Gynecologie Obstetrique Fertilite & Senologie最新文献

{"title":"[Evaluation of the Implementation of a Checklist for the Management of Postpartum Hemorrhage Following Vaginal Delivery].","authors":"Anne-Sophie Boucherie, Emma Gorand, Paul Berveiller, Thibaud Quibel, Anne Rousseau, Juliette François","doi":"10.1016/j.gofs.2026.05.001","DOIUrl":"https://doi.org/10.1016/j.gofs.2026.05.001","url":null,"abstract":"<p><p>Objective To evaluate the impact of a standardized checklist on the rate of severe postpartum hemorrhage (PPH) after vaginal delivery. Methods This before-and-after study was conducted between 2021 and 2023 in a tertiary care maternity unit. All women who delivered vaginally and experienced PPH were included. Cesarean deliveries and deliveries <24 weeks of gestation were excluded. The \"before\" period (September 2021 to February, 2022) corresponded to a period without a checklist. The \"after\" period (September 2022 to February, 2023) corresponded to a period with a checklist. The primary outcome was the rate of severe PPH, defined as total quantified blood loss >1,000 mL Results A total of 133 women was included in the \"before\" period and 116 in the \"after\" period. The rate of severe PPH did not differ significantly between periods (21.1% vs 16.4%, p = 0.35). Blood loss at 60 minutes was significantly lower in the \"after\" period (750 mL [500-1000] vs 600 mL [450-800], p = 0.011), as were total blood losses (750 mL [500-1000] vs 600 mL [500-900], p = 0.049). After adjustment, there was no significant association between severe PPH and study period (adjusted OR = 0.78, 95% CI [0.40-1.50], p = 0.5). Conclusion Implementation of a standardized checklist did not reduce the rate of severe PPH but was associated with lower blood loss at 60 minutes and overall, suggesting a potential benefit through earlier and more active management.</p>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Preventing Human Papillomavirus in Middle School: The Role of an Escape Game].","authors":"Lise Monge, Alice Blin, Chérine Yousfi, Sophie Mariotti, Florence Bretelle, Sylvie Arlotto","doi":"10.1016/j.gofs.2026.04.006","DOIUrl":"https://doi.org/10.1016/j.gofs.2026.04.006","url":null,"abstract":"<p><strong>Objective: </strong>  Cervical cancer remains a major global health concern. In France, approximately 6.400 cancer cases were attributable to human papillomavirus (HPV) in 2023, including 3.159 cervical cancers and 1.100 related deaths. HPV vaccination is the most effective primary prevention strategy, yet vaccination coverage remains low in France, particularly among boys. Innovative, school-based educational interventions may improve adolescents' knowledge and support vaccine uptake. This paper aims to describe baseline knowledge of HPV among middle school students in Marseille, France, and to assess the impact of an educational Escape Game led by healthcare students.</p><p><strong>Methods: </strong> We conducted a longitudinal descriptive study in four Marseille middle schools between February and April 2025. Students completed pre- and post-intervention paper-based questionnaires assessing HPV knowledge. A composite knowledge score (range 0-8) was calculated. Analyses compared results by sex and grade.</p><p><strong>Results: </strong> A total of 346 pre- and 333 post-intervention questionnaires were analyzed. At baseline, 58.4% of students had heard of HPV, mainly from family. The mean knowledge score was 3.76/8 (± 1.23), higher in girls than boys (4,01 vs 3,53 ; p < 0.05), and in 8th graders (4.19) compared to 9th (3.71) and 6th graders (2.65) (p<0.001). After the Escape Game, the mean score increased significantly to 5.14/8 (± 1.36) (p<0.001). Knowledge of sexual transmission, vaccination, and oncological risks improved significantly.</p><p><strong>Conclusions: </strong> Before the intervention, HPV-related knowledge among middle school students was limited. A significant increase in knowledge was observed following the intervention and represents a low-cost, innovative tool to strengthen adolescent health literacy and support national HPV prevention strategies.</p>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Artificial Intelligence in Fetal Heart Assessment: From Childhood to Adolescence.]","authors":"Sifa Turan, Edwin Quarello","doi":"10.1016/j.gofs.2026.04.005","DOIUrl":"https://doi.org/10.1016/j.gofs.2026.04.005","url":null,"abstract":"","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Chorioamnionitis and Long-Term Neurodevelopment in Preterm Infants: What can we learn from the EPIPAGE-2 cohort study?]","authors":"Fanny Salmon, Mathilde Letouzey, Emeline Maisonneuve, Gilles Kayem","doi":"10.1016/j.gofs.2026.04.004","DOIUrl":"https://doi.org/10.1016/j.gofs.2026.04.004","url":null,"abstract":"<p><p>In cases of premature birth, intrauterine inflammation is common and may be harmful to the developing brain. Three analyses from the EPIPAGE-2 national prospective population-based cohort were recently published. This review provides an overview of recent data on the association between birth in the context of clinical and/or histological chorioamnionitis and long-term neurodevelopment in preterm infants. A major strength of this work lies in the examination of neurodevelopment within a homogeneous birth context, in contrast to the majority of previous studies. Indeed, the various causes of prematurity are based on distinct