Pediatrics and Neonatology最新文献

筛选
英文 中文
Corrigendum to “Adenovirus infection is a risk factor for recurrent intussusception in pediatric patients” [Pediatr Neonatol 64 (2023) 428–434]
IF 2.3 4区 医学
Pediatrics and Neonatology Pub Date : 2025-03-01 DOI: 10.1016/j.pedneo.2025.01.005
Wen-Yu Tseng , Hsun-Chin Chao , Chien-Chang Chen , Ming-Wei Lai , Yi-Jung Chang
{"title":"Corrigendum to “Adenovirus infection is a risk factor for recurrent intussusception in pediatric patients” [Pediatr Neonatol 64 (2023) 428–434]","authors":"Wen-Yu Tseng , Hsun-Chin Chao , Chien-Chang Chen , Ming-Wei Lai , Yi-Jung Chang","doi":"10.1016/j.pedneo.2025.01.005","DOIUrl":"10.1016/j.pedneo.2025.01.005","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Page 186"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term effects on growth in preterm and small for gestational age infants: A national birth cohort study 对早产儿和胎龄小婴儿生长的长期影响:全国出生队列研究。
IF 2.3 4区 医学
Pediatrics and Neonatology Pub Date : 2025-03-01 DOI: 10.1016/j.pedneo.2024.06.007
Yi-Yu Su , Chi-Jen Chen , Mei-Huei Chen , Hsi Chang , Chung-Ming Chen , Hsiu-Chen Lin , Yueliang Leon Guo , Wu-Shiun Hsieh , Pau-Chung Chen
{"title":"Long-term effects on growth in preterm and small for gestational age infants: A national birth cohort study","authors":"Yi-Yu Su ,&nbsp;Chi-Jen Chen ,&nbsp;Mei-Huei Chen ,&nbsp;Hsi Chang ,&nbsp;Chung-Ming Chen ,&nbsp;Hsiu-Chen Lin ,&nbsp;Yueliang Leon Guo ,&nbsp;Wu-Shiun Hsieh ,&nbsp;Pau-Chung Chen","doi":"10.1016/j.pedneo.2024.06.007","DOIUrl":"10.1016/j.pedneo.2024.06.007","url":null,"abstract":"<div><h3>Background</h3><div>Premature and small-for-gestational-age (SGA) infants tend to have long-term growth morbidities such as short stature, failure to thrive, and obesity. Although most of these infants show catch-up growth at 2–4 years of age, they are still more susceptible to childhood obesity and related metabolic disorders. Those who fail to achieve catch-up will suffer from pathological short stature and neurodevelopmental impairment through adulthood. This study aims to depict the growth pattern of premature or SGA infants and their growth morbidities in Taiwan.</div></div><div><h3>Methods</h3><div>Data were obtained from a nationally representative cohort of 24,200 pairs of postpartum women and newborns in the Taiwan Birth Cohort Study (TBCS), using structured questionnaire interviews. A total of 16,358 infants were included and three follow-up surveys were completed at 6, 18, and 36 months after the deliveries. We constructed growth curves to conduct an in-depth investigation into anthropometric data, applying a linear mixed model. Logistic regression was used to model the relevant outcomes, with adjustment for various potential confounding factors.</div></div><div><h3>Results</h3><div>Despite being born shorter and lighter, preterm and SGA infants generally showed catch-up growth and had no higher odds ratios (ORs) of developing short stature or failure to thrive compared to appropriate-for-gestational-age (AGA) term infants before 3 years of age. Preterm SGA infants, particularly females, had higher ORs for obesity at the 36-month follow-up.</div></div><div><h3>Conclusion</h3><div>This is the first nationwide population-based study depicting the growth of SGA infants in Taiwan. The growth patterns of preterm and term SGA infants are different from those of preterm and term AGA infants. Further research is necessary to understand the growth trajectories of preterm and SGA infants and their associations with later diseases.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 168-175"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retropharyngeal and parapharyngeal infections in children: A retrospective analysis 儿童咽后和咽旁感染:回顾性分析
IF 2.3 4区 医学
Pediatrics and Neonatology Pub Date : 2025-03-01 DOI: 10.1016/j.pedneo.2023.12.014
