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Evaluation of the therapeutic efficacy of renal artery stenting in patients with atherosclerotic renal artery stenosis.
IF 2.6 4区 综合性期刊
Science Progress Pub Date : 2024-10-01 DOI: 10.1177/00368504241305275
Qiuyue Shi, Min Mao, Jing Chang, Xin Li, Yanwei Li
{"title":"Evaluation of the therapeutic efficacy of renal artery stenting in patients with atherosclerotic renal artery stenosis.","authors":"Qiuyue Shi, Min Mao, Jing Chang, Xin Li, Yanwei Li","doi":"10.1177/00368504241305275","DOIUrl":"10.1177/00368504241305275","url":null,"abstract":"<p><strong>Purpose: </strong>It is currently controversial whether renal artery stenting is beneficial for the clinical outcomes of atherosclerotic renal artery stenosis (ARAS) patients. The study aims to evaluate whether blood pressure (BP) and renal function improve in ARAS patients after stenting.</p><p><strong>Methods: </strong>A retrospective study was conducted on 78 ARAS patients who underwent renal artery stenting at the First Affiliated Hospital of Chongqing Medical University from January 2013 to June 2024. BP, the number of oral antihypertensive medications, renal function, and adverse events were analyzed before and after stenting.</p><p><strong>Results: </strong>A total of 90 stents were implanted. The median follow-up time was 1.59 years. From 24 hours post-operation, significant decline in BP were observed. During follow-up, systolic BP decreased by 24.27 mmHg (95% CI: 16.54-32.00; <i>P </i>< 0.0001) and diastolic BP by 12.27 mmHg (95% CI: 7.25-17.29; <i>P </i>< 0.0001), but the reduction in the number of oral antihypertensive medications was not significant (<i>P </i>> 0.05). Serum creatinine also showed a significant decrease of 8.50 μmol/L at follow-up (<i>P </i>< 0.05). Among the four subgroups, 30 patients with mild renal impaired [eGFR ≥ 60 mL/(min·1.73 m<sup>2</sup>) and <90 mL/(min·1.73 m<sup>2</sup>)] showed an increase of 10.68 mL/(min·1.73 m<sup>2</sup>) in eGFR during follow-up (<i>P </i>< 0.01), while the eGFR of the remaining 48 patients with other renal function stages showed no significant change before and after stenting. Moreover, 24 patients experienced cardiovascular or/and renal adverse events.</p><p><strong>Conclusions: </strong>Renal artery stenting might significantly reduce BP and improve renal function in ARAS patients, particularly those with mild renal impairment, which still requires prospective multicenter studies to confirm.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241305275"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of technology adoption in construction safety management: Case study in China.
IF 2.6 4区 综合性期刊
Science Progress Pub Date : 2024-10-01 DOI: 10.1177/00368504241304198
Jinjing Xu, Jintao Li, Xiaohong Chen
{"title":"Assessment of technology adoption in construction safety management: Case study in China.","authors":"Jinjing Xu, Jintao Li, Xiaohong Chen","doi":"10.1177/00368504241304198","DOIUrl":"10.1177/00368504241304198","url":null,"abstract":"<p><p>The current body of literature indicates that the utilization of emerging digital safety technologies has the potential to enhance the efficacy of safety management in construction significantly. Nevertheless, there has been limited uptake of digital safety technologies within the construction industry in developing countries. This study is focused on evaluating the adoption of digital safety technologies in construction specifically from the perspective of developing countries. Questionnaire data were gathered from project management professionals in China and subjected to analysis using mean ratings, factor analysis, and fuzzy composite evaluation. The developed model for assessing safety technology adoption comprises four primary criterion groups about factors influencing adoption, namely organizational, technological, individual, and external categories. The study results indicate that factors within the technology category exert the most significant influence on the adoption assessment model, followed by those in the external and organizational categories, and finally by individual category factors. These findings contribute to advancing the theory of digital technology adoption in construction safety management research within developing countries. Practitioners can utilize this information to effectively evaluate and compare success rates of safety technology adoption, thereby informing management decisions required for projects. The insights provided by this study will equip practitioners with scientific knowledge for more effective and sustainable program management, ultimately enhancing the success of safety technologies.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241304198"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Jaw vs abdominal Burkitt's lymphoma: An analysis of 25 Iraqi cases.
