Frontiers in Integrative Neuroscience最新文献

{"title":"Synergistic efficacy of combined neurolysis and methylcobalamin in peripheral nerve injury: a randomized clinical trial.","authors":"Xuwei Hu, Zuoshi Li","doi":"10.3389/fnint.2026.1747898","DOIUrl":"https://doi.org/10.3389/fnint.2026.1747898","url":null,"abstract":"<p><strong>Introduction: </strong>Peripheral nerve injury (PNI) imposes significant burdens, requiring therapies targeting both mechanical compression and inflammatory pathophysiology. While neurolysis addresses extrinsic compression and methylcobalamin promotes intrinsic nerve repair, their combined potential is underexplored. This study compared the efficacy of neurolysis monotherapy, methylcobalamin monotherapy, and combination therapy across functional, electrophysiological, and inflammatory outcomes in PNI.</p><p><strong>Methods: </strong>Ninety PNI patients were randomized to three groups (<i>n</i> = 30/group): neurolysis alone, methylcobalamin alone (0.5 mg tid), or combination therapy. Outcomes at 60 days comprised functional recovery (Carroll Scale), nerve conduction velocities (MCV, SCV, AMP, LAT), joint mobility (AROM/PROM), pain severity (Global Pain Scale), and serum cytokines (NF-κB, TNF-α, IL-6 via ELISA).</p><p><strong>Results: </strong>The combination group demonstrated significantly higher total therapeutic efficacy (86.67%) compared to neurolysis alone (50.00%) and methylcobalamin alone (53.33%; <i>P</i> < 0.05). All groups showed significant post-treatment improvements in nerve conduction velocities, joint mobility parameters, pain scores, and inflammatory cytokine levels (<i>P</i> < 0.05). However, combination therapy yielded superior outcomes: it produced the greatest improvements in active and passive range of motion, the most significant reductions in pain scores across all assessed domains, and the lowest post-treatment levels of inflammatory cytokines (NF-κB, TNF-α, IL-6; <i>P</i> < 0.05 versus either monotherapy).</p><p><strong>Discussion: </strong>The combination of neurolysis and methylcobalamin synergistically enhances functional recovery, nerve conduction, joint mobility, pain relief, and anti-inflammatory effects in PNI, demonstrating superior clinical efficacy compared to either treatment administered alone.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"20 ","pages":"1747898"},"PeriodicalIF":2.9,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13099820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The nucleus tractus solitarii across vertebrates: developmental origins, comparative organization, and supranuclear modulation in humans.","authors":"Yong-Shin Hong, Young-Seok Park","doi":"10.3389/fnint.2026.1768344","DOIUrl":"https://doi.org/10.3389/fnint.2026.1768344","url":null,"abstract":"<p><p>The nucleus tractus solitarii (NTS) is a highly conserved brainstem structure that has served as a principal hub for visceral sensory integration across vertebrate evolution. While the NTS has long been described as a relay for cardiovascular and respiratory reflexes, recent work increasingly frames it as an integrative node that transforms diverse afferent signals into adaptive, context-sensitive responses. In this review, we synthesize evidence on the developmental origins of the NTS (including contributions from the dorsal alar plate and epibranchial placodes) and its comparative organization across vertebrate taxa. We argue that many interspecies differences are more plausibly interpreted as functional reweighting within a conserved circuit framework-shaped by species-specific respiratory-feeding strategies and ecological demands-rather than as wholesale rewiring of the core network. Within this comparative context, the extensive supranuclear modulation observed in humans is discussed not as biological \"superiority,\" but as layered control that has become particularly prominent in response to human-specific anatomical constraints and behavioral demands, including those associated with speech and complex social interaction. Clinically, we revisit dysphagia, cough hypersensitivity, and nausea/vomiting as manifestations of network-level dysregulation and gating failure rather than isolated breakdowns of single reflex arcs. Finally, we suggest that neuromodulation strategies, including vagus nerve stimulation, may be best conceptualized as delivering patterned afferent input capable of shaping NTS network plasticity, rather than as non-specific electrical activation.