Hyuna Kim, Dahyun Kang, Yong Hun Jang, Ja-Hye Ahn, Sojin Won, Hyun Ju Lee, Johanna Inhyang Kim
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引用次数: 0
Abstract
Introduction: Symptoms of attention-deficit/hyperactivity disorder (ADHD) are closely associated with impaired executive function. Medication is the first-line treatment for ADHD, yet its effects on brain function and structure remain unclear. To investigate medication-related brain alterations in children with ADHD, we used functional near-infrared spectroscopy, which captures cortical hemodynamic activity, and structural magnetic resonance imaging, which measures subcortical volume.
Methods: We investigated the differences in brain hemodynamic activity between 23 children with ADHD taking medication and 22 children who were not taking medication.
Results: Compared with the medicated ADHD group, the unmedicated ADHD group showed significantly reduced activation in the left rostrolateral prefrontal cortex (channel 9, p = 0.01; channel 13, p = 0.02) and dorsolateral prefrontal cortex (channel 14, p = 0.01). The unmedicated group also exhibited a negative correlation between oxygenated hemoglobin and symptom severity, whereas the medicated group showed a positive correlation. Furthermore, abnormal asymmetry of the thalamic volume was reduced in the medicated group compared to the unmedicated group.
Discussion: These findings suggest that increased prefrontal activation and reduced thalamic asymmetry may reflect medication-related improvements in inhibitory control in children with ADHD.
期刊介绍：
Frontiers in Integrative Neuroscience publishes rigorously peer-reviewed research that synthesizes multiple facets of brain structure and function, to better understand how multiple diverse functions are integrated to produce complex behaviors. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
Our goal is to publish research related to furthering the understanding of the integrative mechanisms underlying brain functioning across one or more interacting levels of neural organization. In most real life experiences, sensory inputs from several modalities converge and interact in a manner that influences perception and actions generating purposeful and social behaviors. The journal is therefore focused on the primary questions of how multiple sensory, cognitive and emotional processes merge to produce coordinated complex behavior. It is questions such as this that cannot be answered at a single level – an ion channel, a neuron or a synapse – that we wish to focus on. In Frontiers in Integrative Neuroscience we welcome in vitro or in vivo investigations across the molecular, cellular, and systems and behavioral level. Research in any species and at any stage of development and aging that are focused at understanding integration mechanisms underlying emergent properties of the brain and behavior are welcome.
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