Journal of Nippon Medical School最新文献

Debranching Thoracic Endovascular Aortic Repair (TEVAR) for Thoracoabdominal Aortic Dissecting Aneurysm Involving the Visceral Arteries: A Case Report. 胸腹主动脉夹层动脉瘤累及内脏动脉的去分支胸血管内主动脉修复术（TEVAR）一例报告。

IF 1.8 4区医学

Journal of Nippon Medical School Pub Date : 2026-08-25 Epub Date: 2025-06-26 DOI: 10.1272/jnms.JNMS.2026_93-401

Anna Tsuji, Naoto Miyagi, Aiko Hirayama, Tomohiro Murata, Ryosuke Amitani, Hitomi Ueda, Hiromasa Yamashita, Takashi Sasaki, Yuji Maruyama, Yasuo Miyagi, Jiro Honda, Yosuke Ishii

{"title":"Debranching Thoracic Endovascular Aortic Repair (TEVAR) for Thoracoabdominal Aortic Dissecting Aneurysm Involving the Visceral Arteries: A Case Report.","authors":"Anna Tsuji, Naoto Miyagi, Aiko Hirayama, Tomohiro Murata, Ryosuke Amitani, Hitomi Ueda, Hiromasa Yamashita, Takashi Sasaki, Yuji Maruyama, Yasuo Miyagi, Jiro Honda, Yosuke Ishii","doi":"10.1272/jnms.JNMS.2026_93-401","DOIUrl":"10.1272/jnms.JNMS.2026_93-401","url":null,"abstract":"Surgical repair of thoracoabdominal aortic aneurysms (TAAA) is a complex procedure that is associated with marked morbidity and mortality. Endovascular TAAA repair, initially reserved for patients at high risk, has yielded promising results and is performed on an increasing range of patients. This case report describes a hybrid approach-a combination of endovascular and open repair-for a patient with high-risk TAAA after aortic dissection. A 79-year-old man had undergone aortic replacement for chronic aortic dissection 20 years previously. His saccular TAAA, extending from the Th12 level to the renal artery origin, demonstrated progressive enlargement (56-60 mm) on computed tomography (CT) scans and compressed the celiac artery. In light of the patient's age and thoracotomy history, a hybrid repair strategy involving total debranching thoracic endovascular aortic repair (TEVAR) with four-branch abdominal reconstruction was selected to minimize surgical risk. The surgery was performed via a midline abdominal incision. Bypass surgery was first performed using a quadrant artificial graft to restore left renal, right renal, superior mesenteric, and common hepatic artery blood flow. The celiac artery was coiled, and TEVAR was completed. Intraoperative contrast and postoperative CT showed no endoleak and a patent debranching graft. The patient recovered without complications and was discharged 10 days postoperatively. The findings for the present hybrid procedure indicate that debranching TEVAR is less invasive and yields better outcomes than open aortic replacement, particularly for patients at high risk.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":" ","pages":"333-337"},"PeriodicalIF":1.8,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell-based Therapies and Drug Repurposing in Stroke. 中风的细胞疗法和药物再利用。

IF 1.8 4区医学

Journal of Nippon Medical School Pub Date : 2026-08-24 DOI: 10.1272/jnms.JNMS.2026_93-510

Satoshi Suda, Yuki Sakamoto, Takashi Shimoyama, Takehiro Katano, Chikako Nito

{"title":"Cell-based Therapies and Drug Repurposing in Stroke.","authors":"Satoshi Suda, Yuki Sakamoto, Takashi Shimoyama, Takehiro Katano, Chikako Nito","doi":"10.1272/jnms.JNMS.2026_93-510","DOIUrl":"https://doi.org/10.1272/jnms.JNMS.2026_93-510","url":null,"abstract":"Ischemic stroke is a leading cause of death and disability worldwide, and contributes substantially to the global burden of disease. Although reperfusion therapies such as intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) and mechanical thrombectomy have transformed acute management, the stringent eligibility criteria, narrow treatment windows, and limited accessibility restrict their use to <20% of patients. Many treated individuals have significant neurological deficits, and this underscores the urgent need for therapies that extend beyond revascularization. Two promising approaches have emerged: cell-based therapy and drug repurposing. Stem cell-based interventions, including mesenchymal stem cells, neural stem cells, and induced pluripotent stem cell-derived products, primarily act via paracrine mechanisms to modulate inflammation, attenuate oxidative stress, promote angiogenesis, and enhance neuroplasticity. Simultaneously, drug repurposing leverages the established safety and pharmacology of existing agents to accelerate clinical translation. Valproic acid, a histone deacetylase inhibitor, and perampanel, a selective AMPA receptor antagonist, target key mechanisms, such as excitotoxicity, oxidative injury, and epigenetic regulation. This review synthesizes the current evidence on both strategies and emphasizes mechanistic overlaps, clinical trial findings, translational barriers, and future directions. Unlike previous reviews that have addressed cell-based therapies or drug repurposing separately, we propose a unique phase-specific integrative framework that rationally combines these complementary strategies with reperfusion therapy and rehabilitation to achieve durable neuroprotection and meaningful recovery in ischemic stroke.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148809517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benign Metastasizing Leiomyoma Presenting as a Solitary Pulmonary Metastasis. 良性转移性平滑肌瘤表现为孤立性肺转移。

