Science Progress最新文献

{"title":"Effect of benign paroxysmal positional vertigo course on residual symptoms after successful canalith repositioning procedures: A prospective controlled trial.","authors":"Lixin Gu, Dekun Gao, Xiaobao Ma, Jiali Shen, Lu Wang, Jin Sun, Wei Wang, Xiangping Chen, Qing Zhang, Yulian Jin, Jun Yang, Shuna Li, Jianyong Chen","doi":"10.1177/00368504241308959","DOIUrl":"10.1177/00368504241308959","url":null,"abstract":"<p><strong>Background: </strong>Following successful canalith repositioning procedures (CRPs), some patients with benign paroxysmal positional vertigo (BPPV) may experience residual symptoms. There is currently no consensus on whether these residual symptoms are related to the disease duration.</p><p><strong>Objective: </strong>To examine the impact of BPPV duration on the persistence of residual symptoms following successful CRP.</p><p><strong>Methods: </strong>A total of 102 idiopathic BPPV patients were enrolled and categorized into short-course and long-course groups based on the duration of the disease. The course of disease in the short-course group was less than or equal to 7 days. The long course of disease was longer than 7 days. All patients underwent swivel-chair-assisted CRP and were followed up 7-10 days after successful CRP. The Dizziness Handicap Inventory (DHI) questionnaire was administered to all patients before and after CRP.</p><p><strong>Results: </strong>Before CRP, significant differences were observed between the two groups in total DHI score and its subdomains: Physical (DHI-P), Functional (DHI-F), and Emotional (DHI-E) (<i>p</i> < 0.05), indicating that long disease duration significantly affected all patient aspects. After CRP, significant differences remained in total DHI, DHI-P, DHI-F, and DHI-E scores (<i>p</i> < 0.05), with the long-course group consistently scoring higher. However, no significant differences were found in the changes in DHI scores across dimensions before and after CRP between the two groups.</p><p><strong>Conclusion: </strong>The duration of BPPV did not influence CRP outcomes, but patients with a longer disease course were more likely to experience residual symptoms after successful CRP.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241308959"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of the role of AIM2/IL-1β in adult laryngeal papilloma.","authors":"Gaofei Yin, Xiaohong Chen, Yang Zhang, Zhigang Huang, Wei Guo","doi":"10.1177/00368504241292457","DOIUrl":"10.1177/00368504241292457","url":null,"abstract":"<p><strong>Objectives: </strong>Human papillomavirus (HPV) infection is closely related to upper respiratory mucosal lesions, and the most common disease is adult upper respiratory papilloma, which has a certain probability of cancer transformation.This study conducted in vitro tissue and cell experiments to explore the inflammatory mechanisms associated with HPV + adult laryngeal papilloma.</p><p><strong>Methods: </strong>We compared differential expression of AIM2 and IL-1β between HPV (High-risk) negative and positive adult laryngeal papilloma patients. In vitro experiments were conducted to investigate the differences in expression of AIM2, Caspase-1, and IL-1β in HPV- and HPV+ upper respiratory mucosal cells.</p><p><strong>Results: </strong>The expression level of AIM2 and IL-1β was higher in HPV (High-risk) positive papilloma tissue than HPV (High-risk) negative papilloma tissue. The expression of AIM2, Caspase-1, and IL-1β in HPV+ cells was also significantly higher than in HPV- cells.</p><p><strong>Conclusions: </strong>The expression of IL-1β mediated by AIM2 was associated with chronic inflammation of upper respiratory mucosal tissue caused by HPV infection, and it may yet be associated with further pathological changes.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241292457"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population pharmacokinetics of colistin sulfate in patients on continuous veno-venous hemodiafiltration.","authors":"Tianmin Huang, Yilin Luo, Yun Wu, Lulu Niu, Yang Xiao, Tingqing Wu, Xin Chen, Yongjun Liu, Jiejiu Lu, Donglan Zhu, Taotao Liu","doi":"10.1177/00368504251325334","DOIUrl":"10.1177/00368504251325334","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to establish a population pharmacokinetic (PK) model for patients undergoing continuous veno-venous hemodiafiltration (CVVHDF) and optimize the dosing regimen of colistin sulfate.</p><p><strong>Methods: </strong>A prospective observational study in a single center was conducted on patients who were administrated with colistin sulfate and CVVHDF for at least 48 h. Blood samples were obtained prior to dosing and four to six blood samples (primarily C_0.5h, C_1h, C_2h, C_4h, and C_6h) after dosing. The blood concentration of colistin sulfate was determined by ultra-high performance liquid chromatography-tandem mass spectrometry assay. The NONMEM program was used to establish the population PK model and perform Monte Carlo simulations. The predictability and stability of the model were internally evaluated by the goodness of fit plots, visual prediction check, and bootstraps.