Frontiers in Integrative Neuroscience最新文献

{"title":"Understanding the neural bases of bodily self-consciousness: recent achievements and main challenges.","authors":"Zoé Dary,&nbsp;Christophe Lopez","doi":"10.3389/fnint.2023.1145924","DOIUrl":"https://doi.org/10.3389/fnint.2023.1145924","url":null,"abstract":"<p><p>The last two decades have seen a surge of interest in the mechanisms underpinning bodily self-consciousness (BSC). Studies showed that BSC relies on several bodily experiences (i.e., self-location, body ownership, agency, first-person perspective) and multisensory integration. The aim of this literature review is to summarize new insights and novel developments into the understanding of the neural bases of BSC, such as the contribution of the interoceptive signals to the neural mechanisms of BSC, and the overlap with the neural bases of conscious experience in general and of higher-level forms of self (i.e., the cognitive self). We also identify the main challenges and propose future perspectives that need to be conducted to progress into the understanding of the neural mechanisms of BSC. In particular, we point the lack of crosstalk and cross-fertilization between subdisciplines of integrative neuroscience to better understand BSC, especially the lack of research in animal models to decipher the neural networks and systems of neurotransmitters underpinning BSC. We highlight the need for more causal evidence that specific brain areas are instrumental in generating BSC and the need for studies tapping into interindividual differences in the phenomenal experience of BSC and their underlying mechanisms.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1145924"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10160039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-activation depression of the Hoffman reflex is not altered by galvanic vestibular stimulation in healthy subjects.","authors":"Mónica Del Carmen Alvarado-Navarrete,&nbsp;Adriana C Pliego-Carrillo,&nbsp;Claudia Ivette Ledesma-Ramírez,&nbsp;Carlos A Cuellar","doi":"10.3389/fnint.2023.1234613","DOIUrl":"https://doi.org/10.3389/fnint.2023.1234613","url":null,"abstract":"<p><p>The comprehension of the neural elements interacting in the spinal cord affected by vestibular input will contribute to the understanding of movement execution in normal and pathological conditions. In this context, Hoffman's reflex (H-reflex) has been used to evaluate transient excitability changes on the spinal cord descending pathways. The post-activation depression (P-AD) of the H-reflex consists of evoking consecutive responses (>1 Hz) provoking an amplitude depression, which has been shown to diminish in pathological conditions (i.e., spasticity, diabetic neuropathy). Galvanic Vestibular Stimulation (GVS) is a non-invasive method that activates the vestibular afferents and has been used to study the excitability of the H-reflex applied as a conditioning pulse. To our knowledge, there are no reports evaluating the P-AD during and after GVS. Our primary aim was to determine if GVS alters the P-AD evoked by stimulating the tibial nerve at 0.1, 1, 5, and 10 Hz, recording in the gastrocnemius and soleus muscles. Direct current stimulation of 2.0 ± 0.6 mA with the cathode ipsilateral (Ipsi) or contralateral (Contra) to the H-reflex electrode montage was applied bilaterally over the mastoid process in 19 healthy subjects. The P-AD's immediate post-GVS response (P Ipsi, P Contra) was also analyzed. Secondarily, we analyzed the excitability of the H-reflex during GVS. Responses evoked at 0.1 Hz with GVS, post-GVS, and a Control (no GVS) condition were used for comparisons. Our results show that P-AD persisted in all subjects despite increased excitability induced by GVS: statistical significance was found when comparing P-AD at 1, 5, and 10 Hz with the corresponding condition (Control, Ipsi, P Ipsi, Contra, P Contra) at 0.1 Hz (<i>p</i> < 0.001). Additionally, the increase in excitability produced by GVS was quantified for the first H-reflex of each P-AD stimulation frequency. The percentage change for all GVS conditions surpassed the Control by at least 20%, being statistically significant for Contra compared to Control (<i>p</i> < 0.01). In summary, although GVS increases the excitability of the vestibulospinal pathway at a premotor level, the neural inhibitory mechanism present in P-AD remains unaltered in healthy subjects.