IF 1.8 4区医学

Journal of Nippon Medical School Pub Date : 2026-08-24 DOI: 10.1272/jnms.JNMS.2027_94-601

Yuuya Tomioka, Hirotoshi Kubokura, Mana Okuni, Norio Motoda, Jitsuo Usuda

{"title":"Benign Metastasizing Leiomyoma Presenting as a Solitary Pulmonary Metastasis.","authors":"Yuuya Tomioka, Hirotoshi Kubokura, Mana Okuni, Norio Motoda, Jitsuo Usuda","doi":"10.1272/jnms.JNMS.2027_94-601","DOIUrl":"https://doi.org/10.1272/jnms.JNMS.2027_94-601","url":null,"abstract":"A 52-year-old female patient was initially evaluated at another hospital for a splenic tumor. Chest computed tomography revealed a 12-mm nodule with well-defined margins and uniform internal density in the S5 segment of the right middle lobe. She was referred to our hospital for follow-up of a suspected benign lung tumor. After 9 months of outpatient observation, the nodule increased in size to 16 mm, prompting referral to our department. Thoracoscopic partial resection of the right lung was performed for both diagnostic and therapeutic purposes. Histopathological examination showed a tumor composed of densely packed spindle-shaped cells with eosinophilic cytoplasm and minimal atypia. The tumor was positive for estrogen receptor and progesterone receptor. Considering the patient' s history of uterine myoma, these findings led to a diagnosis of benign metastasizing leiomyoma (BML). BML is a rare condition in which benign uterine leiomyomas metastasize to the lungs. It should be considered in the differential diagnosis of women with a history of uterine myoma. Although BML typically presents with multiple pulmonary lesions, solitary lesions are rare. The present case, with a single lesion, posed a challenge in preoperative diagnosis. Therefore, we report this case along with a literature review.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148809498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small Intestinal Adhesion at a Parastomal Hernia of the Ileal Conduit and Hernia Repair with Laparoscopy and Tailored Mesh: A Case Report. 回肠导管造口旁疝小肠粘连及腹腔镜及特制补片修补1例报告。

IF 1.8 4区医学

Journal of Nippon Medical School Pub Date : 2026-06-26 Epub Date: 2025-08-26 DOI: 10.1272/jnms.JNMS.2026_93-303

Shin Imura, Yusuke Ogi, Kei Ishimaru, Shigehiro Koga, Motohira Yoshida, Satoshi Akita, Satoshi Kikuchi, Hiroki Sugishita, Jun Kuwabara, Hironori Matsumoto, Kai Goyo, Taro Oshikiri

{"title":"Small Intestinal Adhesion at a Parastomal Hernia of the Ileal Conduit and Hernia Repair with Laparoscopy and Tailored Mesh: A Case Report.","authors":"Shin Imura, Yusuke Ogi, Kei Ishimaru, Shigehiro Koga, Motohira Yoshida, Satoshi Akita, Satoshi Kikuchi, Hiroki Sugishita, Jun Kuwabara, Hironori Matsumoto, Kai Goyo, Taro Oshikiri","doi":"10.1272/jnms.JNMS.2026_93-303","DOIUrl":"10.1272/jnms.JNMS.2026_93-303","url":null,"abstract":"Parastomal hernia of the ileal conduit (PHIC) is a long-term complication of radical cystectomy (RC) for bladder cancer. A systematic review reported an estimated incidence of PHIC after RC of 17%. Several surgical techniques have been reported for treating parastomal hernias. However, few studies have investigated treatment of PHIC, and there are no guidelines for the optimal approach for PHIC repair. Here, we describe a case in which good results were achieved using the laparoscopic Sugarbaker (LS) technique with a tailored mesh for PHIC. An 80-year-old Japanese woman underwent robot-assisted radical cystectomy for bladder cancer. Ten months after surgery, she was diagnosed as having bowel obstruction due to PHIC. The LS technique was performed using a tailored mesh. Severe small-intestinal adhesions from previous surgeries were safely divided using laparoscopic surgery. No hernia recurrence was observed at 2 years postoperatively. We used the LS technique to treat PHIC, and severe small-intestinal adhesions were safely treated using laparoscopic surgery. The LS technique appears to be a viable therapeutic option for such cases.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":" ","pages":"279-283"},"PeriodicalIF":1.8,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possible Role of Local Anesthetics in Permanent Lower Limb Motor Paralysis after Epidural Anesthesia: A Case Report. 局麻药在硬膜外麻醉后永久性下肢运动麻痹中的可能作用：1例报告。

