Journal of Nippon Medical School最新文献_第4页

Tarsal Tunnel Syndrome: A Clinical Review. 跗骨隧道综合征：临床回顾。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-206

Hiroto Yoshida, Kyongsong Kim, Takato Tajiri, Fumiaki Fujihara, Juntaro Matsumoto, Hiroshi Abe, Toyohiko Isu

引用次数: 0

Multiple Functions of Cell Adhesion Molecule 1 (CADM1) and Its Role in the Pathogenesis of Cancer and Other Diseases. 细胞粘附分子1 （CADM1）的多种功能及其在癌症和其他疾病发病中的作用

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-205

Yoshinori Murakami, Yutaka Kasai, Tomoko Masuda, Hiromi Ichihara, Takeshi Ito

{"title":"Multiple Functions of Cell Adhesion Molecule 1 (CADM1) and Its Role in the Pathogenesis of Cancer and Other Diseases.","authors":"Yoshinori Murakami, Yutaka Kasai, Tomoko Masuda, Hiromi Ichihara, Takeshi Ito","doi":"10.1272/jnms.JNMS.2025_92-205","DOIUrl":"https://doi.org/10.1272/jnms.JNMS.2025_92-205","url":null,"abstract":"Cell adhesion molecule 1 (CADM1) is an immunoglobulin superfamily cell adhesion molecule that was first identified as a tumor suppressor in non-small cell lung cancer because of its role in suppressing tumor formation in nude mice. CADM1 forms a homophilic dimer on the cell membrane and associates with actin-binding proteins (4.1s) and scaffold proteins (MAGuKs), which contain PDZ motifs. It forms a ternary protein complex involved in cell adhesion and the formation of epithelium-like structure. While CADM1 is expressed in epithelium, neuronal tissue, and testes, CADM1 expression is absent in many cancers of epithelial origin, including cancers of the lung, esophagus, stomach, liver, pancreas, breast, and prostate. In addition to its tumor-suppressive activity in epithelial cell adhesion, CADM1 acts as a tumor antigen, recognized by activated NK cells and CD8+ T cells through heterophilic interaction with CRTAM, thereby serving as a tumor suppressor in two ways. In contrast, CADM1 is overexpressed in adult T-cell leukemia/lymphoma (ATL) cells, making it a specific diagnostic marker of ATL on FACS analysis. CADM1 is also highly expressed in small cell lung cancer (SCLC) and other neuroendocrine tumors, and promotes metastasis, suggesting its potential as a target for diagnosis and treatment of SCLC. CADM1 also has a role in synapse formation and spermatogenesis, and deficient or abnormal CADM1 is linked to disorders such as male infertility in mice and autism spectrum disorder. Here, we summarize the multiple functions of CADM1 and its involvement in cancer and other diseases, focusing on disorders of aberrant cell adhesion.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 2","pages":"122-131"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phase II Study of Short Hydration without Diuretics for Cisplatin-Based Chemotherapy. 短时间水合无利尿剂用于顺铂化疗的II期研究。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-210

Tetsuya Wako, Ryosuke Arakawa, Shinji Nakamichi, Masaru Matsumoto, Rei Yamaguchi, Kaoruko Shimbu, Tomoyasu Inoue, Takehiro Tozuka, Junichi Aoyama, Yasuhiro Kato, Naomi Onda, Akihiko Miyanaga, Masahiro Seike, Kaoru Kubota

