Journal of Nippon Medical School最新文献_第3页

Virtual Monochromatic Imaging of Half-Iodine-Load, Contrast-Enhanced Computed Tomography with Deep Learning Image Reconstruction in Patients with Renal Insufficiency: A Clinical Pilot Study. 肾功能不全患者半碘负荷、对比度增强计算机断层扫描与深度学习图像重建的虚拟单色成像：一项临床试点研究。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-112

Shingo Harashima, Rika Fukui, Wakana Samejima, Yuta Hirose, Toshiya Kariyasu, Makiko Nishikawa, Hidenori Yamaguchi, Haruhiko Machida

{"title":"Virtual Monochromatic Imaging of Half-Iodine-Load, Contrast-Enhanced Computed Tomography with Deep Learning Image Reconstruction in Patients with Renal Insufficiency: A Clinical Pilot Study.","authors":"Shingo Harashima, Rika Fukui, Wakana Samejima, Yuta Hirose, Toshiya Kariyasu, Makiko Nishikawa, Hidenori Yamaguchi, Haruhiko Machida","doi":"10.1272/jnms.JNMS.2025_92-112","DOIUrl":"10.1272/jnms.JNMS.2025_92-112","url":null,"abstract":"Background: We retrospectively examined image quality (IQ) of thin-slice virtual monochromatic imaging (VMI) of half-iodine-load, abdominopelvic, contrast-enhanced CT (CECT) by dual-energy CT (DECT) with deep learning image reconstruction (DLIR).Methods: In 28 oncology patients with moderate-to-severe renal impairment undergoing half-iodine-load (300 mgI/kg) CECT by DECT during the nephrographic phase, we reconstructed VMI at 40-70 keV with a slice thickness of 0.625 mm using filtered back-projection (FBP), hybrid iterative reconstruction (HIR), and DLIR; measured contrast-noise ratio (CNR) of the liver, spleen, aorta, portal vein, and prostate/uterus; and determined the optimal keV to achieve the maximal CNR. At the optimal keV, two independent radiologists compared each organ's CNR and subjective IQ scores among FBP, HIR, and DLIR to subjectively grade image noise, contrast, sharpness, delineation of small structures, and overall IQ.Results: CNR of each organ increased continuously from 70 to 40 keV using FBP, HIR, and DLIR. At 40 keV, CNR of the prostate/uterus was significantly higher with DLIR than with FBP; however, CNR was similar between FBP and HIR and between HIR and DLIR. The CNR of all other organs increased significantly from FBP to HIR to DLIR (P < 0.05). All IQ scores significantly improved from FBP to HIR to DLIR (P < 0.05) and were acceptable in all patients with DLIR only.Conclusions: The combination of 40 keV and DLIR offers the maximal CNR and a subjectively acceptable IQ for thin-slice VMI of half-iodine-load CECT.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 1","pages":"69-79"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Biologics on Fibrosis-4 Index in Patients with Psoriasis. 生物制剂对银屑病患者纤维化-4指数的影响。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-114

Takashi Morita, Susumu Ichiyama, Michiko Ito, Saeko Ozaki, Taeang Arai, Masanori Atsukawa, Katsuhiko Iwakiri, Teppei Hagino, Toshihiko Hoashi, Naoko Kanda, Hidehisa Saeki