IF 1.8 4区医学

Journal of Nippon Medical School Pub Date : 2026-06-26 Epub Date: 2025-08-26 DOI: 10.1272/jnms.JNMS.2026_93-302

Ichiro Kamiya, Chol Kim, Atsuko Kageyama, Masashi Ishikawa

{"title":"Possible Role of Local Anesthetics in Permanent Lower Limb Motor Paralysis after Epidural Anesthesia: A Case Report.","authors":"Ichiro Kamiya, Chol Kim, Atsuko Kageyama, Masashi Ishikawa","doi":"10.1272/jnms.JNMS.2026_93-302","DOIUrl":"10.1272/jnms.JNMS.2026_93-302","url":null,"abstract":"We present a case of permanent bilateral lower limb paralysis after epidural anesthesia. A 71-year-old woman (height 159 cm; weight 48.5 kg; American Society of Anesthesiologists Physical Status 2) with a history of hypertension (treated with nifedipine), benign goiter (under surveillance), surgeries for appendicitis, and a previous left humerus fracture had received general anesthesia with epidural anesthesia during two surgical procedures, namely, laparoscopic-assisted low anterior resection with colostomy and laparoscopic-assisted colostomy closure. She developed left-predominant lower limb paralysis after the first epidural anesthesia (using ropivacaine and levobupivacaine). The symptoms had no identifiable cause, persisted after removal of the epidural catheter, and gradually resolved during rehabilitation. Her lower limb paralysis recurred and progressed, however, after the second epidural anesthesia (using levobupivacaine alone), and she has abnormal spinal reflexes and elevated myelin basic protein in cerebrospinal fluid. Although these findings suggested that bilateral lower limb paralysis was caused by a lesion in the central nervous system (thoracolumbar spinal cord), postoperative MRI scans of the vertebrae/spinal cord and head failed to identify the site of the damage. We concluded that permanent bilateral lower limb paralysis was likely caused by epidural anesthesia, but the mechanism could not be identified.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":" ","pages":"272-278"},"PeriodicalIF":1.8,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autoimmune Hemolytic Anemia in a Patient with Generalized Pustular Psoriasis Treated with Brodalumab: A Case Report. 布罗达鲁单抗治疗广泛性脓疱性银屑病患者自身免疫性溶血性贫血1例

IF 1.8 4区医学

Journal of Nippon Medical School Pub Date : 2026-06-26 Epub Date: 2025-08-26 DOI: 10.1272/jnms.JNMS.2026_93-301

Toru Sugimoto, Yuri Kinoshita, Keigo Ito, Hidehisa Saeki, Azusa Ogita

{"title":"Autoimmune Hemolytic Anemia in a Patient with Generalized Pustular Psoriasis Treated with Brodalumab: A Case Report.","authors":"Toru Sugimoto, Yuri Kinoshita, Keigo Ito, Hidehisa Saeki, Azusa Ogita","doi":"10.1272/jnms.JNMS.2026_93-301","DOIUrl":"10.1272/jnms.JNMS.2026_93-301","url":null,"abstract":"Psoriasis is a condition characterized by chronic inflammation of the skin, epidermal hyperproliferation, and dysregulated differentiation driven by acceleration of the tumor necrosis factor-alpha/interleukin (IL)-23/IL-17 axis. Herein, we report a case of generalized pustular psoriasis initially managed with etretinate, apremilast, and risankizumab in a Japanese man. Because of side effects, a therapeutic transition was made to brodalumab at 7 months after the initial consultation. His dermatological symptoms improved; however, hemoglobin concentration decreased to 7.6 g/dL after 4 months of treatment. Diagnostic investigation revealed warm autoimmune hemolytic anemia (AIHA). To our knowledge, this is the first report of AIHA during treatment with brodalumab for generalized pustular psoriasis. The etiological association between AIHA and psoriasis is unclear. Future studies should investigate whether AIHA accompanies pustular psoriasis or results from drug-induced AIHA secondary to brodalumab administration. Our findings suggest that the risk of AIHA in patients with psoriasis treated with brodalumab warrants careful consideration.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":" ","pages":"269-271"},"PeriodicalIF":1.8,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melanoma Metastasis to the Left Breast: A Case Report. 黑色素瘤左乳转移1例报告。