</p><p><strong>Results: </strong>A total of 86 plasma concentrations from 20 patients were used for population PK modeling. A two-compartment model with first-order linear elimination best described the population PK characteristics of colistin sulfate. Cystatin C (CysC) and body weight (WT) were identified as covariates for clearance (CL). Internal evaluation results showed that the final model had good stability and prediction performance. Monte Carlo simulations showed that only when the body WT was 50 kg with CysC ≥3.07 mg/l, and when the body WT was 65 kg with CysC = 5.11 mg/l, and minimum inhibitory concentration (MIC) = 0.25 mg/l, the target attainment probability (PTA) of the daily dose of 1.5 million U regimen was ≥90%. All treatment regimens fail to achieve the target PTA when MIC = 1 mg/l.</p><p><strong>Conclusions: </strong>With the decrease of CysC levels and the increase of WT, the dose of colistin sulfate may need to be increased. It may be prudent for colistin sulfate to consider an initial dose doubling and subsequent maintenance dosing regimen of 200-225 million unit daily, administered in 2-3 divided doses, to attain PTA standard. This study was registered at the Chinese Clinical Trial Registry (www.chictr.org.cn) (trial registration number ChiCTR2300072191).</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251325334"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the pathogenesis of sepsis-induced cardiomyopathy: Multilayered mechanisms and clinical responses.","authors":"Jinfang Xue, Ning Zhou, Quan Li, Ruijie Wang, Yan Li, Huadong Zhu, Chuanzhu Lv","doi":"10.1177/00368504251329190","DOIUrl":"10.1177/00368504251329190","url":null,"abstract":"<p><p>Sepsis-induced cardiomyopathy (SIC), as a common complication in the intensive care unit, not only increases the complexity of patient care but also greatly enhances the risk of death. Currently, clinical management of SIC remains challenging, mainly due to the complexity of its pathogenesis and the lack of targeted therapies. Although the specific etiology of SIC is not yet fully understood, existing studies have revealed several vital pathological processes that are intertwined and contribute to the progression of the disease. This narrative review summarizes the existing pathogenesis of SIC, which involves multiple aspects including the inflammatory response, mitochondrial dysfunction, cell death mechanisms, immune regulation, and calcium homeostasis imbalance. Given the multifactorial pathogenesis of SIC, future studies need to explore the interactions between these mechanisms and how to intervene to develop more precise and effective therapeutic strategies to reduce mortality and improve prognosis in patients with SIC.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251329190"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A <i>t</i>-anol/isoeugenol synthase responsible for converting coumaryl acetate to <i>t</i>-anol in <i>Illicium verum</i>.","authors":"Suqin Guo, Fa Zhang, Feng Peng, Haixia Yu, Kun Zhang, Guiyu Tan","doi":"10.1177/00368504251325630","DOIUrl":"10.1177/00368504251325630","url":null,"abstract":"<p><strong>Objective: </strong><i>Illicium verum</i> is an endemic plant of southern China, which is the primary country for its production. Trans-anethole (<i>t</i>-anethole) is the key component of the volatile aromatic essence in <i>I. verum</i>, and it has therapeutic effects such as anti-cancer and anti-diabetes. However, its biosynthetic pathway in <i>I. verum</i> is rarely reported.</p><p><strong>Methods: </strong>In the present study, we cloned and expressed the cDNA encoding <i>t</i>-anol/isoeugenol synthase (IvAIS1) in <i>Escherichia coli</i>. The characteristics of the IvAIS1 were determined and its gene expression in different tissues was measured by real-time polymerase chain reaction.</p><p><strong>Results: </strong>The IvAIS1 protein is 76% identical to <i>Schisandra chinensis</i> isoeugenol synthase, and the two proteins were clustered closely together in the clade of IGS and EGS. IvAIS1 exhibits NADPH-dependent enzyme activity and dual product specificity, and it converts coumaryl acetate and coniferyl acetate to <i>t</i>-anol (the precursor of <i>t</i>-anethole) and isoeugenol, respectively. The Km values for coniferyl acetate and coumaryl acetate were 438.4 ± 44.3 μM and 480.30 ± 86.61 μM, respectively. The catalytic efficiency of IvAIS1 for coniferyl acetate was found to be higher than that for coumaryl acetate. The gene expression profiles showed that IvAIS1 accumulated in the roots, leaves, and fruits, but the levels were relatively low in the stems and flowers of <i>I. verum</i>.</p><p><strong>Conclusions: </strong>This study showed a putative <i>t</i>-anol/isoeugenol synthase responsible for converting coumaryl acetate to <i>t</i>-anol in <i>I. verum.</i> It expands our current knowledge of the enzymes involved in <i>t</i>-anethole biosynthesis.