{"title":"Effects of Biologics on Fibrosis-4 Index in Patients with Psoriasis.","authors":"Takashi Morita, Susumu Ichiyama, Michiko Ito, Saeko Ozaki, Taeang Arai, Masanori Atsukawa, Katsuhiko Iwakiri, Teppei Hagino, Toshihiko Hoashi, Naoko Kanda, Hidehisa Saeki","doi":"10.1272/jnms.JNMS.2025_92-114","DOIUrl":"10.1272/jnms.JNMS.2025_92-114","url":null,"abstract":"Background: Psoriasis is accompanied by systemic inflammation that includes the liver. The fibrosis-4 (FIB-4) index was developed to predict significant liver fibrosis. The present study evaluated the effects of biologics, including TNF inhibitors, on the FIB-4 index in psoriasis patients.Methods: All adult patients with psoriasis who were prescribed biologics (TNF inhibitors, IL-17 inhibitors, or IL-23 inhibitors) at Nippon Medical School from June 2014 to January 2024 for the first time (biologic-naïve patients) were included in this study. The FIB-4 index was calculated before and after 6 months of treatment with biologics.Results: A total of 105 patients were enrolled. The FIB-4 index was higher after 6 months of treatment with TNF inhibitors (P=0.0018) and IL-17 inhibitors (P=0.045) but did not change with IL-23 inhibitors. Aspartate aminotransferase and alanine aminotransferase levels did not change after treatment with TNF inhibitors, IL-17 inhibitors, or IL-23 inhibitors. Platelet count decreased after treatment with TNF inhibitors (P=0.0011) and IL-23 inhibitors (P=0.039) but did not change with IL-17 inhibitors.Conclusions: Downregulation of platelets seems to be a major contributing factor for the increase in FIB-4 index in patients treated with TNF inhibitors. Although the FIB-4 index is a simple marker to screen for liver fibrosis, changes in this index should be interpreted with caution, and imaging findings such as transient elastography should also be used to evaluate the status of liver fibrosis.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 1","pages":"88-96"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tarsal Tunnel Syndrome: A Clinical Review. 跗骨隧道综合征：临床回顾。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-206

Hiroto Yoshida, Kyongsong Kim, Takato Tajiri, Fumiaki Fujihara, Juntaro Matsumoto, Hiroshi Abe, Toyohiko Isu

引用次数: 0

Multiple Functions of Cell Adhesion Molecule 1 (CADM1) and Its Role in the Pathogenesis of Cancer and Other Diseases. 细胞粘附分子1 （CADM1）的多种功能及其在癌症和其他疾病发病中的作用

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-205

Yoshinori Murakami, Yutaka Kasai, Tomoko Masuda, Hiromi Ichihara, Takeshi Ito

{"title":"Multiple Functions of Cell Adhesion Molecule 1 (CADM1) and Its Role in the Pathogenesis of Cancer and Other Diseases.","authors":"Yoshinori Murakami, Yutaka Kasai, Tomoko Masuda, Hiromi Ichihara, Takeshi Ito","doi":"10.1272/jnms.JNMS.2025_92-205","DOIUrl":"https://doi.org/10.1272/jnms.JNMS.2025_92-205","url":null,"abstract":"Cell adhesion molecule 1 (CADM1) is an immunoglobulin superfamily cell adhesion molecule that was first identified as a tumor suppressor in non-small cell lung cancer because of its role in suppressing tumor formation in nude mice. CADM1 forms a homophilic dimer on the cell membrane and associates with actin-binding proteins (4.1s) and scaffold proteins (MAGuKs), which contain PDZ motifs. It forms a ternary protein complex involved in cell adhesion and the formation of epithelium-like structure. While CADM1 is expressed in epithelium, neuronal tissue, and testes, CADM1 expression is absent in many cancers of epithelial origin, including cancers of the lung, esophagus, stomach, liver, pancreas, breast, and prostate. In addition to its tumor-suppressive activity in epithelial cell adhesion, CADM1 acts as a tumor antigen, recognized by activated NK cells and CD8+ T cells through heterophilic interaction with CRTAM, thereby serving as a tumor suppressor in two ways. In contrast, CADM1 is overexpressed in adult T-cell leukemia/lymphoma (ATL) cells, making it a specific diagnostic marker of ATL on FACS analysis. CADM1 is also highly expressed in small cell lung cancer (SCLC) and other neuroendocrine tumors, and promotes metastasis, suggesting its potential as a target for diagnosis and treatment of SCLC. CADM1 also has a role in synapse formation and spermatogenesis, and deficient or abnormal CADM1 is linked to disorders such as male infertility in mice and autism spectrum disorder. Here, we summarize the multiple functions of CADM1 and its involvement in cancer and other diseases, focusing on disorders of aberrant cell adhesion.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 2","pages":"122-131"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phase II Study of Short Hydration without Diuretics for Cisplatin-Based Chemotherapy. 短时间水合无利尿剂用于顺铂化疗的II期研究。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-210