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1234613"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10499171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10268131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing the relationship between cochlear health measures and speech recognition in cochlear implant users.","authors":"Ladan Zamaninezhad,&nbsp;Berkutay Mert,&nbsp;Heval Benav,&nbsp;Jochen Tillein,&nbsp;Carolyn Garnham,&nbsp;Uwe Baumann","doi":"10.3389/fnint.2023.1125712","DOIUrl":"https://doi.org/10.3389/fnint.2023.1125712","url":null,"abstract":"<p><strong>Background: </strong>One factor which influences the speech intelligibility of cochlear implant (CI) users is the number and the extent of the functionality of spiral ganglion neurons (SGNs), referred to as \"cochlear health.\" To explain the interindividual variability in speech perception of CI users, a clinically applicable estimate of cochlear health could be insightful. The change in the slope of the electrically evoked compound action potentials (eCAP), amplitude growth function (AGF) as a response to increased interphase gap (IPG) (IPGE_<i>slope</i>) has been introduced as a potential measure of cochlear health. Although this measure has been widely used in research, its relationship to other parameters requires further investigation.</p><p><strong>Methods: </strong>This study investigated the relationship between IPGE_<i>slope</i>, demographics and speech intelligibility by (1) considering the relative importance of each frequency band to speech perception, and (2) investigating the effect of the stimulus polarity of the stimulating pulse. The eCAPs were measured in three different conditions: (1) Forward masking with anodic-leading (FMA) pulse, (2) Forward masking with cathodic-leading (FMC) pulse, and (3) with alternating polarity (AP). This allowed the investigation of the effect of polarity on the diagnosis of cochlear health. For an accurate investigation of the correlation between IPGE_<i>slope</i> and speech intelligibility, a weighting function was applied to the measured IPGE_{<i>slopes</i>} on each electrode in the array to consider the relative importance of each frequency band for speech perception. A weighted Pearson correlation analysis was also applied to compensate for the effect of missing data by giving higher weights to the ears with more successful IPGE_<i>slope</i> measurements.</p><p><strong>Results: </strong>A significant correlation was observed between IPGE_<i>slope</i> and speech perception in both quiet and noise for between-subject data especially when the relative importance of frequency bands was considered. A strong and significant correlation was also observed between IPGE_<i>slope</i> and age when stimulation was performed with cathodic-leading pulses but not for the anodic-leading pulse condition.</p><p><strong>Conclusion: </strong>Based on the outcome of this study it can be concluded that IPGE_<i>slope</i> has potential as a relevant clinical measure indicative of cochlear health and its relationship to speech intelligibility. The polarity of the stimulating pulse could influence the diagnostic potential of IPGE_<i>slope</i>.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1125712"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10212975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From circuits to behavior: Amygdala dysfunction in fragile X syndrome.","authors":"Matthew N Svalina,&nbsp;Regina Sullivan,&nbsp;Diego Restrepo,&nbsp;Molly M Huntsman","doi":"10.3389/fnint.2023.1128529","DOIUrl":"https://doi.org/10.3389/fnint.2023.1128529","url":null,"abstract":"<p><p>Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by a repeat expansion mutation in the promotor region of the <i>FMR1</i> gene resulting in transcriptional silencing and loss of function of fragile X messenger ribonucleoprotein 1 protein (FMRP). FMRP has a well-defined role in the early development of the brain. Thus, loss of the FMRP has well-known consequences for normal cellular and synaptic development leading to a variety of neuropsychiatric disorders including an increased prevalence of amygdala-based disorders. Despite our detailed understanding of the pathophysiology of FXS, the precise cellular and circuit-level underpinnings of amygdala-based disorders is incompletely understood. In this review, we discuss the development of the amygdala, the role of neuromodulation in the critical period plasticity, and recent advances in our understanding of how synaptic and circuit-level changes in the basolateral amygdala contribute to the behavioral manifestations seen in FXS.