Journal of Stomatology Oral and Maxillofacial Surgery最新文献

{"title":"Analysis of clinical and radiographic outcomes at least 5 years after coronectomy for deeply impacted mandibular third molars.","authors":"Yusuf Tamer, Seçil Çubuk, Efsun Somay, Zafer Özgür Pektaş","doi":"10.1016/j.jormas.2024.102188","DOIUrl":"10.1016/j.jormas.2024.102188","url":null,"abstract":"<p><strong>Objective: </strong>Coronectomy is an alternative to traditional mandibular third molar extraction when the inferior alveolar nerve (IAN) is closely associated with the roots of these molars. Given the paucity of research on the long-term outcomes after coronectomy, we conducted this study to evaluate clinical and radiographic outcomes at least 5 years post-coronectomy.</p><p><strong>Methods: </strong>This retrospective study enrolled all patients with impacted mandibular third molars treated with coronectomy at our institution who were willing to return for follow-up evaluation 5 years or more after their original procedure. Patient data were obtained retrospectively from hospital records and during oral examinations at the follow-up study appointment. We assessed the following postoperative clinical outcomes: injury to the IAN, root migration distance, root exposure in the oral cavity, non-healing sockets, pain or sensitivity in the coronectomy area, and the presence of periapical pathology.</p><p><strong>Results: </strong>Of the 196 patients invited to participate, 66 patients (male, 32 %; female, 68 %) who underwent a total of 75 coronectomies were included in this study. No persistent hypoesthesia of the lower lip were reported during follow-up. Two patients required reoperation because of root eruption into the oral cavity. Approximately two-thirds of residual roots migrated from their position on preoperative radiographs; the mean migration distance was 3.2 ± 1.3 mm. Two patients (2.6 %) had pain in the soft tissues around the coronectomy site.</p><p><strong>Conclusion: </strong>Our findings confirm that coronectomy is an effective treatment option for preventing IAN injury when the nerve is in close proximity to the roots of these molars.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102188"},"PeriodicalIF":2.2,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tongue tip reconstruction with sliding tongue flap.","authors":"Takanori Eguchi, Koji Kawaguchi, Shusuke Yamada, Yoshiki Hamada","doi":"10.1016/j.jormas.2024.102189","DOIUrl":"10.1016/j.jormas.2024.102189","url":null,"abstract":"<p><p>Tongue tip defects cause severe dysfunction of speech and swallowing, yet there are few techniques of reconstruction for tongue tip defects. This report describes the effectiveness of a sliding tongue flap for tongue tip reconstruction following anterior partial glossectomy.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102189"},"PeriodicalIF":2.2,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of COL11A1 on oral squamous cell carcinoma.","authors":"Yuan-Hang Liu, Dan Li, Hao-Lei Zhang, Bo-Hao Zhang, Wei-Jing Song, Tian-Ke Li","doi":"10.1016/j.jormas.2024.102183","DOIUrl":"10.1016/j.jormas.2024.102183","url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral cavity, which is mainly a series of atypical hyperplasia of oral epithelial cells, and the overall prognosis remains poor.</p><p><strong>Methods: </strong>GSE37991 and GSE38517 were downloaded from gene expression omnibus (GEO) to identify differentially expressed genes (DEGs). Functional enrichment analysis of DEGs was performed, weighted gene co-expression network analysis (WGCNA) was used. Protein-protein interaction (PPI) network was constructed. Core gene expression was visualized using a heatmap. Comparative toxicogenomics database (CTD) and miRNA analyses identified related diseases and regulatory miRNAs. Western blot (WB) was conducted to examine expression of COL11A1 and TGF-SMAD signaling components in OSCC samples.</p><p><strong>Results: </strong>5163 DEGs were identified. DEGs were enriched in metabolic processes and signaling pathways, including TGF-β/SMAD and PI3K-Akt. WGCNA identified 11 core modules. PPI network analysis revealed five core genes: COL11A1, AURKA, MELK, CCNA2, and BUB1. Heatmap analysis showed that COL11A1 is highly expressed in OSCC. CTD analysis indicated that COL11A1 is associated with OSCC. miRNA prediction identified potential regulatory factors. Western blot analysis demonstrated that COL11A1 is overexpressed in OSCC and is associated with TGF-SMAD signaling, inflammation, and cell cycle progression.</p><p><strong>Conclusion: </strong>COL11A1 is highly expressed in OSCC and may serve as a target gene interacting with the TGF-SMAD signaling pathway.