Tetsuya Wako, Ryosuke Arakawa, Shinji Nakamichi, Masaru Matsumoto, Rei Yamaguchi, Kaoruko Shimbu, Tomoyasu Inoue, Takehiro Tozuka, Junichi Aoyama, Yasuhiro Kato, Naomi Onda, Akihiko Miyanaga, Masahiro Seike, Kaoru Kubota

{"title":"Phase II Study of Short Hydration without Diuretics for Cisplatin-Based Chemotherapy.","authors":"Tetsuya Wako, Ryosuke Arakawa, Shinji Nakamichi, Masaru Matsumoto, Rei Yamaguchi, Kaoruko Shimbu, Tomoyasu Inoue, Takehiro Tozuka, Junichi Aoyama, Yasuhiro Kato, Naomi Onda, Akihiko Miyanaga, Masahiro Seike, Kaoru Kubota","doi":"10.1272/jnms.JNMS.2025_92-210","DOIUrl":"10.1272/jnms.JNMS.2025_92-210","url":null,"abstract":"Background: Diuretics are commonly used to reduce renal dysfunction during cisplatin-based chemotherapy; however, reports suggest that renal function is unaffected when diuretics are not administered. This phase II trial evaluated the effectiveness and safety of a short hydration method without diuretics.Methods: Patients were included if they were aged 20-74 years, had a thoracic malignancy for which a cisplatin-based regimen (dose: ≥60 mg/m2) was indicated, and had adequate renal function. All patients received cisplatin-based chemotherapy using a short hydration method without diuretics. The primary endpoint was the proportion of patients without grade 2 or higher elevations in creatinine levels during the first cycle of cisplatin.Results: Forty-six patients were enrolled between June 2019 and April 2022. The patients included 38 men and 8 women with a median age of 64 years (range: 45-74 years). Of these, 13 patients received adjuvant chemotherapy, 19 received chemoradiotherapy, 1 received chemotherapy for post-surgical recurrence, and 13 received chemotherapy for advanced disease. The median number of chemotherapy cycles was 3 (range: 1-4). A total of 93.5% (43/46) of the patients completed cisplatin-based chemotherapy without grade 2 or higher creatinine elevation during the first cycle, and 84.8% (39/46) of participants, including those who discontinued treatment, did not show grade 2 or higher creatinine elevation after all cycles of cisplatin-based chemotherapy.Conclusions: Short hydration without diuretics is safe for patients receiving cisplatin-containing chemotherapy. Randomized trials with or without diuretics in this setting are warranted.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 2","pages":"188-195"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Patient-Derived Tumor Organoids in Advanced Cancer Research. 患者来源的肿瘤类器官在晚期癌症研究中的作用。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-310

Taku Sato

引用次数: 0

Cases of Retroverted Uterus Involving Placenta Previa and Low-Lying Placenta Previa Are Significantly Associated with Endometriosis. 后倾子宫合并前置胎盘和低位前置胎盘与子宫内膜异位症有显著相关性。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-106

Eika Harigane, Takashi Matsushima, Asako Watanabe, Hiroki Shinmura, Ryuhei Kurashina, Daisuke Shigemi, Shunji Suzuki

