Pediatrics and Neonatology最新文献

{"title":"Costs and outcomes associated with the administration of Intravenous Acetaminophen in neonates after esophageal atresia and tracheoesophageal fistula repair","authors":"Michael A. Phillipi ,&nbsp;Ashley Y. Song ,&nbsp;Leah Yieh ,&nbsp;Cynthia L. Gong","doi":"10.1016/j.pedneo.2024.02.010","DOIUrl":"10.1016/j.pedneo.2024.02.010","url":null,"abstract":"<div><h3>Background</h3><div>Over the last decade, the intravenous (IV) formulation of acetaminophen (APAP) has gained popularity as a safe and effective first-line analgesic in the neonatal intensive care unit and it is especially useful in peri-operative settings where oral agents are contraindicated. The primary objective was to examine the outcomes and costs associated with the use of IV APAP in combination with opioids versus opioids alone as a pain management strategy after neonatal esophageal atresia (EA) and tracheoesophageal fistula (TEF) repair.</div></div><div><h3>Methods</h3><div>Data from the Pediatric Health Information System was used to examine 1137 hospitalizations for EA/TEF repair from October 2015 to September 2018. Neonates administered opioids only, or IV APAP in combination with opioids as pain management, were included.</div></div><div><h3>Results</h3><div>Neonates receiving IV APAP experienced a longer median LOS, but a significantly lower mortality rate, a decreased mean daily cost, and reduced opioid use compared to neonates given only opioids. The two groups had no significant differences in pharmacy and total costs.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that the use of IV APAP alongside opioids in EA/TEF repair is associated with reduced mortality and opioid use, as well as longer LOS.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 157-161"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of neonatal COVID-19 encephalopathy: White matter injury and subsequent infantile spasms","authors":"Jung Sook Yeom ,&nbsp;Young-Soo Kim","doi":"10.1016/j.pedneo.2024.07.009","DOIUrl":"10.1016/j.pedneo.2024.07.009","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 180-181"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal and postmortem MRI findings highlight the progression of brainstem compression from a fetal brain tumor","authors":"Syunsuke Nagara ,&nbsp;Emi Tannaka ,&nbsp;Shinji Usui ,&nbsp;Miwa Kawashiri ,&nbsp;Kana Hayashi ,&nbsp;Shigenori Iwagaki ,&nbsp;Atsushi Yamagishi","doi":"10.1016/j.pedneo.2024.10.010","DOIUrl":"10.1016/j.pedneo.2024.10.010","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 178-179"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Omicron BA.2 outbreak in Taiwan: Pediatric healthcare challenges and lessons learned","authors":"Daniel Tsung-Ning Huang MD, PhD","doi":"10.1016/j.pedneo.2025.01.004","DOIUrl":"10.1016/j.pedneo.2025.01.004","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Page 93"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infantile Tullio phenomenon: Ocular tilt reaction to high-pitched sound in a 7-month-old preterm infant","authors":"Yoshiko Seki ,&nbsp;Hiromi Watanabe ,&nbsp;Satoshi Takei ,&nbsp;Kazushige Ikeda","doi":"10.1016/j.pedneo.2024.11.003","DOIUrl":"10.1016/j.pedneo.2024.11.003","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 184-185"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The shifting landscape of orbital complications in the pneumococcal vaccine era: Progress, paradoxes, and perspectives","authors":"Chun-Hsien Yu","doi":"10.1016/j.pedneo.2025.01.003","DOIUrl":"10.1016/j.pedneo.2025.01.003","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 91-92"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early- and late-onset candidemia in very low birth weight infants in the Korean neonatal network, 2013–2017","authors":"Yu Jin Jung","doi":"10.1016/j.pedneo.2024.01.006","DOIUrl":"10.1016/j.pedneo.2024.01.006","url":null,"abstract":"<div><h3>Background</h3><div>Candidiasis is a critical infection that is associated with very low birth weight (VLBW; &lt;1500 g). This study investigated the characteristics and clinical presentation of candidiasis in Korean VLBW infants according to the onset of candidemia.</div></div><div><h3>Methods</h3><div>All VLBW infants with candidemia, defined as blood culture-positive candidiasis and registered in a multicenter database with data from 70 neonatal units of the Korean Neonatal Network between 2013 and 2017, were included in this study. Early-onset candidemia (EOC; ≤10 days) and late-onset candidemia (LOC; &gt;10 days) were analyzed. The demographic characteristics, clinical presentations, and outcomes of candidemia were also determined.</div></div><div><h3>Results</h3><div>The overall incidence of candidemia was 2% (209/10,397) and 4% (173/3934) in VLBW and extremely very low birth weight (ELBW; &lt;1000 g) infants, respectively. In ELBW infants, gestational age was significantly younger at EOC than at LOC (<em>P</em> = 0.015). Cesarean section, respiratory distress syndrome, severe bronchopulmonary disease, pulmonary hemorrhage, prior-bacteremia, neonatal seizures, and periventricular leukomalacia were significantly more common in the LOC group than in the EOC group (<em>P</em> &lt; 0.05). The duration of invasive ventilation, total parenteral nutrition, and hospital stay were significantly longer in the LOC group than in the EOC group (<em>P</em> &lt; 0.05). Most infections were caused by <em>Candida</em> spp. (91.8%). The mortality rate of ELBW infants with candidemia was 41%, which was higher than that of those without candidemia (29%) (<em>P</em> &lt; 0.001). Mortality due to infection was also higher in infants with candidemia (55%) than in those without candidemia (15%) (<em>P</em> &lt; 0.001); however, there were no significant differences between the EOC and LOC groups.