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102183"},"PeriodicalIF":2.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet-rich fibrin associated to bovine bone induces bone regeneration in model of critical-sized calvaria defect of rats submitted to Zoledronic Acid therapy: PRF induces bone healing.","authors":"Bárbara Gressy Duarte Souza Carneiro, Thays Allane Cordeiro Maia, Vanessa Costa, Simone Peixe Frieddrichsdorf, Delane Viana Gondim, Karuza Maria Alves Pereira, Mirna Marques Bezerra, Paula Goes","doi":"10.1016/j.jormas.2024.102175","DOIUrl":"10.1016/j.jormas.2024.102175","url":null,"abstract":"<p><strong>Purpose: </strong>Reconstruction of bone defects prior to implant installation is a challenge, especially when the patient uses bisphosphonates. Given this difficulty, many studies investigate biomaterials that can improve the bone regeneration process. In this context, this study aimed to investigate the effect of platelet-rich fibrin (PRF) and Bio-Oss (BO) on bone regeneration of rats submitted to critical-sized calvaria defects and treated with ZA.</p><p><strong>Methods: </strong>Thirty Wistar rats received a single dose of ZA (120 μg/kg) and after 7 days, were submitted to an 8 mm calvaria defect. The animals were divided into 5 groups (n = 6): ZA, BO, PRF or BO+PRF; animals from control group did not receive ZA. All animals were euthanized 12 weeks after surgical procedure and calvaria collected to histological, histomorphometric and micro-CT analyses.</p><p><strong>Results: </strong>BO+PRF increased the number of osteoblasts (33 %) and osteoclasts (58 %), as well as blood vessels (70 %) and Type I collagen (52 %) (p < 0.05) compared to ZA group.</p><p><strong>Conclusion: </strong>In summary, the association of BO+PRF improved bone healing of large bone defect in rats receiving ZA and this may be an interesting approach for the treatment to be tested in patients under anti-resorptive therapy.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102175"},"PeriodicalIF":2.2,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of super-enhancers in head and neck cancer and its potential therapeutic targets.","authors":"Chuhuan Zhou, Gunan Guo, Qi Li","doi":"10.1016/j.jormas.2024.102182","DOIUrl":"10.1016/j.jormas.2024.102182","url":null,"abstract":"<p><p>Head and neck squamous cell carcinoma (HNSCC) poses a significant global health challenge, with over 660,000 new cases diagnosed and more than 325,000 deaths each year. Despite advances in treatment, long-term survival rates for HNSCC patients remain disappointingly low, underscoring the critical need for innovative therapeutic strategies. This review delves into the role of super-enhancers in HNSCC, highlighting their pivotal function in regulating key oncogenes such as KLF4, FOSL1, and ΔNp63, which are crucial for tumor progression and metastasis. Moreover, it explores how super-enhancers contribute to the maintenance of cancer stem cell characteristics by controlling genes like SOX2, BRD4. thereby promoting self-renewal and pluripotency.The study also underscores the potential of BET bromodomain inhibitors, exemplified by JQ1, and CDK7 inhibitors like THZ1, which demonstrate substantial therapeutic promise by effectively disrupting the function of super-enhancers in HNSCC. Overall, this research provides a comprehensive overview of the importance of super-enhancers in HNSCC.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102182"},"PeriodicalIF":2.2,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium nano particles versus nano vitamin D3 in modulating anastrozole-induced osteoporosis on the mandibular alveolar bone of albino rats.","authors":"Souhayla Gamal Elmalah, Rania Osama M Mohsen, Rabab Hassan","doi":"10.1016/j.jormas.2024.102181","DOIUrl":"10.1016/j.jormas.2024.102181","url":null,"abstract":"<p><strong>Aim: </strong>Compare the efficiency of selenium nanoparticles (SeNPs) and Nano vitamin D3 in modulating alveolar bone osteoporosis induced by anastrozole in albino rats.</p><p><strong>Materials and methods: </strong>28 female albino rats were randomly divided into 4 groups (7/group); Control group (GP I): rats were received distilled water orally. Anastrozole group (GP II): rats were orally given anastrozole (1 mg/kg/day) dissolved in distilled water. SeNP treated Anastrozole group (GP III): rats were orally given anastrozole with SeNP (0.5 mg/kg/day). Nano vitamin D3 treated Anastrozole group (GP IV): rats were orally given anastrozole with Nano vitamin D3 (40 IU/kg/day). After 4 weeks of drugs administration, mandibles were prepared and stained with hematoxylin & eosin, Masson trichrome and anti-osteocalcin antibody. New collagen area% in Masson trichrome and positive anti-osteocalcin osteoblasts count were measured and statistically analyzed.