pathophysiological mechanisms that may influence a child's neurodevelopment differently. This limitation may partially account for the divergence observed with previous publications.These three studies included, from the EPIPAGE-2 cohort, children born alive between 24 and 34 weeks of gestation, following spontaneous labor or premature rupture of membranes. Clinical chorioamnionitis and histological chorioamnionitis, diagnosed after a standardized placental examination, were studied separately. The children's neurodevelopment was assessed at 2 and 5 years of age using standardized tools.At 2 years of age, clinical chorioamnionitis was associated with an increased risk of cerebral palsy (aOR = 2.1; 95% CI: 1.1-4.1). In contrast, no significant association was observed between clinical chorioamnionitis and moderate-to-severe neurodevelopmental disorders at 5 years of age. Similarly, isolated histological chorioamnionitis was not associated with neurodevelopmental disorders at 2 or 5 years of age.Among children born prematurely following spontaneous labor or preterm rupture of membranes, exposure to clinical or histological chorioamnionitis does not appear to be associated with adverse neurodevelopmental outcomes at 5 years of age.</p>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The role of the fetal medicine specialist in supporting couples who choose to continue a pregnancy despite a prenatal diagnosis of a lethal fetal condition.]","authors":"Manon Marquet, Barthelemy Tosello, Cécile Chau, Claude D'Ercole, Pierre Castel","doi":"10.1016/j.gofs.2026.04.003","DOIUrl":"https://doi.org/10.1016/j.gofs.2026.04.003","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the role of the fetal medicine specialist in supporting couples who choose to continue a pregnancy despite a prenatal diagnosis of a lethal fetal condition, through a local study and a literature review.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted from 2018 to 2023 in the two prenatal diagnosis centres (CPDPN) of Marseille, including patients who continued a pregnancy resulting in a live birth despite a diagnosis of a lethal fetal condition. Data were extracted from the Viewpoint software. A narrative literature review was also conducted to identify factors influencing parental decision-making, the experiences of parents and healthcare providers, and current practices in perinatal palliative care.</p><p><strong>Results: </strong>Eleven patients were included. The most frequent diagnoses were congenital heart defects, chromosomal abnormalities, and cerebral or renal malformations. A consultation with a neonatologist was systematically offered. In 18% of cases, palliative care was provided at home. The average postnatal survival was 5 days. The literature review highlighted the importance of ethical, cultural, and emotional factors in parental decisions, as well as the lack of training among healthcare professionals for such support.</p><p><strong>Conclusions: </strong>The fetal medicine specialist plays a pivotal role in coordinating care and preparing for a palliative approach. A structured, interdisciplinary, and individualised framework is essential to provide ethical, empathetic, and coherent support to couples facing these complex and emotionally charged situations.</p>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Maternal serum markers profiles for Down syndrome : review of comments and actionable recommendations.]","authors":"Gilles Renom, Magali Pettazzoni, Jean Guibourdenche, Corinne Sault, Valérie Moal, Alain Liquier, Safouane Hamdi, Simon Samaan, Etienne Voirin-Mathieu, Fabienne Artur, Jérôme Massardier, Véronique Debarge, Aba","doi":"10.1016/j.gofs.2026.04.002","DOIUrl":"https://doi.org/10.1016/j.gofs.2026.04.002","url":null,"abstract":"<p><p>In France, for the vast majority of patients, screening for Down syndrome using circulating cell-free fetal DNA is contingent upon prior assessment of maternal serum markers and calculation of a specific risk estimate for this aneuploidy. Certain marker profiles may also suggest other fetal or maternal pathologies. This article therefore aims (i) to clarify and explain any comments that may appear in laboratory reports ; (ii) to propose a clinical interpretation and a procedure to be followed for the monitoring of the considered pregnancy. It updates a first article published in 2014 and, like its predecessor, reflects broad consensus among the biologists authorised to perform this screening.</p>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Réparation d’une myéloméningocèle par fœtoscopie (avec vidéo)","authors":"Lucie Guilbaud ,&nbsp;Timothée de Saint Denis ,&nbsp;Sabine Irtan ,&nbsp;Jean-Marie Jouannic","doi":"10.1016/j.gofs.2025.09.087","DOIUrl":"10.1016/j.gofs.2025.09.087","url":null,"abstract":"","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"54 4","pages":"Pages 239-240"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRIUM-Cell : programme de réparation in utero des myéloméningocèles utilisant des cellules stromales mésenchymateuses","authors":"Lucie Guilbaud ,&nbsp;Yoann Athiel ,&nbsp;Justine Nasone ,&nbsp;Timothée de Saint-Denis ,&nbsp;Éléonore Blondiaux ,&nbsp;Hina Simonnet ,&nbsp;Pauline Lallemant-Dudek ,&nbsp;Agnès Rigouzzo ,&nbsp;Marie-Pierre Bonnet ,&nbsp;Jean-Roch Fabreguettes ,&nbsp;Jérôme Larghero ,&nbsp;Jean-Marie