IF 2.6 4区 综合性期刊
Science Progress Pub Date : 2024-10-01 DOI: 10.1177/00368504241306992
Alaa W Izzat, Ban Al-Drobie, Fatimah J Ismael, Bashar Abdullah
{"title":"Jaw vs abdominal Burkitt's lymphoma: An analysis of 25 Iraqi cases.","authors":"Alaa W Izzat, Ban Al-Drobie, Fatimah J Ismael, Bashar Abdullah","doi":"10.1177/00368504241306992","DOIUrl":"10.1177/00368504241306992","url":null,"abstract":"<p><strong>Objectives: </strong>This study compared the clinicopathological, immunohistochemical characteristics and Epstein-Barr virus (EBV) detection of Burkitt's lymphoma (BL) in the abdomen and jaw of Iraqi patients.</p><p><strong>Methods: </strong>A cohort/retrospective study was carried out between August and September 2024 using 25 tissue blocks (14 gnathic and 11 abdominal BL) from the Oral and Maxillofacial Laboratory, University of Baghdad, College of Dentistry, and the National Centre for Educational Laboratories. The sections were stained with haematoxylin and eosin (H&E), while CD10, CD20, Bcl-2, BCl-6, C-Myc and Ki-67 markers were used for diagnosis. The DNA detection of the EBV was performed by polymerase chain reaction (PCR).</p><p><strong>Results: </strong>The tumours showed 22 classical and 3 atypical histological patterns. The mean age of the patients was 6.3 years, and the male-to-female ratio was 3.1:1. The younger patients were affected by the gnathic BL (<i>P = </i>0.01), and the EBV was detected with a positive correlation (<i>P = </i>0.005) in 14% of the gnathic and 72% of the abdominal tumours. There was no significant correlation between the Ki-67 expression and the clinicopathological features.</p><p><strong>Conclusions: </strong>A critical finding of this study was that gnathic BL tends to affect people of a younger age. In addition, the abdominal presentation of EBV suggests a regional pattern of viral exposure, while there was no correlation between the aggressiveness of BL and viral exposure or the tumour site.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241306992"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coexistence of uterine adenosarcoma and endometrioid endometrial carcinoma: A case report and literature review. 子宫腺肉瘤和子宫内膜样内膜癌并存:病例报告和文献综述。
IF 2.6 4区 综合性期刊
Science Progress Pub Date : 2024-10-01 DOI: 10.1177/00368504241296291
Wenyan Wang, Jianyu Li, Juan Xu, Hao Tang, Ying Chen, Deyu Guo
{"title":"Coexistence of uterine adenosarcoma and endometrioid endometrial carcinoma: A case report and literature review.","authors":"Wenyan Wang, Jianyu Li, Juan Xu, Hao Tang, Ying Chen, Deyu Guo","doi":"10.1177/00368504241296291","DOIUrl":"10.1177/00368504241296291","url":null,"abstract":"<p><p>Uterine adenosarcoma coexisting with endometrial carcinoma is a very rare disease. Herein, we reported the case of uterine adenosarcoma coexisting with endometrioid endometrial carcinoma. Transvaginal ultrasound, computed tomography, and magnetic resonance imaging examinations all indicated a space-occupying lesion in the uterine cavity, and initially was considered endometrial carcinoma. Subsequently, total hysterectomy combined with bilateral salpingo-oophorectomy, pelvic lymphadenectomy, and para-aortic lymphadenectomy were performed. The coexistence of uterine adenosarcoma and endometrioid endometrial carcinoma was histologically confirmed postoperatively. The patient recovered well after surgery and was discharged on postoperative day 7. At a follow-up examination 10 months after surgery, we found no evidence of discomforting symptoms and recurrence or metastasis. Since the coexistence of uterine adenosarcoma and endometrial carcinoma is rare, it is easy to be overlooked the presence of uterine adenosarcoma on imaging or morphology, and thus be misdiagnosed as a more common disease, namely endometrial carcinoma. Observing the cystic structure within the lesion on magnetic resonance imaging is helpful for the diagnosis of uterine adenosarcoma. This article summarizes the imaging characteristics, clinicopathological features, molecular correlation, treatment, and prognosis of the disease.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241296291"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precise control algorithm of rotational speed of the valve-controlled hydraulic motor under load fluctuating conditions. 负载波动条件下阀控液压马达转速的精确控制算法。
IF 2.6 4区 综合性期刊
Science Progress Pub Date : 2024-10-01 DOI: 10.1177/00368504241296299
Kai Hu, Wenyi Zhang