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1128529"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10034113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9546055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Noise-induced hearing loss: From basic to clinical research.","authors":"Zhiwu Huang,&nbsp;Wei Qiu,&nbsp;Vicky Zhang,&nbsp;Hui Wang,&nbsp;Bin Ye,&nbsp;Qixuan Wang","doi":"10.3389/fnint.2023.1172081","DOIUrl":"https://doi.org/10.3389/fnint.2023.1172081","url":null,"abstract":"COPYRIGHT © 2023 Huang, Qiu, Zhang, Wang, Ye and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Editorial: Noise-induced hearing loss: From basic to clinical research","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1172081"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9241067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Mind-body medicine and its impacts on psychological networks, quality of life, and health.","authors":"Steffen Schulz,&nbsp;Dirk Cysarz,&nbsp;Georg Seifert","doi":"10.3389/fnint.2023.1188638","DOIUrl":"https://doi.org/10.3389/fnint.2023.1188638","url":null,"abstract":"COPYRIGHT © 2023 Schulz, Cysarz and Seifert. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Editorial: Mind-body medicine and its impacts on psychological networks, quality of life, and health","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1188638"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9753991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of select psychiatric disorders with incident brain aneurysm and subarachnoid hemorrhage among veterans.","authors":"Daniel L Cooke,&nbsp;Hui Shen,&nbsp;Madhavi Duvvuri,&nbsp;Daniel Thompson,&nbsp;Thomas Neylan,&nbsp;William Wolfe,&nbsp;Steven Hetts,&nbsp;Bruce Ovbiagele,&nbsp;Mary Whooley,&nbsp;Beth Cohen","doi":"10.3389/fnint.2023.1207610","DOIUrl":"https://doi.org/10.3389/fnint.2023.1207610","url":null,"abstract":"<p><strong>Background: </strong>Brain aneurysms represent a significant cause of hemorrhagic stroke. Prior research has demonstrated links between stress and stroke, including brain aneurysms. We aimed to determine relationships between select psychiatric disorders and aneurysms and aneurysmal SAH.</p><p><strong>Methods: </strong>We performed retrospective, case-control study of a National Veterans Affairs population with two experimental groups (aneurysm-only and aneurysmal SAH) and 10-fold controls per group matched by age, date, and clinical data source. The studied the presence of 4 psychiatric disorders: Posttraumatic stress disorder (PTSD), major depressive disorder (MDD), generalized anxiety disorder (GAD), and other mood disorders. Our main outcomes Unadjusted and multivariable adjusted ORs of PTSD, MDD, GAD, and mood disorders within aneurysm-only and aSAH groups.</p><p><strong>Results: </strong>In 6,320,789 US Veterans who were enrolled for at least 5 years in Medicare and/or the Veterans Health Administration, we identified 35,094 cases of aneurysm without SAH and 5,749 cases of aneurysm with SAH between 1/2005 and 12/2019. In analyses adjusted for sex, hypertension, and tobacco use, patients with aneurysm were more likely than matched controls to have a history of PTSD (OR 1.48), MDD (OR 1.33), GAD (OR 1.26), and other mood disorders (OR 1.34) (all <i>p</i>-values < 0.0001). Similarly, patients with aSAH were more likely than controls to have a history of PTSD (OR 1.35), MDD (OR 1.38), GAD (OR 1.18), and other mood disorders (OR 1.30) (all <i>p</i>-values < 0.0001).</p><p><strong>Conclusion: </strong>The study, the largest of its kind, further suggests links between psychiatric disorders and stroke. This is important as patients with aneurysms are not routinely screened for such psychiatric risk factors. Additional research on this topic could lead to novel strategies to improve stroke prevention.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1207610"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10105524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychiatric feature-based subgrouping reveals neural sensory processing spectrum in female FMR1 premutation carriers: A pilot study.","authors":"Jordan E Norris,&nbsp;Lauren M Schmitt,&nbsp;Lisa A De Stefano,&nbsp;Ernest V Pedapati,&nbsp;Craig A Erickson,&nbsp;John A Sweeney,&nbsp;Lauren E Ethridge","doi":"10.3389/fnint.2023.898215","DOIUrl":"https://doi.org/10.3389/fnint.2023.898215","url":null,"abstract":"<p><strong>Introduction: </strong>Fragile X Syndrome (FXS) is rare genetic condition characterized by a repeat expansion (CGG) in the Fragile X messenger ribonucleoprotein 1 (FMR1) gene where individuals with greater than 200 repeats are defined as full mutation. FXS clinical presentation often includes intellectual disability, and autism-like symptoms, including anxiety and sensory hypersensitivities. Individuals with 55 to <200 CGG repeats are said to have the FMR1 premutation, which is not associated with primary characteristics of the full mutation, but with an increased risk for anxiety, depression, and other affective conditions, as well as and impaired cognitive processing differences that vary in severity. Defining subgroups of premutation carriers based on distinct biological features may identify subgroups with varying levels of psychiatric, cognitive, and behavioral alterations.