Science Progress最新文献

{"title":"CXCL8 upregulation mediates inflammatory cell infiltration and accelerates abdominal aortic aneurysm progression.","authors":"Yulong Huang, Xinsheng Xie, Guoqiang Huang, Xiang Hong, Weifeng Lu, Weiguo Fu, Lixin Wang","doi":"10.1177/00368504251328754","DOIUrl":"10.1177/00368504251328754","url":null,"abstract":"<p><strong>Objective: </strong>To explore abdominal aortic aneurysm (AAA) pathogenesis and identify early diagnostic markers, providing a theoretical basis for novel preventive and therapeutic strategies.</p><p><strong>Methods: </strong>Gene expression profiles were retrieved from the Gene Expression Omnibus database (datasets: GSE7084, GSE47472, and GSE57691) comprising messenger RNA data from the aortic samples of 69 patients with AAA and 25 non-AAA controls. Data were merged and normalized; bioinformatics analysis was conducted on upregulated differentially expressed genes.</p><p><strong>Results: </strong>C-X-C motif chemokine ligand 8 (CXCL8) was prominently involved in regulating the chemokine signaling pathway. CXCL8 expression was significantly higher in the aortic walls of patients with AAA than that of controls. NLRP3, interleukin (IL)-18, and IL-1β expression levels were upregulated in patients with AAA and positively correlated with CXCL8 expression. CXCL8 may directly or indirectly interact with NLRP3.</p><p><strong>Conclusions: </strong>CXCL8 was upregulated in patients with AAA and induced inflammatory cell infiltration and cytokine secretion. CXCL8-induced NLRP3 inflammasome regulation triggered pyroptosis in vascular smooth muscle cells, exacerbating inflammation and tissue damage in the aortic wall. This degeneration of the aortic media accelerated AAA progression.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251328754"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the fungal contamination and potential impact of ochratoxigenic <i>Aspergillus</i> species on cocoa beans from cocoa-growing regions of Ghana.","authors":"Joel Cox Menka Banahene, Isaac Williams Ofosu, Herman Erick Lutterodt, William Otoo Ellis","doi":"10.1177/00368504241311963","DOIUrl":"10.1177/00368504241311963","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the fungal contamination profile of cocoa beans from cocoa-growing regions in Ghana, with particular emphasis on the potential impact of ochratoxigenic <i>Aspergillus</i> species.</p><p><strong>Methods: </strong>A total of 104 fermented and dried cocoa beans were randomly collected from farmers for analysis. Fungal isolation was conducted using potato dextrose agar and malt extract agar media. Species-level identification was performed through macroscopic and microscopic techniques. Ochratoxin A (OTA) quantification and confirmation were carried out using high-performance liquid chromatography with fluorescence detection and liquid chromatography-tandem mass spectrometry (LC-MS/MS).</p><p><strong>Results: </strong>The investigation revealed 163 fungal isolates representing 14 distinct species across 10 genera. <i>Aspergillus</i> species, including <i>Aspergillus flavus</i>, <i>Aspergillus niger</i>, <i>Aspergillus parasiticus</i>, and <i>Aspergillus fumigatus</i>, were predominant. No statistically significant differences in fungal species occurrence were observed among the different cocoa-growing regions. However, certain species exhibited preferential growth on specific media, emphasizing the importance of medium selection in mycological studies. Of the 14 fungal species tested, only <i>Aspergillus niger</i> demonstrated the ability to produce OTA <i>in vitro</i>, as confirmed by LC-MS/MS analysis.</p><p><strong>Conclusion: </strong>This discovery holds substantial implications for both the cocoa industry and public health, considering that OTA is a potent mycotoxin subject to strict regulatory limits in food commodities. It is crucial to implement enhanced monitoring and control measures to mitigate fungal contamination in cocoa beans, particularly targeting OTA-producing species. The study also highlights the need for improved post-harvest handling practices, optimized storage conditions, and potential biocontrol approaches.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241311963"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation and analysis of the transmission route of sigmoid sinus tinnitus by HRCT of the temporal bone: A retrospective analysis.","authors":"Houyong Kang, Xi Ouyang, Bin Xiang, Xiaodong Wen, Jing Xiao, Jie Hou, Dongbao Yang","doi":"10.1177/00368504241312295","DOIUrl":"10.1177/00368504241312295","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to analyze anatomical parameters of the transmission route of sigmoid sinus tinnitus (SST) to explore its mechanism and speculate on possible responsible anatomical abnormalities.