{"title":"Precise control algorithm of rotational speed of the valve-controlled hydraulic motor under load fluctuating conditions.","authors":"Kai Hu, Wenyi Zhang","doi":"10.1177/00368504241296299","DOIUrl":"https://doi.org/10.1177/00368504241296299","url":null,"abstract":"<p><p>The present study focuses on the analysis and design of a novel fuzzy adaptive PID control algorithm, aiming to enhance the speed control accuracy of valve-controlled hydraulic motors under load fluctuating conditions. The method of model identification was adopted to calculate the transfer function of valve-controlled hydraulic motor based on the established hydraulic technology scheme. The chassis of the valve-controlled hydraulic motor is subsequently investigated, and a model for E-grade pavement is constructed using the harmonic superposition method. Through dynamic simulation, the load fluctuation range under two common operating conditions is determined. The fuzzy adaptive PID algorithm was subsequently designed in detail, with the error and its rate of change being considered as input parameters, while the increments of the proportional coefficient, integral constant, and differential constant were regarded as output parameters. Co-simulation data indicate that, compared with the PID algorithm, the average error of the fuzzy adaptive PID algorithm can be reduced by more than 50% and the rise time is reduced by 0.04 seconds. To validate the theoretical analysis, a tracked hydraulic chassis was developed and tested. At an expected speed of 200 rev/min, the average error decreased by 1.68 rev/min, while at an expected speed of 1000 rev/min, the average error reduced by 2.68 rev/min. The designed intelligent control algorithm can effectively improve the control accuracy and stability under load fluctuating conditions.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241296299"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and validation of an LC-MS/MS method for the detection of sodium pentachlorophenolate residues on cutting boards. 开发和验证用于检测砧板上五氯酚钠残留物的 LC-MS/MS 方法。
IF 2.6 4区 综合性期刊
Science Progress Pub Date : 2024-10-01 DOI: 10.1177/00368504241300638
Shicheng Liao, Wanna Xu, Jie Jiang, Honghe Liu, Zhuoying Zeng
{"title":"Development and validation of an LC-MS/MS method for the detection of sodium pentachlorophenolate residues on cutting boards.","authors":"Shicheng Liao, Wanna Xu, Jie Jiang, Honghe Liu, Zhuoying Zeng","doi":"10.1177/00368504241300638","DOIUrl":"10.1177/00368504241300638","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this study was to develop and validate an automated solid-phase extraction (SPE) coupled with ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the detection of sodium pentachlorophenolate (PCP-Na) residues on cutting boards. Given the potential hazards and environmental persistence of PCP-Na, a sensitive and reliable method is crucial for monitoring its residues in food contact materials to ensure consumer safety.</p><p><strong>Methods: </strong>Wood shavings from cutting boards were extracted using 10% methanol in water, followed by purification using an automated SPE system. The eluent was concentrated, reconstituted, and analyzed by UPLC-MS/MS. An isotope-labeled internal standard was used to mitigate matrix effects, enhancing detection sensitivity. The method was validated by assessing linearity, limit of detection (LOD), limit of quantification (LOQ), recovery rates, and relative standard deviations (RSDs) across various concentration levels.</p><p><strong>Results: </strong>The method demonstrated excellent linearity over a concentration range of 0 to 100 μg/L with a regression equation of Y = 1.035X-0.7771 and an R² of 0.9996. The LOD and LOQ were determined to be 0.4 and 1.0 μg/kg, respectively. Recovery rates ranged from 71.75% to 96.50% with RSDs between 5.19% and 16.66%. When applied to 30 market cutting board samples, PCP-Na residues were detected in 50% of the samples, with concentrations ranging from 0 to 83,990 µg/kg.</p><p><strong>Conclusion: </strong>This study presents a robust UPLC-MS/MS method for the detection of PCP-Na on cutting boards, offering improved sensitivity and simplified sample preparation. The high detection rate in commercial samples underscores the need for stringent monitoring and regulatory measures to mitigate the exposure risk to consumers.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241300638"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spoofing attack recognition for GNSS-based train positioning using a BO-LightGBM method. 使用 BO-LightGBM 方法识别基于 GNSS 的列车定位的欺骗攻击。
IF 2.6 4区 综合性期刊
Science Progress Pub Date : 2024-10-01 DOI: 10.1177/00368504241272731
Jiaqi Bi, Jiang Liu, Baigen Cai, Jian Wang
