Science Progress最新文献

{"title":"Pulpotomy for irreversible pulpitis in mature permanent teeth: An overview of systematic reviews of randomized controlled trials.","authors":"Ajay Chhabra, B Saravana Prathap, Ramya Kp, Priyanka Yadav, Himani, Sona J Parvathy, Vandana Chhabra","doi":"10.1177/00368504251346677","DOIUrl":"10.1177/00368504251346677","url":null,"abstract":"<p><p>BackgroundPulpotomy is widely used in primary and immature permanent teeth, but its effectiveness in mature permanent teeth with irreversible pulpitis remains controversial.ObjectiveTo identify and evaluate the existing systematic reviews of randomized controlled trials (RCTs) assessing pulpotomy as a treatment for irreversible pulpitis in mature permanent teeth.MethodsA protocol-guided search was conducted across PubMed, ProQuest, EMBASE, and Cochrane up to March 2024, targeting systematic reviews based on RCTs. Eligibility, selection, data extraction, and risk of bias assessment were performed independently by two reviewers. Quality was assessed using the AMSTAR 2 tool.ResultsOf the 52 articles retrieved, only one systematic review met inclusion criteria. The review included four RCTs involving 874 patients. Reported clinical success rates ranged from 81.2% to 98.19%, and radiographic success ranged from 38.4% to 95%, with the highest outcomes observed for calcium-enriched mixture and mineral trioxide aggregate. The AMSTAR 2 assessment rated the systematic review as critically low quality.ConclusionCurrent evidence from systematic reviews is insufficient to definitively recommend pulpotomy for irreversible pulpitis in mature permanent teeth. However, favorable clinical outcomes and the minimally invasive, cost-effective nature of the procedure suggest that pulpotomy may serve as a practical alternative to root canal treatment in select cases. High-quality RCTs and systematic reviews are urgently needed to strengthen the evidence base.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251346677"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 5-year limb salvage for long-term limb salvage in chronic limb-threatening ischemia without options for revascularization, utilizing a hybrid deep venous arterialization technique: A case report.","authors":"Lucas Ferrer, Lynsey Malin, Panagiotis Koutakis, Dimitrios Miserlis","doi":"10.1177/00368504251352033","DOIUrl":"10.1177/00368504251352033","url":null,"abstract":"<p><p>Chronic limb-threatening ischemia represents the most severe form of peripheral arterial disease, with a 40% amputation rate and 20% mortality at 6 months without revascularization. Deep venous arterialization is an alternative for patients with advanced peripheral arterial disease who have no conventional revascularization surgery option based on their anatomy-no distal artery target to redirect arterial blood. Hybrid deep venous arterialization, which combines open surgical bypass with venous endovascular arterialization and valvulotomy, is a technique under investigation for limb salvage with limited current long-term data. We present a successful limb salvage case report of an early 60s male with no conventional revascularization options who presented with a wound in his foot and underwent a successful hybrid deep venous arterialization. The hybrid deep venous arterialization technique has shown promising preliminary results for long-term limb salvage at 5 years after surgery. This case report establishes a tangible example of the potential role of hybrid deep venous arterialization in the management of patients with no-option chronic limb-threatening ischemia. After a 5-year follow-up, the reported patient has no ischemic symptoms, and he is able to ambulate without support.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251352033"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suppression of SRC protein kinase activity alleviates the severity of aganglionosis by impairing CAV1/FLNA expression.","authors":"Xiaogang Xu, Yanqing Liu, Menglong Lan, Fei Liu, Huimin Xia, Jixiao Zeng","doi":"10.1177/00368504251336287","DOIUrl":"https://doi.org/10.1177/00368504251336287","url":null,"abstract":"<p><p>ObjectiveHirschsprung's disease (HSCR) is a rare congenital disorder attributed to the defects of enteric neural crest cells. We aim to identify characteristic phosphorylation proteins and preliminarily explore underlying related action mechanisms in HSCR.MethodsColon samples from HSCR patients underwent proteomic and phosphoproteomic sequencing to identify differentially expressed phosphoproteins (DEPPs) and proteins (DEPs). Interaction network construction and analysis of correlations with upstream phosphorylating kinases were employed to pinpoint core proteins. HSCR rat models were established through enema administration of Benzalkonium chloride and evaluated by measuring colon cross-sectional area, colon weight, AchE, and PGP9.5 levels. Histopathological damage was assessed via hematoxylin and eosin staining. Protein expression was analyzed using western blotting. Furthermore, the impact of SRC kinase in HSCR was investigated utilizing an SRC-specific inhibitor in HSCR rat models.ResultsA total of 5725 DEPPs were identified, with SRC kinase emerging as a key regulatory protein. In the HSCR rat model, SRC expression was elevated along with increased pCAV1 and FLNA levels. Notably, inhibition of SRC protein kinase activity by 1-(tert-butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d] pyrimidin-4-amine (PP2) led to reduced colon cross-sectional area and weight, an increase in the number of colonic ganglion cells, heightened AchE levels, enhanced PGP9.5 expression, and slight enlargement of the crypt, thereby alleviating HSCR symptoms in rats. Additionally, SRC kinase inhibition following PP2 treatment decreased the expression of pCAV1 and FLNA.ConclusionsInhibition of SRC kinase activity may potentially reduce CAV1/FLNA expression, ultimately alleviating the severity of HSCR in rats.