</p><p><strong>Methods: </strong>Clinical data were retrospectively collected from SST and sigmoid sinus wall dehiscence (SSWD) patients suggested by temporal bone high resolution computed tomography (HRCT), with and without tinnitus, at the First Affiliated Hospital of Chongqing Medical University from January 2015 to August 2022. Patients were divided into SSWD tinnitus (<i>n</i> = 61), and non-tinnitus (<i>n</i> = 60) groups based on HRCT features. Mimics Medical 22.0 and 3-matic Medical 13.0 software measured curvature of the sigmoid sinus bone wall, defect distribution, related parameters, distance to the tympanic sinus and cochlear window, degree of mastoid pneumatization, temporal bone air chamber surface area, volume, and S/V value. Mechanisms were analyzed by comparing clinical data and imaging anatomical parameters between groups.</p><p><strong>Results: </strong>The tinnitus group was significantly younger and had more severe low-frequency hearing loss (<i>P</i> = 0.002). The degree of mastoid pneumatization was significantly lower in the tinnitus group (<i>P</i> = 0.032). The volume of the temporal bone air chamber was smaller (<i>P</i> = 0.020), and the S/V value was higher in the tinnitus group (<i>P</i> = 0.001). Bone wall defects in the lower curvature were protective against tinnitus (<i>P</i> = 0.007, OR = 0.071). Larger maximum transverse diameter of the defect increased tinnitus risk (<i>P</i> = 0.030, OR = 1.875). Higher S/V value was also a significant risk factor (<i>P</i> = 0.009, OR = 24.210).</p><p><strong>Conclusions: </strong>SST patients exhibit significant female and right-sided predominance, with low-frequency hearing loss. Defects in the superior curvature and descending part of the sigmoid groove are more likely to cause tinnitus. Larger transverse diameters and higher S/V values are independent risk factors for tinnitus. Over-pneumatized temporal bones do not facilitate transmission of sigmoid sinus blood flow murmur, highlighting the importance of specific anatomical features in SST development.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241312295"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of NO in oxidant and initial temperature on working characteristics of MON-X/MMH liquid space thruster.","authors":"Yu-Hao Zhou, Rong-Pei Jiang, Guo-Xiu Li, Hong-Meng Li, Tao Fang, Kun Tong","doi":"10.1177/00368504251315801","DOIUrl":"10.1177/00368504251315801","url":null,"abstract":"<p><p>With the progress of deep space exploration activities, low freezing point propellants are required to ensure the normal operation of aerospace engines in deep space environments. Blending NO and nitrogen tetroxide is a commonly used method to decrease freezing point of propellant, which is called MON-X. Researches on MON-X/methyl hydrazine thruster with impinging injection and influences of initial temperature are rare, and there hasn't been a comparison between nitrogen tetroxide/methyl hydrazine thrusters and MON-X/methyl hydrazine thrusters. In order to study the operation characteristics of nitrogen tetroxide/methyl hydrazine and MON-25/methyl hydrazine bipropellant thrusters with impinging injection and investigate the influence of initial temperature on performances, simulation model was developed for a 25 N thruster, starting and stable working process of thrusters was numerically simulated with different oxidant types and initial temperatures. The results show that NO in the oxidant leads to differences in operating characteristics of nitrogen tetroxide thruster and MON-25 thruster. During starting and stable operating processes, dominant reactions of methyl hydrazine dehydrogenation are self-decomposition of methyl hydrazine and extraction of H from methyl hydrazine by NO₂, respectively. The main reactions that affect the temperature rise of combustion chamber are the oxidation of CH₃ to H₂O by OH, as well as small molecule oxidation-reduction reactions such as CO generated by HCN and OH. In a stable operating state, the smaller mass fraction of N₂O₄ in MON-25 leads to a lower temperature in the middle of the cylindrical section of MON-25 thruster than that in nitrogen tetroxide thruster. The combustion chamber pressure of MON-25 thruster does not change significantly in the initial temperature range from 293 K to 263 K. When the initial temperature of MON-25 thruster is 243 K and lower, severe lost on working performance of thruster occurred due to the impact of temperature on propellant gasification.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251315801"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lighting a green future: The role of FinTech in the renewable energy transition.","authors":"Qi Qin, Linfang Tan","doi":"10.1177/00368504251323566","DOIUrl":"10.1177/00368504251323566","url":null,"abstract":"<p><p>With the severity of global climate change becoming increasingly evident, the shift to renewable energy has become the key to achieving sustainable development. Using data from the prefecture level in China, we construct a comprehensive FinTech index from the institutional and individual levels using the entropy method, aiming to capture the multi-dimensional value of FinTech comprehensively. This paper quantifies the momentum that FinTech provides to the urban renewable energy transition. Our investigation shows that FinTech can play a crucial role in enhancing urban renewable energy transition, especially in cities with strict environmental policies, relatively developed economies, and eastern and midland cities. This study further reveals the impact path of FinTech-driven urban renewable energy transformation, and we find that the key path is to curb capital misallocation, strengthen public environmental attention, and improve green innovation. These results expand the research perspective of renewable energy transition and provide a path choice for China to realize renewable energy transition under the dual-carbon goal.