohit Bhowmik, Nihar Ranjan Mishra, Rimjhim Sonowal, Nibedita Sarma, Sumit Mukherjee, Kalyan Goswami","doi":"10.1016/j.pedneo.2024.10.001","DOIUrl":"https://doi.org/10.1016/j.pedneo.2024.10.001","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of neonatal COVID-19 encephalopathy: White matter injury and subsequent infantile spasms. 一例新生儿 COVID-19 脑病:白质损伤和随后的婴儿痉挛。
IF 2.3 4区 医学
Pediatrics and Neonatology Pub Date : 2024-10-23 DOI: 10.1016/j.pedneo.2024.07.009
Jung Sook Yeom, Young-Soo Kim
{"title":"A case of neonatal COVID-19 encephalopathy: White matter injury and subsequent infantile spasms.","authors":"Jung Sook Yeom, Young-Soo Kim","doi":"10.1016/j.pedneo.2024.07.009","DOIUrl":"https://doi.org/10.1016/j.pedneo.2024.07.009","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Iatrogenic pharyngoesophageal perforation in very low birth weight infants. 极低出生体重儿先天性咽食管穿孔。
IF 2.3 4区 医学
Pediatrics and Neonatology Pub Date : 2024-10-21 DOI: 10.1016/j.pedneo.2024.10.002
Chung-Ming Chen
{"title":"Iatrogenic pharyngoesophageal perforation in very low birth weight infants.","authors":"Chung-Ming Chen","doi":"10.1016/j.pedneo.2024.10.002","DOIUrl":"https://doi.org/10.1016/j.pedneo.2024.10.002","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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