{"title":"Spoofing attack recognition for GNSS-based train positioning using a BO-LightGBM method.","authors":"Jiaqi Bi, Jiang Liu, Baigen Cai, Jian Wang","doi":"10.1177/00368504241272731","DOIUrl":"10.1177/00368504241272731","url":null,"abstract":"<p><p>Trustworthy positioning is critical in the operational control and management of trains. For a train positioning system (TPS) based on a global navigation satellite system (GNSS), a spoofing attack significantly threatens the trustworthiness of positioning. However, the influence and recognition of GNSS spoofing attacks are not considered in the existing research on GNSS-enabled TPS. Spoofing attacks affect the performance of GNSS observations and the positioning results, allowing the development of data-driven spoofing recognition solutions. This study aims to achieve effective spoofing recognition for active security protection in TPS. Different features were designed to reflect the effects of a spoofing attack, including GNSS observation-related indicators and odometer-enabled parameters, and a novel Bayesian optimization-light gradient boosting machine (BO-LightGBM) solution was proposed. In particular, a Bayesian optimization technique was introduced into the LightGBM framework to improve the hyperparameter determination capability for recognition model training. Using a GNSS spoofing test platform with a specific GNSS signal generator and the SimSAFE spoofing test tool, different spoofing attack modes were tested to collect sample datasets for model training and evaluation. The results of model establishment and comparison of the model performance indicators illustrated the advantages of the proposed solution, its adaptability to different spoofing attack situations, and its superiority over state-of-the-art modeling strategies.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241272731"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sustainable development and utilization of marine genetic resources in areas beyond national jurisdiction: A Chinese perspective. 国家管辖范围以外区域海洋遗传资源的可持续开发和利用:中国视角。
IF 2.6 4区 综合性期刊
Science Progress Pub Date : 2024-10-01 DOI: 10.1177/00368504241292449
Zhengkai Mao, Zhijun Zhang, Jinpeng Wang, Shiyang Zhang
{"title":"Sustainable development and utilization of marine genetic resources in areas beyond national jurisdiction: A Chinese perspective.","authors":"Zhengkai Mao, Zhijun Zhang, Jinpeng Wang, Shiyang Zhang","doi":"10.1177/00368504241292449","DOIUrl":"10.1177/00368504241292449","url":null,"abstract":"<p><p>Breakthroughs in marine science and technology have profoundly expanded our knowledge of the ocean, driving unprecedented levels of marine resource utilization. Consequently, the immense value of marine genetic resources (MGRs) in areas beyond national jurisdiction (ABNJ) has catapulted them to the forefront of international competition. In response to the existing gap in international legal frameworks governing the conservation and sustainable use of biodiversity in ABNJ, the Agreement under the United Nations Convention on the Law of the Sea on the Conservation and Sustainable Use of Marine Biological Diversity of Areas Beyond National Jurisdiction (BBNJ Agreement) was adopted on 19 June 2023. This study aimed to explore China's participation in this new frontier of global ocean governance, focusing on the opportunities and challenges it faces. By employing document analysis and policy analysis, the study delved into international legal frameworks such as the United Nations Convention on the Law of the Sea (UNCLOS) and the BBNJ Agreement, as well as China's domestic policies related to marine resource development. It systematically examined the relevant legal frameworks and their historical contexts. Additionally, comparative analysis was used to contrast the policy-making and development practices of developed and developing countries, allowing for a comprehensive assessment of China's role and challenges in the sustainable use of MGRs in ABNJ. It is concluded that while China has made remarkable progress in MGR research, it still lags behind traditional maritime powers in patent accumulation and the commercialization of MGRs. China also lacks comprehensive domestic legislation to address issues such as benefit-sharing and effective regulation of MGRs in ABNJ. Therefore, China must enhance its scientific research and innovation capabilities, actively participate in the follow-up work of the BBNJ Agreement, and promote global marine biodiversity conservation guided by the concept of a Maritime Community with a Shared Future.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241292449"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A predictive model of computed tomography and clinical features of EGFR gene mutation in lung adenocarcinoma. 肺腺癌表皮生长因子受体基因突变的计算机断层扫描和临床特征预测模型。
IF 2.6 4区 综合性期刊
Science Progress Pub Date : 2024-10-01 DOI: 10.1177/00368504241293008
Youjian Yao, Nengde Zhang, Caiwei Lu, Lianhua Liu, Yu Fu, Mei Gui