Savithiri Ratnapalan , Jeffrey Thevaranjan , Niranjala Perera , Basheer Nassarallah , Nikolaus E. Wolter
{"title":"Retropharyngeal and parapharyngeal infections in children: A retrospective analysis","authors":"Savithiri Ratnapalan ,&nbsp;Jeffrey Thevaranjan ,&nbsp;Niranjala Perera ,&nbsp;Basheer Nassarallah ,&nbsp;Nikolaus E. Wolter","doi":"10.1016/j.pedneo.2023.12.014","DOIUrl":"10.1016/j.pedneo.2023.12.014","url":null,"abstract":"<div><h3>Objectives</h3><div>To describe presentations, management and outcomes of retropharyngeal and parapharyngeal infections in children presenting to a tertiary care pediatric emergency department.</div></div><div><h3>Methods</h3><div>A retrospective chart review of children with deep neck infections such as retropharyngeal or parapharyngeal infection from January 2008 to December 2018 was conducted at a pediatric hospital.</div></div><div><h3>Results</h3><div>There were 176 retropharyngeal, 18 parapharyngeal and 6 with both retropharyngeal and parapharyngeal infections treated during the 10-year study period. Males were 60% of the cohort and the mean age was 4.3 (SD: 3.2) years. No significant differences in age or sex ratio or presentations were seen in children with retropharyngeal infections compared with parapharyngeal infections. All received parenteral antibiotics; 42% (84/200) of children underwent surgery and four of them had more than one surgical drainage. Age &lt;12 months and the diagnosis of parapharyngeal infections were associated with significantly higher rates of surgical treatment. Children under 12 months of age were sicker at presentation and had a high complication rate of 23% compared with 1% in the older children (p = 0.002). Seven children had co-existence of Kawasaki disease with deep neck infections.</div></div><div><h3>Conclusions</h3><div>Early diagnosis of retropharyngeal and parapharyngeal infections especially in infants under a year of age is important as they are more likely to have complications and need surgical management. Most paediatric patients with retropharyngeal and parapharyngeal infections have a phlegmon or very small abscesses and are treated non-operatively with parenteral antibiotics.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 162-167"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A preliminary study of the effectiveness of video visitation on depression and stress in mothers with preterm infants during the pandemic 关于视频探视对早产儿母亲在大流行期间的抑郁和压力的影响的初步研究
IF 2.3 4区 医学
Pediatrics and Neonatology Pub Date : 2025-03-01 DOI: 10.1016/j.pedneo.2023.12.011
Ling-Ying Wang , Hsiu-Min Tsai , Yi-Wen Chen , Jing-Yi Jhang , Pei-Jhen Wu , Yu-Ting Huang , Ming-Ying Lee , Li-Chen Chen , Wen-Pin Yu , Ming-Chou Chiang
{"title":"A preliminary study of the effectiveness of video visitation on depression and stress in mothers with preterm infants during the pandemic","authors":"Ling-Ying Wang ,&nbsp;Hsiu-Min Tsai ,&nbsp;Yi-Wen Chen ,&nbsp;Jing-Yi Jhang ,&nbsp;Pei-Jhen Wu ,&nbsp;Yu-Ting Huang ,&nbsp;Ming-Ying Lee ,&nbsp;Li-Chen Chen ,&nbsp;Wen-Pin Yu ,&nbsp;Ming-Chou Chiang","doi":"10.1016/j.pedneo.2023.12.011","DOIUrl":"10.1016/j.pedneo.2023.12.011","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Parents of preterm infants experience anxiety and stress in the neonatal intensive care unit (NICU). Visitation restrictions due to COVID-19 have increased maternal pressure and limited bonding opportunities. Little research exists in Taiwan on using video conferencing as a solution. This study investigates depression and stress levels in mothers of preterm infants and evaluates the effectiveness of video visitation during NICU restrictions.