Science Progress最新文献

{"title":"Improving the employment in less-developed areas through low-carbon city pilot policy: A study on old revolutionary areas in China.","authors":"Zhonghua Wang, Zeyi Gong, Fengxiu Zhou","doi":"10.1177/00368504251320699","DOIUrl":"10.1177/00368504251320699","url":null,"abstract":"<p><strong>Objectives: </strong>Understanding approaches to promoting green development as well as to increasing employment in old revolutionary areas from the perspective of the \"dual carbon\" goals is important and, hence, needs to be studied.</p><p><strong>Methods: </strong>Using city and enterprise panel data from 2007 to 2019, this study used a differential model to assess the impact of China's low-carbon city pilot policies on employment in old revolutionary base areas.</p><p><strong>Results: </strong>The results showed that the low-carbon city pilot policies could significantly reduce the carbon emissions of old revolutionary base areas as well as significantly promote an improvement in employment levels. Specifically, low-carbon policies could promote the green technological innovation of enterprises and optimize the industrial structure through both output effects and factor-substitution effects to create more jobs. In addition, the impact of low-carbon city pilot policies on employment in different industries and factor intensity was heterogeneous, and the employment promotion effect was more significant in low-energy industries and non-labor-intensive enterprises.</p><p><strong>Conclusions: </strong>The research results can enrich the theoretical basis of regional development planning in China, and provide important references that can be used to both stabilize the employment of residents and promote high-quality development in underdeveloped areas.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251320699"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A unique novel-based FLC approach for enhancing MPPT operation of solar systems considering sudden/gradual variation in weather conditions.","authors":"Kareem M AboRas, Mohammed Hassan El-Banna, Ashraf Ibrahim Megahed","doi":"10.1177/00368504251323732","DOIUrl":"10.1177/00368504251323732","url":null,"abstract":"<p><p>Solar power is one renewable energy source that has great promise. Photovoltaic systems are becoming increasingly popular. Using maximum power point tracker technologies is essential for maximizing the amount of power that can be harvested from a solar system. The variability of the highest power point of a solar system is thought to be caused by the interaction of external elements with the system. In light of the foregoing, the study's overarching goal is to figure out how to use an innovative fuzzy logic controller to track a boost converter-based photovoltaic system's peak power point. We use the fuzzy logic controller to make the system more dynamically sensitive to changes in ambient temperature, quick and moderate variations in irradiance, and other environmental factors. The major objective of this research is to improve the fuzzy logic controller's scaling factors and membership functions. There is a correlation between these features and the controller's accuracy, stability, and speed. For the concept of optimization to be executed well, the cutting-edge metaheuristic method known as Arctic puffin optimization was employed. Arctic Puffin Optimization draws its motivation from nature. Comparisons and analyses with other effective optimization algorithms, such as particle swarm optimization and gray wolf optimizer, have shown that Arctic Puffin Optimization outperforms these other optimization procedures when it comes to fuzzy logic controller tuning. Using the MATLAB/Simulink R2020a environment, we test each method for tracking accuracy, efficiency, response time, transient overshoot, and steady-state ripple. A broad variety of weather conditions was used to conduct the investigation. The Arctic puffin optimization-based fuzzy maximum power point tracker controller's tracking efficacy was consistently over 99.8% in all the conditions investigated, according to the simulation findings.