Science Progress最新文献

{"title":"Predicting and evaluating settlement of shallow foundation using machine learning approach.","authors":"Thi Thanh Huong Ngo, Van Quan Tran","doi":"10.1177/00368504241302972","DOIUrl":"10.1177/00368504241302972","url":null,"abstract":"<p><p>This study presents a novel approach to accurately predict the settlement of shallow foundations using advanced machine learning techniques while assessing the influence of key variables. Four machine learning models Gradient Boosting (GB), Random Forest (RF), Support Vector Machine (SVM), and K-Nearest Neighbor (KNN) are enhanced with Particle Swarm Optimization (PSO) for hyperparameter tuning, resulting in hybrid models GB-PSO, RF-PSO, SVM-PSO, and KNN-PSO. The experimental dataset comprises 189 samples, and model performance is rigorously evaluated through K-Fold Cross-Validation alongside R², RMSE, MAE, and MAPE metrics. The results indicate that PSO tuning does not consistently improve the prediction accuracy, with the original models, particularly GB and RF, outperforming their PSO-optimized counterparts. Sensitivity analysis via Shapley Additive Explanation (SHAP) highlights average Standard Penetration Test blow count (SPT) and footing width (B) as the most influential variables, with footing embedment ratio (D_f/B) and net applied pressure (q) also significantly impacting settlement predictions. The study offers a new Excel tool based on the GB model, facilitating practical applications for civil engineers, and providing a dependable, user-friendly tool to predict shallow foundation settlement.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241302972"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From trauma to chronicity: Understanding the incidence and early immune changes of chronic complications in polytrauma patients.","authors":"Cong Zhang, Deng Chen, Qian Wan, Gang Yin, Yang Liu, Jialiu Luo, Shunyao Chen, Zhiqiang Lin, Shuaipeng Gu, Hui Li, Teding Chang, Liming Dong, Peidong Zhang, Zhaohui Tang","doi":"10.1177/00368504241305901","DOIUrl":"10.1177/00368504241305901","url":null,"abstract":"<p><strong>Objective: </strong>Polytrauma is a complex condition associated with poor outcomes and high mortality rates resulting from severe damage and complicated complications. This study sought to ascertain the incidence of chronic complications in polytrauma patients, as well as the early immune changes and risk factors.</p><p><strong>Methods: </strong>A multicenter, prospective and observational cohort study was conducted at the emergency surgery or traumatic intensive care unit (TICU) of the Advanced Trauma Center from August 2020 to July 2023. A total of 2033 consecutive trauma patients were included in the study. In the first 1, 7, and 14 days after admission, flow cytometry and immunoassay kits were used to examine cytokine release and lymphocyte count.</p><p><strong>Results: </strong>Trauma patients were reported 33.8% (687/2033) chronic complication rates, with monotrauma patients reported 8.1% (55/683) and polytrauma patients reported 59.4% (802/1350). And the four most frequent chronic complications in polytrauma patients were chronic musculoskeletal pain (30.4%), post-traumatic osteoarthritis (27.2%), chronic wound (21.6%), and chronic lung injury (14.1.%) .There were significant differences in lymphocyte ratios and cytokine levels, at 1, 7, and 14 day of admission between chronic complication groups (CCP) and not chronic complication groups (N-CCP) in polytrauma. Polytrauma patients with characteristics of higher ratio of Ts_7d ratio (95% CI: 2.01-6.21), Treg_14d (95% CI: 1.12-5.43) and level of IL-6_7d (95% CI: 1.22-4.43), TNF-α_7d (95% CI: 1.05-3.83), IL-10_14d (95% CI: 2.01-6.84) were found to have a higher likelihood of experiencing a chronic complication. Conversely, a higher ratio of Tc_1d (95% CI: 0.53-0.86), Th_1d (95% CI: 0.64-0.95) and Th/Ts_14d (95% CI: 0.21-0.64) were identified as independent protective factors against a chronic complication event.</p><p><strong>Conclusion: </strong>Polytrauma patients exhibit a notable prevalence of chronic complications. Some immune and inflammatory indicators can be observed early in combination after injury to predict the risk of chronic complications after polytrauma.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241305901"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benzodiazepine use and incident risk of sudden cardiac arrest in patients with cardiovascular diseases.","authors":"Chunbao Mo, Shuang Wang, Xia Li, Furong Li, Cheng Jin, Bo Bai, Haolong Pei, Jing Zheng, Fengchao Liang","doi":"10.1177/00368504241295325","DOIUrl":"10.1177/00368504241295325","url":null,"abstract":"<p><strong>Background: </strong>Benzodiazepines (BZDs) are commonly prescribed as adjunctive drugs for patients with cardiovascular diseases (CVDs), particularly those who experience anxiety or insomnia. However, the relationship between the use of BZDs and incident risk of sudden cardiac arrest (SCA) has not been well investigated. In this study, we aimed to examine the association between the use of BZDs and the incident risk of SCA among patients with CVD.