Journal of Stomatology Oral and Maxillofacial Surgery最新文献

{"title":"Platelet-rich fibrin associated to bovine bone induces bone regeneration in model of critical-sized calvaria defect of rats submitted to Zoledronic Acid therapy: PRF induces bone healing.","authors":"Bárbara Gressy Duarte Souza Carneiro, Thays Allane Cordeiro Maia, Vanessa Costa, Simone Peixe Frieddrichsdorf, Delane Viana Gondim, Karuza Maria Alves Pereira, Mirna Marques Bezerra, Paula Goes","doi":"10.1016/j.jormas.2024.102175","DOIUrl":"10.1016/j.jormas.2024.102175","url":null,"abstract":"<p><strong>Purpose: </strong>Reconstruction of bone defects prior to implant installation is a challenge, especially when the patient uses bisphosphonates. Given this difficulty, many studies investigate biomaterials that can improve the bone regeneration process. In this context, this study aimed to investigate the effect of platelet-rich fibrin (PRF) and Bio-Oss (BO) on bone regeneration of rats submitted to critical-sized calvaria defects and treated with ZA.</p><p><strong>Methods: </strong>Thirty Wistar rats received a single dose of ZA (120 μg/kg) and after 7 days, were submitted to an 8 mm calvaria defect. The animals were divided into 5 groups (n = 6): ZA, BO, PRF or BO+PRF; animals from control group did not receive ZA. All animals were euthanized 12 weeks after surgical procedure and calvaria collected to histological, histomorphometric and micro-CT analyses.</p><p><strong>Results: </strong>BO+PRF increased the number of osteoblasts (33 %) and osteoclasts (58 %), as well as blood vessels (70 %) and Type I collagen (52 %) (p < 0.05) compared to ZA group.</p><p><strong>Conclusion: </strong>In summary, the association of BO+PRF improved bone healing of large bone defect in rats receiving ZA and this may be an interesting approach for the treatment to be tested in patients under anti-resorptive therapy.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102175"},"PeriodicalIF":2.2,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of super-enhancers in head and neck cancer and its potential therapeutic targets.","authors":"Chuhuan Zhou, Gunan Guo, Qi Li","doi":"10.1016/j.jormas.2024.102182","DOIUrl":"10.1016/j.jormas.2024.102182","url":null,"abstract":"<p><p>Head and neck squamous cell carcinoma (HNSCC) poses a significant global health challenge, with over 660,000 new cases diagnosed and more than 325,000 deaths each year. Despite advances in treatment, long-term survival rates for HNSCC patients remain disappointingly low, underscoring the critical need for innovative therapeutic strategies. This review delves into the role of super-enhancers in HNSCC, highlighting their pivotal function in regulating key oncogenes such as KLF4, FOSL1, and ΔNp63, which are crucial for tumor progression and metastasis. Moreover, it explores how super-enhancers contribute to the maintenance of cancer stem cell characteristics by controlling genes like SOX2, BRD4. thereby promoting self-renewal and pluripotency.The study also underscores the potential of BET bromodomain inhibitors, exemplified by JQ1, and CDK7 inhibitors like THZ1, which demonstrate substantial therapeutic promise by effectively disrupting the function of super-enhancers in HNSCC. Overall, this research provides a comprehensive overview of the importance of super-enhancers in HNSCC.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102182"},"PeriodicalIF":2.2,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium nano particles versus nano vitamin D3 in modulating anastrozole-induced osteoporosis on the mandibular alveolar bone of albino rats.","authors":"Souhayla Gamal Elmalah, Rania Osama M Mohsen, Rabab Hassan","doi":"10.1016/j.jormas.2024.102181","DOIUrl":"10.1016/j.jormas.2024.102181","url":null,"abstract":"<p><strong>Aim: </strong>Compare the efficiency of selenium nanoparticles (SeNPs) and Nano vitamin D3 in modulating alveolar bone osteoporosis induced by anastrozole in albino rats.</p><p><strong>Materials and methods: </strong>28 female albino rats were randomly divided into 4 groups (7/group); Control group (GP I): rats were received distilled water orally. Anastrozole group (GP II): rats were orally given anastrozole (1 mg/kg/day) dissolved in distilled water. SeNP treated Anastrozole group (GP III): rats were orally given anastrozole with SeNP (0.5 mg/kg/day). Nano vitamin D3 treated Anastrozole group (GP IV): rats were orally given anastrozole with Nano vitamin D3 (40 IU/kg/day). After 4 weeks of drugs administration, mandibles were prepared and stained with hematoxylin & eosin, Masson trichrome and anti-osteocalcin antibody. New collagen area% in Masson trichrome and positive anti-osteocalcin osteoblasts count were measured and statistically analyzed.</p><p><strong>Results: </strong>Deleterious changes in the alveolar bone were detected in Gp II, while being markedly improved in treated groups. Moreover, GP II demonstrated large areas of old collagen, with positive anti-osteocalcin immunoreactivity in some osteoblasts and few osteocytes, meanwhile, control and treated groups showed more predominant newly formed collagen with positive immunoreactivity in nearly all osteoblasts, osteocytes, and some areas of bone matrix. Statistically, Gp III and Gp IV showed the significantly highest newly formed collagen mean area% and positive osteoblasts count, then Gp I, while Gp II represented the least recorded data.