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251323732"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A hybrid long short-term memory-convolutional neural network multi-stream deep learning model with Convolutional Block Attention Module incorporated for monkeypox detection.","authors":"Benjamin Appiah Yeboah, Kojo Sam Micah, Isaac Acquah, Kofi Ampomah Mensah","doi":"10.1177/00368504251331706","DOIUrl":"10.1177/00368504251331706","url":null,"abstract":"<p><p>BackgroundMonkeypox (mpox) is a zoonotic infectious disease caused by the mpox virus and characterized by painful body lesions, fever, headaches, and exhaustion. Since the report of the first human case of mpox in Africa, there have been multiple outbreaks, even in nonendemic regions of the world. The emergence and re-emergence of mpox highlight the critical need for early detection, which has spurred research into applying deep learning to improve diagnostic capabilities.ObjectiveThis research aims to develop a robust hybrid long short-term memory (LSTM)-convolutional neural network (CNN) model with a Convolutional Block Attention Module (CBAM) to provide a potential tool for the early detection of mpox.MethodsA hybrid LSTM-CNN multi-stream deep learning model with CBAM was developed and trained using the Mpox Skin Lesion Dataset Version 2.0 (MSLD v2.0). We employed LSTM layers for preliminary feature extraction, CNN layers for further feature extraction, and CBAM for feature conditioning. The model was evaluated with standard metrics, and gradient-weighted class activation maps (Grad-CAM) and local interpretable model-agnostic explanations (LIME) were used for interpretability.ResultsThe model achieved an F1-score, recall, and precision of 94%, an area under the curve of 95.04%, and an accuracy of 94%, demonstrating competitive performance compared to the state-of-the-art models. This robust performance highlights the reliability of our model. LIME and Grad-CAM offered insights into the model's decision-making process.ConclusionThe hybrid LSTM-CNN multi-stream deep learning model with CBAM successfully detects mpox, providing a promising early detection tool that can be integrated into web and mobile platforms for convenient and widespread use.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251331706"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peak serum lactate as a robust predictor of imminent death in life-sustaining treatment decisions: A study of 73,927 patients.","authors":"Dong Jung Kim, Hyun Joo Kim, Hyoung Woo Chang","doi":"10.1177/00368504241311966","DOIUrl":"https://doi.org/10.1177/00368504241311966","url":null,"abstract":"<p><strong>Objective: </strong>The physician order for life-sustaining treatment has been implemented in clinical practice for several years. However, the determination that a patient is in the terminal phase of life, a prerequisite for the withdrawal of life-sustaining treatment, lacks objective criteria. This study aimed to evaluate whether hyperlactatemia could serve as a reliable objective indicator for determining the terminal phase.</p><p><strong>Methods: </strong>In this retrospective cohort study, we included 73,927 patients admitted to our institution from 2018 to 2023 who had at least one blood lactate measurement. We collected data on the highest blood lactate level measured during hospitalization, mortality, medical department, and intensive care unit (ICU) details. The primary endpoint was 30-day mortality, and we analyzed how well the highest lactate level during hospitalization predicted 30-day mortality across different age groups, medical departments, and ICUs.</p><p><strong>Results: </strong>Among the patients, 5493 died within 30 days of the maximum lactate measurement. The area under the receiver operating characteristic curve (AUROC) for predicting 30-day mortality based on the maximum lactate level was 0.870 (95% confidence interval [CI] 0.865-0.875) in all patients, indicating high accuracy. Setting the cutoff for the maximum lactate level at 20 mmol/L resulted in a precision of 87% and specificity of 99.8%. Subgroup analyses by age, medical department, and ICU yielded consistent results.</p><p><strong>Conclusions: </strong>Severe hyperlactatemia during hospitalization showed high precision and specificity for predicting 30-day mortality across various patient groups. These findings suggest that hyperlactatemia could serve as an objective auxiliary indicator for determining the terminal phase, potentially improving consistency in end-of-life decision-making in clinical practice.