Gynecologie Obstetrique Fertilite & Senologie最新文献

{"title":"Hantavirus et grossesse : quelles implications obstétricales face à l’émergence du virus Andes ?","authors":"Romane Cousin, Christelle Vauloup-Fellous, Olivier Picone","doi":"10.1016/j.gofs.2026.05.003","DOIUrl":"10.1016/j.gofs.2026.05.003","url":null,"abstract":"","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"54 7","pages":"Pages 398-399"},"PeriodicalIF":1.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147960569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstruire, mais comment évaluer ? Une revue critique des outils esthétiques en reconstruction mammaire","authors":"Raphaëlle Rousseau,&nbsp;Caroline Bouche,&nbsp;Elodie Gauroy,&nbsp;Ariane Weyl,&nbsp;Charlotte Vaysse","doi":"10.1016/j.gofs.2025.12.006","DOIUrl":"10.1016/j.gofs.2025.12.006","url":null,"abstract":"<div><h3>Objectives</h3><div>This systematic review aims to evaluate the various tools used to clinically assess aesthetic outcomes following breast reconstruction (BR) after mastectomy. It builds upon the most recent synthesis published in 2015, in a context where post-breast cancer quality of life, particularly with regard to aesthetic results, has become a major concern.</div></div><div><h3>Methods</h3><div>The review was conducted following the PRISMA-COSMIN guidelines. A comprehensive search was carried out across PubMed, Elsevier, Web of Science, Springer, and Google Scholar databases for studies published between 2015 and 2025. Only studies focusing on objective tools used to evaluate aesthetic outcomes after breast reconstruction were included. The analysis was based on established methodological criteria, including conceptual framework, reliability, validity, interpretability, responsiveness, user burden, and concordance with patient perceptions.</div></div><div><h3>Results</h3><div>Six articles met the inclusion criteria. While some tools demonstrated good reliability or convergent validity, none fully satisfied all methodological standards. Key aspects such as validity, responsiveness, and user burden were seldom assessed, and only a few tools showed strong concordance between professional assessments and patient-reported outcomes. The highest score among the tools reviewed was 4 out of 7.</div></div><div><h3>Conclusions</h3><div>Since 2015, several evaluation scales have been developed, but none meet all the essential criteria for optimal clinical application. There remains a need for a more rigorous, reliable, and patient-aligned tool for assessing aesthetic outcomes after mastectomy. Such a tool would facilitate more meaningful comparisons between surgical techniques and support shared decision-making focused on patient expectations.</div></div>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"54 7","pages":"Pages 390-397"},"PeriodicalIF":1.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caractéristiques des femmes ayant recours à l’IVG entre 14 et 16 SA","authors":"Lena Segui,&nbsp;Alexia Duprez,&nbsp;Constance Devemy,&nbsp;Carine Martin,&nbsp;Hortense Baffet,&nbsp;Anne-Laure Rolland,&nbsp;Damien Subtil,&nbsp;Sophie Catteau-Jonard","doi":"10.1016/j.gofs.2026.03.003","DOIUrl":"10.1016/j.gofs.2026.03.003","url":null,"abstract":"<div><h3>Objective</h3><div>In our country, the deadline for abortion was recently extended from 14 to 16 weeks of pregnancy. Information about the characteristics of women who have late abortions is limited. This article aims to compare the characteristics of women having a late abortion with those having an abortion before 14 weeks.</div></div><div><h3>Materials and methods</h3><div>A case-control study was conducted on women who had an abortion at our centre between December 2022 and May 2023. The cases were women who had a late abortion and the controls were women who had an abortion before 14 weeks.</div></div><div><h3>Results</h3><div>Of the 422 women treated at our centre during the study period, 323 were included in the study: 30 cases (9.3%) and 293 controls. Women undergoing late abortion were more frequently multiparous (53.3% vs. 28.0%, <em>P</em> <!-->=<!--> <!-->0.004), less frequently students (6.7% vs. 22.9%, <em>P</em> <!-->=<!--> <!-->0.04), and more frequently unemployed (43.3% vs. 26.3%, <em>P</em> <!-->=<!--> <!-->0.05). The pregnancy was more frequently desired or accepted at the time (30.0% vs. 3.8%, <em>P</em> <!