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251336287"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of cranial bone signal intensity to multiple sclerosis clinical course and progression.","authors":"Furkan Sarıdaş, Rıfat Özpar, Ülkünur Fikriye Özdemir, Yasemin Dinç, Emel Oğuz Akarsu, Emine Rabia Koç, Güven Özkaya, Bahattin Hakyemez, Ömer Faruk Turan","doi":"10.1177/00368504251336090","DOIUrl":"https://doi.org/10.1177/00368504251336090","url":null,"abstract":"<p><p>ObjectivesMultiple sclerosis (MS) usually relapses, about half become progressive after a period of time, few are progressive from the onset. Leptomeningeal ectopic lymphoid follicles with cell flow from the cranial bone marrow may be associated with progression. The aim of this retrospective study was to determine the predictive value of cranial bone signal intensity and to correlate it with other clinical features.MethodsRetrospective clinical and radiological characteristics of 96 MS patients (16 primary progressive multiple sclerosis, 80 relapsing-remitting multiple sclerosis (RRMS)) and 60 controls (tension-type headache) were recorded. Frontal (F), occipital (O), clivus (C) and vitreous body (V) signal intensities were measured. The relationship between clinical features, disease course and radiological findings were analyzed.ResultsThe mean age was 39.58±0.84 years. Twenty-five patients converted to secondary progressive multiple sclerosis (SPMS). Changes in the ratio of F, O, C density to V were similar between groups. At baseline, ratio of frontal bone marrow intensity to vitreous body intensity (F/V) was lower in SPMS and RRMS compared to control, and ratio of occipital bone marrow intensity to vitreous body intensity (O/V) was lower in SPMS compared to control. Low F/V on initial magnetic resonance imaging had diagnostic potential for RRMS, and low F/V and low O/V had diagnostic marker potential for conversion to SPMS.ConclusionsCranial bone intensity in multiple sclerosis patients may be a clue for future disease severity or conversion to SPMS.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251336090"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective analysis of 137 head and neck keratinocyte cancer excisions and their pre-operative biopsy correlation in a regional Australian otolaryngology centre.","authors":"Timothy Sapsford, Zachary Wilson, Daniel Anderson","doi":"10.1177/00368504251344182","DOIUrl":"10.1177/00368504251344182","url":null,"abstract":"<p><p>ObjectiveKeratinocyte cancers (KCs) account for significant healthcare burden in regional Australia. Effective surgical management relies on accurate pre-operative biopsy to inform risk status and guide clinical excision margins. Through retrospective analysis, we aim to describe correlation rates of pre-operative biopsy and final pathology in head and neck KC excisions.MethodsFrom July 2023 to June 2024, 137 KC excisions performed in a regional Australian Otolaryngology Head and Neck surgery outpatient skin unit were analysed. Patient demographics, lesion characteristics, preoperative biopsy, and final histopathology were examined.ResultsExcisions were undertaken for 101 basal cell carcinomas (BCCs), 30 squamous cell carcinomas (SCCs), and six intra-epidermal carcinomas. Nineteen excisions were performed without pre-operative biopsy and 15 further excisions were re-excisions for close or involved margins and were not included in correlation analysis. Of the remaining 97 KC, there was concordance between biopsy and formal pathology risk status in 47.4%. Upgraded (higher) risk formal pathology was reported in 19.6% while downgraded (lower) risk formal pathology was reported in 8.2%. Within the higher risk group, three BCC excisions reported close margins when their lower risk subtype (if confirmed) would have been considered clear. There was no residual malignancy in 24.7% of KC excisions. Pathologic concordance rates after subgroup analysis were 58.7% for BCCs and 9.1% for SCCs.ConclusionAccurate pre-operative biopsy to guide treatment options and inform clinical margins is especially important for head and neck KCs, where functional and cosmetic constraints are greatest. The correlation rate for surgically excised head and neck KCs has not been previously investigated in the Australian regional setting. This work highlights the importance of counselling patients on the potential for higher risk final pathology when discussing the risk of requiring further treatment.