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241311966"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical outcomes of subclavian steal syndrome combined with carotid artery stenosis: A single-center retrospective observational study.","authors":"Haotian Huanggu, Guangchao Gu, Fangda Li, Rong Zeng, Jiang Shao, Xiaojun Song, Zhili Liu, Yuehong Zheng","doi":"10.1177/00368504241307470","DOIUrl":"10.1177/00368504241307470","url":null,"abstract":"<p><strong>Objective: </strong>To explore the prevalence and risk factors of carotid artery (CA) stenosis among subclavian steal syndrome (SSS) patients and to record their prognoses.</p><p><strong>Methods: </strong>This observational study was retrospective. From January 2015 to October 2022, 169 patients were diagnosed with SSS. Among them, 51 combined with CA stenosis have surgical indications for both diseases. In this cohort, 24 were treated for subclavian artery (23 endovascular, 1 open), 12 for CA (6 endovascular, 6 open), and 5 for both (1 endovascular, 1 open, 3 hybrid). The primary end point was mortality, and the secondary end points were vessel re-stenosis and other complications. Patients were followed up through outpatient, online, or telephone.</p><p><strong>Results: </strong>Compared with simple SSS, patients who suffered from both were older (60.51 ± 9.304 versus 66.69 ± 7.921, <i>P</i> < 0.001) and more males (57.6% versus 86.3%, <i>P</i> < .001). Besides, they presented a higher prevalence of hyperhomocysteinemia (<i>P</i> = .015), diabetes mellitus (<i>P</i> = .036), and CVA/TIA (<i>P</i> = .036). No patient died within 30 days after surgery; four complications occurred (1 stroke, 1 hearing loss, 1 TIA, 1 infection). During a median follow-up of 37.6 months, two patients died without relation to the operation, three appeared in-stent restenosis, and one developed contrast nephropathy.</p><p><strong>Discussion: </strong>This study observed and analyzed different intervention methods and their prognosis in SSS combined with CA stenosis patients, and due to the limited number of participants, more data support would be needed.</p><p><strong>Conclusions: </strong>The management of SSS patients combined with CA stenosis is more challenging compared to simple SSS. Our research demonstrated different surgical methods and their prognosis.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241307470"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation, screening, and characterization of heavy metal-resistant bacteria from solid waste dumping sites in Central Gondar, Northwest, Ethiopia.","authors":"Abebech Dinku, Tamene Milkessa Jiru","doi":"10.1177/00368504251315807","DOIUrl":"10.1177/00368504251315807","url":null,"abstract":"<p><strong>Objective: </strong>Heavy metal pollution is one of the more recent problems of environmental degradation caused by rapid industrialization and human activity. The objective of this study was to isolate, screen, and characterize heavy metal-resistant bacteria from solid waste disposal sites.</p><p><strong>Methods: </strong>In this study, a total of 18 soil samples were randomly selected from mechanical sites, metal workshops, and agricultural land that received wastewater irrigation. Isolation and screening of the isolates were based on multiple heavy metal (copper (Cu), chromium (Cr), and lead (Pb)) resistance potential. Morphological, biochemical, and 16S rRNA gene sequencing techniques were used to identify the isolates. The minimum inhibitory concentration (MIC) of the potential isolates was further examined at various concentrations (3, 6, 12, 25, 50, and 100 µg/mL). Each isolate's ability to biodegrade and resist antibiotics was also examined.</p><p><strong>Results: </strong>About 21 bacterial isolates were obtained. Among these, six potential isolates (Agri10^-2Is2, Agri10^-3Is2, Agri10^-3Is1, AL10^-1Is2, AL10^-3Is1, and GA10^-2Is1) were selected. The isolates displayed varied colony morphologies and biochemical characterization features. Phylogenetic tree results revealed that Agri10^-2Is2, Agri10^-3Is2, Agri10^-3Is1, AL10^-1Is2, AL10^-3Is1, and GA10^-2Is1 were identified as <i>Bacillus subtilis</i>, <i>Bacillus subtilis</i>, <i>Bacillus</i> species, <i>Bacillus tequilensis</i>, <i>Klebiesella</i> species, and <i>Cronobacter sakazakii</i>, respectively. Every isolate gave a different MIC value. The biodegradation capacity of Agri10^-2Is2, Agri10^-3Is2, Agri10^-3Is1, AL10^-1Is2, AL10^-3Is1, and GA10^-2Is1 was 92.2%, 92.57%, 92.37%, 92.66%, 92.85%, and 92.52% against Cu; 95.07%, 94.07%, 93.07%, 93.4%, 91.4%, and 94.4% on Cr; and 95.51%, 94.53%, 95.62%, 96.87%, 94.86%, and 97.09% against Pb, respectively. All isolates were found to be resistant to the tested antibiotics.