Quantification of post-COVID-19 symptoms and pulmonary functional capacity in children with COVID-19.

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology Pub Date : 2025-07-30 DOI:10.1016/j.pedneo.2024.08.009

Jeng-Hung Wu, Ching-Chia Wang, Yi Pan, Frank Leigh Lu, En-Ting Wu

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引用次数: 0

Abstract

Background: Children with coronavirus disease 2019 (COVID-19) present with mild but persistent pulmonary disease. Limited studies have explored post-infection aerobic capacity and quantification of symptoms. This study aimed to quantify post-COVID-19 fatigue, dyspnea, and pulmonary functional capacity while exploring associated factors.

Methods: This prospective cohort study enrolled 6-12-year-old children with COVID-19. Participants' parents completed questionnaires assessing post-COVID-19 fatigue (Pediatric Quality of Life Inventory Multidimensional Fatigue Scale, including general, sleep, and cognition, with high scores indicating less severity) and dyspnea (Modified Medical Research Council Dyspnea Scale). Six-minute walk tests (6MWT) were performed with records of distances to assess pulmonary functional capacity.

Results: This study enrolled 21 children with seven (33 %) exhibiting persistent symptoms post-COVID-19 infection. These children had a lower COVID-19 vaccination rate (57 % vs. 100 %, p = 0.026) and a reduced sleep-related fatigue scale (69.0 vs. 80.4, p = 0.043) than those without persistent symptoms. Nineteen children performed the 6MWT achieving a mean distance of 623 m (standard deviation, SD: 231) and a mean Z-score of 2.8 (SD: 1.4). Linear regression analysis identified older age as a risk factor for fatigue (β-coefficient -0.45, p = 0.040), and the cognitive fatigue scale correlated with the Z-score of the 6MWT distances (β-coefficient: -0.56, p = 0.013).

Conclusion: Children with post-COVID-19 symptoms had lower vaccination rates and higher sleep-related fatigue levels. Older children experienced more severe fatigue and the performance of 6MWT correlated with cognition-related fatigue scale.

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COVID-19儿童COVID-19后症状和肺功能的量化

背景：2019冠状病毒病（COVID-19）患儿表现为轻度但持续性肺部疾病。有限的研究探讨了感染后的有氧能力和症状的量化。本研究旨在量化covid -19后的疲劳、呼吸困难和肺功能，同时探索相关因素。方法：这项前瞻性队列研究纳入了6-12岁的COVID-19儿童。参与者的父母完成了评估covid -19后疲劳的问卷（儿科生活质量量表多维疲劳量表，包括一般、睡眠和认知，得分高表明严重程度较低）和呼吸困难（修订医学研究委员会呼吸困难量表）。进行6分钟步行试验（6MWT），记录距离以评估肺功能容量。结果：本研究纳入了21名儿童，其中7名（33%）在covid -19感染后表现出持续症状。与没有持续症状的儿童相比，这些儿童的COVID-19疫苗接种率较低（57%对100%，p = 0.026），睡眠相关疲劳量表较低（69.0对80.4,p = 0.043）。19名儿童进行了6MWT，平均距离为623 m（标准差，SD: 231），平均z分数为2.8 （SD: 1.4）。线性回归分析发现，年龄是疲劳的危险因素（β-系数为-0.45,p = 0.040），认知疲劳量表与6MWT距离的z -得分相关（β-系数为-0.56,p = 0.013）。结论：出现covid -19后症状的儿童疫苗接种率较低，睡眠相关疲劳水平较高。年龄越大的儿童疲劳程度越严重，6MWT的表现与认知相关疲劳量表相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatrics and Neonatology PEDIATRICS-

CiteScore

3.10

自引率

0.00%

发文量

170

审稿时长

48 days

期刊介绍： Pediatrics and Neonatology is the official peer-reviewed publication of the Taiwan Pediatric Association and The Society of Neonatology ROC, and is indexed in EMBASE and SCOPUS. Articles on clinical and laboratory research in pediatrics and related fields are eligible for consideration.