</p><p><strong>Results: </strong>Deleterious changes in the alveolar bone were detected in Gp II, while being markedly improved in treated groups. Moreover, GP II demonstrated large areas of old collagen, with positive anti-osteocalcin immunoreactivity in some osteoblasts and few osteocytes, meanwhile, control and treated groups showed more predominant newly formed collagen with positive immunoreactivity in nearly all osteoblasts, osteocytes, and some areas of bone matrix. Statistically, Gp III and Gp IV showed the significantly highest newly formed collagen mean area% and positive osteoblasts count, then Gp I, while Gp II represented the least recorded data.</p><p><strong>Conclusions: </strong>SeNPs and Nano Vitamin D3 improve the structural and cellular quality of mandibular alveolar bone in anastrozole-induced osteoporosis of albino rats.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102181"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in the position of the inferior alveolar nerve after sagittal split ramus osteotomy and its effect on postoperative neurosensory disturbances.","authors":"Chingyi Cheung, Liwei Huang, Zhaokun Zhu, Zhen Liu, Yao Liu, En Luo","doi":"10.1016/j.jormas.2024.102180","DOIUrl":"10.1016/j.jormas.2024.102180","url":null,"abstract":"<p><strong>Aim of the study: </strong>To analyze the positional changes of the inferior alveolar nerve after sagittal split ramus osteotomy (SSRO) and assess the impact of these changes on postoperative sensory nerve disturbances.</p><p><strong>Material and methods: </strong>Preoperative and postoperative (one year) spiral CT scans were used to categorize the inferior alveolar nerve into the extended side (n = 30) and retrogressive side (n = 30). Measurement software was used to observe and measure positional changes of the mandibular nerve canal, followed by a comparative analysis.</p><p><strong>Results: </strong>Post-surgical analysis revealed that the inferior alveolar nerve was displaced laterally and superiorly on the extended side, and medially and inferiorly on the retrogressive side, with statistically significant differences (p < 0.05). Correlation analysis demonstrated a significant association between nerve displacement in the first molar region and sensory nerve impairment (p < 0.05).</p><p><strong>Conclusion: </strong>Significant positional changes in the inferior alveolar nerve were observed post-surgery, particularly on the extended migration side, with these changes being correlated with the occurrence of neurological symptoms.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102180"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Propranolol and Pingyangmycin combination therapy in infantile hemangiomas: Correlation with VEGF levels.","authors":"Jing Zhou, Chunling Gong, Yu Zhang","doi":"10.1016/j.jormas.2024.102176","DOIUrl":"10.1016/j.jormas.2024.102176","url":null,"abstract":"<p><strong>Background: </strong>Infantile hemangiomas (IH) represent the most prevalent vascular tumors in infants, often necessitating prompt medical intervention due to their potential for rapid growth and complications. This retrospective study aims to evaluate the efficacy of propranolol combined with Pingyangmycin in the treatment of IH and to investigate its correlation with vascular endothelial growth factor (VEGF) levels.</p><p><strong>Methods: </strong>A prospective, observational study was conducted over 12 months, enrolling 120 IH patients. Patients received a combination therapy of propranolol and pingyangmycin for 3 to 6 months. Hemangioma Activity Score (HAS) and serum VEGF levels were assessed at baseline, 30th day, and 90th day post-treatment.</p><p><strong>Results: </strong>A total of 120 patients diagnosed with IH, including 68 males and 52 females with a mean age of 1.2 years, were enrolled in this study. The HAS at baseline was 8.5 ± 1.7, which significantly decreased to 4.2 ± 1.0 by Day 30 and further reduced to 2.1 ± 0.8 by Day 90 (P < 0.001 for both comparisons). Serum VEGF levels also showed a significant reduction from a baseline of 235.6 ± 42.1 pg/mL to 180.3 ± 34.7 pg/mL at Day 30 and to 122.8 ± 28.9 pg/mL at Day 90 (P = 0.02 and P = 0.01, respectively). The correlation analysis revealed a positive correlation between VEGF levels and HAS scores at all time points, with Pearson correlation coefficients ranging from -0.82 to -0.89 (P < 0.001). Adverse events were mild and transient, occurring in 15 % of patients, with the most common being mild hypoglycemia (8 %), transient bronchospasm (5 %), and gastrointestinal discomfort (2 %). All adverse events resolved with symptomatic treatment, and no patient discontinued therapy due to adverse reactions.