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251325630"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attention-based handwritten Chinese recognition for power grid maintenance documents.","authors":"Dajun Xiao, Xialing Xu, Lianfei Shan, Tao Liu, Xin Li, Yue Zhang","doi":"10.1177/00368504241309786","DOIUrl":"10.1177/00368504241309786","url":null,"abstract":"<p><p>Recognizing handwritten Chinese documents can improve efficiency and productivity, which makes it a crucial task for power grid enterprises. This paper proposes a novel handwritten document recognition method to enhance recognition accuracy. First, spatial features are extracted from the input images using an inception module, which captures multi-scale spatial characteristics. Subsequently, a space channel parallel attention module is employed to emphasize significant features and suppress interference. The spatial features are then transformed by a bidirectional long short-term memory network, which predicts the probabilities of outputting Chinese characters. Finally, a transcription layer computes the prediction loss for each character, and the final prediction results are obtained after removing redundant placeholders. Validation experiments demonstrate that the accurate rate and correct rate of the proposed method reach 96.92% and 97.66%, respectively, indicating its effectiveness in capturing handwritten character features and improving accuracy, even under the challenge of diverse handwriting styles.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241309786"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spanish language version of the \"Medical Quality Video Evaluation Tool\" (MQ-VET): Cross-cultural AI-supported adaptation and validation study.","authors":"Alvaro Manuel Rodriguez-Rodriguez, Marta De la Fuente-Costa, Mario Escalera de la Riva, Borja Perez-Dominguez, Sergio Hernandez-Sanchez, Gustavo Paseiro-Ares, Fernando Ramos-Gomez, Jose Casaña-Granell, María Blanco-Diaz","doi":"10.1177/00368504251327507","DOIUrl":"10.1177/00368504251327507","url":null,"abstract":"<p><strong>Background: </strong>The Medical Quality Video Evaluation Tool (MQ-VET) is a standardized instrument for assessing health-related video quality, yet it is only available in English. This study addresses the growing demand for a Spanish version to better support the increasing Spanish-speaking population seeking reliable digital health content.</p><p><strong>Objective: </strong>To adapt and validate the MQ-VET into Spanish, ensuring robust psychometric reliability and validity through rigorous cross-cultural adaptation methods, augmented by the integration of artificial intelligence (AI) tools.</p><p><strong>Materials and methods: </strong>Following international guidelines, the MQ-VET was translated, back-translated, and reviewed by experts. AI-based tools were employed to refine linguistic and cultural accuracy. Psychometric properties were evaluated by 60 participants (30 healthcare and 30 nonhealthcare professionals), focusing on reliability, agreement, and concurrent validity with the DISCERN instrument.</p><p><strong>Results: </strong>The Spanish MQ-VET showed excellent reliability (Cronbach's alpha>0.90, ICC=0.81) and strong concurrent validity (Pearson r = 0.9435, Spearman r = 0.9482, p < 0.0001), alongside with a robust linear regression result (R²=0.8902). Bland-Altman analysis confirmed a robust agreement, and AI-driven tools performed the factorial analysis that revealed a clear three-factor structure explaining 81.1% of the variance.</p><p><strong>Conclusions: </strong>The Spanish MQ-VET is a reliable and valid instrument for assessing the quality of health-related videos, applicable to both healthcare professionals and individuals outside the healthcare field. Leveraging AI-driven methodologies, it serves as a robust resource for enhancing digital health literacy and promoting critical appraisal of video content among Spanish-speaking populations.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251327507"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive prediction of coronary artery disease severity: Comparative analysis of electrocardiographic findings and risk factors with SYNTAX and Gensini score.","authors":"Farzaneh-Sadat Mirjalili, Tahere Baghiani, Faezeh Badkoubeh, Abbas Andishmand, Mohammadtaghi Sarebanhassanabadi, Hamidreza Mohammadi, Amin Salehi-Abargouei, Maryam Motallaei, Seyed Mostafa Seyedhosseini","doi":"10.1177/00368504241309454","DOIUrl":"10.1177/00368504241309454","url":null,"abstract":"<p><strong>Objective: </strong>Coronary artery disease (CAD) remains a significant global health burden, characterized by the narrowing or blockage of coronary arteries. Treatment decisions are often guided by angiography-based scoring systems, such as the Synergy Between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) and Gensini scores, although these require invasive procedures. This study explores the potential of electrocardiography (ECG) as a noninvasive diagnostic tool for predicting CAD severity, alongside traditional risk factors.