</p><p><strong>Conclusion: </strong>This study concludes that the selected bacterial isolates could be potential agents for bioremediation of heavy metal-polluted environments.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251315807"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stability, bifurcation, and large-amplitude vibration analysis of a symmetric magnetic spherical pendulum.","authors":"Akuro Big-Alabo, Maruchi Triumph Chuku","doi":"10.1177/00368504251315805","DOIUrl":"10.1177/00368504251315805","url":null,"abstract":"<p><p>Existing studies on the symmetric spherical pendulum are limited to small- and moderate-amplitude vibrations. This study was conducted to obtain accurate solutions for analysis of the large-amplitude vibration of a symmetric magnetic spherical pendulum using the continuous piecewise linearization method (CPLM). The stability conditions and bifurcation of the pendulum were derived based on the critical points, while the CPLM was used to estimate the frequency response and vibration histories to less than 0.1% and 1.0% relative error respectively when compared to numerical solutions. The CPLM was found to be significantly more accurate than the Laplace transform homotopy perturbation method and predicted the large-amplitude bi-stable vibrations accurately. The stability analysis that was conducted enabled the characterization of all bounded symmetric vibrations based on the relationship between the cyclotron frequency and azimuthal velocity, whereas the bifurcation analysis confirmed that the symmetric vibrations can undergo pitchfork bifurcation that results in transition from single-well to double-well (or bi-stable) vibrations and vice versa. Finally, a parametric analysis was conducted to study the effect of the cyclotron frequency and uniform azimuthal velocity on the frequency-amplitude response and vibration histories The parametric analysis showed that the frequency-amplitude response has a strong dependence on the cyclotron frequency and azimuthal velocity for all amplitudes. On the other hand, the oscillation profile only depends on the cyclotron frequency and azimuthal velocity for some amplitudes. The results of this study can be applied in the design of energy harvesters and elliptic tanks for liquid transport.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251315805"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in folic acid, phenolic components, and angiotensin-converting enzyme inhibitory activity in cowpea (<i>Vigna unguiculata</i>) green pods with different pod maturity.","authors":"Haruki Ishikawa, Ryo Matsumoto, Kohtaro Iseki","doi":"10.1177/00368504251320163","DOIUrl":"10.1177/00368504251320163","url":null,"abstract":"<p><strong>Objective: </strong>Cowpea is an important dry bean in developing countries, and its young leaves and green pods are consumed as fresh vegetables. Consuming green pods provides vitamins, minerals, and functional components for small-scale farmers with limited access to vegetables. However, the accumulation process of functional components in young cowpea pods is unknown. Therefore, we evaluated the concentrations of folic acid, phenolic components, and angiotensin-converting enzyme (ACE) inhibitory activity in green pods throughout maturity to determine the accumulation process of functional components.</p><p><strong>Methods: </strong>Four cowpea genotypes were selected from a mini-core subset of the world cowpea germplasm collection based on protein content, seed size, and seed coat color. The accumulation process of functional components in young cowpea pods was evaluated by measuring the concentrations of folic acid, phenolic components, and ACE inhibitory activity in green pods throughout pod growth (10 days after flowering (DAF): pod elongated, 15 and 20 DAF: seed growth, and 25 DAF: ready for harvest).</p><p><strong>Results: </strong>Our results demonstrate that consuming green cowpea pods during the early growth stages (10-15 DAF) can simultaneously provide a high content of dual nutrition, folic acid, and phenolic components. In addition, the pod had high ACE inhibitory activity. Folic acid and phenolic components were highest in the early stages of 10 DAF, whereas ACE inhibitory activity remained constant during 10-25 DAF.