Christos Chatzakis, Nicolas Bourgon, Marianne Leruez-Ville, Yves Ville
{"title":"[Secondary Prevention of Fetal Cytomegalovirus Infection Through Valacyclovir Administration in Maternal Primary Infections During the Periconceptional Period and First Trimester of Pregnancy].","authors":"Christos Chatzakis, Nicolas Bourgon, Marianne Leruez-Ville, Yves Ville","doi":"10.1016/j.gofs.2025.03.010","DOIUrl":"https://doi.org/10.1016/j.gofs.2025.03.010","url":null,"abstract":"<p><strong>Objectives: </strong>Oral administration of valacyclovir at 8 g/day significantly reduces the rate of vertical transmission of CMV in women with a primary CMV infection acquired during the periconceptional period or the first trimester. The aim of this study is to expand the findings of previously published studies by including all recent cohorts on the subject.</p><p><strong>Methods: </strong>The MEDLINE, Scopus, Cochrane Central Register of Controlled Trials (Central), and \"clinical trial\" registry (www.</p><p><strong>Clinicaltrials: </strong>gov) were consulted. Randomized controlled trials and cohort studies administering oral valacyclovir at 8 g/day to pregnant women with a primary CMV infection acquired during the periconceptional period or the first trimester were included. Cochrane's Risk of Bias 2 and ROBINS-I tools were used to assess the risk of bias. The result of the CMV PCR in the amniotic fluid was the primary outcome. A two-step individual patient data meta-analysis was conducted, and a subgroup analysis was performed, evaluating periconceptional and first-trimester infections separately.</p><p><strong>Results: </strong>Four studies (1 RCT and 3 cohorts) were included in the analysis (n=860 women). A significant reduction in the rate of the CMV vertical transmission was observed in the Valacyclovir group (aOR=0.39, 95% CI 0.25-0.59). This reduction was significant for both the periconceptional period (aOR=0.30, 95% CI 0.13-0.68) and the first trimester (aOR=0.47, 95% CI 0.28-0.78). Valacyclovir also reduced the rate of neonatal infections, aOR=0.45 (95% CI 0.25-0.83), for both periods considered (aOR=0.42, 95% CI 0.20-0.90, and aOR=0.54, 95% CI 0.29-0.99).</p><p><strong>Conclusions: </strong>The current evidence suggests that oral valacyclovir (8 g/day) is associated with reduction of the rate of vertical transmission of CMV following maternal primary infection acquired during the periconceptional period or the first trimester of pregnancy.</p>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Découverte d’une tumeur utérine ressemblant à une tumeur des cordons sexuels de l’ovaire suite à une hypercalcémie","authors":"Laura Panza , Catherine Riera , Stéphanie Blondel , Maïté Godfrin","doi":"10.1016/j.gofs.2024.10.006","DOIUrl":"10.1016/j.gofs.2024.10.006","url":null,"abstract":"","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"53 4","pages":"Pages 218-221"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Évaluation de l’anxiété et la dépression chez les femmes enceintes hospitalisées à domicile en cours de grossesse","authors":"Anais Malandain , Mathilde Barrois","doi":"10.1016/j.gofs.2024.12.002","DOIUrl":"10.1016/j.gofs.2024.12.002","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to identify factors associated with depressive and anxious symptomatology in pregnant women hospitalized during the antepartum period in home care management (Hospitalisation à domicile).</div></div><div><h3>Method</h3><div>This is a quantitative, single-center, observational, and descriptive study that included all French-speaking women hospitalized in the HAD of AP–HP between September 2022 and February 2023. Anxious and depressive symptoms were assessed using the self-administered HADS (Hospital Anxiety and Depression Scale) questionnaire. Analyses were conducted according to two distinct groups, comparing patients with an anxiety or depression scores below 8 on the HADS to those with a score of 8 or above (the threshold set on the questionnaire corresponding to intermediate symptomatology). A second questionnaire created for the study detailed maternal history, pregnancy experience, and lifestyle.</div></div><div><h3>Results</h3><div>A total of sixty-four women were included from September 20, 2022, to February 15, 2023. Eighteen women (28%) evaluated had anxious symptomatology and thirteen women (20%) had depressive symptomatology. Factors significantly associated with anxiety were poor pregnancy experience (<em>P</em> <!-->=<!--> <!-->0.04), the need for psychological follow-up during pregnancy (<em>P</em> <!--><<!--> <!-->0.01), country of birth (<em>P</em> <!-->=<!--> <!-->0.022), as well as psychiatric history such as previous consultations with a mental health specialist (<em>P</em> <!-->=<!--> <!-->0.015) and previous psychotropic treatment (<em>P</em> <!-->=<!--> <!-->0.028). Additionally, a history of violence (respectively, <em>P</em> <!-->=<!--> <!-->0.034 and <em>P</em> <!--><<!--> <!-->0.01) and the women's belief that a consultation with a psychologist would benefit them were also associated with anxious and depressive symptomatology (respectively, <em>P</em> <!--><<!--> <!-->0.01 and <em>P</em> <!--><<!--> <!-->0.01)</div></div><div><h3>Conclusion</h3><div>Our results highlight the importance and necessity of enhancing the screening and prevention of various mental disorders during pregnancy. It would be interesting to implement organized screening for anxiety, similar to depression, in pregnant women hospitalized at home and for the entire obstetric population.</div></div>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"53 4","pages":"Pages 167-172"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lise Capillon , Rodolphe Manaquin , Antoine Bertolotti , Vincent Balaya , Julie Marcadet , Mohamed Khettab , Franck Ah Pine , Camille Brochard , Malik Boukerrou , Phuong Lien Tran