</p><p><strong>Conclusions: </strong>SeNPs and Nano Vitamin D3 improve the structural and cellular quality of mandibular alveolar bone in anastrozole-induced osteoporosis of albino rats.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102181"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in the position of the inferior alveolar nerve after sagittal split ramus osteotomy and its effect on postoperative neurosensory disturbances.","authors":"Chingyi Cheung, Liwei Huang, Zhaokun Zhu, Zhen Liu, Yao Liu, En Luo","doi":"10.1016/j.jormas.2024.102180","DOIUrl":"10.1016/j.jormas.2024.102180","url":null,"abstract":"<p><strong>Aim of the study: </strong>To analyze the positional changes of the inferior alveolar nerve after sagittal split ramus osteotomy (SSRO) and assess the impact of these changes on postoperative sensory nerve disturbances.</p><p><strong>Material and methods: </strong>Preoperative and postoperative (one year) spiral CT scans were used to categorize the inferior alveolar nerve into the extended side (n = 30) and retrogressive side (n = 30). Measurement software was used to observe and measure positional changes of the mandibular nerve canal, followed by a comparative analysis.</p><p><strong>Results: </strong>Post-surgical analysis revealed that the inferior alveolar nerve was displaced laterally and superiorly on the extended side, and medially and inferiorly on the retrogressive side, with statistically significant differences (p < 0.05). Correlation analysis demonstrated a significant association between nerve displacement in the first molar region and sensory nerve impairment (p < 0.05).</p><p><strong>Conclusion: </strong>Significant positional changes in the inferior alveolar nerve were observed post-surgery, particularly on the extended migration side, with these changes being correlated with the occurrence of neurological symptoms.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102180"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Buccal fat pad lift: A technical note.","authors":"C Debortoli, F Afota, B Lerhe, G d' Andrea, S Latreche, O Rios, C Savoldelli","doi":"10.1016/j.jormas.2024.102161","DOIUrl":"10.1016/j.jormas.2024.102161","url":null,"abstract":"<p><strong>Introduction: </strong>The buccal fat pad is largely involved to close oro-antral communication (OAC) . The implant rehabilitation of the maxillary posterior area after OAC is a surgical challenge. The difficulty of this rehabilitation remains in the absence of a lateral and crestal bone wall.</p><p><strong>Technical note: </strong>The buccal fat pad lift was performed under general anaesthesia. This involved lifting the buccal fat pad and the sinus mucosa, which they were fused and filled the gap with a biomaterial. The osteogenic properties of the environment will enable osseointegration of the biomaterial.</p><p><strong>Conclusion: </strong>This technique requires a relevant surgical experience. It is a reliable and valid surgical solution to rehabilitate the maxillary posterior area for dental implant placement.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102161"},"PeriodicalIF":2.2,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Midline destructive disease : a rapidly evolving case report.","authors":"Anne Fevre, Dylan Gozel, Narcisse Zwetyenga, Vivien Moris","doi":"10.1016/j.jormas.2024.102177","DOIUrl":"10.1016/j.jormas.2024.102177","url":null,"abstract":"","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102177"},"PeriodicalIF":2.2,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Propranolol and Pingyangmycin combination therapy in infantile hemangiomas: Correlation with VEGF levels.","authors":"Jing Zhou, Chunling Gong, Yu Zhang","doi":"10.1016/j.jormas.2024.102176","DOIUrl":"10.1016/j.jormas.2024.102176","url":null,"abstract":"<p><strong>Background: </strong>Infantile hemangiomas (IH) represent the most prevalent vascular tumors in infants, often necessitating prompt medical intervention due to their potential for rapid growth and complications. This retrospective study aims to evaluate the efficacy of propranolol combined with Pingyangmycin in the treatment of IH and to investigate its correlation with vascular endothelial growth factor (VEGF) levels.</p><p><strong>Methods: </strong>A prospective, observational study was conducted over 12 months, enrolling 120 IH patients. Patients received a combination therapy of propranolol and pingyangmycin for 3 to 6 months. Hemangioma Activity Score (HAS) and serum VEGF levels were assessed at baseline, 30th day, and 90th day post-treatment.</p><p><strong>Results: </strong>A total of 120 patients diagnosed with IH, including 68 males and 52 females with a mean age of 1.2 years, were enrolled in this study. The HAS at baseline was 8.5 ± 1.7, which significantly decreased to 4.2 ± 1.0 by Day 30 and further reduced to 2.1 ± 0.8 by Day 90 (P < 0.001 for both comparisons). Serum VEGF levels also showed a significant reduction from a baseline of 235.6 ± 42.1 pg/mL to 180.3 ± 34.7 pg/mL at Day 30 and to 122.8 ± 28.9 pg/mL at Day 90 (P = 0.02 and P = 0.01, respectively). The correlation analysis revealed a positive correlation between VEGF levels and HAS scores at all time points, with Pearson correlation coefficients ranging from -0.82 to -0.89 (P < 0.001). Adverse events were mild and transient, occurring in 15 % of patients, with the most common being mild hypoglycemia (8 %), transient bronchospasm (5 %), and gastrointestinal discomfort (2 %). All adverse events resolved with symptomatic treatment, and no patient discontinued therapy due to adverse reactions.