</p><p><strong>Method: </strong>In this retrospective cohort study, a total of 74,715 eligible patients with new-onset CVD as a primary cause of hospitalization between July 2016 and August 2022 were included from the health information platform in Shenzhen, China. Among them, 61,761 BZD non-initiators were identified and matched to 12,954 BZD initiators by propensity score at a maximum ratio of 5:1. Propensity score-matched Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Over a 12-month follow-up period, 29 (2.24 per 1000 person-years) and 137 (2.22 per 1000 person-years) SCA cases occurred among propensity score-matched BZD initiators and non-initiators, respectively. Patients who initiated BZD treatment were associated with a 101% increased risk of SCA incidence compared with patients without BZD treatment (adjusted HR: 2.01, 95% CI: 1.42, 2.83). Furthermore, compared with the non-use (0 defined daily dose, DDD), the adjusted HR was 1.43 (95% CI: 1.32, 1.56) for the BZD consumption of ≤1 DDD and 2.58 (95% CI: 2.37, 2.81) for the BZD consumption of >1 DDD (<i>P</i> for trend < 0.001) within a 12-month follow-up period.</p><p><strong>Conclusion: </strong>This study provides evidence that BZD initiation may be associated with an increased incident risk of SCA in patients with CVD. Our finding highlights the importance of cautious prescribing BZDs in the health management of patients with CVD.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241295325"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semantic segmentation models with frozen weights for railway track detection.","authors":"Seungmin Lee, Beomseong Kim, Heesung Lee","doi":"10.1177/00368504241304204","DOIUrl":"10.1177/00368504241304204","url":null,"abstract":"<p><p>In recent years, the application of pretrained models in specialized domains has become increasingly important. Traditionally, adapting these models involved fine-tuning their parameters and structures through retraining. However, these fine-tuning methods can be inefficient, particularly when addressing data from specific domains or when modifications are needed in the lower layers of large-scale pretrained models. This study aims to investigate the effectiveness of using pretrained models with frozen weights for downstream tasks in the context of railway track detection, particularly focusing on the railway system. To achieve this, we employed a large-scale semantic segmentation model that had been pretrained on extensive datasets. The models utilized were kept with fixed weights, eliminating the need for retraining. We conducted a comparative analysis of various pretrained models sourced from different datasets to identify the most suitable model for the track detection system. The findings from our experiments revealed the performance metrics of the selected pretrained models, highlighting their effectiveness in the specific domain of railway track detection. Overall, this research demonstrates the practical applicability of pretrained models with frozen weights in specialized fields such as railway systems, offering insights into their usefulness and potential for improving detection algorithms in this domain.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241304204"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sliding mode control with self-adaptive parameters of a 5-DOF hybrid robot.","authors":"Yanqin Zhao, Mingkun Wu, Jiangping Mei, Wen Zhao, Yan Jin","doi":"10.1177/00368504241286381","DOIUrl":"10.1177/00368504241286381","url":null,"abstract":"<p><p>Due to the advantages of high stiffness, high precision, high load capacity and large workspace, hybrid robots are applicable to drilling and milling of complicated components with large sizes, for instance car panels. However, the difficulty in establishing an exact dynamic model and external disturbances affect the high accuracy control directly, which will decrease the machining accuracy and thereby affect the machining quality and efficiency of the system. Sliding mode control is an effective approach for high-order nonlinear dynamic systems since that it is very insensitive to disturbances and parameter variations. However, chattering may exist in traditional sliding mode control with fixed parameters, which results from a constant approaching speed. Besides, the approaching speed will affect the chattering strength directly. To solve these problems, a modified sliding mode controller with self-adaptive parameters is proposed to enhance the trajectory-tracking performance of a 5-degree-of-freedom hybrid robot. Firstly, the kinematic model of the robot is established. Then adopting the principle of virtual work, a rigid dynamic model of the robot is built. Based on the built dynamic model, a modified sliding mode control method is developed, of which the approaching speed is dependent on the system state. Finally, the sliding mode controller with self-adaptive parameters is created for a hybrid robot. The proposed sliding mode controller can achieve a rapid approaching speed and suppress chattering simultaneously. Simulation results demonstrate that the proposed modified sliding mode controller can achieve a comparatively accurate and smooth trajectory, which owns good robustness to external disturbances.