{"title":"Impact d’une formation sur le papillomavirus au personnel des collèges avant la campagne nationale de vaccination à la Réunion","authors":"Lise Capillon , Rodolphe Manaquin , Antoine Bertolotti , Vincent Balaya , Julie Marcadet , Mohamed Khettab , Franck Ah Pine , Camille Brochard , Malik Boukerrou , Phuong Lien Tran","doi":"10.1016/j.gofs.2025.01.007","DOIUrl":"10.1016/j.gofs.2025.01.007","url":null,"abstract":"<div><h3>Objective</h3><div>In February 2023, the French government announced the generalization of vaccination against human papillomavirus (HPV) infections for all voluntary 5th graders free of charge. Regional Health Agency and Reunion's rectorate asked two practitioners to run a training course on HPV, for principal education advisors, science and earth life teachers, and school nurses/doctors of all Reunion's middle schools.</div></div><div><h3>Methods</h3><div>Our aim was to assess the impact of this training on knowledge and acceptability of HPV vaccination among middle school staff. A first questionnaire (Q1) was filled in by participants during the training course, a second (Q2) at the immediate end of the course and a third (Q3) 2 months later, at the start of the new school year.</div></div><div><h3>Results</h3><div>In Q1, 198 respondants obtained 45.1% of good answers, in Q2, there were 83.5% of good answers among 58 respondants and in Q3, 59.7% for 27 respondants. HPV vaccination training improved the knowledge of middle school staff, but the knowledge score decreased over time. In addition, middle-school staff seemed to be generally in favor of HPV vaccination. But their intention to have their own children (or future children) vaccinated seemed to decrease over time, at a distance from the training (80.7% at time of Q2 and 66.7% at Q3).</div></div><div><h3>Conclusion</h3><div>Regular refresher courses seem necessary to maintain knowledge levels and motivation in vaccination intention.</div></div>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"53 4","pages":"Pages 173-178"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ornella Maltese , Pierre Macé , Alice Faure , Rachel Reynaud , Jean Philippe Bault , Guillaume Gorincour , Edwin Quarello
{"title":"Conduite à tenir devant un fœtus suspect d’une variation du développement génital (VDG)","authors":"Ornella Maltese , Pierre Macé , Alice Faure , Rachel Reynaud , Jean Philippe Bault , Guillaume Gorincour , Edwin Quarello","doi":"10.1016/j.gofs.2024.12.006","DOIUrl":"10.1016/j.gofs.2024.12.006","url":null,"abstract":"<div><div>The management of a fetus suspected of having a difference in genital sexual development (DSD) is a complex situation. In cases of complete discordance or an unusual appearance of the external genitalia (EG), management always begins with a diagnostic morphological ultrasound. This ultrasound aims to provide detailed imaging of the EG and internal genitalia (IG), focusing on identifying the presence of Müllerian derivatives and detecting any associated malformations. During a multidisciplinary meeting, we should assess the appropriateness of determining the genetic sex through cell-free DNA analysis and to refer the patient to an expert center if necessary. These clinical situations include all atypical presentations of the genital organs with the inability to determine the phenotype, as well as any hypospadias associated with other genital organ involvement. Patients presenting with isolated posterior (or proximal) hypospadias also benefit from an assessment at an expert center. Isolated anterior and middle hypospadias (with negative genetic findings) are excluded from this protocol. Performing an invasive sampling is almost always indicated. The expert center provides the couple with information on the different variations of genital development and the perspectives of managing the child, explaining the recently proposed paradigm shift, according to the new French decree of November 15, 2022, in application of Article L-2131-6 of the Public Health Code, which now entails, in some of these situations, delayed surgical management. The diagnostic and prognostic uncertainty of the DSD is communicated to the couples. Multidisciplinary care is therefore essential to establish an accurate diagnosis, define the anatomical and functional prognosis, and propose the most appropriate surgical strategy, taking into account the associated morbidities, defining whether or not to adopt a surgical strategy, and providing the most suitable surgical approach, as well as supporting the couple and the child in dealing with this situation.</div></div>","PeriodicalId":56056,"journal":{"name":"Gynecologie Obstetrique Fertilite & Senologie","volume":"53 4","pages":"Pages 193-211"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}