{"title":"A predictive model of computed tomography and clinical features of EGFR gene mutation in lung adenocarcinoma.","authors":"Youjian Yao, Nengde Zhang, Caiwei Lu, Lianhua Liu, Yu Fu, Mei Gui","doi":"10.1177/00368504241293008","DOIUrl":"10.1177/00368504241293008","url":null,"abstract":"<p><p><b>Purpose:</b> This study aims to develop a predictive model for epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma by integrating computed tomography (CT) imaging features with clinical characteristics. <b>Methods:</b> A retrospective analysis was conducted using electronic medical records from 194 patients diagnosed with lung adenocarcinoma between January 2016 and December 2020, with approval from the institutional review board. Features were selected using LASSO regression, and predictive models were built using logistic regression, support vector machine, and random forest methods. Individual models were created for clinical features, CT imaging features, and a combined model to predict EGFR mutations. <b>Results:</b> The training set revealed that alcohol consumption, intrapulmonary metastasis, and pleural effusion were statistically significant in distinguishing between wild-type and mutation groups (p < 0.05). In the testing set, hilar and mediastinal lymphadenopathy showed statistical significance (p < 0.05). The combined model outperformed the individual clinical and CT imaging feature models. In the testing set, the logistic regression model achieved the highest AUC of 0.827, with sensitivity, specificity, and accuracy of 0.714, 0.712, and 0.712, respectively. Nomogram analysis identified lobulation as an important feature, with a predicted probability of up to 0.9. The decision curve analysis showed that the CT imaging feature model provided a higher net benefit compared to both the clinical feature model and the combined model. <b>Conclusion:</b> In summary, while the combined model outperformed the individual feature models in the testing set, the CT imaging feature model demonstrated the greatest clinical net benefit. Lobulation was identified as an important predictor of EGFR mutations in lung adenocarcinoma.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241293008"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated diagnosis optimization design of the electronic equipment based on spatial mapping. 基于空间映射的电子设备综合诊断优化设计。
IF 2.6 4区 综合性期刊
Science Progress Pub Date : 2024-10-01 DOI: 10.1177/00368504241285770
Xu-Ping Gu, Xian-Jun Shi
{"title":"Integrated diagnosis optimization design of the electronic equipment based on spatial mapping.","authors":"Xu-Ping Gu, Xian-Jun Shi","doi":"10.1177/00368504241285770","DOIUrl":"10.1177/00368504241285770","url":null,"abstract":"<p><p>The complexity of test and fault information within electronic devices makes their integrated diagnosis a challenging problem when designing equipment reliability. Current integrated diagnosis is analyzed for test optimization and test resource optimization. However, this neglects the connection between them. This paper proposes a design strategy for integrated diagnosis optimization based on the spatial mapping principle to quantitatively describe the constraint relationship between them. The integrated diagnosis optimization model is established by constructing the logical mapping relationship between test space, resource space, and fault space, and the optimal test configuration and test resource configuration are sought based on the grey wolf optimization algorithm. Seven high-dimensional benchmark functions and an integrated diagnosis model of electronic equipment are used to verify the efficiency of the algorithm proposed in this paper. The proposed algorithm is compared with the other four in terms of the algorithm's optimization speed and accuracy. The results indicate that the electronic equipment after integrated diagnosis optimization has critical fault detection, fault detection, fault isolation, and false alarm rates of 100%, 99.99%, 98.99%, and 0.2993%, respectively. After the integrated diagnosis optimization, the number of tests of the equipment is reduced by 88.9%, and the test cost is saved by 89%. Compared with the other algorithms, grey wolf optimization achieves the best optimization results, reduces the number of tests by 42%-55%, and decreases the test cost by 77.63%-83.91%. This strategy not only considers the test optimization of equipment and test resources optimization but also dramatically reduces the test cost while improving the test efficiency.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241285770"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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