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241286381"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11483726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on influencing factors of controllable mechanical behavior of rock-like porous materials.","authors":"Xiaojing Zhu, Qingxin Qi, Yonghui Xiao, Haitao Li","doi":"10.1177/00368504241291395","DOIUrl":"10.1177/00368504241291395","url":null,"abstract":"<p><p>Due to the discrete and non-homogeneous of similar materials and the inability to realize large-size and original scale modeling, it is difficult to restore the structure and stress state of underground coal and rock mass in similar simulation tests. To solve this problem, a lightweight and suitable for large-scale modeling similar material, rock-like porous material has been developed. The quasi-static uniaxial compression experiment was carried out by using the large tonnage multi-module electronic control test system. And the influencing factors of controllable mechanical behavior of rock-like porous materials were studied. The results showed that, under uniaxial compression conditions, the material stress-strain curve exhibits three phases: elastic stage, failure stage, and platform stage. The uniaxial compressive strength, elasticity modulus, stress drop, and softening modulus of rock-like porous materials basically increase with the increase of density. The stress after peak strength changes from a slow decrease to a \"stepped\" or even \"cliff like\" downward trend. Polypropylene fibers have the effect of enhancing the uniaxial compressive strength, elasticity modulus, stress drop, softening modulus, shear deformation, and residual strength stability of rock-like porous materials. The rock-like porous material has a critical loading velocity, and it increases with density. At the critical loading velocity, the material shows obvious shear failure, and the shear inclination angle is the largest, and so is the uniaxial compressive strength. Through the experimental research, the influence laws of density, polypropylene fiber, and loading velocity on the failure mode, mechanical parameters, and mechanical behavior of the material are clarified, and the quantitative relationship between density and each mechanical parameter is obtained. The research is helpful to realize the accurate control of mechanical behavior of rock-like porous materials and further inverts the deformation and failure mechanism of underground coal and rock structures through indoor similar simulation tests.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241291395"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guillain-Barrè syndrome after treatment with anti-tumour necrosis factor α (etanercept) in a rheumatoid arthritis patient: Case report and literature review.","authors":"Mera H Doden, Mahmoud R Manasra, Bara M AbuIrayyeh, Alaa R Al-Ihribat, Maram Albandak","doi":"10.1177/00368504241304203","DOIUrl":"10.1177/00368504241304203","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) is often treated with anti-tumor necrosis factor α (anti-TNF-α) medications. While these drugs can cause common side effects such as injection-site and infusion reactions, rare cases of Guillain-Barré syndrome (GBS) have been reported. It's a potentially life-threatening condition characterized by progressive, ascending weakness of the extremities and areflexia, with an incidence of about 1.5 cases per 100,000 annually and a mortality rate of around 5%. It has been linked to various triggers, including infections, vaccinations, and medications like TNF inhibitors. Anti-TNF-α treatments may induce GBS by activating latent infections, increasing susceptibility, triggering autoimmune responses, or disrupting the balance of TNF-α in the peripheral nervous system. We report a 39-year-old female with a 26-year history of RA, initially treated with methotrexate until it was discontinued due to myelosuppression. She was then prescribed etanercept. A few weeks later, she developed numbness and burning pain in her limbs. GBS was suspected based on her symptoms, and nerve conduction studies confirmed the diagnosis. She was successfully treated with plasmapheresis.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241304203"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal condition confirmation of treatment conditions through analysis of intratumoral apoptotic temperature range of microwave ablation for various microwave frequencies and antenna insertion depth.","authors":"Donghyuk Kim, Hyunjung Kim","doi":"10.1177/00368504241300855","DOIUrl":"10.1177/00368504241300855","url":null,"abstract":"<p><p>Microwave ablation is a therapeutic technique that kills tumors by inducing heat generation in biological tissue through microwave emissions. Microwave ablation is a minimally invasive treatment technique, which has the advantage of treating deeply located tumors with less bleeding than traditional surgical techniques. In this study, the therapeutic effect of microwave ablation was analyzed from the perspective of the temperature range where apoptosis and necrosis occur. Through the numerical modelling, the tumor located inside the liver tissue was implemented, and the temperature distribution in the hepatic tissue was calculated by varying value of the microwave frequency, microwave antenna input power, and the insertion depth of the microwave coaxial antenna. Microwave frequencies were selected as 915, and 2450 MHz, and the insertion depth of the