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"20 ","pages":"1768344"},"PeriodicalIF":2.9,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Somato-Psychic Pathway: a universal developmental trajectory linking somatic structural-functional integrity, autonomic regulation, and the emergence of mind.","authors":"Boris Živný","doi":"10.3389/fnint.2026.1771123","DOIUrl":"https://doi.org/10.3389/fnint.2026.1771123","url":null,"abstract":"<p><p>The Somato-Psychic Pathway (SPP) is proposed as a universal ontogenetic developmental trajectory through which somatic structural-functional integrity and autonomic regulation shape the emergence and stability of the mind under both physiological and pathological conditions. Integrating insights from developmental neuroscience, evolutionary biology, and clinical neurodevelopment, SPP conceptualizes mental functions as interpretive extensions of bodily and autonomic states rather than as their primary generators. The framework delineates a developmentally constrained directional sequence beginning with somatic organization, proceeding through proprioceptive and interoceptive accuracy, and culminating in autonomic regulation, emotional stability, and cognitive-social maturation. Disruption of this trajectory-most prominently through axial dysfunction, distorted joint-muscle-fascial proprioception, persistent low-grade nociceptive drive, or direct mechanical influences on peripheral autonomic structures-is proposed to lead to Somato-Psychic Autonomic Dysregulation (SPAD), a state characterized by chronically reduced autonomic flexibility and heightened threat responsivity. Prolonged operation of the pathway in this pathological mode gives rise to the clinical phenotype termed Somato-Psychic Syndrome (SPS). The SPP framework emerged from longitudinal clinical observation of disrupted and restituted developmental trajectories, providing a unique ontogenetic perspective on the directionality of neurodevelopmental regulation. By integrating the somatic, autonomic, emotional, and cognitive domains into a single regulatory continuum, SPP offers a biologically grounded model with implications for understanding childhood neurodevelopmental disorders and guiding future therapeutic strategies.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"20 ","pages":"1771123"},"PeriodicalIF":2.9,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12989534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and meta-analysis reveal positive therapeutic effects of music in brain damage rehabilitation.","authors":"Laura Navarro, Nour El Zahraa Mallah, Jacobo Pardo-Seco, Alberto Gómez-Carballa, Sara Pischedda, Wiktor Nowak, Emma Segura, Antoni Rodríguez-Fornells, Federico Martinón-Torres, Antonio Salas","doi":"10.3389/fnint.2026.1720473","DOIUrl":"10.3389/fnint.2026.1720473","url":null,"abstract":"<p><p>Brain damage (BD) caused by stroke, traumatic brain injury (TBI), or neurodegenerative conditions often results in persistent cognitive, motor, and emotional impairments. Music-based interventions (MI) have been explored as adjunctive rehabilitation strategies; however, the evidence remains fragmented. This systematic review and meta-analysis synthesize available research on the effects of MI on functional recovery following BD, due to acquired brain injury (ABI), including both TBI and non-TBI. From a total of 868 publications screened in PubMed, Embase, Scopus, Cochrane Library, Web of Science, and ClinicalTrials.gov, 90 were included, of which 41 met the criteria for quantitative evaluation and meta-analysis, to assess the state-of-the-art of research on music and BD in the fields of neuropsychology and cognitive sciences. The reviewed studies span a range of methodologies, including randomized controlled trials and qualitative research, and incorporate diverse MI strategies, such as active music-making, structured listening, and improvisational techniques. The findings indicate that music supports recovery across motor, cognitive, and, albeit to a lesser extent, communicative and psychosocial domains. The findings suggest beneficial effects of MI, particularly in gait function (<i>z</i> = 3.46, <i>P</i> < 0.01), upper extremity function (<i>z</i> = 6.11, <i>P</i> < 0.01; UEF), communication (<i>z</i> = 3.21, <i>P</i> < 0.01), cognitive rehabilitation (<i>z</i> = 3.29, <i>P</i> < 0.01), and emotional, behavioral, and social outcomes (<i>z</i> = 2.35, <i>P</i> = 0.02); notably, these effects were often supported by consistent statistical significance across multiple subgroup analyses (e.g., gait, UEF). This study highlights the therapeutic potential of music in neurorehabilitation and supports its integration into multidisciplinary treatment programs. Despite these promising findings, methodological heterogeneity, small sample sizes, and short intervention durations limit the generalizability of results. The evidence suggests that music may modulate key neurobiological pathways in BD, supporting its integration into evidence-based neurorehabilitation programs.