</div></div><div><h3>Methods</h3><div>This study adopts a cross-sectional design and a qualitative survey. Mothers of premature infants were recruited and they participated in the study. Interventions for video visits were scheduled on the third day of admission to the NICU (T1) and during the second week of the study (T2). After each video visit, participants completed an online survey. The study's online survey used structured questionnaires including demographics, the Edinburgh Postnatal Depression Scale (EPDS) and the Parental Stress Scale (PSS): Infant Hospitalization (IH).</div></div><div><h3>Results</h3><div>A total of 51 mothers of preterm infants participated in the study. During the T1 and T2 periods, single mothers with lower educational levels and those aged below 30 experienced depression and high levels of stress. Lower birth weight and gestational age were associated with maternal depression. Video visitation intervention led to a significant decrease in depression scores (EPDS, T1: 11.3 ± 5.5 vs. T2: 10.1 ± 5.2, p = 0.039). Positive correlations were observed between EPDS and PSS: IH scores (p &lt; 0 .005).</div></div><div><h3>Conclusion</h3><div>Video visitation intervention can reduce maternal depression in mothers with preterm infants. Since it is practical, video visitation may be applied even after the pandemic.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 127-133"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141391030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enterococcal bacteremia in children: Clinical Significance of vancomycin resistance 儿童肠球菌菌血症:万古霉素耐药性的临床意义
IF 2.3 4区 医学
Pediatrics and Neonatology Pub Date : 2025-03-01 DOI: 10.1016/j.pedneo.2024.01.007
Kyo Jin Jo , Hyeon Seo Lee , Narae Lee , Shin Yun Byun , Chulhun Chang , Su Eun Park
{"title":"Enterococcal bacteremia in children: Clinical Significance of vancomycin resistance","authors":"Kyo Jin Jo ,&nbsp;Hyeon Seo Lee ,&nbsp;Narae Lee ,&nbsp;Shin Yun Byun ,&nbsp;Chulhun Chang ,&nbsp;Su Eun Park","doi":"10.1016/j.pedneo.2024.01.007","DOIUrl":"10.1016/j.pedneo.2024.01.007","url":null,"abstract":"<div><h3>Background</h3><div>We aimed to describe the clinical and microbiological characteristics of enterococcal bacteremia, as well as the effect of <em>Enterococcus</em> resistance against vancomycin on clinical outcomes in Korean children.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed the medical records of children diagnosed with enterococci isolated from blood cultures at Pusan National University Children's Hospital between December 2009 and November 2021.</div></div><div><h3>Results</h3><div>In total, 64 patients were enrolled in the study. The median age was 0 years (range 0–15), and 43 (67.2%) patients were male. <em>Enterococcus faecalis</em> (50%) was the most commonly identified bacterial strain. Significant underlying diseases were present in 60 patients (93.8%), and the source of bacteremia was identified in 36 patients (56.3%). Among these, intravascular device was the most common identifiable source. Fifty-six (87.5%) patients had previously received broad-spectrum antibiotics and 54 (84.4%) patients were nosocomial in origin. Twenty-nine (45.3%) strains were resistant to ampicillin, and 16 (25%) strains were resistant to vancomycin. All patients with vancomycin-resistant enterococci (VRE) had underlying disease (<em>P</em> = 0.199), and focus of bacteremia was significantly more frequent in VRE patients (<em>P</em> = 0.014). Of all the patients, after appropriate antibiotic treatment, five (7.8%) patients had recurrent enterococcal bacteremia, and seven (10.9%) patients were diagnosed with bacteremia, defined as other pathogens from blood culture. The 30-day mortality rate was 7.8%.</div></div><div><h3>Conclusion</h3><div>Enterococcal bacteremia in children is usually nosocomial and occurs in children with serious underlying diseases. Because the number of enrolled patients and mortality were small in our study, it is difficult to identify whether the factor that determines prognosis in patients with enterococcal bacteremia is VRE or an underlying disease. Further studies with a large number of patients in a specific group are needed.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 142-146"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141406706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric primary extragonadal choriocarcinoma - A study on male patients at a single tertiary medical institution 小儿原发性对角线外绒毛膜癌--对一家三级医疗机构男性患者的研究。