{"title":"Phase II Study of Short Hydration without Diuretics for Cisplatin-Based Chemotherapy.","authors":"Tetsuya Wako, Ryosuke Arakawa, Shinji Nakamichi, Masaru Matsumoto, Rei Yamaguchi, Kaoruko Shimbu, Tomoyasu Inoue, Takehiro Tozuka, Junichi Aoyama, Yasuhiro Kato, Naomi Onda, Akihiko Miyanaga, Masahiro Seike, Kaoru Kubota","doi":"10.1272/jnms.JNMS.2025_92-210","DOIUrl":"10.1272/jnms.JNMS.2025_92-210","url":null,"abstract":"Background: Diuretics are commonly used to reduce renal dysfunction during cisplatin-based chemotherapy; however, reports suggest that renal function is unaffected when diuretics are not administered. This phase II trial evaluated the effectiveness and safety of a short hydration method without diuretics.Methods: Patients were included if they were aged 20-74 years, had a thoracic malignancy for which a cisplatin-based regimen (dose: ≥60 mg/m2) was indicated, and had adequate renal function. All patients received cisplatin-based chemotherapy using a short hydration method without diuretics. The primary endpoint was the proportion of patients without grade 2 or higher elevations in creatinine levels during the first cycle of cisplatin.Results: Forty-six patients were enrolled between June 2019 and April 2022. The patients included 38 men and 8 women with a median age of 64 years (range: 45-74 years). Of these, 13 patients received adjuvant chemotherapy, 19 received chemoradiotherapy, 1 received chemotherapy for post-surgical recurrence, and 13 received chemotherapy for advanced disease. The median number of chemotherapy cycles was 3 (range: 1-4). A total of 93.5% (43/46) of the patients completed cisplatin-based chemotherapy without grade 2 or higher creatinine elevation during the first cycle, and 84.8% (39/46) of participants, including those who discontinued treatment, did not show grade 2 or higher creatinine elevation after all cycles of cisplatin-based chemotherapy.Conclusions: Short hydration without diuretics is safe for patients receiving cisplatin-containing chemotherapy. Randomized trials with or without diuretics in this setting are warranted.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 2","pages":"188-195"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Patient-Derived Tumor Organoids in Advanced Cancer Research. 患者来源的肿瘤类器官在晚期癌症研究中的作用。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-310

Taku Sato

引用次数: 0

Cases of Retroverted Uterus Involving Placenta Previa and Low-Lying Placenta Previa Are Significantly Associated with Endometriosis. 后倾子宫合并前置胎盘和低位前置胎盘与子宫内膜异位症有显著相关性。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-106

Eika Harigane, Takashi Matsushima, Asako Watanabe, Hiroki Shinmura, Ryuhei Kurashina, Daisuke Shigemi, Shunji Suzuki

{"title":"Cases of Retroverted Uterus Involving Placenta Previa and Low-Lying Placenta Previa Are Significantly Associated with Endometriosis.","authors":"Eika Harigane, Takashi Matsushima, Asako Watanabe, Hiroki Shinmura, Ryuhei Kurashina, Daisuke Shigemi, Shunji Suzuki","doi":"10.1272/jnms.JNMS.2025_92-106","DOIUrl":"10.1272/jnms.JNMS.2025_92-106","url":null,"abstract":"Background: The purpose of this study was to determine whether cases of placenta previa and low-lying placenta previa in patients with retroverted uterus are significantly associated with endometriosis.Methods: Participants were patients who underwent cesarean section at our hospital with a diagnosis of placenta previa or low-lying placenta previa within a 7-year period from January 2015 to December 2022. Of these, patients with multiple pregnancies and those without a complete uterine image in the medical record at less than 12 weeks' gestation were excluded. Included patients were divided into two groups according to the presence or absence of endometriosis. The presence of endometriosis was determined based on intraoperative findings. A retrospective case-control study was conducted by examining the presence or absence of retroverted uterus during early pregnancy and the presence or absence of posterior placenta.Results: A total of 110 patients were included, 32 in the group with endometriosis and 78 in the group without endometriosis. There were 15 (46.9%) cases of retroverted uterus in the group with endometriosis and 17 (21.8%) in the group without endometriosis, indicating significantly more cases in the group with endometriosis (P=0.01). There were 15 (46.9%) cases of retroverted uterus with posterior placenta in the group with endometriosis and 16 cases (20.5%) in the group without endometriosis, indicating significantly more cases in the group with endometriosis (P=0.009).Conclusion: Placenta previa and low-lying placenta previa in cases of retroverted uterus are significantly associated with endometriosis.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 1","pages":"22-28"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Perfusion CT on Time Required to Evaluate Indications for Thrombectomy for Acute Cerebral Infarction. 灌注CT对急性脑梗死取栓指征评估时间的影响。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-115