-->&lt;<!--> <!-->0.001) but tended to occur more often in the context of separation (31.0% vs. 10.3%, <em>P</em> <!-->=<!--> <!-->0.004) or intimate partner violence (41.4% vs. 25.6%, <em>P</em> <!-->=<!--> <!-->0.07).</div></div><div><h3>Conclusion</h3><div>Women who undergo late abortions at our centre tend to be multiparous and more accepting of their pregnancy initially than women who have abortions before 14 weeks of gestation. They are also more likely to experience relationship difficulties and are more likely to be victims of intimate partner violence.</div></div>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"54 7","pages":"Pages 379-383"},"PeriodicalIF":1.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147460989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Usefulness of routine fetal echocardiography in pregnancies with pre-existing maternal diabetes].","authors":"Anne-Laure Fijean, Maelle Feret, Julien Simon, Jean-Marc Jellimann, Christelle Langbour-Remy, Olivier Morel, Gaelle Ambroise, Matthieu Dap","doi":"10.1016/j.gofs.2026.06.004","DOIUrl":"10.1016/j.gofs.2026.06.004","url":null,"abstract":"<p><strong>Objectives: </strong>The primary objective of this study was to assess the contribution of fetal echocardiography in a population of women with pre-gestational diabetes to the detection of severe fetal heart disease. The secondary objective was to analyse the prevalence of heart disease according to periconceptional HbA1c levels.</p><p><strong>Methods: </strong>Observational, single-centre, retrospective study conducted over ten years (2014-2024), including all pregnancies complicated by pre-gestational diabetes monitored in a type III maternity unit. The type of diabetes, periconceptional HbA1c, ultrasound data and perinatal outcomes were collected. Severe congenital heart disease was confirmed postnatally and defined by the need for neonatal surgical intervention.</p><p><strong>Results: </strong>A total of 331 women corresponding to 428 pregnancies were included. All underwent fetal echocardiography by a paediatric cardiologist. The overall prevalence of congenital heart disease was 4.4% (19/428), including 1.5% of severe forms (6/428). All severe heart defects were detected during screening ultrasound. Among women, 6.9% with a periconceptional HbA1c ≥10% had severe heart disease.</p><p><strong>Conclusions: </strong>Systematic fetal echocardiography by a paediatric cardiologist does not appear to offer any additional benefit for the sensitivity of primary screening for severe diabetes-related heart disease. Echocardiography should be reserved for the precise characterisation of heart disease if it is detected during screening and diagnostic ultrasound and/or in cases of uncontrolled diabetes.</p>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Metformin for the prevention of hyperemesis gravidarum: From a GDF15-based rationale to early clinical evidence].","authors":"Philippe Deruelle, Francesca Arcieri, Romain Martineau","doi":"10.1016/j.gofs.2026.06.002","DOIUrl":"10.1016/j.gofs.2026.06.002","url":null,"abstract":"<p><strong>Background: </strong>Hyperemesis gravidarum (HG) remains one of the most disabling complications of the first trimester, with a high risk of recurrence after a prior episode that weighs heavily on family planning and on patients' mental health. Recent work places GDF15 at the core of HG pathophysiology, suggesting that a low pre-gestational baseline GDF15 level may predispose to hypersensitivity when its concentration rises sharply in the first trimester. The preconception desensitization hypothesis therefore opens a path to preventing recurrence. Observational data indicate that metformin, which increases GDF15, could reduce the risk of HG when used before conception. One observational cohort reports a non-significant trend toward lower HG risk after preconception metformin exposure (aOR ≈ 0.50 ; 95% CI 0.07-3.39) but no effect on nausea and vomiting of pregnancy (NVP); results are limited by low statistical power. In parallel, a large retrospective survey reports a substantial and statistically significant reduction in the risk of HG and severe NVP with preconception metformin (aOR ≈ 0.29 for a first pregnancy; aOR ≈ 0.18 for a second pregnancy after adjustment for recurrence).