Frontiers in Integrative Neuroscience最新文献

{"title":"Case Report: Clinical features and management of anti-mGluR1 encephalitis: case illustration and review of the literature.","authors":"Min Deng, Jing Xiong, Zhaohong Kong, Xufeng Wang, Tao Li","doi":"10.3389/fnint.2025.1580767","DOIUrl":"10.3389/fnint.2025.1580767","url":null,"abstract":"<p><strong>Background: </strong>Anti-metabotropic glutamate receptor 1 (mGluR1) encephalitis is a rare autoimmune disease affecting cerebellar Purkinje cells. Only thirty-nine cases have been reported globally, with inconsistent documentation of treatments and outcomes. A systematic review is needed to identify prognostic factors and expand clinical understanding and treatment options.</p><p><strong>Methods: </strong>Observational follow-up data of anti-mGluR1 encephalitis cases were collected. All anti-mGluR1 encephalitis cases published in the PubMed and Google Scholar databases in English before November 1, 2024 were included. Clinical information and possible predictive factors from both current and previously reported cases were statistically analyzed.</p><p><strong>Results: </strong>We present a case of anti-mGluR1 encephalitis successfully treated with ofatumumab. During the patient's initial episode, she partially recovered after first-line treatment. She experienced a relapse 6 months later and was treated with ofatumumab, resulting in complete recovery. Forty cases of anti-mGluR1 encephalitis, including our case, were summarized. The prevalence was similar between men and women, with 50% of patients aged 40-59 years. The most common clinical manifestations were ataxia and dysarthria. Cerebrospinal fluid analysis showed normal white blood cell count and IgG index in 37.1% of patients. Almost half of the patients (48.6%) exhibited cerebellar atrophy on cerebral MRI scans at initial presentation or during follow-up. Only 25% of patients recovered completely. According to the modified Rankin Scale (mRS) scores at the last follow-up, patients with poor outcome (<i>n</i> = 13, 32.5%) had a lower proportion of first-line immunotherapy (62%, <i>P</i> = 0.017) and a longer follow-up time (median 36 months, <i>P</i> = 0.038).</p><p><strong>Conclusion: </strong>The peak incidence of anti-mGluR1 encephalitis occurs between ages of 40-59 years. More than one-third of patients have normal cell counts and IgG index in the cerebrospinal fluid. Therefore, patients suspected of having this encephalitis should be tested for the presence of anti-mGluR1 antibodies in serum and cerebrospinal fluid. Notably, the first-line immunotherapy may be a critical factor influencing clinical outcomes.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"19 ","pages":"1580767"},"PeriodicalIF":2.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Mind-body medicine and its impacts on psychological networks, quality of life, and health, Volume II.","authors":"Steffen Schulz, Dirk Cysarz, Frauke Musial, Georg Seifert","doi":"10.3389/fnint.2025.1658381","DOIUrl":"10.3389/fnint.2025.1658381","url":null,"abstract":"","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"19 ","pages":"1658381"},"PeriodicalIF":2.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CCL4L2 is a potential biomarker for differentiating central and peripheral vertigo.","authors":"Xia Hong, Yuan Li, Chenjuan Tao, Gaofeng Wang","doi":"10.3389/fnint.2025.1620845","DOIUrl":"10.3389/fnint.2025.1620845","url":null,"abstract":"<p><strong>Background: </strong>Central vertigo and peripheral vertigo are common clinical conditions with different underlying pathophysiologies. The identification of reliable biomarkers for differential diagnosis remains a challenge.</p><p><strong>Objectives: </strong>This study aimed to explore the differential expression of CCL4L2 in the serum of patients with central and peripheral vertigo and assess its diagnostic potential.</p><p><strong>Methods: </strong>A total of 180 patients (90 central vertigo, 90 peripheral vertigo) were enrolled. RNA sequencing was on serum samples to identify differentially expressed genes (DEGs). Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis revealed relevant biological pathways. The expression of CCL4L2 was measured using RT-qPCR, and its diagnostic performance was evaluated by Receiver operating characteristic (ROC) curve analysis. The correlation between CCL4L2 expression and biomarkers NSE and S100β was also assessed.