IF 2.3 4区 医学
Pediatrics and Neonatology Pub Date : 2025-03-01 DOI: 10.1016/j.pedneo.2024.03.008
Jui-Ju Tseng , Chi-Yen Chen , Chiung-Wen Liang , Fang-Liang Huang
{"title":"Pediatric primary extragonadal choriocarcinoma - A study on male patients at a single tertiary medical institution","authors":"Jui-Ju Tseng ,&nbsp;Chi-Yen Chen ,&nbsp;Chiung-Wen Liang ,&nbsp;Fang-Liang Huang","doi":"10.1016/j.pedneo.2024.03.008","DOIUrl":"10.1016/j.pedneo.2024.03.008","url":null,"abstract":"<div><h3>Background</h3><div>Primary extragonadal choriocarcinoma (PEGCC) in male is rare. It is highly malignant, typically presents with distant metastasis at the time of diagnosis, and responds poorly to treatment. Because of its associated high levels of PD-L1, the PD-1/PD-L1 pathway is a likely therapeutic target. Herein, we report our experience of treating pediatric PEGCC in six boys at a tertiary hospital.</div></div><div><h3>Methods</h3><div>We analyzed the data of six boys with pathologically confirmed PEGCC between 2009 and 2021. Their clinicodemographic and histopathological characteristics as well as treatments and clinical outcomes were retrieved from their medical charts.</div></div><div><h3>Results</h3><div>The patients' median age was 15 (range: 12–17) years. The most common primary tumor site was the mediastinum (67%, 4/6), with one case each in the retroperitoneum (16.7%) and brain (16.7%). Except for the patient with brain PEGCC, all presented with metastasis at the time of diagnosis. The following metastatic sites were observed: the lungs (100%, 5/5), brain (3/5, 60%), liver (3/5, 60%), kidneys (2/5, 40%), and spleen (1/5, 20%). Most patients had dry cough, dyspnea, and hemoptysis at initial presentation, likely due to lung metastasis. Serum human chorionic gonadotropin (HCG) levels were highly elevated in all patients. All patients received platinum-based cytotoxic chemotherapy. The patient with brain choriocarcinoma underwent surgical tumor resection; all others underwent only surgical biopsy. Strong positive PD-L1 immunohistochemical staining was noted for two patients. One patient received the PD-L1 inhibitor pembrolizumab and achieved a good response. Our cohort's 1-year survival rate was 33.3%, with a median survival of 4.34 months. Serum HCG levels remained normal in the two survivors during follow-up visits.</div></div><div><h3>Conclusion</h3><div>The poor response to current platinum-based chemotherapy remains a major challenge in the management of pediatric PEGCC. Adding pembrolizumab to a conventional chemotherapy regimen may improve the outcomes in boys with PEGCC.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 152-156"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Near-infrared spectroscopy (NIRS) as a tool to prevent cerebral desaturation in newborns with bradycardia events: A systematic review 近红外光谱(NIRS)作为预防新生儿心动过缓事件脑去饱和的工具:系统综述。
IF 2.3 4区 医学
Pediatrics and Neonatology Pub Date : 2025-03-01 DOI: 10.1016/j.pedneo.2024.07.011
Raffaele Falsaperla , Guido Leone , Alessandro Giallongo , Valentina Giacchi , Giulia Lombardo , Agata Polizzi , Catia Romano , Martino Ruggieri