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251344182"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apophyseal injury of the fifth lumbar transverse process in adolescent athletes: A report of two cases.","authors":"Yuya Fukuda, Kinshi Kato, Kenichi Otoshi, Takuya Nikaido, Michiyuki Hakozaki, Yoichi Kaneuchi, Yoshihiro Matsumoto","doi":"10.1177/00368504251344840","DOIUrl":"10.1177/00368504251344840","url":null,"abstract":"<p><p>Lumbar transverse process injuries are rare in adolescent athletes, with very few documented cases related to sports activities, particularly involving the fifth lumbar region. This report aims to highlight the clinical presentation, diagnosis, and management of apophyseal injuries of the fifth lumbar transverse process in two adolescent athletes. Two adolescent athletes, a 14-year-old boy and a 15-year-old girl, presented with subacute onset of unilateral lower back pain (LBP) following repetitive athletic activities. Both patients had a history of spondylolysis that had previously healed. Initial clinical assessments, including physical examination and imaging studies (CT and MRI), were performed to diagnose the nature of their injuries. Conservative treatment, including rest and specific rehabilitation exercises, was employed. Both patients exhibited right-sided LBP exacerbated by specific movements, mimicking symptoms of lumbar spondylolysis. Imaging studies revealed no evidence of spondylolysis but indicated a slight widening of the growth plate and high-intensity signal changes in the right fifth lumbar transverse process apophysis. Both patients returned to their sports activities within a month of starting treatment, with no recurrence of symptoms reported during follow-ups. Apophyseal injuries of the fifth lumbar transverse process, though rare, should be considered in the differential diagnosis of adolescent athletes presenting with unilateral LBP, especially in the absence of acute trauma.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251344840"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of high doses of statins to prevent contrast-induced acute kidney injury, based on cystatin C levels: A meta-analysis.","authors":"Daniel Cesar M Fernandes, Flavia Velasco, Lucas Velasco Magalhaes Fernandes, Matheus Bertanha, Marcone Sobreira","doi":"10.1177/00368504251344838","DOIUrl":"10.1177/00368504251344838","url":null,"abstract":"<p><p>ObjectiveThe potential benefit of measures to prevent contrast-induced acute kidney injury (CIAKI) remains uncertain. This uncertainty is partly due to the reliance on serum creatinine, a biomarker influenced by non-renal factors such as muscle mass, hydration status, and age. Therefore, this study aims to evaluate CIAKI prevention based on cystatin C levels-a more stable and earlier biomarker of renal dysfunction, which may improve diagnostic precision and the assessment of therapeutic efficacy.MethodsWe performed a systematic review and meta-analysis of all randomized clinical trials (RCTs) on preventive measures of contrast-induced acute kidney injury, based on cystatin C levels, in patients who underwent percutaneous procedures. We searched PubMed, Scopus, and Cochrane Central for studies comparing the use of high-dose statins in prevention. The outcome of interest was an acute kidney injury based on increased serum cystatin C after the procedure. Statistical analysis was performed using RevMan 5.4. This systematic review with meta-analysis was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under protocol (CRD42023441815).ResultsWe included four studies with a total of 1167 patients, of whom 594 (50.8%) received high-dose statins (atorvastatin or rosuvastatin). On the baseline characteristics of the study population, 65% were male; 79.2% had hypertension; 44.3% had diabetes; 35.7% had dyslipidemia, and 35.4% were currently smokers. Overall, high doses of statins were associated with a lower incidence the CIAKI (OR 0.31; 95% CI [0.19,0.53]; <i>P</i> < .0001).ConclusionOur findings suggest that high doses of statins may play an important role as a measure to prevent CIAKI. If this result is confirmed, we will be able to set up CIAKI prevention protocols, thus expanding the number of patients who will undergo contrast-enhanced exams.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251344838"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of polysaccharide drug delivery systems in the treatment of intestinal diseases: A review.","authors":"Ling Dong, Huiying He, Xuexia Liu, Shuang Ma, Ruying Qiao, Zanwen Peng, Wencong Liu","doi":"10.1177/00368504251353024","DOIUrl":"10.1177/00368504251353024","url":null,"abstract":"<p><p>Intestinal diseases (IDs), as a type of complex immune-related diseases, have long faced challenges such as low drug delivery efficiency, insufficient targeting, and significant systemic toxic and side effects in their treatment strategies. Although oral administration is widely adopted due to its noninvasiveness and high patient compliance, the heterogeneity of the gastrointestinal environment severely limits the precise release and effective accumulation of drugs in the colon. Therefore, developing a new type of drug carrier system that can overcome physiological barriers and achieve colonic targeted delivery has become one of the core research directions in the field of ID therapy. Drug delivery systems based on natural polysaccharides have received extensive attention due to their unique biocompatibility, modifiers, and environmental response characteristics. Polysaccharides not only have excellent drug loading capacity but also can respond to the specific pH value, enzyme environment, and redox state of the colon through chemical modification or physical embedding strategies, thereby precisely regulating drug release kinetics. This article reviews the therapeutic effect of polysaccharide delivery systems in IDs, providing more approaches for the treatment of ID.