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"20 ","pages":"1720473"},"PeriodicalIF":2.9,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral rhythmic stimulation as a possible modulator of meningeal lymphatic flow: a regulatory T cell-centered neuroimmune hypothesis of eye movement desensitization and reprocessing.","authors":"Ioulia Milovanov","doi":"10.3389/fnint.2026.1758529","DOIUrl":"https://doi.org/10.3389/fnint.2026.1758529","url":null,"abstract":"<p><p>Eye Movement Desensitization and Reprocessing (EMDR) is an established therapeutic intervention for post-traumatic stress disorder and related conditions, yet its neurobiological mechanisms remain incompletely understood. While prevailing models emphasize cognitive processes such as working memory taxation and memory reconsolidation, these accounts may not fully explain the durability and generalization of therapeutic effects. Here, we propose a hypothesis in which bilateral rhythmic stimulation associated with EMDR modulates neuroimmune interactions through state-dependent changes in autonomic balance and meningeal lymphatic dynamics. Within this framework, regulatory T cells are conceptualized as contributors to baseline neuroimmune tone, influencing microglial activation states, synaptic stability, and network-level regulation. By integrating findings from autonomic physiology, lymphatic biology, and neuroimmunology, this hypothesis generates testable predictions linking behavioral interventions to sustained neural and behavioral outcomes. The model is intended to guide future experimental investigation rather than assert definitive causal pathways.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"20 ","pages":"1758529"},"PeriodicalIF":2.9,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147367287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase-specific postural adjustments in children and adults during a challenging balance task.","authors":"Ludvík Valtr, Lucia Bizovská, Reza Abdollahipour, Bouwien Smits-Engelsman","doi":"10.3389/fnint.2026.1734938","DOIUrl":"https://doi.org/10.3389/fnint.2026.1734938","url":null,"abstract":"<p><strong>Introduction: </strong>Anticipatory postural adjustments (APAs) stabilize the body before voluntary movement. Although present early in life, their refinement continues into adolescence, especially during complex balance tasks.</p><p><strong>Aim: </strong>This study examined developmental differences in APA control between typically developing children (9-12 years) and young adults (19-25 years) during a self-initiated Can Placement Task (CPT).</p><p><strong>Methods: </strong>Thirty children and twenty-two adults performed the CPT while standing on one leg. The task was divided into five phases (quiet stance, stooping, can transfer, straightening up, stabilization). Center of pressure (COP) displacement and velocity in anteroposterior (AP) and mediolateral (ML) directions and vertical ground reaction force (GRF) on the can were measured using dual force platforms. Both discrete outcomes and Statistical Parametric Mapping (SPM) were analyzed.</p><p><strong>Results: </strong>No differences were observed in static balance (Phase I). In dynamic phases, adults showed larger backward COP shifts during stooping, higher normalized COP velocity, and reduced reliance on the can for support compared with children. Children exhibited slower COP adjustments and higher GRF on the can, indicating greater use of external support. SPM revealed group differences mainly during stooping and straightening phases. Adults' faster COP control likely reflects efficient feedforward strategies, while children adopted more conservative, stability-oriented approaches.</p><p><strong>Conclusion: </strong>Children aged 9-12 years can generate APAs but remain less efficient in adapting them to task demands. Phase-specific and SPM analyses revealed subtle developmental differences not evident in static balance. The CPT provides a sensitive framework for assessing postural control and may guide age-appropriate clinical interventions.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"20 ","pages":"1734938"},"PeriodicalIF":2.9,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12953375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conceptualizing the studies of time perception in spinal cord injury.","authors":"Ekaterina D Slovenko, Pavel E Musienko, Olga V Sysoeva","doi":"10.3389/fnint.2026.1711553","DOIUrl":"https://doi.org/10.3389/fnint.2026.1711553","url":null,"abstract":"","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"20 ","pages":"1711553"},"PeriodicalIF":2.9,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12946141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation in chronic pain: a systematic review of randomized clinical trials.","authors":"Luciano Maia Alves Ferreira, Ana Beatriz Cabral Oliveira, Jose João Baltazar Mendes, Gabrielle Vitoria Costa, Izadora Reis Silva, Gabrielly Nogueira Santos, Gabrielly Santos Pereira, Marcelo Lourenço Silva","doi":"10.3389/fnint.2026.1717372","DOIUrl":"https://doi.org/10.3389/fnint.2026.1717372","url":null,"abstract":"<p><strong>Introduction: </strong>Photobiomodulation (PBM) stands out as a promising therapeutic alternative for the management of chronic pain, but there is still controversy regarding its efficacy and safety, given the diversity of protocols and populations evaluated.</p><p><strong>Objectives: </strong>To critically review the available literature on the use of PBM in adults with chronic pain conditions, synthesizing the evidence on analgesic and functional effects, impact on quality of life, and safety profile. Methods: A systematic search was conducted in PubMed, Embase, Scopus, LILACS, and MEDLINE, including articles published between September 2015 and September 2025. Randomized clinical trials that compared PBM protocols to placebo, sham, or conventional care were selected. The outcomes investigated included pain intensity (primary), function, quality of life, and occurrence of adverse events (secondary).