{"title":"Near-infrared spectroscopy (NIRS) as a tool to prevent cerebral desaturation in newborns with bradycardia events: A systematic review","authors":"Raffaele Falsaperla ,&nbsp;Guido Leone ,&nbsp;Alessandro Giallongo ,&nbsp;Valentina Giacchi ,&nbsp;Giulia Lombardo ,&nbsp;Agata Polizzi ,&nbsp;Catia Romano ,&nbsp;Martino Ruggieri","doi":"10.1016/j.pedneo.2024.07.011","DOIUrl":"10.1016/j.pedneo.2024.07.011","url":null,"abstract":"<div><h3>Objective</h3><div>Near infrared spectroscopy (NIRS) is a non-invasive tool providing real-time continuous measurement of regional cerebral blood oxygenation and indirect blood flow. The aim of this review is to determine the best evidence to guide the use of NIRS to detect and avoid abnormalities of cerebral perfusion and oxygenation in newborns with bradycardia.</div></div><div><h3>Design</h3><div>For this systematic review according to PRISMA Statement, we reviewed papers from 2000 to 2023. Research articles, trial, classical articles, observational studies applying NIRS in term and preterm neonates with bradycardia were selected if the title and/or abstract suggested an association between bradycardia or bradycardia associated with apnoea and modification of cerebral oxygenation.</div></div><div><h3>Main results</h3><div>All included studies (Table 1) were conducted on male and female newborns with gestational age (GA) between 22.6 and 42 weeks and birth weight (BW) between 212 and 3460 g. The definition of bradycardia and cerebral desaturation differed among authors. Seven out of nine papers agreed on association between bradycardia and cerebral desaturation, but no author indicated the cut-off of heart rate (HR) under which cerebral desaturations occur. No study focused on long-term outcome related to cerebral desaturation.</div></div><div><h3>Conclusions</h3><div>Even if cut-off values of HR causing cerebral desaturation are not clear and a well-fixed definition of cerebral desaturation has not yet been standardized, the studies demonstrated that bradycardia events lead to reduction of cerebral saturation. Continuous monitoring of HR and cerebral saturation by non-invasive tools could play a key role in the assessment of newborns.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 94-101"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Orbital complications of pediatric acute rhinosinusitis in the pneumococcal conjugate vaccine era 肺炎球菌结合疫苗时代小儿急性鼻窦炎的眼眶并发症
IF 2.3 4区 医学
Pediatrics and Neonatology Pub Date : 2025-03-01 DOI: 10.1016/j.pedneo.2023.12.009
Lior Friedrich , Re'em Sadeh , Itai Hazan , Sofia Kordeluk , El-Saied Sabri , Erez Tsumi , Elchanan Zloczower , Ron Leibovitz , Eugene Leibovitz , Daniel Kaplan , Mordechai Kraus , Oren Ziv
{"title":"Orbital complications of pediatric acute rhinosinusitis in the pneumococcal conjugate vaccine era","authors":"Lior Friedrich ,&nbsp;Re'em Sadeh ,&nbsp;Itai Hazan ,&nbsp;Sofia Kordeluk ,&nbsp;El-Saied Sabri ,&nbsp;Erez Tsumi ,&nbsp;Elchanan Zloczower ,&nbsp;Ron Leibovitz ,&nbsp;Eugene Leibovitz ,&nbsp;Daniel Kaplan ,&nbsp;Mordechai Kraus ,&nbsp;Oren Ziv","doi":"10.1016/j.pedneo.2023.12.009","DOIUrl":"10.1016/j.pedneo.2023.12.009","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the impact of the pneumococcal conjugate vaccines (PCVs) introduction on the orbital complications of acute rhino-sinusitis (OC-ARS).</div></div><div><h3>Methods</h3><div>A retrospective cohort study of all pediatric patients with OC-ARS during the period 2002–2019. Data included clinical, demographic, laboratory, and microbiology findings. Patients were divided into three groups: before PCV7 introduction (group 1), after PCV7 and before PCV13 (group 2), and after PCV13 (group 3).</div></div><div><h3>Results</h3><div>Of 265 enrolled patients, 117, 39, and 109 were assigned to groups 1, 2, and 3. During the study period, a significant decrease was recorded in the percentages of patients in Chandler classification severity category 1, with an increase in patients in category 3 (P = 0.011). The yearly incidence of OC-ARS decreased from 12.64 cases per 100,000 population in 2002 to 5.56 per 100,000 in 2008, and 2.99 per 100,000 in 2019 (P &lt; 0.001). Patients aged 0–4 years showed a dramatic decrease from 29 cases per 100,000 population in 2002 to 4.27 per 100,000 in 2019 (P &lt; 0.001). The pathogens retrieved from all cultures performed were <em>Streptococcus pneumoniae</em> (32.5%), non-typeable <em>Haemophilus influenzae</em> (27.5%), <em>Streptococcus</em> Species, (12.5%), and <em>Staphylococcus aureus</em> (20%), with no changes in distribution during the study periods. Surgery was performed in 28 (10.6%) patients.