</p><p><strong>Methods: </strong>This retrospective cross-sectional study was conducted on 348 CAD patients who underwent coronary angiography. Demographic data, ECG findings, SYNTAX, and Gensini scores were collected. The association between ECG findings and demographic information with the severity of coronary artery stenosis, as assessed by SYNTAX and Gensini scores, was investigated using SPSS software, version 23.</p><p><strong>Results: </strong>Significant associations were observed between CAD severity and risk factors such as male gender, diabetes mellitus (DM), and smoking. Additionally, certain ECG indicators, including Q waves and ST depression (STD), showed significant correlations with CAD severity, particularly according to the Gensini score.</p><p><strong>Conclusion: </strong>This study underscores the utility of ECG and clinical factors in identifying severe CAD, offering cost-effective diagnostic alternatives to angiography. Integrating various parameters into a single score is crucial in clinical practice, providing a stronger diagnostic and prognostic tool without increasing costs. Further comprehensive studies are warranted to refine risk prediction models and improve CAD management strategies.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241309454"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11713963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The bidirectional relationship between cilia and PCP signaling pathway core protein Vangl2.","authors":"Huanyong Qin, Ting Liang, Chuanfen Zhang, Junlin Wu, Xin Sheng","doi":"10.1177/00368504241311964","DOIUrl":"10.1177/00368504241311964","url":null,"abstract":"<p><p>Vangl2, a core component of the PCP signaling pathway, serves as a scaffold protein on the cell membrane, playing a crucial role in organizing protein complexes. Cilia, dynamic structures on the cell surface, carry out a wide range of functions. Research has highlighted a bidirectional regulatory interaction between Vangl2 and cilia, underscoring their interconnected roles in cellular processes. This relationship is demonstrated by the localization of Vangl2 at the base and proximal regions of cilia, where it plays essential roles in ciliary positioning, asymmetric distribution, and ciliogenesis. In contrast, the absence of cilia can disrupt Vangl2-mediated signal transduction processes. This review offers a narrative review of recent research on Vangl2's function in cilia and examines the regulatory effects of cilia on Vangl2-mediated signaling.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241311964"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intramuscular pH monitoring before and during exercise in individuals with intermittent claudication compared to healthy controls: A feasibility study.","authors":"Andrew D Ablett, Patrick Collins, Derek Ball, Julie Brittenden, Alan J Johnstone","doi":"10.1177/00368504241292126","DOIUrl":"10.1177/00368504241292126","url":null,"abstract":"<p><strong>Objective: </strong>In this feasibility study, firstly, we aimed to assess whether intramuscular pH (IMpH) could be measured with a glass-tipped electrode. Secondly, we aimed to explore whether we could monitor changes in skeletal muscle pH before and throughout static (isometric) and after dynamic (treadmill) exercise, comparing individuals with intermittent claudication (IC) to a group of healthy controls.</p><p><strong>Methods: </strong>Forty participants with IC (mean age ± SD) 68 ± 8) and 40 healthy volunteers (63 ± 10) were recruited. Participants in the IC group had an ankle brachial pressure index of <0.7 (mean: 0.62 ± 0.13). The first 20 participants in each group underwent isometric ankle dorsiflexion for 120 s at 30% of maximum voluntary contraction and the remainder underwent treadmill exercise (3.6 km/h, 5° incline) to maximal walking distance. A sterilised reusable 1.5 mm shatterproof, heat strengthened glass tipped pH probe inserted using a peripheral venous cannula and in combination with a pH meter was used to measure IMpH of the tibialis anterior muscle prior to, during and continuously for 1 h after exercise.</p><p><strong>Results: </strong>Resting IMpH was similar between the groups (median 6.8 (interquartile range (IQR) 6.7-6.9)) for IC individuals and 6.7 (6.6 to 6.8) for controls). Following isometric exercise, the magnitude of the decrease in IMpH was greatest in the IC group (median ΔpH max. in patients -0.2 (IQR: -0.2 to -0.1) versus -0.1 (IQR: -0.2 to -0.1) in the control group (<i>p = </i>0.002). After treadmill exercise, the magnitude of the decrease in IMpH (ΔpH max) was greatest in individuals with IC (median ΔpH max. in patients -0.3 (IQR: -0.3 to -0.3) versus 0 (IQR: -0.2 to 0) in the control group, <i>p = </i>0.04.</p><p><strong>Conclusions: </strong>IMpH monitoring with a flexible glass probe inserted into the tibialis anterior muscle is viable and changes in IMpH during static and dynamic exercises are detected.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241292126"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}