Jouannic","doi":"10.1016/j.gofs.2025.10.020","DOIUrl":"10.1016/j.gofs.2025.10.020","url":null,"abstract":"<div><h3>Background and rationale</h3><div>Myelomeningocele (MMC), also known as Spina Bifida, is a congenital malformation of the spinal cord that results in a complex disability including motor deficits, sphincter disorders and cerebral anomalies. Benefit of fetal MMC surgery has been demonstrated since 2011, but remains partial, with persistent motor and sphincter disorders. We have developed an adjuvant treatment to improve spinal cord repair during fetal surgery: a patch composed of umbilical cord-derived mesenchymal stromal cells (UC-MSCs). Our in vitro and in vivo experiments in the ovine model of MMC demonstrated that the UC-MSC patch improves motor and urinary functions by promoting neuronal preservation in the spinal cord. We also confirmed the absence of maternal, fetal, and neonatal adverse effects. Our hypothesis is that this adjuvant therapy can similarly improve spinal cord repair in human fetuses, thereby improving clinical outcomes in affected children. The goal of the PRIUM-Cell clinical trial is to assess the use of UC-MSC patches as an adjuvant therapy during open fetal surgery for MMC in humans.</div></div><div><h3>Study design and methods</h3><div>This is an open-label study enrolling pregnant individuals with a fetus diagnosed with MMC located between spinal levels T1 and S1, associated with Chiari type 2 malformation. The allogeneic UC-MSC patch will contain 17 million UC-MSCs embedded in a semi-rigid scaffold. The patch will be applied directly to the fetal spinal cord during open fetal surgery performed between 23 and 26 weeks, following our center's standard protocol. Intensive maternal-fetal monitoring will be conducted for 7 days postoperatively during hospitalization, then weekly until delivery. The primary endpoint is successful completion of surgery with no neonatal adverse events. Secondary endpoints will be efficacy for the child at 8 weeks and 36 months, and safety for the mother from surgery to the postpartum period, and for the child up to 36 months of age.</div></div><div><h3>Future directions</h3><div>If our hypotheses are confirmed, we intend to conduct a Europe-wide phase III clinical trial.</div></div>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"54 4","pages":"Pages 228-233"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment je fais… une résection de la plaque aréolo-mamelonnaire (PAM) avec oncoplastie","authors":"Margaux Menel ,&nbsp;Claire Bonneau ,&nbsp;Katia Mahiou ,&nbsp;Louise Maumy ,&nbsp;Ornella Ammendola ,&nbsp;Christine Burghardt ,&nbsp;Léa Pauly ,&nbsp;Leslie Elahi ,&nbsp;Virginie Pineau ,&nbsp;Louise Benoit","doi":"10.1016/j.gofs.2025.09.086","DOIUrl":"10.1016/j.gofs.2025.09.086","url":null,"abstract":"","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"54 4","pages":"Pages 234-238"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact du questionnaire WAST-fr pour le dépistage des violences conjugales au cours des consultations de pré-IVG","authors":"Clarisse Habbouche ,&nbsp;Brigitte Delemer ,&nbsp;Paul Fornès ,&nbsp;Domitille Callon ,&nbsp;Anne Fèvre","doi":"10.1016/j.gofs.2025.10.025","DOIUrl":"10.1016/j.gofs.2025.10.025","url":null,"abstract":"<div><h3>Objectives</h3><div>Unintended pregnancies are more strongly associated with the risk of intimate partner violence (and/or sexual violence). While healthcare professionals are on the front line of screening, and guidelines recommend systematically asking about violence, such cases are rarely detected. This article aims to measure the impact of the WAST questionnaire in screening for intimate partner violence during pre-abortion consultations and its acceptability among healthcare professionals.</div></div><div><h3>Method</h3><div>This is a single-center retrospective analytical study involving patients seeking abortion at the sexual health center of the University Hospital of Reims over a six-month period, combined with an analysis of professional practices. We compared two screening methods: a direct question asked during the medical history and the use of the WAST questionnaire.</div></div><div><h3>Results</h3><div>We observed better screening results with the WAST than with a closed question, although it did not increase the number of reported cases of violence. We identified factors significantly associated with violence, serving as warning signs: repeated abortions, delayed requests, or advanced gestational age. Regarding healthcare professionals, this was an informed group that agreed a questionnaire could facilitate screening. After using it, they reported finding it useful.</div></div><div><h3>Conclusion</h3><div>All healthcare professionals should be trained in screening for intimate partner (and/or sexual) violence and in its management, so that patients can feel confident to discuss it. Moreover, during pregnancy, it is possible to have an impact on medico-legal management (judicial reporting, filing a complaint). Our study shows that the use of the WAST has a positive impact on screening for intimate partner violence and is considered a useful tool by professionals in the context of pre-abortion consultations.</div></div>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"54 4","pages":"Pages 187-191"},"PeriodicalIF":0.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145508162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}