Riku Mihara, Minoru Ideguchi, Kyongsong Kim, Kenta Koketsu, Yasuo Murai

{"title":"Effect of Perfusion CT on Time Required to Evaluate Indications for Thrombectomy for Acute Cerebral Infarction.","authors":"Riku Mihara, Minoru Ideguchi, Kyongsong Kim, Kenta Koketsu, Yasuo Murai","doi":"10.1272/jnms.JNMS.2025_92-115","DOIUrl":"10.1272/jnms.JNMS.2025_92-115","url":null,"abstract":"Background: Rapid treatment of patients with emergency large vessel occlusion (ELVO) improves outcomes. With Vitrea software, the cerebral infarct size and penumbra can be quantified, and 4D images can be constructed quickly. We investigated the performance of Vitrea in ELVO patients.Methods: To evaluate indications for mechanical thrombectomy, we performed plain brain CT, then MRI (group 1, n=30). In May 2022 we acquired perfusion CT scans with Vitrea after plain CT on the same equipment (group 2, n=27) and then compared time from onset to the end of mechanical thrombectomy. At 1 month post-treatment we recorded the neurological outcome by using the modified Rankin scale (mRS). We also compared the infarction areas identified with Vitrea and MRI the day after treatment using DWI-ASPECTS in 25 of 27 patients in group 2. We excluded 2 patients with basilar artery occlusion because this type of occlusion is not included in DWI-ASPECTS.Results: There were no significant intergroup differences in patient characteristics, time from admission or puncture to re-canalization, and outcome 1 month after treatment. Vitrea overestimated the infarct area in 1 of 25 patients (4.0%). Times from admission to transit for examination, to the examination end, and time from admission to puncture, were significantly shorter in group 2.Conclusions: In ascertaining indications for thrombectomy in patients with acute cerebral stroke, perfusion CT with Vitrea shortened time to treatment. However, further investigation is needed to confirm the accuracy of Vitrea in determining the infarct area.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 1","pages":"97-103"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perioperative Anesthesia Management: The Role of MicroRNAs. 围手术期麻醉管理：microrna的作用。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-116

Masashi Ishikawa

{"title":"Perioperative Anesthesia Management: The Role of MicroRNAs.","authors":"Masashi Ishikawa","doi":"10.1272/jnms.JNMS.2025_92-116","DOIUrl":"10.1272/jnms.JNMS.2025_92-116","url":null,"abstract":"MicroRNA (miRNA) is a small RNA molecule that does not code for proteins, and organ- and disease-specific miRNAs are being investigated as diagnostic tools and therapeutic targets, particularly for cardiovascular disease and cancer. Much remains unknown about how anesthetics, other drugs, and perioperative management affect miRNAs, but miRNA-targeted drugs might eventually be used perioperatively. This review examines changes in miRNA expression related to anesthesia management. Sevoflurane results in gene expression patterns that differ by organ. The author investigated changes in miRNA expression induced by anesthetics in the brain, lungs, and liver and found that changes in miRNA expression differ by drug and organ. Since miRNA does not have a one-to-one correspondence with its target mRNA and exhibits complex effects within and between cells, as well as remotely, drug- and organ-specific changes in mRNA expression caused by anesthetics likely involve complex alterations. Cardiovascular disease and cancer are related to perioperative management via miRNAs. Inhalational anesthetics may exacerbate or suppress cellular activity, depending on the type of cancer, and the mechanisms of action differ depending on the inhalational anesthetic. These findings suggest that propofol is more likely to contribute to suppression of cancer cells through intercellular communication. The role of miRNA in perioperative management remains unclear. In the future, it is expected that changes in miRNA expression will be considered when selecting and administering anesthetic drugs perioperatively.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 1","pages":"14-21"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Effects of Remimazolam and Midazolam plus Sevoflurane on Intraoperative Hemodynamics and Opioid Administration: A Retrospective Cohort Study. 雷马唑仑与咪达唑仑加七氟醚对术中血流动力学和阿片类药物给药影响的回顾性队列研究。