{"title":"Cases of Retroverted Uterus Involving Placenta Previa and Low-Lying Placenta Previa Are Significantly Associated with Endometriosis.","authors":"Eika Harigane, Takashi Matsushima, Asako Watanabe, Hiroki Shinmura, Ryuhei Kurashina, Daisuke Shigemi, Shunji Suzuki","doi":"10.1272/jnms.JNMS.2025_92-106","DOIUrl":"10.1272/jnms.JNMS.2025_92-106","url":null,"abstract":"Background: The purpose of this study was to determine whether cases of placenta previa and low-lying placenta previa in patients with retroverted uterus are significantly associated with endometriosis.Methods: Participants were patients who underwent cesarean section at our hospital with a diagnosis of placenta previa or low-lying placenta previa within a 7-year period from January 2015 to December 2022. Of these, patients with multiple pregnancies and those without a complete uterine image in the medical record at less than 12 weeks' gestation were excluded. Included patients were divided into two groups according to the presence or absence of endometriosis. The presence of endometriosis was determined based on intraoperative findings. A retrospective case-control study was conducted by examining the presence or absence of retroverted uterus during early pregnancy and the presence or absence of posterior placenta.Results: A total of 110 patients were included, 32 in the group with endometriosis and 78 in the group without endometriosis. There were 15 (46.9%) cases of retroverted uterus in the group with endometriosis and 17 (21.8%) in the group without endometriosis, indicating significantly more cases in the group with endometriosis (P=0.01). There were 15 (46.9%) cases of retroverted uterus with posterior placenta in the group with endometriosis and 16 cases (20.5%) in the group without endometriosis, indicating significantly more cases in the group with endometriosis (P=0.009).Conclusion: Placenta previa and low-lying placenta previa in cases of retroverted uterus are significantly associated with endometriosis.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 1","pages":"22-28"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Perfusion CT on Time Required to Evaluate Indications for Thrombectomy for Acute Cerebral Infarction. 灌注CT对急性脑梗死取栓指征评估时间的影响。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-115

Riku Mihara, Minoru Ideguchi, Kyongsong Kim, Kenta Koketsu, Yasuo Murai

{"title":"Effect of Perfusion CT on Time Required to Evaluate Indications for Thrombectomy for Acute Cerebral Infarction.","authors":"Riku Mihara, Minoru Ideguchi, Kyongsong Kim, Kenta Koketsu, Yasuo Murai","doi":"10.1272/jnms.JNMS.2025_92-115","DOIUrl":"10.1272/jnms.JNMS.2025_92-115","url":null,"abstract":"Background: Rapid treatment of patients with emergency large vessel occlusion (ELVO) improves outcomes. With Vitrea software, the cerebral infarct size and penumbra can be quantified, and 4D images can be constructed quickly. We investigated the performance of Vitrea in ELVO patients.Methods: To evaluate indications for mechanical thrombectomy, we performed plain brain CT, then MRI (group 1, n=30). In May 2022 we acquired perfusion CT scans with Vitrea after plain CT on the same equipment (group 2, n=27) and then compared time from onset to the end of mechanical thrombectomy. At 1 month post-treatment we recorded the neurological outcome by using the modified Rankin scale (mRS). We also compared the infarction areas identified with Vitrea and MRI the day after treatment using DWI-ASPECTS in 25 of 27 patients in group 2. We excluded 2 patients with basilar artery occlusion because this type of occlusion is not included in DWI-ASPECTS.Results: There were no significant intergroup differences in patient characteristics, time from admission or puncture to re-canalization, and outcome 1 month after treatment. Vitrea overestimated the infarct area in 1 of 25 patients (4.0%). Times from admission to transit for examination, to the examination end, and time from admission to puncture, were significantly shorter in group 2.Conclusions: In ascertaining indications for thrombectomy in patients with acute cerebral stroke, perfusion CT with Vitrea shortened time to treatment. However, further investigation is needed to confirm the accuracy of Vitrea in determining the infarct area.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 1","pages":"97-103"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perioperative Anesthesia Management: The Role of MicroRNAs. 围手术期麻醉管理：microrna的作用。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-116