</p><p><strong>Conclusion: </strong>Propranolol treatment for infants with proliferative hemangiomas is significantly effective with minor adverse effects. The mechanism of action may be associated with the downregulation of serum VEGF levels.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102176"},"PeriodicalIF":2.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative scientific illustration training for surgery residents in Paris.","authors":"V Sounthakith, R Fawaz, R H Khonsari","doi":"10.1016/j.jormas.2024.102178","DOIUrl":"10.1016/j.jormas.2024.102178","url":null,"abstract":"","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102178"},"PeriodicalIF":2.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difference in survival and prognosis between malignant tumors of odontogenic origin.","authors":"Quentin Hennocq, William Pouillot, Chloé Bertolus, Jean-Philippe Foy","doi":"10.1016/j.jormas.2024.102179","DOIUrl":"10.1016/j.jormas.2024.102179","url":null,"abstract":"<p><strong>Introduction: </strong>The prognosis of metastatic ameloblastoma (METAM), now defined as a benign tumor, and malignant odontogenic tumors (MOT) is poorly studied in the literature. The aim of this study was to determine the prognosis and factors influencing the survival of these patients.</p><p><strong>Material and methods: </strong>Using the SEER database, we retrieved clinical data of patients with malignant tumors of dental origin between 1975 and 2020. They include 3 histological groups: metastatic ameloblastoma (METAM), malignant odontogenic tumors (MOT, including odontogenic carcinoma, odontogenic sarcoma, primary intraosseous carcinoma, and ameloblastic carcinoma) and ameloblastic fibrosarcoma (AFS).</p><p><strong>Results: </strong>On 251 patients, we observed no significant difference in disease-specific survival (DSS) between the three histological groups, with 5-year DSS of 77.4 % (59.9 - 100), 84.0 % (78.7 - 89.7) and 71.1 % (50.7 - 99.7) for METAM, MOT and AFS respectively (p = 0.460). In the MOT group, using a multivariate analysis, surgical treatment appeared to be a protective factor for DSS (HR = 0.483 [0.243 - 0.960], p = 0.038) after taking into account the potential confounding factors mentioned above. No variable significantly influenced DSS in the METAM and AFS group in univariate analysis.</p><p><strong>Discussion: </strong>We found no difference in specific survival between the three histological groups. Although metastatic ameloblastoma was reclassified as a benign tumor by the WHO in 2017, the vital risk for patients remains consequent, and statistically similar to malignant odontogenic tumors.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102179"},"PeriodicalIF":2.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the biomechanical effect of distal implants placed at different angles in the all-on-four technique: A nonlinear finite element analysis.","authors":"Yildiz Unuvar, Aylin Calis, Osman Koc","doi":"10.1016/j.jormas.2024.102157","DOIUrl":"10.1016/j.jormas.2024.102157","url":null,"abstract":"<p><strong>Introduction: </strong>The \"All-on-four\" technique addresses this by placing two vertical implants in the anterior region and two posterior implants angled up to 45°. This study evaluates stress distribution on bone, implants, abutments, gingiva, and prostheses based on posterior implant angulation, using both standard and angled neck implants. Additionally, angled neck implants were used alongside standard implants.</p><p><strong>Methods: </strong>To evaluate the biomechanical stress and displacement behavior of implants placed at 15°, 30°, 45°, and 30° neck-angled in the interforaminal region of using the All-on-four technique, under a 200 N masticatory force on bone, implant, abutment, and prosthesis, using the FEA method with a nonlinear solver.</p><p><strong>Results: </strong>The stress values measured in the neck region of the angled implant and abutment placed in the distal region were highest in model IV (305 and 420 MPa), followed model III (282 and 359 MPa), model II (192 and 337 MPa) and lowest in model I (177 and 225 MPa), respectively. The mean elemental von Mises stress in the mandibular bone region where the implant was placed was highest in model I (56 MPa) and lowest in model III (40.4 MPa).</p><p><strong>Conclusion: </strong>As the angle of insertion of the implant into the bone increases, the biomechanical stress value on the implant and abutment also increases. Among the models, the lowest von Mises stress values on the implant and abutment were measured in model I and model II. Models with low stress values can be recommended for patients with clinical conditions and biomechanical risk factors.</p>","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102157"},"PeriodicalIF":2.2,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}