IF 1.4 4区医学

Journal of Nippon Medical School Pub Date : 2026-03-11 Epub Date: 2025-06-26 DOI: 10.1272/jnms.JNMS.2026_93-102

Megumi Sano, Keiko Yanagihara, Mio Yagi, Koji Nagata, Hiroyuki Takei

引用次数: 0

Large First Branchial Cyst Extending into the Parapharyngeal Space: A Case Report. 第一鳃裂大囊肿伸入咽旁间隙1例。

IF 1.4 4区医学

Journal of Nippon Medical School Pub Date : 2026-01-10 Epub Date: 2025-03-22 DOI: 10.1272/jnms.JNMS.2025_92-601

Takeshi Matsunobu, Takaomi Kurioka, Kimihiro Okubo

引用次数: 0

Accurate Diagnosis of Familial Mediterranean Fever Improved Quality of Life for a Patient and Her Family: A Case Report. 家族性地中海热的准确诊断改善了患者及其家庭的生活质量：一个病例报告。

IF 1.4 4区医学

Journal of Nippon Medical School Pub Date : 2026-01-10 Epub Date: 2025-06-26 DOI: 10.1272/jnms.JNMS.2025_92-610

Mami Kurihara, Toru Igarashi, Ryu Ishii, Hanako Tajima, Jun Hayakawa, Makoto Migita

{"title":"Accurate Diagnosis of Familial Mediterranean Fever Improved Quality of Life for a Patient and Her Family: A Case Report.","authors":"Mami Kurihara, Toru Igarashi, Ryu Ishii, Hanako Tajima, Jun Hayakawa, Makoto Migita","doi":"10.1272/jnms.JNMS.2025_92-610","DOIUrl":"10.1272/jnms.JNMS.2025_92-610","url":null,"abstract":"Periodic fever syndrome is diagnosed on the basis of duration of fever, associated symptoms, and blood and genetic test results. During a 6-month period, a 3-year-old girl experienced monthly fever (39°C) episodes persisting 5 to 12 days and two episodes of ankle arthralgia and skin rash during fever. No abdominal or chest pain was noted. Blood tests performed at the time of fever revealed elevated CRP levels and blood sedimentation rates. Urinalysis and bone marrow examination results were unremarkable. Genetic testing for hereditary autoinflammatory disease syndromes showed E84K MEFV gene mutations. After diagnosing atypical familial Mediterranean fever, oral colchicine alleviated the febrile attacks and improved family quality of life. Fever, arthralgia, and skin rash disappeared after oral colchicine, which is effective for atypical familial Mediterranean fever. During the 6 months before the diagnosis, periodic fever disrupted the daily lives of the entire family. The patient was absent from nursery school during fever. The patient's illness affected her mother's health. The mother was concerned about her child's unknown fever, which resulted in depression and the need for psychiatric medication. Colchicine resolved the febrile episodes, and resolution of the patient's symptoms alleviated her mother's depression. This case shows that genetic testing for periodic fever syndrome can improve family quality of life.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":" ","pages":"480-485"},"PeriodicalIF":1.4,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aggravation of Pre-Existing Cervical Spondylotic Myelopathy with Limb Paralysis Following Lumbar Puncture: A Case Report. 腰椎穿刺后原有脊髓型颈椎病伴肢体瘫痪加重1例报告。

IF 1.4 4区医学

Journal of Nippon Medical School Pub Date : 2026-01-10 Epub Date: 2025-03-22 DOI: 10.1272/jnms.JNMS.2025_92-602

Akiko Yamazaki, Masahiro Mishina, Masanori Sakamaki, Takehiko Nagao, Kazumi Kimura

引用次数: 0