</div></div><div><h3>Conclusions</h3><div>LOC was more common than EOC in VLBW infants. Considering the risk factors of LOC, active weaning from invasive ventilators and aggressive enteral feeding are required to decrease LOC. Furthermore, preventing candidemia is necessary to reduce mortality in VLBW infants.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 110-115"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of corticosteroids and epinephrine use in neonates for the first extubation attempt: A retrospective study","authors":"Chen-Yu Yeh ,&nbsp;Yu-Jun Chang ,&nbsp;Lih-Ju Chen ,&nbsp;Cheng-Han Lee ,&nbsp;Hsiao-Neng Chen ,&nbsp;Jia-Yuh Chen ,&nbsp;Chien-Chou Hsiao","doi":"10.1016/j.pedneo.2023.12.010","DOIUrl":"10.1016/j.pedneo.2023.12.010","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to analyze the use of corticosteroids and epinephrine in neonates for the first extubation attempt and compared clinical characteristics of infants with successful and failed extubation events.</div></div><div><h3>Methods</h3><div>This was a retrospective cohort study conducted at a single level III neonatal intensive care unit in Taiwan. The study included 215 infants born between 2020 and 2021 who had been intubated for more than 48 h before their first extubation attempt. We compared perinatal and peri-extubation characteristics and outcomes between the two groups. Successful extubation was defined as freedom from invasive ventilatory support 72 h after extubation. The relationship between corticosteroids, local epinephrine, and successful extubation was determined using multivariate logistic regression analysis.</div></div><div><h3>Results</h3><div>In the univariate analysis, the failed extubation group received a significantly higher proportion of intravenous dexamethasone (p = 0.006) than the successful extubation group. Furthermore, the failed extubation group had a longer duration of nebulized epinephrine (p = 0.034) and more episodes of local application of epinephrine to the superior larynx (p = 0.003) than the successful extubation group. Multivariate analysis revealed that the absence of lung atelectasis, tachycardia 72 h after extubation, and lower post-extubation PCO₂ were the key factors associated with successful extubation.</div></div><div><h3>Conclusions</h3><div>There were trends toward systemic dexamethasone, local application of epinephrine to the superior larynx, and longer duration of nebulized epinephrine in the reintubation group. However, corticosteroid or local epinephrine use was not significantly associated with successful extubation. Lung atelectasis, elevated levels of carbon dioxide, and tachycardia were identified as risk factors for extubation failure.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 122-126"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141410912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety profile of introducing less invasive surfactant administration in management of respiratory distress syndrome: A retrospective cohort study in a tertiary neonatal unit in Hong Kong","authors":"Wing Kan Julianna Bao ,&nbsp;Qi Feng ,&nbsp;King Shun Liu ,&nbsp;Yok Chiu Ho","doi":"10.1016/j.pedneo.2023.12.013","DOIUrl":"10.1016/j.pedneo.2023.12.013","url":null,"abstract":"<div><h3>Background</h3><div>The objective was to evaluate the efficacy of introducing less invasive surfactant administration (LISA) for management of preterm neonates with respiratory distress syndrome (RDS).</div></div><div><h3>Methods</h3><div>This was a retrospective cohort study identifying preterm neonates with RDS born between 2017 and 2022 in a tertiary neonatal unit, where LISA was introduced in January 2020. Time trend analysis comparing cohort of neonates born before (2017–2020) and after LISA introduction (2020–2022) was performed. The primary outcomes were incidence and severity of bronchopulmonary dysplasia (BPD). Multivariable regression models were used to estimate the association between introducing LISA to RDS management and health and safety outcomes.</div></div><div><h3>Results</h3><div>In total, 261 neonates with RDS were included (114 born after LISA was introduced). Neonates receiving invasive surfactant administration had lower gestational age, birth weight, lower Apgar scores, and higher oxygen requirement, compared to those receiving LISA. In the time trend analysis, introduction of LISA was associated with lower incidence of BPD (odds ratio (95% confidence interval) 0.34 (0.16, 0.72)), and lower severity of BPD (0.31 (0.16, 0.59)). Pre- and post-LISA period showed similar treatment safety profiles.</div></div><div><h3>Conclusion</h3><div>Introduction of LISA was associated with improved prognosis in neonates with RDS in Hong Kong.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 147-151"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double-outlet right ventricle in a patient with Takenouchi–Kosaki syndrome","authors":"Po-Jung Lai ,&nbsp;Wei-Chieh Tseng ,&nbsp;Hui-An Chen ,&nbsp;Rai-Hseng Hsu ,&nbsp;Yin-Hsiu Chien ,&nbsp;Wuh-Liang Hwu ,&nbsp;Ni-Chung Lee","doi":"10.1016/j.pedneo.2024.11.002","DOIUrl":"10.1016/j.pedneo.2024.11.002","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 176-177"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}