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251353024"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon policy and firms' OFDI in the digital era: Insights from China.","authors":"Jing Cheng, Zhihui Zhao, Wei Liu, Ruzhen Fang, Fengwei Wang","doi":"10.1177/00368504251330079","DOIUrl":"10.1177/00368504251330079","url":null,"abstract":"<p><p>ObjectiveCreating a low-carbon economy has become an essential goal in fostering green development. In the context of achieving sustainability, in 2014, China implemented a carbon emission trading system (ETS) to conserve energy and reduce emissions. This study examined the effect of the carbon ETS on the outward foreign direct investment (OFDI) of Chinese listed firms.MethodsThis study employed a difference-in-differences approach using the data of Chinese listed firms from 2010 to 2017. The data were sourced from the CSMAR database. Firms located in the trial areas of the carbon ETS were considered the treatment group.ResultsThe carbon ETS had a significant positive impact on firms' OFDI, even after several robustness checks. The carbon ETS positively influenced the OFDI of private firms, firms not belonging to polluting industries, and highly profitable firms but not the OFDI of state-owned firms, firms belonging to polluting industries, and less profitable firms. Technological innovation mediated the impact of the carbon ETS on firms' OFDI but increased production costs did not. Digitalization enhanced the positive effects of the carbon ETS on firms' OFDI.ConclusionThe results present vital implications for deepening two-way investments across economies in the era of digitalization. Developing governments should actively promote carbon emission trading policies and digitalization to help enterprises realize green transformation and improve their competitiveness in \"going global.\"</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251330079"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and characterization of gelatin microgel-stabilized silver nanoparticles loaded with curcumin: Evaluation of antibacterial, antioxidant, and antiproliferative activities.","authors":"Thi Le Na Nguyen, Ngoc Huyen Nguyen, Cong Doanh Sai, Viet Ha Bui Thi, Huu Quyet Do, Thi Thao Vu, Duy Minh Vu","doi":"10.1177/00368504251338628","DOIUrl":"https://doi.org/10.1177/00368504251338628","url":null,"abstract":"<p><p>ObjectiveCurcumin is a polyphenol extracted from the roots of <i>Curcuma longa L</i>. It is a multifunctional biological substance that has notable antioxidant, anti-inflammatory, anti-cancer, and antibacterial properties, as reported in numerous previous papers. However, curcumin has limited bioavailability due to its low water solubility. Furthermore, pH, temperature, and light all have the potential to decrease curcumin's biopharmaceutical activities. Silver nanoparticles have excellent antibacterial characteristics and are used in various applications. The main objective of this work was to synthesize the gelatin microgel-stabilized silver nanoparticles loaded with curcumin (GelCurAg complex) to increase the biopharmaceutical activities of the complex.MethodsNumerous techniques, including UV-vis spectroscopy, FTIR spectroscopy, Zetasizer Nano instruments, TEM images, and XDR patterns, were used for investigating the characterization of the GelCurAg complex. The various methods, such as the DPPH antioxidant assay, cytotoxicity analysis, and the agar-well diffusion method, were used for the analysis of the biopharmaceutical activities of the GelCurAg complex.ResultsWe successfully synthesized and characterized the GelCurAg complex, consisting of gelatin, curcumin, and silver nanoparticle biofilms using polyvinylpyrrolidone. The average nanoparticle size was 50 nm. The GelCurAg complex improved water solubility and dispersion compared with the single curcumin component. The IC₅₀ value for antioxidant activity was 4.87 μg/mL, and for antiproliferation on SK-MEL-28, it was 3.98 µg/mL. GelCurAg solution provided remarkable antibacterial activities against four bacterial strains: <i>Bacillus cereus</i>, <i>Escherichia coli, Pseudomonas aeruginosa,</i> and <i>Staphylococcus aureus</i>. The GelCurAg complex showed better antibacterial activities than the single curcumin component, with the antibacterial inhibition zone in the range of 0.9--1.6 cm.ConclusionsThe GelCurAg complex enhanced the solubility and dispersion of curcumin in water while increasing its antibacterial activity compared to curcumin. The GelCurAg complex has excellent biopharmaceutical properties to suggest its various applications in the future.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251338628"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}