IF 1.4 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-403

Yukiko Tashiro, Daisuke Hayashi, Dai Namizato, Yuya Ise, Masashi Ishikawa

{"title":"Comparison of Effects of Remimazolam and Midazolam plus Sevoflurane on Intraoperative Hemodynamics and Opioid Administration: A Retrospective Cohort Study.","authors":"Yukiko Tashiro, Daisuke Hayashi, Dai Namizato, Yuya Ise, Masashi Ishikawa","doi":"10.1272/jnms.JNMS.2025_92-403","DOIUrl":"https://doi.org/10.1272/jnms.JNMS.2025_92-403","url":null,"abstract":"Background: Remimazolam is an ultrashort-acting benzodiazepine that maintains stable hemodynamics during anesthesia. However, few reports have focused on hemodynamic stability and opioid use during cardiac surgery with remimazolam. We hypothesized that administration of remimazolam for induction and maintenance of anesthesia for transcatheter aortic valve implantation would maintain hemodynamics as effectively as conventional anesthetics and allow use of an appropriate dose of opioids. We compared intraoperative hemodynamics and opioid use in patients with severe aortic stenosis who received remimazolam or conventional anesthetics.Methods: This retrospective cohort study analyzed data for patients who underwent transcatheter aortic valve implantation from October 2022 to September 2023. The 23 patients were divided into two groups: a remimazolam group and midazolam + sevoflurane group. The primary outcome was intraoperative blood pressure. The secondary outcomes were the doses of vasoconstrictors, vasodilators, and opioids used.Results: There was no significant difference in any patient characteristic or intraoperative blood pressure between the two groups (before anesthesia: 92.0 [87.0-99.8] vs. 91.0 [86.0-107.0] mm Hg, P=0.935; 1 minute after induction of anesthesia: 91.0 [83.0-98.5] vs. 90.0 [86.3-95.3] mm Hg, P=0.843; at the start of surgery: 77.0 [70.0-79.0] vs. 82.5 [75.5-105.5] mm Hg, P=0.072; at the end of surgery: 74.0 [71.0-78.0] vs. 82.5 [75.5-90.8] mm Hg, P=0.082). The maximum rate of remifentanil administration was significantly higher in the remimazolam group (0.10 [0.10-0.20] vs. 0.10 [0.013-0.10] μg/kg/min, P=0.012).Conclusions: Remimazolam maintained hemodynamics as effectively as midazolam + sevoflurane, even when used in combination with opioids. Remimazolam thus appears to be noninferior to midazolam + sevoflurane.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 4","pages":"313-320"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the Optimal Interval of Perioperative Serum Flomoxef Administration in Hepatobiliary-Pancreatic Surgery. 肝胆胰手术围手术期血清氟莫昔最佳给药间隔的探讨。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-211

Yoko Takayama, Toshiaki Komatsu, Satomi Tsumuraya, Hidefumi Kubo, Nobuyuki Nishizawa, Hiroshi Tajima, Takashi Kaizu, Katsuya Otori, Hirotsugu Okamoto, Yusuke Kumamoto, Hideaki Hanaki

{"title":"Investigation of the Optimal Interval of Perioperative Serum Flomoxef Administration in Hepatobiliary-Pancreatic Surgery.","authors":"Yoko Takayama, Toshiaki Komatsu, Satomi Tsumuraya, Hidefumi Kubo, Nobuyuki Nishizawa, Hiroshi Tajima, Takashi Kaizu, Katsuya Otori, Hirotsugu Okamoto, Yusuke Kumamoto, Hideaki Hanaki","doi":"10.1272/jnms.JNMS.2025_92-211","DOIUrl":"https://doi.org/10.1272/jnms.JNMS.2025_92-211","url":null,"abstract":"Background: Perioperative prophylactic antimicrobials are re-administered at intervals of twice their half-life. However, the actual concentrations of antimicrobial agents and the degree of elevation remain unelucidated.Methods: This prospective cohort study was conducted at a single tertiary care center. Serum concentrations were evaluated in patients who underwent hepatobiliary-pancreatic surgery between April 2019 and December 2020 and received an additional dose of flomoxef (FMOX) every 3 h or 5 h during the surgical procedure based on their renal function.Results: Among the 31 participants, 25 and six received FMOX every 3 h and 5 h, respectively. Analysis based on renal function revealed median FMOX concentrations of 9.88 mg/L and 9.85 mg/L (p = 0.09) for patients with creatinine clearance (Ccr) >60 mL/min and 14.26 mg/L and 20.03 mg/L (p = 0.02) for the patients with Ccr ≤60 mL/min at 3 h and 6 h, respectively, with notable elevation at Ccr ≤60 mL/min. Moreover, the serum FMOX concentration at 6 h for the 3-h dosing patients with Ccr ≤60 mL/min was significantly higher than the concentration at 5 h for the 5-h dosing patients with Ccr ≤60 mL/min (20.03 mg/L vs. 12.85 mg/L, p = 0.04). Although serum concentrations at 3-h and 6-h intervals did not differ significantly in patients with Ccr ≥60 mL/min, these significantly increased in patients with Ccr <60 mL/min.Conclusions: Administering FMOX every 3 h when Ccr is ≥60 mL/min and every 5 h when Ccr is <60 mL/min are appropriate.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 2","pages":"196-203"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Informed Consent for Breast Cancer: The Perspective of Physicians in Japan. 乳腺癌的知情同意：日本医生的观点。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-105

Erika Suzuki, Hiroyuki Takei

引用次数: 0