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251323566"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study between unilateral and bilateral extrapedicular approaches for osteoporotic vertebral compression fractures: A retrospective study.","authors":"Xuequan Zhao, Xixi Han, Chenxu Li, Baoguo Han, Tianjiao Zhu, Yuxue Shi, Qinglei Liu, Yafeng Zhang","doi":"10.1177/00368504251318194","DOIUrl":"10.1177/00368504251318194","url":null,"abstract":"<p><strong>Objective: </strong>Percutaneous vertebroplasty (PVP) is a primary treatment for osteoporotic vertebral compression fractures (OVCF). Historically, surgeons preferred a bilateral approach for PVP; however, this approach may impose greater financial strain on patients. This retrospective study examines the efficacy of the unilateral approach compared to the bilateral approach.</p><p><strong>Methods: </strong>A total of193 patients were categorized into Group A (unilaterally extrapedicular approach) and Group B (bilateral approach) based on the operative method. Efficacy was evaluated using perioperative indicators, follow-up results, and imaging evaluation results.</p><p><strong>Results: </strong>Out of the 193 patients involved, 169 were eligible for analysis. All patients completed follow-up visits lasting 49-70 months. Compared to Group B, Group A exhibited significantly shorter operation time, puncture duration, amount of bone cement injected, and number of X-ray fluoroscopies (<i>P </i>< 0.05). While initial pain reduction, as measured by the visual analog scale and Oswestry Disability Index scores, was lower in Group A, the difference between the groups narrowed by the final follow-up. At the final imaging follow-up, no statistically significant differences were observed between the two groups regarding the relative height of the injured vertebral bodies and local Cobb angle measurements.</p><p><strong>Conclusions: </strong>This technique holds the potential for accelerated patient rehabilitation and reduced hospitalization expenses, presenting a promising treatment option for OVCF patients.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251318194"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11800245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of benign paroxysmal positional vertigo course on residual symptoms after successful canalith repositioning procedures: A prospective controlled trial.","authors":"Lixin Gu, Dekun Gao, Xiaobao Ma, Jiali Shen, Lu Wang, Jin Sun, Wei Wang, Xiangping Chen, Qing Zhang, Yulian Jin, Jun Yang, Shuna Li, Jianyong Chen","doi":"10.1177/00368504241308959","DOIUrl":"10.1177/00368504241308959","url":null,"abstract":"<p><strong>Background: </strong>Following successful canalith repositioning procedures (CRPs), some patients with benign paroxysmal positional vertigo (BPPV) may experience residual symptoms. There is currently no consensus on whether these residual symptoms are related to the disease duration.</p><p><strong>Objective: </strong>To examine the impact of BPPV duration on the persistence of residual symptoms following successful CRP.</p><p><strong>Methods: </strong>A total of 102 idiopathic BPPV patients were enrolled and categorized into short-course and long-course groups based on the duration of the disease. The course of disease in the short-course group was less than or equal to 7 days. The long course of disease was longer than 7 days. All patients underwent swivel-chair-assisted CRP and were followed up 7-10 days after successful CRP. The Dizziness Handicap Inventory (DHI) questionnaire was administered to all patients before and after CRP.</p><p><strong>Results: </strong>Before CRP, significant differences were observed between the two groups in total DHI score and its subdomains: Physical (DHI-P), Functional (DHI-F), and Emotional (DHI-E) (<i>p</i> < 0.05), indicating that long disease duration significantly affected all patient aspects. After CRP, significant differences remained in total DHI, DHI-P, DHI-F, and DHI-E scores (<i>p</i> < 0.05), with the long-course group consistently scoring higher. However, no significant differences were found in the changes in DHI scores across dimensions before and after CRP between the two groups.</p><p><strong>Conclusion: </strong>The duration of BPPV did not influence CRP outcomes, but patients with a longer disease course were more likely to experience residual symptoms after successful CRP.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241308959"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of the role of AIM2/IL-1β in adult laryngeal papilloma.","authors":"Gaofei Yin, Xiaohong Chen, Yang Zhang, Zhigang Huang, Wei Guo","doi":"10.1177/00368504241292457","DOIUrl":"10.1177/00368504241292457","url":null,"abstract":"<p><strong>Objectives: </strong>Human papillomavirus (HPV) infection is closely related to upper respiratory mucosal lesions, and the most common disease is adult upper respiratory papilloma, which has a certain probability of cancer transformation.This study conducted in vitro tissue and cell experiments to explore the inflammatory mechanisms associated with HPV + adult laryngeal papilloma.