</div></div><div><h3>Conclusions</h3><div>A significant decrease was seen in the overall incidence of OC-ARS, mainly attributable to the decrease in patients aged 0–4 years. An increase was recorded in the severity of the disease following PCVs introduction.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 116-121"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141414825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic granulomatous disease: A single-center experience in Central Anatolia 慢性肉芽肿病:安纳托利亚中部的单中心经验。
IF 2.3 4区 医学
Pediatrics and Neonatology Pub Date : 2025-03-01 DOI: 10.1016/j.pedneo.2024.02.008
Yahya Gul , Esra Hazar , Hasan Kapaklı , Şukru Nail Guner , Rabia Nayir , Sinan Kutuk , Mustafa Yavuz Köker , Sevgi Keleş , İsmail Reisli
{"title":"Chronic granulomatous disease: A single-center experience in Central Anatolia","authors":"Yahya Gul ,&nbsp;Esra Hazar ,&nbsp;Hasan Kapaklı ,&nbsp;Şukru Nail Guner ,&nbsp;Rabia Nayir ,&nbsp;Sinan Kutuk ,&nbsp;Mustafa Yavuz Köker ,&nbsp;Sevgi Keleş ,&nbsp;İsmail Reisli","doi":"10.1016/j.pedneo.2024.02.008","DOIUrl":"10.1016/j.pedneo.2024.02.008","url":null,"abstract":"<div><h3>Background</h3><div>Chronic granulomatous disease (CGD), one of the phagocytic cell defects, is the primary immunodeficiency caused by dysfunction of the NADPH oxidase complex in neutrophils.</div></div><div><h3>Methods</h3><div>The clinical, demographic and laboratory findings of 17 CGD patients who were followed-up between 2002 and 2021 were obtained retrospectively from the records of the patients.</div></div><div><h3>Results</h3><div>The number of male and female patients was 10/7. The median age at diagnosis was 5.3 months (range 4–120) for 3 patients with X-CGD, and 42.4 months (range 8–350) for 14 patients with AR-CGD. We have investigated rare <em>CYBA</em> exon 3–6 deletion in 7 patients and hotspot mutation with delGT at the beginning of exon 2 of <em>NCF1</em> in 5 patients. The most common clinical findings were pneumonia and lymphadenitis with recurrent fever, respectively (41.2%, 35.3%). A total of 154 microbial infections requiring hospital admission (27 in 3 XL and 127 in 14 AR patients) were detected in the follow-up of the patients and median infection number for a patient was 9 in both groups. Eight of 17 patients had stem cell transplantation and the survival rate was 87.5%.</div></div><div><h3>Conclusions</h3><div>X-CGD patients are more rapidly recognized by family history and severe infections than those with AR-CGD and early prophylaxis may decrease infectious episodes. We have investigated the large deletion suggesting a possible founder effect for <em>CYBA</em> exon 3–6 deletion in Central Anatolia. Additionally, HSCT transplantation leads to a high survival rate for the patients with CGD.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 134-141"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141452298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accidental ingestion of a sharp metal divider 误食锋利的金属隔板。
IF 2.3 4区 医学
Pediatrics and Neonatology Pub Date : 2025-03-01 DOI: 10.1016/j.pedneo.2024.10.007
Chetan Padashetty, Shalini G. Hegde
{"title":"Accidental ingestion of a sharp metal divider","authors":"Chetan Padashetty,&nbsp;Shalini G. Hegde","doi":"10.1016/j.pedneo.2024.10.007","DOIUrl":"10.1016/j.pedneo.2024.10.007","url":null,"abstract":"","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 2","pages":"Pages 182-183"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信