Masashi Ishikawa

{"title":"Perioperative Anesthesia Management: The Role of MicroRNAs.","authors":"Masashi Ishikawa","doi":"10.1272/jnms.JNMS.2025_92-116","DOIUrl":"10.1272/jnms.JNMS.2025_92-116","url":null,"abstract":"MicroRNA (miRNA) is a small RNA molecule that does not code for proteins, and organ- and disease-specific miRNAs are being investigated as diagnostic tools and therapeutic targets, particularly for cardiovascular disease and cancer. Much remains unknown about how anesthetics, other drugs, and perioperative management affect miRNAs, but miRNA-targeted drugs might eventually be used perioperatively. This review examines changes in miRNA expression related to anesthesia management. Sevoflurane results in gene expression patterns that differ by organ. The author investigated changes in miRNA expression induced by anesthetics in the brain, lungs, and liver and found that changes in miRNA expression differ by drug and organ. Since miRNA does not have a one-to-one correspondence with its target mRNA and exhibits complex effects within and between cells, as well as remotely, drug- and organ-specific changes in mRNA expression caused by anesthetics likely involve complex alterations. Cardiovascular disease and cancer are related to perioperative management via miRNAs. Inhalational anesthetics may exacerbate or suppress cellular activity, depending on the type of cancer, and the mechanisms of action differ depending on the inhalational anesthetic. These findings suggest that propofol is more likely to contribute to suppression of cancer cells through intercellular communication. The role of miRNA in perioperative management remains unclear. In the future, it is expected that changes in miRNA expression will be considered when selecting and administering anesthetic drugs perioperatively.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 1","pages":"14-21"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Oikawa-Nagao Mouse: A Polygenic Animal Model for Unraveling the Pathophysiology of Type 2 Diabetes and Obesity. Oikawa-Nagao小鼠：揭示2型糖尿病和肥胖病理生理的多基因动物模型。

IF 1.2 4区医学

Journal of Nippon Medical School Pub Date : 2025-01-01 DOI: 10.1272/jnms.JNMS.2025_92-104

Mototsugu Nagao, Shinichi Oikawa

{"title":"The Oikawa-Nagao Mouse: A Polygenic Animal Model for Unraveling the Pathophysiology of Type 2 Diabetes and Obesity.","authors":"Mototsugu Nagao, Shinichi Oikawa","doi":"10.1272/jnms.JNMS.2025_92-104","DOIUrl":"10.1272/jnms.JNMS.2025_92-104","url":null,"abstract":"The Oikawa-Nagao (ON) mouse is a polygenic animal model of type 2 diabetes and obesity developed by selective breeding of mice with inferior glucose tolerance [diabetes-prone (ON mouse DP®; ON-DP) strain] and superior glucose tolerance [diabetes-resistant (ON mouse DR®; ON-DR) strain]. Hybrid mice of three different inbred strains (C57BL/6, AKR, and AKR) were fed a high-fat diet and then selectively bred for higher and lower post-challenge blood glucose levels in oral glucose tolerance tests over 20 generations. Compared to ON-DR mice, ON-DP mice were found to be predisposed to develop obesity and diabetes after being fed a high-fat diet. Our recent studies suggest that the emergence of these phenotypes is associated with novel pathophysiology of type 2 diabetes and obesity, such as low insulin secretion capacity associated with high CD36 expression in pancreatic β-cells and hypoleptinemia preceding obesity due to low leptin secretion capacity in adipocytes. In addition, it has been suggested that ON-DP mice fed an atherogenic diet are a suitable model to reproduce atherosclerotic lesion formation due to fluctuations in blood glucose levels. This may facilitate the elucidation of mechanisms underlying diabetic macrovascular complications. This review will present the development strategy of the ON mouse strain, representative metabolic phenotypes and their underlying mechanisms. Furthermore, their relevance to the pathophysiology of type 2 diabetes and obesity in humans will be discussed.","PeriodicalId":56076,"journal":{"name":"Journal of Nippon Medical School","volume":"92 1","pages":"2-9"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0