</p><p><strong>Position: </strong>The mechanistic rationale is compelling and the clinical signals are encouraging, but no randomized trial has yet demonstrated the preventive efficacy of metformin; additional studies are needed before any practice recommendation can be made.</p>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148195205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[From PubMed to GPT: A narrative review of the emerging role of Large Language Models in systematic reviews].","authors":"Benjamin Birene, Benjamin Popoff, Olivier Graesslin, Vincent Vuiblet, Olivier Morel","doi":"10.1016/j.gofs.2026.05.004","DOIUrl":"10.1016/j.gofs.2026.05.004","url":null,"abstract":"<p><strong>Objective: </strong>Systematic reviews are a cornerstone of evidence-based medicine but remain time-consuming and prone to human error. Large Language Models (LLMs), such as ChatGPT or Claude, offer new opportunities for partial automation of these tasks. This articles aims to provide a critical synthesis of the current uses of LLMs across the key stages of systematic reviews and meta-analyses in healthcare.</p><p><strong>Methods: </strong>We conducted a narrative review based on a literature search in PubMed and Scopus (2019-2025), including empirical studies, scoping reviews, preprints, and technical reports discussing the use of LLMs in any stage of the systematic review process.</p><p><strong>Results: </strong>LLMs can support research question formulation, search strategy development, reference screening, data extraction, meta-analysis scripting, and result synthesis. Reported performances are often high, especially for screening and quantitative data extraction, with sensitivities of 95-98%. However, significant limitations persist: hallucinations, bias, misinterpretations, and variability across models. Independent validation remains scarce.</p><p><strong>Conclusion: </strong>LLMs show promising potential to accelerate several stages of systematic reviews, provided their use is methodologically controlled. A semi-automated approach, combining AI capabilities with human expertise, currently appears the safest. Prompt structuring, result validation, and transparent reporting of AI involvement are essential to ensure the quality and reliability of the synthesized evidence.</p>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148037867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Réparation d’une myéloméningocèle par fœtoscopie (avec vidéo)","authors":"Lucie Guilbaud ,&nbsp;Timothée de Saint Denis ,&nbsp;Sabine Irtan ,&nbsp;Jean-Marie Jouannic","doi":"10.1016/j.gofs.2025.09.087","DOIUrl":"10.1016/j.gofs.2025.09.087","url":null,"abstract":"","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"54 4","pages":"Pages 239-240"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRIUM-Cell : programme de réparation in utero des myéloméningocèles utilisant des cellules stromales mésenchymateuses","authors":"Lucie Guilbaud ,&nbsp;Yoann Athiel ,&nbsp;Justine Nasone ,&nbsp;Timothée de Saint-Denis ,&nbsp;Éléonore Blondiaux ,&nbsp;Hina Simonnet ,&nbsp;Pauline Lallemant-Dudek ,&nbsp;Agnès Rigouzzo ,&nbsp;Marie-Pierre Bonnet ,&nbsp;Jean-Roch Fabreguettes ,&nbsp;Jérôme Larghero ,&nbsp;Jean-Marie Jouannic","doi":"10.1016/j.gofs.2025.10.020","DOIUrl":"10.1016/j.gofs.2025.10.020","url":null,"abstract":"<div><h3>Background and rationale</h3><div>Myelomeningocele (MMC), also known as Spina Bifida, is a congenital malformation of the spinal cord that results in a complex disability including motor deficits, sphincter disorders and cerebral anomalies. Benefit of fetal MMC surgery has been demonstrated since 2011, but remains partial, with persistent motor and sphincter disorders. We have developed an adjuvant treatment to improve spinal cord repair during fetal surgery: a patch composed of umbilical cord-derived mesenchymal stromal cells (UC-MSCs). Our in vitro and in vivo experiments in the ovine model of MMC demonstrated that the UC-MSC patch improves motor and urinary functions by promoting neuronal preservation in the spinal cord. We also confirmed the absence of maternal, fetal, and neonatal adverse effects. Our hypothesis is that this adjuvant therapy can similarly improve spinal cord repair in human fetuses, thereby improving clinical outcomes in affected children. The goal of the PRIUM-Cell clinical trial is to assess the use of UC-MSC patches as an adjuvant therapy during open fetal surgery for MMC in humans.