</p><p><strong>Results: </strong>Fourteen studies were included, covering populations with fibromyalgia, peripheral neuropathies, orofacial pain, and musculoskeletal pain. Most trials demonstrated significant pain reduction with PBM, particularly in fibromyalgia and neuropathy. In some studies, functional gains and improved quality of life were observed. The incidence of adverse events was low, reinforcing the method's safety, although the heterogeneity of technical parameters compromises the standardization of results.</p><p><strong>Conclusion: </strong>PBM has analgesic potential and a safe profile for managing chronic pain, especially in cases difficult to control with conventional therapies. However, the variability of clinical parameters and limited follow-up still hinder more comprehensive recommendations. Additional multicenter studies with standardized protocols are needed to consolidate clinical guidelines.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD420251140711, Identifier: CRD420251140711.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"20 ","pages":"1717372"},"PeriodicalIF":2.9,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12909510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Agency in posttraumatic stress disorder: theoretical approach and therapeutic perspectives.","authors":"Vladimir Adrien, Marion Trousselard, Félix Schoeller","doi":"10.3389/fnint.2026.1785574","DOIUrl":"https://doi.org/10.3389/fnint.2026.1785574","url":null,"abstract":"","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"20 ","pages":"1785574"},"PeriodicalIF":2.9,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12907341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kiperin Mind Focus supplement mitigates chronic stress-induced neuroinflammation and molecular dysregulation and improves stress-related affective and exploratory behaviors in rats.","authors":"Lutfiye Karcioglu Batur, Cuneyd Yavas, Aysu Kilic, Tunay Dogan, Mert Yilmaz, Ahsen Pektas, Huri Demirci, Savas Ustunova","doi":"10.3389/fnint.2025.1745274","DOIUrl":"10.3389/fnint.2025.1745274","url":null,"abstract":"<p><strong>Background: </strong>Chronic stress is known to impair emotional regulation and adaptive behavioral responses through neuroinflammatory activation, oxidative imbalance, and dysregulation of neuroplasticity-related genes. Kiperin Mind Focus, a nootropic nutraceutical containing L-theanine, citicoline, phosphatidylserine, <i>Rhodiola rosea, Ginkgo biloba</i>, caffeine, and Lion's Mane mushroom extract has been formulated to support stress resilience, mood regulation and neural health. This study aimed to investigate the neuroprotective and neuroregulatory effects of the combined formulation on behavioral, biochemical, histopathological, and molecular parameters in rats exposed to chronic unpredictable mild stress (CUMS).</p><p><strong>Methods: </strong>Thirty-two adult male Wistar rats were randomized into four groups (<i>n</i> = 8): Control, Stress, Kiperin Mind Focus (MF), and Stress + Mind Focus (SMF). CUMS was applied for 45 days, and the combined formulation was administered by oral gavage (130 mg/kg/day). Behavioral outcomes were evaluated using the sucrose preference (SPT), open field (OFT), elevated plus maze (EPM), and forced swim (FST) tests. Serum and tissue cytokine levels (<i>IL-1</i>β<i>, IL-6, IL-10, TNF</i>-α) and oxidative stress index (TOS/TAS ratio) were measured. Hippocampal and prefrontal gene expression of <i>FOS, DBH, NMB, BDNF, CREB1, GRIN2A</i>, and <i>GABRB1</i> was assessed via qPCR, and histopathological changes were semi-quantitatively scored.</p><p><strong>Results: </strong>Chronic stress induced anhedonia, anxiety-like behavior, and behavioral despair, accompanied by elevated proinflammatory cytokines, oxidative imbalance, and neuronal degeneration in the hippocampus and prefrontal cortex. The supplementation significantly improved SPT, OFT, EPM, and FST performance, normalized cytokine and oxidative parameters, and reduced neuronal injury scores. At the molecular level, supplementation attenuated stress-induced upregulation of <i>FOS</i>, <i>DBH</i>, and <i>NMB</i> while maintaining neurotrophic (<i>BDNF</i>, <i>CREB1</i>) and GABAergic (<i>GABRB1</i>) expression near control levels.</p><p><strong>Conclusion: </strong>Kiperin Mind Focus exerted robust neuroprotective, anti-inflammatory, and antioxidant effects under chronic stress, restoring molecular homeostasis and stabilizing stress-related behavioral outcomes. These findings support its role as a stress-buffering and mood-stabilizing supplement, that promotes emotional regulation and adaptive exploratory behavior under prolonged stress conditions.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"19 ","pages":"1745274"},"PeriodicalIF":2.9,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12894388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}