Considerations and procedures for acquiring EEG as part of multi-site studies for Rett syndrome and other genetic neurodevelopmental disorders.

IF 2.6 3区 医学 Q2 BEHAVIORAL SCIENCES
Frontiers in Integrative Neuroscience Pub Date : 2025-06-09 eCollection Date: 2025-01-01 DOI:10.3389/fnint.2025.1574758
Joni N Saby, Eric D Marsh
{"title":"Considerations and procedures for acquiring EEG as part of multi-site studies for Rett syndrome and other genetic neurodevelopmental disorders.","authors":"Joni N Saby, Eric D Marsh","doi":"10.3389/fnint.2025.1574758","DOIUrl":null,"url":null,"abstract":"<p><p>There is increasing interest in the utility of electrophysiological measures such as resting EEG and evoked potential (EPs) to serve as biomarkers to facilitate therapeutic development for rare genetic neurodevelopmental disorders (NDDs). Research on this topic thus far has been encouraging, but has also revealed the necessity for unique methods when acquiring EEG and EPs in children with genetic NDDs. Details of these methods are typically beyond the scope of research publications, yet are crucial to the quality and ultimately, usability of the data. In the current manuscript, we detail the methods that we have developed for acquiring EEG and EPs as part of multi-site studies with participants with Rett syndrome, CDKL5 deficiency disorder, MECP2 duplication syndrome, and FOXG1 syndrome. By making our methods accessible, we hope to support other groups interested in acquiring EEG and/or EPs as part of clinical trials or research studies with individuals with genetic NDDs, including groups without prior experience with EEG/EP acquisition. The paper is presented as step-by-step procedures followed by a discussion of issues that may arise during acquisition and ways to troubleshoot these issues. We then discuss considerations for choosing EEG equipment and study paradigms and briefly, considerations for data analysis.</p>","PeriodicalId":56016,"journal":{"name":"Frontiers in Integrative Neuroscience","volume":"19 ","pages":"1574758"},"PeriodicalIF":2.6000,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183233/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Integrative Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fnint.2025.1574758","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

There is increasing interest in the utility of electrophysiological measures such as resting EEG and evoked potential (EPs) to serve as biomarkers to facilitate therapeutic development for rare genetic neurodevelopmental disorders (NDDs). Research on this topic thus far has been encouraging, but has also revealed the necessity for unique methods when acquiring EEG and EPs in children with genetic NDDs. Details of these methods are typically beyond the scope of research publications, yet are crucial to the quality and ultimately, usability of the data. In the current manuscript, we detail the methods that we have developed for acquiring EEG and EPs as part of multi-site studies with participants with Rett syndrome, CDKL5 deficiency disorder, MECP2 duplication syndrome, and FOXG1 syndrome. By making our methods accessible, we hope to support other groups interested in acquiring EEG and/or EPs as part of clinical trials or research studies with individuals with genetic NDDs, including groups without prior experience with EEG/EP acquisition. The paper is presented as step-by-step procedures followed by a discussion of issues that may arise during acquisition and ways to troubleshoot these issues. We then discuss considerations for choosing EEG equipment and study paradigms and briefly, considerations for data analysis.

作为Rett综合征和其他遗传性神经发育障碍多位点研究的一部分,获取脑电图的考虑和程序。
人们对静息脑电图和诱发电位(EPs)等电生理指标的应用越来越感兴趣,这些指标可作为生物标志物,促进罕见遗传性神经发育障碍(ndd)的治疗发展。迄今为止,关于这一主题的研究令人鼓舞,但也揭示了在遗传性ndd儿童中获取脑电图和EPs时需要独特方法的必要性。这些方法的细节通常超出了研究出版物的范围,但对数据的质量和最终的可用性至关重要。在当前的手稿中,我们详细介绍了我们开发的用于获取EEG和EPs的方法,作为Rett综合征,CDKL5缺乏症,MECP2重复综合征和FOXG1综合征参与者的多位点研究的一部分。通过使我们的方法易于获取,我们希望支持其他有兴趣获取EEG和/或EP的群体,作为对遗传ndd个体的临床试验或研究的一部分,包括之前没有EEG/EP获取经验的群体。本文以一步一步的程序呈现,随后讨论了在收购过程中可能出现的问题以及解决这些问题的方法。然后,我们讨论了选择EEG设备和研究范式的考虑因素,并简要地讨论了数据分析的考虑因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Frontiers in Integrative Neuroscience
Frontiers in Integrative Neuroscience Neuroscience-Cellular and Molecular Neuroscience
CiteScore
4.60
自引率
2.90%
发文量
148
审稿时长
14 weeks
期刊介绍: Frontiers in Integrative Neuroscience publishes rigorously peer-reviewed research that synthesizes multiple facets of brain structure and function, to better understand how multiple diverse functions are integrated to produce complex behaviors. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Our goal is to publish research related to furthering the understanding of the integrative mechanisms underlying brain functioning across one or more interacting levels of neural organization. In most real life experiences, sensory inputs from several modalities converge and interact in a manner that influences perception and actions generating purposeful and social behaviors. The journal is therefore focused on the primary questions of how multiple sensory, cognitive and emotional processes merge to produce coordinated complex behavior. It is questions such as this that cannot be answered at a single level – an ion channel, a neuron or a synapse – that we wish to focus on. In Frontiers in Integrative Neuroscience we welcome in vitro or in vivo investigations across the molecular, cellular, and systems and behavioral level. Research in any species and at any stage of development and aging that are focused at understanding integration mechanisms underlying emergent properties of the brain and behavior are welcome.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信