</div></div><div><h3>Study design and methods</h3><div>This is an open-label study enrolling pregnant individuals with a fetus diagnosed with MMC located between spinal levels T1 and S1, associated with Chiari type 2 malformation. The allogeneic UC-MSC patch will contain 17 million UC-MSCs embedded in a semi-rigid scaffold. The patch will be applied directly to the fetal spinal cord during open fetal surgery performed between 23 and 26 weeks, following our center's standard protocol. Intensive maternal-fetal monitoring will be conducted for 7 days postoperatively during hospitalization, then weekly until delivery. The primary endpoint is successful completion of surgery with no neonatal adverse events. Secondary endpoints will be efficacy for the child at 8 weeks and 36 months, and safety for the mother from surgery to the postpartum period, and for the child up to 36 months of age.</div></div><div><h3>Future directions</h3><div>If our hypotheses are confirmed, we intend to conduct a Europe-wide phase III clinical trial.</div></div>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"54 4","pages":"Pages 228-233"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment je fais… une résection de la plaque aréolo-mamelonnaire (PAM) avec oncoplastie","authors":"Margaux Menel ,&nbsp;Claire Bonneau ,&nbsp;Katia Mahiou ,&nbsp;Louise Maumy ,&nbsp;Ornella Ammendola ,&nbsp;Christine Burghardt ,&nbsp;Léa Pauly ,&nbsp;Leslie Elahi ,&nbsp;Virginie Pineau ,&nbsp;Louise Benoit","doi":"10.1016/j.gofs.2025.09.086","DOIUrl":"10.1016/j.gofs.2025.09.086","url":null,"abstract":"","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"54 4","pages":"Pages 234-238"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact du questionnaire WAST-fr pour le dépistage des violences conjugales au cours des consultations de pré-IVG","authors":"Clarisse Habbouche ,&nbsp;Brigitte Delemer ,&nbsp;Paul Fornès ,&nbsp;Domitille Callon ,&nbsp;Anne Fèvre","doi":"10.1016/j.gofs.2025.10.025","DOIUrl":"10.1016/j.gofs.2025.10.025","url":null,"abstract":"<div><h3>Objectives</h3><div>Unintended pregnancies are more strongly associated with the risk of intimate partner violence (and/or sexual violence). While healthcare professionals are on the front line of screening, and guidelines recommend systematically asking about violence, such cases are rarely detected. This article aims to measure the impact of the WAST questionnaire in screening for intimate partner violence during pre-abortion consultations and its acceptability among healthcare professionals.</div></div><div><h3>Method</h3><div>This is a single-center retrospective analytical study involving patients seeking abortion at the sexual health center of the University Hospital of Reims over a six-month period, combined with an analysis of professional practices. We compared two screening methods: a direct question asked during the medical history and the use of the WAST questionnaire.</div></div><div><h3>Results</h3><div>We observed better screening results with the WAST than with a closed question, although it did not increase the number of reported cases of violence. We identified factors significantly associated with violence, serving as warning signs: repeated abortions, delayed requests, or advanced gestational age. Regarding healthcare professionals, this was an informed group that agreed a questionnaire could facilitate screening. After using it, they reported finding it useful.</div></div><div><h3>Conclusion</h3><div>All healthcare professionals should be trained in screening for intimate partner (and/or sexual) violence and in its management, so that patients can feel confident to discuss it. Moreover, during pregnancy, it is possible to have an impact on medico-legal management (judicial reporting, filing a complaint). Our study shows that the use of the WAST has a positive impact on screening for intimate partner violence and is considered a useful tool by professionals in the context of pre-abortion consultations.</div></div>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"54 4","pages":"Pages 187-191"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145508162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}