Research progress of polysaccharide drug delivery systems in the treatment of intestinal diseases: A review.

IF 2.6 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES
Science Progress Pub Date : 2025-04-01 Epub Date: 2025-06-27 DOI:10.1177/00368504251353024
Ling Dong, Huiying He, Xuexia Liu, Shuang Ma, Ruying Qiao, Zanwen Peng, Wencong Liu
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引用次数: 0

Abstract

Intestinal diseases (IDs), as a type of complex immune-related diseases, have long faced challenges such as low drug delivery efficiency, insufficient targeting, and significant systemic toxic and side effects in their treatment strategies. Although oral administration is widely adopted due to its noninvasiveness and high patient compliance, the heterogeneity of the gastrointestinal environment severely limits the precise release and effective accumulation of drugs in the colon. Therefore, developing a new type of drug carrier system that can overcome physiological barriers and achieve colonic targeted delivery has become one of the core research directions in the field of ID therapy. Drug delivery systems based on natural polysaccharides have received extensive attention due to their unique biocompatibility, modifiers, and environmental response characteristics. Polysaccharides not only have excellent drug loading capacity but also can respond to the specific pH value, enzyme environment, and redox state of the colon through chemical modification or physical embedding strategies, thereby precisely regulating drug release kinetics. This article reviews the therapeutic effect of polysaccharide delivery systems in IDs, providing more approaches for the treatment of ID.

多糖给药系统治疗肠道疾病的研究进展
肠道疾病作为一种复杂的免疫相关疾病,长期以来在治疗策略上面临着药物递送效率低、靶向性不足、全身性毒副作用大等挑战。尽管口服给药因其无创性和患者依从性高而被广泛采用,但胃肠道环境的异质性严重限制了药物在结肠中的精确释放和有效蓄积。因此,开发一种能够克服生理障碍,实现结肠靶向给药的新型药物载体系统成为ID治疗领域的核心研究方向之一。基于天然多糖的给药系统因其独特的生物相容性、修饰剂和环境响应特性而受到广泛关注。多糖不仅具有优良的载药能力,而且可以通过化学修饰或物理包埋策略对结肠的特定pH值、酶环境和氧化还原状态做出反应,从而精确调节药物释放动力学。本文就多糖传递系统在糖尿病中的治疗作用进行综述,为糖尿病的治疗提供更多途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Science Progress
Science Progress Multidisciplinary-Multidisciplinary
CiteScore
3.80
自引率
0.00%
发文量
119
期刊介绍: Science Progress has for over 100 years been a highly regarded review publication in science, technology and medicine. Its objective is to excite the readers'' interest in areas with which they may not be fully familiar but which could facilitate their interest, or even activity, in a cognate field.
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