</p><p><strong>Methods: </strong>The current pilot study utilized 3 cluster subgroupings defined by previous k means cluster analysis on neuropsychiatric, cognitive, and resting EEG variables in order to examine basic sensory auditory chirp task-based EEG parameters from 33 females with the FMR1 premutation (ages 17-78).</p><p><strong>Results: </strong>Based on the predefined, neuropsychiatric three-cluster solution, premutation carriers with increased neuropsychiatric features and higher CGG repeat counts (cluster 1) showed decreased stimulus onset response, similar to previous ERP findings across a number of psychiatric disorders but opposite to findings in individuals with full mutation FXS. Premutation carriers with increased executive dysfunction and resting gamma power (cluster 2) exhibited decreased gamma phase locking to a chirp stimulus, similar to individuals with full mutation FXS. Cluster 3 members, who were relatively unaffected by psychiatric or cognitive symptoms, showed the most normative task-based EEG metrics.</p><p><strong>Discussion: </strong>Our findings suggest a spectrum of sensory processing characteristics present in subgroups of premutation carriers that have been previously understudied due to lack of overall group differences. Our findings also further validate the pre-defined clinical subgroups by supporting links between disturbances in well-defined neural pathways and behavioral alterations that may be informative for identifying the mechanisms supporting specific risk factors and divergent therapeutic needs in individuals with the FMR1 premutation.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"898215"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10766165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preterm birth accelerates the maturation of spontaneous and resting activity in the visual cortex.","authors":"Isabelle F Witteveen,&nbsp;Emily McCoy,&nbsp;Troy D Holsworth,&nbsp;Catherine Z Shen,&nbsp;Winnie Chang,&nbsp;Madelyn G Nance,&nbsp;Allison R Belkowitz,&nbsp;Avery Dougald,&nbsp;Meghan H Puglia,&nbsp;Adema Ribic","doi":"10.3389/fnint.2023.1149159","DOIUrl":"https://doi.org/10.3389/fnint.2023.1149159","url":null,"abstract":"<p><p>Prematurity is among the leading risks for poor neurocognitive outcomes. The brains of preterm infants show alterations in structure and electrical activity, but the underlying circuit mechanisms are unclear. To address this, we performed a cross-species study of the electrophysiological activity in the visual cortices of prematurely born infants and mice. Using electroencephalography (EEG) in a sample of healthy preterm (<i>N</i> = 29) and term (<i>N</i> = 28) infants, we found that the maturation of the aperiodic EEG component was accelerated in the preterm cohort, with a significantly flatter 1/f slope when compared to the term infants. The flatter slope was a result of decreased spectral power in the theta and alpha bands and was correlated with the degree of prematurity. To determine the circuit and cellular changes that potentially mediate the changes in 1/f slope after preterm birth, we used <i>in vivo</i> electrophysiology in preterm mice and found that, similar to infants, preterm birth results in a flattened 1/f slope. We analyzed neuronal activity in the visual cortex of preterm (<i>N</i> = 6) and term (<i>N</i> = 9) mice and found suppressed spontaneous firing of neurons. Using immunohistochemistry, we further found an accelerated maturation of inhibitory circuits. In both preterm mice and infants, the functional maturation of the cortex was accelerated, underscoring birth as a critical checkpoint in cortical maturation. Our study points to a potential mechanism of preterm birth-related changes in resting neural activity, highlighting the utility of a cross-species approach in studying the neural circuit mechanisms of preterm birth-related neurodevelopmental conditions.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1149159"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9741771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: High levels of <i>Bifidobacteriaceae</i> are associated with the pathogenesis of Parkinson's disease.","authors":"ShuJia Zuo,&nbsp;HaiJing Wang,&nbsp;Qiang Zhao,&nbsp;Jie Tang,&nbsp;Min Wang,&nbsp;Yu Zhang,&nbsp;Ming Sang,&nbsp;Jing Tian,&nbsp;Puqing Wang","doi":"10.3389/fnint.2023.1229949","DOIUrl":"https://doi.org/10.3389/fnint.2023.1229949","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fnint.2022.1054627.].</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"17 ","pages":"1229949"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9921040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}