</p><p><strong>Conclusion: </strong>Propranolol treatment for infants with proliferative hemangiomas is significantly effective with minor adverse effects. The mechanism of action may be associated with the downregulation of serum VEGF levels.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102176"},"PeriodicalIF":2.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the biomechanical effect of distal implants placed at different angles in the all-on-four technique: A nonlinear finite element analysis.","authors":"Yildiz Unuvar, Aylin Calis, Osman Koc","doi":"10.1016/j.jormas.2024.102157","DOIUrl":"10.1016/j.jormas.2024.102157","url":null,"abstract":"<p><strong>Introduction: </strong>The \"All-on-four\" technique addresses this by placing two vertical implants in the anterior region and two posterior implants angled up to 45°. This study evaluates stress distribution on bone, implants, abutments, gingiva, and prostheses based on posterior implant angulation, using both standard and angled neck implants. Additionally, angled neck implants were used alongside standard implants.</p><p><strong>Methods: </strong>To evaluate the biomechanical stress and displacement behavior of implants placed at 15°, 30°, 45°, and 30° neck-angled in the interforaminal region of using the All-on-four technique, under a 200 N masticatory force on bone, implant, abutment, and prosthesis, using the FEA method with a nonlinear solver.</p><p><strong>Results: </strong>The stress values measured in the neck region of the angled implant and abutment placed in the distal region were highest in model IV (305 and 420 MPa), followed model III (282 and 359 MPa), model II (192 and 337 MPa) and lowest in model I (177 and 225 MPa), respectively. The mean elemental von Mises stress in the mandibular bone region where the implant was placed was highest in model I (56 MPa) and lowest in model III (40.4 MPa).</p><p><strong>Conclusion: </strong>As the angle of insertion of the implant into the bone increases, the biomechanical stress value on the implant and abutment also increases. Among the models, the lowest von Mises stress values on the implant and abutment were measured in model I and model II. Models with low stress values can be recommended for patients with clinical conditions and biomechanical risk factors.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102157"},"PeriodicalIF":2.2,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival outcomes of surgically treated oral cavity squamous cell carcinoma patients at tertiary care hospital in Northern Thailand.","authors":"Tapanut Ariyanon, Hanpon Klibngern, Pichit Sittitrai, Donyarat Ruenmarkkaew, Weerachai Watcharatsiriyuth","doi":"10.1016/j.jormas.2024.102166","DOIUrl":"10.1016/j.jormas.2024.102166","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the survival outcomes of surgically treated oral squamous cell carcinoma (OSCC) patients with or without adjuvant therapies and factors predicting treatment outcomes from the largest head and neck cancer center in Northern Thailand.</p><p><strong>Methods: </strong>Two hundred and sixty OSCC patients curatively treated between 2017 and 2021 were retrospectively recruited into the study to analyze the clinicopathological characteristics and oncological outcomes and compare them with historical data. A multivariate Cox proportional hazards model analysis was performed to evaluate factors affecting survival outcomes.</p><p><strong>Results: </strong>Males were slightly predominant (58.1 %). The most common subsite was an oral tongue (48.5 %), followed by an alveolar ridge (18.5 %). Advanced stages (III-IV) presented most at 88.5 %. The majority of the patients (52.3 %) received surgery and chemoradiotherapy, followed by surgery and radiotherapy (36.9 %), and surgery alone (10.8 %). The five-year overall survival (OS), disease-specific survival, and disease-free survival were 28.8 %, 44.0 %, and 46.3 %, respectively. Age > 45, ECOG performance status 2, and positive surgical margin status were found to be independent predictors for decreased OS (aHR 1.74, 95 % CI 1.01-3.00, aHR 2.64, 95 % CI 1.22-5.68, and aHR 1.76, 95 % CI 1.18-2.63, respectively).</p><p><strong>Conclusions: </strong>Survival outcomes of OSCC in the study remain poor compared to other studies. The high prevalence of locally advanced stage presentation and inadequate surgical margin are the main problems. Public awareness, cancer screening programs, and intraoperative specimen-driven evaluation might help obtain adequate surgical margins and improve survival outcomes.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102166"},"PeriodicalIF":2.2,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}