microwave coaxial antenna was set at a distance difference between the tumor tip and the slot of 4 to 16 mm. In addition, the microwave antenna input power was set to a range of 0 to 60 W. Based on the obtained temperature distribution, the apoptotic variables, which are parameters specifically defined apoptosis ratios that can quantitatively verify the therapeutic effect, were calculated to derive the microwave ablation treatment condition that maximizes the therapeutic effect for each microwave frequency. Through the quantitative analysis of apoptotic variables, the optimal conditions for maximum therapeutic effect were derived for each microwave frequency analyzed in this study. For frequencies of 915 MHz, the optimal insertion depth of the antenna is 8 mm above the bottom of the tumor, and the optimal microwave input power is 40 W. For 2450 MHz, the optimal insertion depth and input power were found to be 4 mm and 4 W, respectively. Ultimately, it is expected that the results presented in this study will lead to more improved treatment of microwave ablation in practice.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241300855"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventional treatment of right lower lobe bronchial schwannoma under bronchoscopy: A case report and literature review.","authors":"Xiyue Li, Ximiao Yu, Ruiqi Luo, Xun Wang","doi":"10.1177/00368504241305911","DOIUrl":"10.1177/00368504241305911","url":null,"abstract":"<p><p>Bronchial schwannoma is a rare benign tumor traditionally managed through surgical resection. This case report describes a 69-year-old Chinese woman with an asymptomatic bronchial schwannoma incidentally discovered during routine health check-up. Computed tomography (CT) and bronchoscopy revealed a broad-based mass (27 mm × 16 mm) at the right lower lobe bronchus, causing complete obstruction of the dorsal segment and severe stenosis (>80%) of the basal segment. Histopathological and immunohistochemical analyses confirmed the diagnosis of schwannoma. The patient underwent a single-session multimodal bronchoscopic treatment combining cryotherapy, high-frequency electrocoagulation, and laser therapy, with minimal bleeding (<5 ml). Post-intervention evaluation showed a fully patent right lower lobe bronchus, and at 8-month follow-up, CT confirmed complete resolution without tumor recurrence. This case demonstrates that carefully planned bronchoscopic intervention can effectively manage selected cases of bronchial schwannoma while preserving lung function and minimizing procedural risks.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241305911"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11672384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and functional analysis of genes mediating osteoclast-driven progression of osteoporosis.","authors":"Qu Xu, Gangning Feng, Zhihai Zhang, Jiangbo Yan, Zhiqun Tang, Rui Wang, Penggang Ma, Ye Ma, Guang Zhu, Qunhua Jin","doi":"10.1177/00368504241300723","DOIUrl":"10.1177/00368504241300723","url":null,"abstract":"<p><strong>Objective: </strong>The pathological mechanism of osteoporosis (OP) involves increased bone resorption mediated by osteoclasts and decreased bone formation mediated by osteoblasts, leading to an imbalance in bone homeostasis. Identifying key molecules in osteoclast-mediated OP progression is crucial for the prevention and treatment of OP.</p><p><strong>Methods: </strong>Differential expression analysis and weighted gene co-expression network analysis (WGCNA) were performed on the OP patient datasets from the GEO database. The results were intersected with the differential expression results from the osteoclast differentiation dataset to identify key genes. These key genes were then subjected to disease relevance analysis, and consensus clustering was performed on OP patient samples based on their expression profiles. The subgroups were analyzed for differences, followed by GO, KEGG, GSEA, and GSVA analyses, and immune infiltration. Finally, osteoclast differentiation model was constructed. After validating the success of the model using TRAP and F-actin staining, the differential expression of key genes was validated in vitro via Western blot.</p><p><strong>Results: </strong>CTRL, ARHGEF5, PPAP2C, VSIG2, and PBLD were identified as key genes. These genes exhibited strong disease relevance (AUC > 0.9). Functional enrichment results also indicated their close association with OP and osteoclast differentiation. In vitro differential expression validation showed that during osteoclast differentiation, CTRL was downregulated, while ARHGEF5, PPAP2C, VSIG2, and PBLD were upregulated, with all differences being statistically significant (<i>P </i>< 0.05).</p><p><strong>Discussion: </strong>Currently, there are no studies on the effects of these five genes on osteoclast differentiation. Therefore, it is meaningful to design in vivo and in vitro perturbation experiments to observe the impact of each gene on osteoclast differentiation and OP progression.</p><p><strong>Conclusion: </strong>CTRL, ARHGEF5, PPAP2C, VSIG2, and PBLD show high potential as molecular targets for basic and clinical research in osteoclast-mediated OP.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241300723"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}