</p><p><strong>Conclusion: </strong>Our findings suggest that including green cowpea pods in diets can boost folic acid and phenolic component intakes without disrupting the ACE inhibitory activity. Furthermore, underutilized genetic resources featuring colored seeds would enhance the nutritional value of cowpeas in breeding programs, thereby increasing the nutritional benefits derived from cowpea consumption.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251320163"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upregulation of long noncoding RNAs <i>LINC00941</i> and <i>ABHD11-AS1</i> is associated with intrahepatic cholangiocarcinoma.","authors":"Olga Y Burenina, Natalia L Lazarevich, Inna F Kustova, Daria A Shavochkina, Ekaterina A Moroz, Nikolay E Kudashkin, Yuriy I Patyutko, Maria P Rubtsova, Olga A Dontsova","doi":"10.1177/00368504251330019","DOIUrl":"10.1177/00368504251330019","url":null,"abstract":"<p><p>ObjectiveMany long noncoding RNAs (lncRNAs) are associated with liver cancers, mainly hepatocellular carcinoma (HCC) and to a smaller extent intrahepatic cholangiocarcinoma (CCA). Most of such lncRNAs show similar dysregulation patterns when the two types of tumors are compared, suggesting that these aberrations are characteristic features of these liver tumor types. In the present study, we aimed to identify some candidate lncRNAs that are associated specifically with CCA.MethodsAccording to The Cancer Genome Atlas data, we chose <i>LINC00941</i>, <i>ABHD11-AS1</i>, and <i>CASC8</i> as promising biomarkers dysregulated in CCA but unaffected in HCC. We first verified their upregulation in an existing transcriptomic dataset for CCA patients. Next, we estimated expression levels of these three lncRNAs by reverse-transcription quantitative PCR in a group of paired (tumorous/adjacent) postsurgery tissue samples from 110 patients with various liver lesions: CCA, HCC, combined HCC-CCA, or benign liver tumors.ResultsSignificant upregulation of <i>LINC00941</i> and <i>ABHD11-AS1</i> was noted in most of the investigated CCA samples, whereas in HCC samples, increased expression of these two lncRNAs was observed only in some types of cases (mainly characterized by an advanced tumor stage). In contrast, <i>CASC8</i> manifested extremely low expression and no diagnostic potential in all the tested liver samples. Analyzing expression correlations of lncRNAs with candidate genes, we obtained strong evidence for <i>LINC00941</i>-mediated upregulation of <i>CAPRIN2</i> in CCA.ConclusionsFor the first time, we show the upregulation of <i>LINC00941</i> and <i>ABHD11-AS1</i> in CCA and report their good potential as diagnostic biomarkers for this type of liver tumor.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251330019"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CXCL8 upregulation mediates inflammatory cell infiltration and accelerates abdominal aortic aneurysm progression.","authors":"Yulong Huang, Xinsheng Xie, Guoqiang Huang, Xiang Hong, Weifeng Lu, Weiguo Fu, Lixin Wang","doi":"10.1177/00368504251328754","DOIUrl":"10.1177/00368504251328754","url":null,"abstract":"<p><strong>Objective: </strong>To explore abdominal aortic aneurysm (AAA) pathogenesis and identify early diagnostic markers, providing a theoretical basis for novel preventive and therapeutic strategies.</p><p><strong>Methods: </strong>Gene expression profiles were retrieved from the Gene Expression Omnibus database (datasets: GSE7084, GSE47472, and GSE57691) comprising messenger RNA data from the aortic samples of 69 patients with AAA and 25 non-AAA controls. Data were merged and normalized; bioinformatics analysis was conducted on upregulated differentially expressed genes.</p><p><strong>Results: </strong>C-X-C motif chemokine ligand 8 (CXCL8) was prominently involved in regulating the chemokine signaling pathway. CXCL8 expression was significantly higher in the aortic walls of patients with AAA than that of controls. NLRP3, interleukin (IL)-18, and IL-1β expression levels were upregulated in patients with AAA and positively correlated with CXCL8 expression. CXCL8 may directly or indirectly interact with NLRP3.</p><p><strong>Conclusions: </strong>CXCL8 was upregulated in patients with AAA and induced inflammatory cell infiltration and cytokine secretion. CXCL8-induced NLRP3 inflammasome regulation triggered pyroptosis in vascular smooth muscle cells, exacerbating inflammation and tissue damage in the aortic wall. This degeneration of the aortic media accelerated AAA progression.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251328754"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}