</p><p><strong>Results: </strong>RNA sequencing revealed significant differences in gene expression between central vertigo and peripheral vertigo groups. The KEGG pathway analysis identified several enriched pathways, including NF-κB signaling, where CCL4L2 was a key gene. CCL4L2 expression was significantly higher in the CV group compared to the PV group (<i>p</i> < 0.001). ROC analysis demonstrated high diagnostic accuracy for CCL4L2 in distinguishing CV from PV (AUC = 0.909, <i>p</i> < 0.001). Additionally, moderate positive correlations were observed between CCL4L2 and NSE (r = 0.475, <i>p</i> < 0.001), and a weaker correlation with S100β (r = 0.364, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>CCL4L2 may serve as a potential biomarker for differentiating central from peripheral vertigo. Its expression is closely associated with inflammatory pathways, making it a promising target for further investigation in vertigo diagnostics.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"19 ","pages":"1620845"},"PeriodicalIF":2.9,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The gut and heart's role in reward processing.","authors":"Minel Arinel, Karim Abdelaal","doi":"10.3389/fnint.2025.1479923","DOIUrl":"10.3389/fnint.2025.1479923","url":null,"abstract":"<p><p>Reward processing, which ensures survival, has evolved to also shape emotions, learning, and overall well-being. While traditional models of reward have focused predominantly on central neural circuits, emerging evidence underscores the role of peripheral bodily signals. This represents a new opportunity by which we may understand neurological and neuropsychiatric health. In this review, we explore the gut-brain and heart-brain interfaces in reward processing, delineating their contributions across distinct phases of reward and offering insights into their bioenergetic significance. By framing this interplay within an adaptive and clinical context, we propose new avenues for understanding and treating neuropsychiatric disorders through a mind-body medicine lens.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"19 ","pages":"1479923"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Autism: the movement (sensing) perspective a decade later.","authors":"Elizabeth B Torres, Brittany G Travers, Jonathan T Delafield-Butt, Ashok Srinivasan","doi":"10.3389/fnint.2025.1634265","DOIUrl":"https://doi.org/10.3389/fnint.2025.1634265","url":null,"abstract":"","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"19 ","pages":"1634265"},"PeriodicalIF":2.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations and procedures for acquiring EEG as part of multi-site studies for Rett syndrome and other genetic neurodevelopmental disorders.","authors":"Joni N Saby, Eric D Marsh","doi":"10.3389/fnint.2025.1574758","DOIUrl":"10.3389/fnint.2025.1574758","url":null,"abstract":"<p><p>There is increasing interest in the utility of electrophysiological measures such as resting EEG and evoked potential (EPs) to serve as biomarkers to facilitate therapeutic development for rare genetic neurodevelopmental disorders (NDDs). Research on this topic thus far has been encouraging, but has also revealed the necessity for unique methods when acquiring EEG and EPs in children with genetic NDDs. Details of these methods are typically beyond the scope of research publications, yet are crucial to the quality and ultimately, usability of the data. In the current manuscript, we detail the methods that we have developed for acquiring EEG and EPs as part of multi-site studies with participants with Rett syndrome, CDKL5 deficiency disorder, MECP2 duplication syndrome, and FOXG1 syndrome. By making our methods accessible, we hope to support other groups interested in acquiring EEG and/or EPs as part of clinical trials or research studies with individuals with genetic NDDs, including groups without prior experience with EEG/EP acquisition. The paper is presented as step-by-step procedures followed by a discussion of issues that may arise during acquisition and ways to troubleshoot these issues. We then discuss considerations for choosing EEG equipment and study paradigms and briefly, considerations for data analysis.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"19 ","pages":"1574758"},"PeriodicalIF":2.