</p><p><strong>Methods: </strong>We compared differential expression of AIM2 and IL-1β between HPV (High-risk) negative and positive adult laryngeal papilloma patients. In vitro experiments were conducted to investigate the differences in expression of AIM2, Caspase-1, and IL-1β in HPV- and HPV+ upper respiratory mucosal cells.</p><p><strong>Results: </strong>The expression level of AIM2 and IL-1β was higher in HPV (High-risk) positive papilloma tissue than HPV (High-risk) negative papilloma tissue. The expression of AIM2, Caspase-1, and IL-1β in HPV+ cells was also significantly higher than in HPV- cells.</p><p><strong>Conclusions: </strong>The expression of IL-1β mediated by AIM2 was associated with chronic inflammation of upper respiratory mucosal tissue caused by HPV infection, and it may yet be associated with further pathological changes.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241292457"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attention-based handwritten Chinese recognition for power grid maintenance documents.","authors":"Dajun Xiao, Xialing Xu, Lianfei Shan, Tao Liu, Xin Li, Yue Zhang","doi":"10.1177/00368504241309786","DOIUrl":"10.1177/00368504241309786","url":null,"abstract":"<p><p>Recognizing handwritten Chinese documents can improve efficiency and productivity, which makes it a crucial task for power grid enterprises. This paper proposes a novel handwritten document recognition method to enhance recognition accuracy. First, spatial features are extracted from the input images using an inception module, which captures multi-scale spatial characteristics. Subsequently, a space channel parallel attention module is employed to emphasize significant features and suppress interference. The spatial features are then transformed by a bidirectional long short-term memory network, which predicts the probabilities of outputting Chinese characters. Finally, a transcription layer computes the prediction loss for each character, and the final prediction results are obtained after removing redundant placeholders. Validation experiments demonstrate that the accurate rate and correct rate of the proposed method reach 96.92% and 97.66%, respectively, indicating its effectiveness in capturing handwritten character features and improving accuracy, even under the challenge of diverse handwriting styles.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241309786"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spanish language version of the \"Medical Quality Video Evaluation Tool\" (MQ-VET): Cross-cultural AI-supported adaptation and validation study.","authors":"Alvaro Manuel Rodriguez-Rodriguez, Marta De la Fuente-Costa, Mario Escalera de la Riva, Borja Perez-Dominguez, Sergio Hernandez-Sanchez, Gustavo Paseiro-Ares, Fernando Ramos-Gomez, Jose Casaña-Granell, María Blanco-Diaz","doi":"10.1177/00368504251327507","DOIUrl":"10.1177/00368504251327507","url":null,"abstract":"<p><strong>Background: </strong>The Medical Quality Video Evaluation Tool (MQ-VET) is a standardized instrument for assessing health-related video quality, yet it is only available in English. This study addresses the growing demand for a Spanish version to better support the increasing Spanish-speaking population seeking reliable digital health content.</p><p><strong>Objective: </strong>To adapt and validate the MQ-VET into Spanish, ensuring robust psychometric reliability and validity through rigorous cross-cultural adaptation methods, augmented by the integration of artificial intelligence (AI) tools.</p><p><strong>Materials and methods: </strong>Following international guidelines, the MQ-VET was translated, back-translated, and reviewed by experts. AI-based tools were employed to refine linguistic and cultural accuracy. Psychometric properties were evaluated by 60 participants (30 healthcare and 30 nonhealthcare professionals), focusing on reliability, agreement, and concurrent validity with the DISCERN instrument.</p><p><strong>Results: </strong>The Spanish MQ-VET showed excellent reliability (Cronbach's alpha>0.90, ICC=0.81) and strong concurrent validity (Pearson r = 0.9435, Spearman r = 0.9482, p < 0.0001), alongside with a robust linear regression result (R²=0.8902). Bland-Altman analysis confirmed a robust agreement, and AI-driven tools performed the factorial analysis that revealed a clear three-factor structure explaining 81.1% of the variance.</p><p><strong>Conclusions: </strong>The Spanish MQ-VET is a reliable and valid instrument for assessing the quality of health-related videos, applicable to both healthcare professionals and individuals outside the healthcare field. Leveraging AI-driven methodologies, it serves as a robust resource for enhancing digital health literacy and promoting critical appraisal of video content among Spanish-speaking populations.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251327507"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}