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: The primate's sensorimotor system and its relationship with emotion, cognition, and decision-making.","authors":"Luciano Simone, Marzio Gerbella, Luca Fornia","doi":"10.3389/fnint.2025.1629851","DOIUrl":"10.3389/fnint.2025.1629851","url":null,"abstract":"","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"19 ","pages":"1629851"},"PeriodicalIF":2.6,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: The role, and underlying neural mechanisms of, physical activity in treating substance and alcohol use disorders.","authors":"Kolter B Grigsby, Zaynah S Usmani, Christina J Perry, Angela R Ozburn","doi":"10.3389/fnint.2025.1589088","DOIUrl":"10.3389/fnint.2025.1589088","url":null,"abstract":"","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"19 ","pages":"1589088"},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auditory evoked neuromagnetic response latency is associated with language ability in preschoolers with an elevated likelihood of intellectual or developmental disability.","authors":"Yuhan Chen, Lauren Young, Mina Kim, Shannon Watson, Victoria Kaufman, Bethany Beal, Ilona Tuomi, Bekah Wang, Donna M McDonald-McGinn, J Christopher Edgar, Emily S Kuschner, Timothy P L Roberts","doi":"10.3389/fnint.2025.1585567","DOIUrl":"10.3389/fnint.2025.1585567","url":null,"abstract":"<p><strong>Introduction: </strong>We have shown that a delayed auditory cortex neural response is associated with language ability in school-age children with autism spectrum disorder and related syndromes, with this delay exacerbated in the context of co-occurring intellectual disability (ID). As a clinical diagnosis of ID is generally not made until school age, identification of neural measures that precede a behaviorally assessed ID diagnosis would help identify young children likely to benefit from early treatment. The present study evaluated if the speed of auditory cortex neural activity (M50 latency) would predict language ability in 3-year-old children who have an existing diagnosis that is a risk factor associated with a range of later functional outcomes, including ID or developmental delay (DD), irrespective of autism spectrum disorder diagnosis.</p><p><strong>Methods: </strong>Thirty 3-year-old children with elevated likelihood for ID or DD (ID/DD-EL) were enrolled. Evaluable magnetoencephalography (MEG) data as well as language and cognitive ability measures were obtained from 23 participants.</p><p><strong>Results: </strong>A longer time to encode auditory stimuli (i.e., a delayed M50 cortical evoked response) in the left hemisphere predicted lower language ability. Left M50 latency was not associated with cognitive ability. Right hemisphere M50 latency was not associated with language or cognitive ability.</p><p><strong>Discussion: </strong>Present observations demonstrate that non-invasive brain imaging in conjunction with a passive auditory task (with early primary/secondary auditory cortex neural responses) can identify paths for variable language outcome in preschool children with ID/DD-EL. This lays the foundation for further investigation of these neural mechanisms as early indications for treatment as well as early signals of response to treatment.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"19 ","pages":"1585567"},"PeriodicalIF":2.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of medication on the rostrolateral prefrontal oxygenation and thalamic volume asymmetry in youths with ADHD.","authors":"Hyuna Kim, Dahyun Kang, Yong Hun Jang, Ja-Hye Ahn, Sojin Won, Hyun Ju Lee, Johanna Inhyang Kim","doi":"10.3389/fnint.2025.1591465","DOIUrl":"10.3389/fnint.2025.1591465","url":null,"abstract":"<p><strong>Introduction: </strong>Symptoms of attention-deficit/hyperactivity disorder (ADHD) are closely associated with impaired executive function. Medication is the first-line treatment for ADHD, yet its effects on brain function and structure remain unclear. To investigate medication-related brain alterations in children with ADHD, we used functional near-infrared spectroscopy, which captures cortical hemodynamic activity, and structural magnetic resonance imaging, which measures subcortical volume.</p><p><strong>Methods: </strong>We investigated the differences in brain hemodynamic activity between 23 children with ADHD taking medication and 22 children who were not taking medication.</p><p><strong>Results: </strong>Compared with the medicated ADHD group, the unmedicated ADHD group showed significantly reduced activation in the left rostrolateral prefrontal cortex (channel 9, <i>p</i> = 0.01; channel 13, <i>p</i> = 0.02) and dorsolateral prefrontal cortex (channel 14, <i>p</i> = 0.01). The unmedicated group also exhibited a negative correlation between oxygenated hemoglobin and symptom severity, whereas the medicated group showed a positive correlation. Furthermore, abnormal asymmetry of the thalamic volume was reduced in the medicated group compared to the unmedicated group.</p><p><strong>Discussion: </strong>These findings suggest that increased prefrontal activation and reduced thalamic asymmetry may reflect medication-related improvements in inhibitory control in children with ADHD.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"19 ","pages":"1591465"},"PeriodicalIF":2.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}